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Prof

William Heath

Professor
Microbiology And Immunology
science & technology
life sciences & biomedicine
animals
mice
immunology
dendritic cells
mice, transgenic
mice, inbred c57bl
cd8-positive t-lymphocytes
William Heath's Profile Picture
Prof

William Heath

 
Division
Medicine, Dentistry And Health Sciences
William Heath's Profile Picture
Prof

William Heath

 

Projects

Displaying the 39 most recent projects by William Heath.

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A Cellular Hub For The Organisation Of T Cell Priming

This project aims to delineate the cellular interactions involved in the initiation of immune responses by utilising advanced in vivo imagin..

2019 - 2021
Active
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Testing Vironova Herpes Ab Antiviral Formulations

2018 - 2020
Completed
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Testing Oligos For Induction Of Liver Trm

2017 - 2017
Completed
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Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
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Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
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Targeting Antigen To Clec9a On Dendritic Cell For Humoral Immunity

Dendritic cells capture infectious organisms and display them to other immune cells to initiate immunity. The process of capturing organisms..

2017 - 2019
Completed
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Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
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Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
Project icon

Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
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Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
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Novel Peptide Vaccines For Broad Application

2016 - 2022
Active
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Comparing Vironova Drug Treatment For Hsv Infections To Current Best Available Treatment

2016 - 2017
Completed
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Characterization And Prevention Of “Stunning”, A Cytotoxic T Lymphocyte Inactivating Program That Impairs Adoptive Cell Therapy Against Cancer

2016 - 2018
Completed
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Single Molecule Imaging Laboratory - UOM Contribution (Non-Lead Lief 2015)

The goal of the project is to establish a single molecule imaging laboratory to close the gap between structural imaging and cellular imagin..

2015 - 2015
Completed
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ARC Centre Of Excellence For Advanced Molecular Imaging

2014 - 2020
Active
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ARC Centre Of Excellence For Advanced Molecular Imaging

The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex mol..

2014 - 2020
Active
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ARC Centre Of Excellence For Advanced Molecular Imaging

The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex mol..

2014 - 2020
Active
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ARC Centre Of Excellence For Advanced Molecular Imaging

2014 - 2020
Active
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ARC Centre Of Excellence For Advanced Molecular Imaging

The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex mol..

2014 - 2020
Active
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ARC Centre Of Excellence For Advanced Molecular Imaging

2014 - 2020
Active
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An Advanced In Vivo Imaging Facility

This project will establish an advanced In Vivo Imaging Facility (IVIF) for examining host-microbe interactions and associated immunological..

2014 - 2015
Completed
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An Advanced In Vivo Imaging Facility

This project will establish an advanced In Vivo Imaging Facility (IVIF) for examining host-microbe interactions and associated immunological..

2014 - 2015
Completed
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Harnessing Dendritic Cells For Immunotherapy

Potent vaccination might be achieved by using monoclonal antibodies as magic bullets to target vaccines to special cells in the body. We sho..

2014 - 2016
Completed
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Immunity To Intracellular Infections

This immune system provides our body’s defense against invading organisms like viruses, preventing disease and maintaining health. Immunity ..

2014 - 2018
Completed
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Defining The Immune Properties Of Killer T Cells Resident In Organs

Infections induce immune cells that are thought to recirculate through the blood. Recently, we discovered a population of immune cells that ..

2013 - 2015
Completed
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Imaging Of T Cell Responses To Malaria Infection

2012 - 2013
Completed
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Antigen Presentation Recognition And The Immune System

This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techn..

2012 - 2016
Completed
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Antigen Presentation Recognition And The Immune System

This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techn..

2012 - 2016
Completed
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An Advanced Flow Cytometry Facility For The Peter Doherty Institute

The establishment of a flow cytometry facility in the new Peter Doherty Institute for Infection and Immunity will enhance capacity to invest..

2011 - 2012
Completed
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A Dendritic Cell Subset Targeting Approach For Generating Humoral Immunity

Potent vaccination might be achieved by using monoclonal antibodies as magic bullets to target vaccines to special cells in the body. We sho..

2011 - 2013
Completed
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Advanced Fluorescence Imaging Facility: From Super High Resolution To Whole Animal Imaging

The establishment of this advanced fluorescence imaging facility will provide cutting-edge infrastructure to examine cells, pathogens and in..

2011 - 2012
Completed
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Dendritic Cell Targetting Antibodies

2010
Active
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Dendritic Cell Subsets And T Cell Immunity To Blood Stage Malaria Infection

2008 - 2010
Completed
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NHMRC Research Fellowship 2007 - Heath

I am an cellular immunologist determining the mechanisms by which immunity to foreign organisms is generated, how tolerance to self tissues ..

2008 - 2011
Completed
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A Dendritic Cell Subset Targeting Approach For Defining Immune Function And Tailoring Immunotherapy

Dendritic cells are important sentinel cells of the immune system that orchestrate our immune responses against invading pathogens. There ar..

2008 - 2010
Completed
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In Vivo Imaging Of The Immune System In Self Tolerance And Infectious Disease

This proposal will introduce sophisticated imaging technology into our cutting-edge research program. Our approach will permit high resoluti..

2008 - 2013
Completed
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2007 Program Grant - (Antigen Presentation, Recognition And The Immune Response)

The early events in immunity require various molecular interactions. We will examine the structural and biophysical basis for some of these ..

2007 - 2011
Completed
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Antigen Presentation, Recognition And The Immune Response

nan

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Multi-Photon Imaging For Infection, Immunity, And Self Recognition

This proposal will address a gap in our imaging capabilities, allowing us to visualise the movement of immune cells and infectious agents su..

39

Projects

Project Types

30

Research Grant

5

Research Contracts

4

Internal Research Grant

Scholarly Works

Displaying the 265 most recent scholarly works by William Heath.

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A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  Cell Host & Microbe

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

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Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria

Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.

Journal article  |  2020  |  Science Immunology

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..

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Raster adaptive optics for video rate aberration correction and large FOV multiphoton imaging

Yongxiao Li, Yean J Lim, Qiongkai Xu, Lynette Beattie, Elizabeth E Gardiner, Katharina Gaus, William R Heath, Woei Ming Lee

Journal article  |  2020  |  Biomedical Optics Express

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Visualizing MHC-II restricted response to rodent malaria.

M Enders, L Beattie, D Fernandez Ruiz, E Mass, WR Heath

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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Antigen presentation by dendritic cells for B cell activation

William R Heath, Yu Kato, Thiago M Steiner, Irina Caminschi

Journal article  |  2019  |  Current Opinion in Immunology

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Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection

Christopher M Harpur, Yu Kato, Shinta T Dewi, Sanda Stankovic, Darryl N Johnson, Sammy Bedoui, Paul G Whitney, Mireille H Lahoud, Irina Caminschi, William R Heath, Andrew G Brooks, Thomas Gebhardt

Journal article  |  2019  |  The Journal of Immunology

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CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz, Julia E Prier, David Freestone, Thiago M Steiner, Kieran English, Darryl N Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M Davey, Dale Godfrey, Katsuyuki Yui, Laura K Mackay, Mireille H Lahoud, Irina Caminschi, Geoffrey McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R Heath

Journal article  |  2018  |  Cell Reports

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Cerebral Malaria in Mouse and Man

Nazanin Ghazanfari, Scott N Mueller, William R Heath

Journal article  |  2018  |  Frontiers in Immunology

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Rational design of cancer vaccines by targeting dendritic cells

F Esselborn, J Li, F Ahmet, JM Nickson, PS Tan, P Faridi, AW Purcell, MH Lahoud, WR Heath, I Caminschi

Conference Proceedings  |  2018  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection

Kylie R James, Megan SF Soon, Ismail Sebina, Daniel Fernandez-Ruiz, Gayle Davey, Urijah N Liligeto, Arya Sheela Nair, Lily G Fogg, Chelsea L Edwards, Shannon E Best, Lianne IM Lansink, Kate Schroder, Jane AC Wilson, Rebecca Austin, Andreas Suhrbier, Steven W Lane, Geoffrey R Hill, Christian R Engwerda, William R Heath, Ashraful Haque

Journal article  |  2018  |  The Journal of Immunology

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Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells

Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui

Journal article  |  2018  |  Journal of Virology

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Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay

Journal article  |  2018  |  Nature Immunology

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Development of a Novel CD4( ) TCR Transgenic Line That Reveals a Dominant Role for CD8( ) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M Jones, Wei Yi Ng, Gayle M Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Matthias H Enders, Ganchimeg Bayarsaikhan, Sanne H Hendriks, Lianne IM Lansink, Jessica A Engel, Megan SF Soon, Kylie R James, Anton Cozijnsen, Vanessa Mollard, Alessandro D Uboldi, Christopher J Tonkin, et al.

Journal article  |  2017  |  The Journal of Immunology

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Migratory CD11b( ) conventional dendritic cells induce T follicular helper cell-dependent antibody responses

Jayendra Kumar Krishnaswamy, Uthaman Gowthaman, Biyan Zhang, Johan Mattsson, Louis Szeponik, Dong Liu, Renee Wu, Theresa White, Samuele Calabro, Lan Xu, Magalie A Collet, Marina Yurieva, Samuel Alsen, Per Fogelstrand, Anne Walter, William R Heath, Scott N Mueller, Ulf Yrlid, Adam Williams, Stephanie C Eisenbarth

Journal article  |  2017  |  Science Immunology

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Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation

Ali Zaid, Jyh Liang Hor, Susan N Christo, Joanna R Groom, William R Heath, Laura K Mackay, Scott N Mueller

Journal article  |  2017  |  The Journal of Immunology

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A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

Frederic Sierro, Maximilien Evrard, Simone Rizzetto, Michelle Melino, Andrew J Mitchell, Manuela Florido, Lynette Beattie, Shaun B Walters, Szun Szun Tay, Bo Lu, Lauren E Holz, Ben Roediger, Yik Chun Wong, Alessandra Warren, William Ritchie, Claire McGuffog, Wolfgang Weninger, David G Le Couteur, Florent Ginhoux, Warwick J Britton, et al.

Journal article  |  2017  |  Immunity

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Resident memory CD8( ) T cells in the upper respiratory tract prevent pulmonary influenza virus infection

Angela Pizzolla, Thi HO Nguyen, Jeffrey M Smith, Andrew G Brooks, Katherine Kedzierska, William R Heath, Patrick C Reading, Linda M Wakim

Journal article  |  2017  |  SCIENCE IMMUNOLOGY

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Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves T(H)1/T-FH fate bifurcation in malaria

Tapio Lonnberg, Valentine Svensson, Kylie R James, Daniel Fernandez-Ruiz, Ismail Sebina, Ruddy Montandon, Megan SF Soon, Lily G Fogg, Arya Sheela Nair, Urijah N Liligeto, Michael JT Stubbington, Lam-Ha Ly, Frederik Otzen Bagger, Max Zwiessele, Neil D Lawrence, Fernando Souza-Fonseca-Guimaraes, Patrick T Bunn, Christian R Engwerda, William R Heath, Oliver Billker, et al.

Journal article  |  2017  |  Science Immunology

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Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids

HA McNamara, Y Cai, MV Wagle, Y Sontani, CM Roots, LA Miosge, JH O'Connor, HJ Sutton, VV Ganusov, WR Heath, P Bertolino, CG Goodnow, IA Parish, A Enders, IA Cockburn

Journal article  |  2017  |  Science Immunology

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Neutrophils are dispensable in the modulation of T cell immunity against cutaneous HSV-1 infection

Jyh Liang Hor, William R Heath, Scott N Mueller

Journal article  |  2017  |  Scientific Reports

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Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

Julia L Gregory, Anne Walter, Yannick O Alexandre, Jyh Liang Hor, Ruijie Liu, Joel Z Ma, Sapna Devi, Nobuko Tokuda, Yuji Owada, Laura K Mackay, Gordon K Smyth, William R Heath, Scott N Mueller

Journal article  |  2017  |  Cell Reports

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CD14 is not involved in the uptake of synthetic CpG oligonucleotides

Jessica Li, Fatma Ahmet, Meredith O'Keeffe, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2017  |  Molecular Immunology

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Dynamic control over field of view in polygon mirror-based laser scanning multiphoton microscope

Y Li, HM Huang, G Burgio, W Heath, WM Lee

Conference Proceedings  |  2017  |  Optics in the Life Sciences Congress

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LIVER-RESIDENT MEMORY T CELLS CAN BE HARNESSED FOR UNPRECEDENTED PROTECTION AGAINST MALARIA

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren Holz, Anton Cozijnsen, Vanessa Mollard, Roghieh Skandari, Jonathan H Manton, Szun Szun Tay, David G Bowen, Friedrich Koch-Nolte, Bjorn Rissiek, Francis R Carbone, Brendan S Crabb, Scott N Mueller, Patrick Bertolino, Geoffrey I McFadden, Irina Caminschi, William R Heath

Conference Proceedings  |  2017  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

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Liver-Resident Memory CD8( ) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren E Holz, Joel Z Ma, Ali Zaid, Yik Chun Wong, Lei Shong Lau, Vanessa Mollard, Anton Cozijnsen, Nicholas Collins, Jessica Li, Gayle M Davey, Yu Kato, Sapna Devi, Roghieh Skandari, Michael Pauley, Jonathan H Manton, Dale I Godfrey, Asolina Braun, Szun Szun Tay, et al.

Journal article  |  2016  |  Immunity

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Protective immunity to liver-stage malaria

Lauren E Holz, Daniel Fernandez-Ruiz, William R Heath

Journal article  |  2016  |  Clinical & Translational Immunology

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Temporal mixture modelling of single-cell RNA-seq data resolves a CD4 T cell fate bifurcation

Tapio Lönnberg, Valentine Svensson, Kylie James, Daniel Fernandez-Ruiz, Ismail Sebina, Ruddy Montandon, Megan Soon, Lily Fogg, Michael Stubbington, Frederik Otzen Bagger, Max Zwiessele, Neil Lawrence, Fernando Souza-Fonseca-Guimaraes, William Heath, Oliver Billker, Oliver Stegle, Ashraful Haque, Sarah Teichmann

Journal article  |  2016

Abstract Differentiation of naïve CD4 + T cells into functionally distinct T helper subsets is crucial for the orchestration of im..

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Spatiotemporally distinct interactions with DC subsets facilitates CD4 and CD8 T cell activation to localized viral infection

JL Hor, PG Whitney, A Zaid, AG Brooks, WR Heath, SN Mueller

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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Single-cell RNA-sequencing resolves Th1-Tfh bifurcation

T Lonnberg, KR James, V Svensson, D Fernandez-Ruiz, I Sebina, R Montandon, M Soon, MJT Stubbington, F Souza-Fonseca-Guimaraes, WR Heath, O Billker, A Haque, SA Teichmann

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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Whole organ imaging for analysis of immune responses in lymph nodes

S Devi, JL Hor, JK Loi, WR Heath, SN Mueller

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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T cell help amplifies innate signals in CD8 DC for optimal CD8 T cell priming

M Greyer, PG Whitney, AT Stock, GM Davey, C Tebartz, A Bachem, JD Mintern, RA Strugnell, SJ Turner, T Gebhardt, M O'Keeffe, WR Heath, S Bedoui

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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Using a "prime-and-trap" vaccine strategy to generate liver TRM and protect mice form malaria liver-stage infection

WY Ng, D Fernandez-Ruiz, J Ma, A Zaid, YC Wong, LS Lau, V Mollard, A Cozijnsen, N Collins, J Li, GM Davey, L Holz, SS Tay, PS Tan, DG Bowen, F Koch-Nolte, R Bjoern, FR Carbone, BS Crabb, M Lahoud, et al.

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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Direct analysis of natural killer T (NKT) cell responses and their interactions with APCs in situ

DN Johnson, JL Hor, A Zaid, DG Pellicci, AP Uldrich, SN Mueller, WR Heath, D Godfrey

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

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CD4( ) T-cell help amplifies innate signals for primary CD8( ) T-cell immunity

Sammy Bedoui, William R Heath, Scott N Mueller

Journal article  |  2016  |  Immunological Reviews

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Single cell analysis of CD4 T cell differentiation reveals three major cell states and progressive acceleration of proliferation (vol 17, 103, 2016)

Valentina Proserpio, Andrea Piccolo, Liora Haim-Vilmovsky, Gozde Kar, Tapio Lonnberg, Valentine Svensson, Jhuma Pramanik, Kedar Nath Natarajan, Weichao Zhai, Xiuwei Zhang, Giacomo Donati, Melis Kayikci, Jurij Kotar, Andrew NJ McKenzie, Ruddy Montandon, Kylie R James, Daniel Fernandez-Ruiz, William R Heath, Ashraful Haque, Oliver Billker, et al.

Journal article  |  2016  |  GENOME BIOLOGY

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Skin CD4( ) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Nicholas Collins, Xiaodong Jiang, Ali Zaid, Bethany L Macleod, Jane Li, Chang Ook Park, Ashraful Haque, Sammy Bedoui, William R Heath, Scott N Mueller, Thomas S Kupper, Thomas Gebhardt, Francis R Carbone

Journal article  |  2016  |  NATURE COMMUNICATIONS

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Resolving T helper cell fate decisions using single-cell RNA-sequencing

Tapio Loennberg, Kylie James, Valentine Svensson, Daniel Fernandez-Ruiz, Ismail Sebina, Ruddy Montandon, Megan Soon, Michael Stubbington, Fernando Souza-Fonseca-Guimaraes, William Heath, Oliver Billker, Ashraful Haque, Sarah Teichmann

Conference Proceedings  |  2016  |  SCANDINAVIAN JOURNAL OF IMMUNOLOGY

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T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming

Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui

Journal article  |  2016  |  Cell Reports

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Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4( ) and CD8( ) T Cell Activation to Localized Viral Infection

Jyh Liang Hor, Paul G Whitney, Ali Zaid, Andrew G Brooks, William R Heath, Scott N Mueller

Journal article  |  2015  |  Immunity

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Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall

Yu Kato, Ali Zaid, Gayle M Davey, Scott N Mueller, Stephen L Nutt, Dimitra Zotos, David M Tarlinton, Ken Shortman, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2015  |  The Journal of Immunology

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Kruppel-ling of IRF4-Dependent DCs into Two Functionally Distinct DC Subsets

Sammy Bedoui, William R Heath

Journal article  |  2015  |  Immunity

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Temporal regulation of T cell priming during peripheral infection

Scott Mueller, Jyh Liang Hor, William Heath

Conference Proceedings  |  2015  |  JOURNAL OF IMMUNOLOGY

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Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates

Jessica Li, Fatma Ahmet, Lucy C Sullivan, Andrew G Brooks, Stephen J Kent, Robert De Rose, Andres M Salazar, Caetano Reis e Sousa, Ken Shortman, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2015  |  European Journal of Immunology

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Impaired antigen presentation following Systemic Inflammatory Response Syndrome (SIRS) is caused by the local induction of a paralysis program in developing dendritic cells

Javier Vega-Ramos, Antoine Roquilly, Yifan Zhan, Daniel Fernandez Ruiz, Irina Caminschi, Aaron Lun, Gordon Smyth, William Heath, Jose A Villadangos

Conference Proceedings  |  2014  |  Cytokine

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Intrahepatic Activation of Naive CD4( ) T Cells by Liver-Resident Phagocytic Cells

Szun S Tay, Yik Chun Wong, Ben Roediger, Frederic Sierro, Bo Lu, David M McDonald, Claire M McGuffog, Nicholas J Meyer, Ian E Alexander, Ian A Parish, William R Heath, Wolfgang Weninger, G Alex Bishop, Jennifer R Gamble, Geoffrey W McCaughan, Patrick Bertolino, David G Bowen

Journal article  |  2014  |  The Journal of Immunology

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Distinct APC Subtypes Drive Spatially Segregated CD4 and CD8 T-Cell Effector Activity during Skin Infection with HSV-1

Bethany L Macleod, Sammy Bedoui, Jyh Liang Hor, Scott N Mueller, Tiffany A Russell, Natasha A Hollett, William R Heath, David C Tscharke, Andrew G Brooks, Thomas Gebhardt

Journal article  |  2014  |  PLoS Pathogens

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CD8( ) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria

Lei Shong Lau, Daniel Fernandez-Ruiz, Vanessa Mollard, Angelika Sturm, Michelle A Neller, Anton Cozijnsen, Julia L Gregory, Gayle M Davey, Claerwen M Jones, Yi-Hsuan Lin, Ashraful Haque, Christian R Engwerda, Catherine Q Nie, Diana S Hansen, Kenneth M Murphy, Anthony T Papenfuss, John J Miles, Scott R Burrows, Tania de Koning-Ward, Geoffrey I McFadden, et al.

Journal article  |  2014  |  PLOS PATHOGENS

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Persistence of skin-resident memory T cells within an epidermal niche

Ali Zaid, Laura K Mackay, Azad Rahimpour, Asolina Braun, Marc Veldhoen, Francis R Carbone, Jonathan H Manton, William R Heath, Scott N Mueller

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

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The developmental pathway for CD103( )CD8( ) tissue-resident memory T cells of skin

Laura K Mackay, Azad Rahimpour, Joel Z Ma, Nicholas Collins, Angus T Stock, Ming-Li Hafon, Javier Vega-Ramos, Pilar Lauzurica, Scott N Mueller, Tijana Stefanovic, David C Tscharke, William R Heath, Michael Inouye, Francis R Carbone, Thomas Gebhardt

Journal article  |  2013  |  Nature Immunology

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The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

William R Heath, Francis R Carbone

Journal article  |  2013  |  Nature Immunology

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Distinct resident and recirculating memory T cell subsets in non-lymphoid tissues

Francis R Carbone, Laura K Mackay, William R Heath, Thomas Gebhardt

Journal article  |  2013  |  Current Opinion in Immunology

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Identification of a MHC I-restricted epitope of DsRed in C57BL/6 mice

Gayle M Davey, Scott N Mueller, Catherine van Vliet, Michelle Gigowski, Ali Zaid, Brooke Davies, Francis R Carbone, William R Heath

Journal article  |  2013  |  Molecular Immunology

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DEC-205 is a cell surface receptor for CpG oligonucleotides

Irina Caminschi, Simone Meuter, William R Heath

Journal article  |  2013  |  OncoImmunology

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Memory T Cell Subsets, Migration Patterns, and Tissue Residence

Scott N Mueller, Thomas Gebhardt, Francis R Carbone, William R Heath

Journal article  |  2013  |  Annual Review of Immunology

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Peripheral tissue surveillance and residency by memory T cells

Thomas Gebhardt, Scott N Mueller, William R Heath, Francis R Carbone

Journal article  |  2013  |  Trends in Immunology (formerly Immunology Today)

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DEC-205 is a cell surface receptor for CpG oligonucleotides

Mireille H Lahoud, Fatma Ahmet, Jian-Guo Zhang, Simone Meuter, Antonia N Policheni, Susie Kitsoulis, Chin-Nien Lee, Meredith O'Keeffe, Lucy C Sullivan, Andrew G Brooks, Richard Berry, Jamie Rossjohn, Justine D Mintern, Javier Vega-Ramos, Jose A Villadangos, Nicos A Nicola, Michel C Nussenzweig, Katryn J Stacey, Ken Shortman, William R Heath, et al.

Journal article  |  2012  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Trafficking and functions of memory CD4 and CD8 T cell populations in peripheral tissues

S Mueller, WR Heath, T Gebhardt, FR Carbone

Conference Proceedings  |  2012  |  IMMUNOLOGY

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Hair follicles: gatekeepers to the epidermis

William R Heath, Scott N Mueller

Journal article  |  2012  |  Nature Immunology

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Breakdown in Repression of IFN-gamma mRNA Leads to Accumulation of Self-Reactive Effector CD8( ) T Cells

Pheh-Ping Chang, Sau K Lee, Xin Hu, Gayle Davey, Guowen Duan, Jae-Ho Cho, Guna Karupiah, Jonathan Sprent, William R Heath, Edward M Bertram, Carola G Vinuesa

Journal article  |  2012  |  Journal of Immunology

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Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene

Dillon W Leong, Jasper C Komen, Chelsee A Hewitt, Estelle Arnaud, Matthew McKenzie, Belinda Phipson, Melanie Bahlo, Adrienne Laskowski, Sarah A Kinkel, Gayle M Davey, William R Heath, Anne K Voss, Rene P Zahedi, James J Pitt, Roman Chrast, Albert Sickmann, Michael T Ryan, Gordon K Smyth, David R Thorburn, Hamish S Scott

Journal article  |  2012  |  Journal of Biological Chemistry

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Long-lived epithelial immunity by tissue-resident memory T (T-RM) cells in the absence of persisting local antigen presentation

Laura K Mackay, Angus T Stock, Joel Z Ma, Claerwen M Jones, Stephen J Kent, Scott N Mueller, William R Heath, Francis R Carbone, Thomas Gebhardt

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

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Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics

Liv Eidsmo, Angus T Stock, William R Heath, Sammy Bedoui, Francis R Carbone

Journal article  |  2012  |  Journal of Pathology

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Maintenance of T Cell Function in the Face of Chronic Antigen Stimulation and Repeated Reactivation for a Latent Virus Infection

Laura K Mackay, Linda Wakim, Catherine J van Vliet, Claerwen M Jones, Scott N Mueller, Oliver Bannard, Douglas T Fearon, William R Heath, Francis R Carbone

Journal article  |  2012  |  Journal of Immunology

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T Cell Receptor Antagonist Peptides Induce Positive Selection

Kristin A Hogquist, Stephen C Jameson, William R Heath, Jane L Howard, Michael J Bevan, Francis R Carbone

Journal article  |  2012  |  Journal of Immunology

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NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8( ) T cells

Andreas Kupz, Greta Guarda, Thomas Gebhardt, Leif E Sander, Kirsty R Short, Dimitri A Diavatopoulos, Odilia LC Wijburg, Hanwei Cao, Jason C Waithman, Weisan Chen, Daniel Fernandez-Ruiz, Paul G Whitney, William R Heath, Roy Curtiss, Juerg Tschopp, Richard A Strugnell, Sammy Bedoui

Journal article  |  2012  |  Nature Immunology

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Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice

Irina Caminschi, David Vremec, Fatma Ahmet, Mireille H Lahoud, Jose A Villadangos, Kenneth M Murphy, William R Heath, Ken Shortman

Journal article  |  2012  |  Molecular Immunology

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Targeting dencritic cells in vivo for cancer therapy

Irina Caminschi, Eugene Maraskovsky, William Ross Heath

Journal article  |  2012  |  Frontiers in Immunology

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Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8( ) T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery

Lei Shong Lau, Daniel Fernandez Ruiz, Gayle M Davey, Tania F de Koning-Ward, Anthony T Papenfuss, Francis R Carbone, Andrew G Brooks, Brendan S Crabb, William R Heath

Journal article  |  2011  |  Journal of Infectious Diseases

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A Local Role for CD103( ) Dendritic Cells in Atherosclerosis

Sammy Bedoui, William R Heath

Journal article  |  2011  |  Immunity

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Different patterns of peripheral migration by memory CD4( ) and CD8( ) T cells

Thomas Gebhardt, Paul G Whitney, Ali Zaid, Laura K Mackay, Andrew G Brooks, William R Heath, Francis R Carbone, Scott N Mueller

Journal article  |  2011  |  Nature

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Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

Francois-Xavier Hubert, Sarah A Kinkel, Gayle M Davey, Belinda Phipson, Scott N Mueller, Adrian Liston, Anna I Proietto, Ping ZF Cannon, Simon Forehan, Gordon K Smyth, Li Wu, Christopher C Goodnow, Francis R Carbone, Hamish S Scott, William R Heath

Journal article  |  2011  |  Blood

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Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype

Mireille H Lahoud, Fatma Ahmet, Susie Kitsoulis, Soo San Wan, David Vremec, Chin-Nien Lee, Belinda Phipson, Wei Shi, Gordon K Smyth, Andrew M Lew, Yu Kato, Scott N Mueller, Gayle M Davey, William R Heath, Ken Shortman, Irina Caminschi

Journal article  |  2011  |  Journal of Immunology

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Granzyme B Expression by CD8( ) T Cells Is Required for the Development of Experimental Cerebral Malaria

Ashraful Haque, Shannon E Best, Klara Unosson, Fiona H Amante, Fabian de Labastida, Nicholas M Anstey, Gunasegaran Karupiah, Mark J Smyth, William R Heath, Christian R Engwerda

Journal article  |  2011  |  Journal of Immunology

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Rapid recruitment and activation of CD8( ) T cells after herpes simplex virus type 1 skin infection

Angus T Stock, Claerwen M Jones, William R Heath, Francis R Carbone

Journal article  |  2011  |  Immunology and Cell Biology

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Cross-Priming: Its Beginnings

Francis R Carbone, William R Heath

Journal article  |  2010  |  Journal of Immunology

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Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

Rachel J Lundie, Louise J Young, Gayle M Davey, Jose A Villadangos, Francis R Carbone, William R Heath, Brendan S Crabb

Journal article  |  2010  |  European Journal of Immunology

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Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysis

Elodie Segura, Eugene Kapp, Nishma Gupta, June Wong, Justin Lim, Hong Ji, William R Heath, Richard Simpson, Jose A Villadangos

Journal article  |  2010  |  Molecular Immunology

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The CD8 dendritic cell subset

Ken Shortman, William R Heath

Journal article  |  2010  |  Immunological Reviews

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Cutting Edge: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression In Vivo

Gayle M Davey, Magdalena Wojtasiak, Anna I Proietto, Francis R Carbone, William R Heath, Sammy Bedoui

Journal article  |  2010  |  Journal of Immunology

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Dendritic cell subsets in primary and secondary T cell responses at body surfaces

William R Heath, Francis R Carbone

Journal article  |  2009  |  Nature Immunology

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The C-Type Lectin Clec12A Present on Mouse and Human Dendritic Cells Can Serve as a Target for Antigen Delivery and Enhancement of Antibody Responses

Mireille H Lahoud, Anna I Proietto, Fatma Ahmet, Susie Kitsoulis, Liv Eidsmo, Li Wu, Priyanka Sathe, Suzanne Pietersz, Hsuen-Wen Chang, Ian D Walker, Eugene Maraskovsky, Hal Braley, Andrew M Lew, Mark D Wright, William R Heath, Ken Shortman, Irina Caminschi

Journal article  |  2009  |  Journal of Immunology

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Autoimmune Regulator Controls T Cell Help for Pathogenetic Autoantibody Production in Collagen-Induced Arthritis

Ian K Campbell, Sarah A Kinkel, Sarah F Drake, Annemarie van Nieuwenhuijze, Francois-Xavier Hubert, David M Tarlinton, William R Heath, Hamish S Scott, Ian P Wicks

Journal article  |  2009  |  Arthritis and Rheumatism

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The molecular signature of CD8( ) T cells undergoing deletional tolerance

Ian A Parish, Sudha Rao, Gordon K Smyth, Torsten Juelich, Gareth S Denyer, Gayle M Davey, Andreas Strasser, William R Heath

Journal article  |  2009  |  Blood

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Cross-presentation of viral and self antigens by skin-derived CD103( ) dendritic cells

Sammy Bedoui, Paul G Whitney, Jason Waithman, Liv Eidsmo, Linda Wakim, Irina Caminschi, Rhys S Allan, Magdalena Wojtasiak, Ken Shortman, Francis R Carbone, Andrew G Brooks, William R Heath

Journal article  |  2009  |  Nature Immunology

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Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Thomas Gebhardt, Linda M Wakim, Liv Eidsmo, Patrick C Reading, William R Heath, Francis R Carbone

Journal article  |  2009  |  Nature Immunology

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IP-10-Mediated T Cell Homing Promotes Cerebral Inflammation over Splenic Immunity to Malaria Infection

Catherine Q Nie, Nicholas J Bernard, M Ursula Norman, Fiona H Amante, Rachel J Lundie, Brendan S Crabb, William R Heath, Christian R Engwerda, Michael J Hickey, Louis Schofield, Diana S Hansen

Journal article  |  2009  |  PLoS Pathogens

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Characterization of an Immediate Splenic Precursor of CD8( ) Dendritic Cells Capable of Inducing Antiviral T Cell Responses

Sammy Bedoui, Sandro Prato, Justine Mintern, Thomas Gebhardt, Yifan Zhan, Andrew M Lew, William R Heath, Jos A Villadangos, Elodie Segura

Journal article  |  2009  |  Journal of Immunology

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Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype

Francois-Xavier Hubert, Sarah A Kinkel, Pauline E Crewther, Ping ZF Cannon, Kylie E Webster, Maire Link, Raivo Uibo, Moira K O'Bryan, Anthony Meager, Simon P Forehan, Gordon K Smyth, Laureane Mittaz, Stylianos E Antonarakis, Paert Peterson, William R Heath, Hamish S Scott

Journal article  |  2009  |  Journal of Immunology

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Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

Ian A Parish, Jason Waithman, Gayle M Davey, Gabrielle T Belz, Justine D Mintern, Christian Kurts, Robyn M Sutherland, Francis R Carbone, William R Heath

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

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Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process

Sammy Bedoui, Gayle M Davey, Andrew M Lew, William R Heath

Journal article  |  2009  |  Immunology and Cell Biology

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Differential Migration of Epidermal and Dermal Dendritic Cells during Skin Infection

Liv Eidsmo, Rhys Allan, Irina Caminschi, Nico van Rooijen, William R Heath, Francis R Carbone

Journal article  |  2009  |  Journal of Immunology

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Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells

Susan Johnson, Yifan Zhan, Robyn M Sutherland, Adele M Mount, Sammy Bedoui, Jamie L Brady, Emma M Carrington, Lorena E Brown, Gabrielle T Belz, William R Heath, Andrew M Lew

Journal article  |  2009  |  Immunity

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Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants

PJ White, F Anastasopoulos, JE Church, C-Y Kuo, BJ Boyd, PLC Hickey, L Sze Tu, P Burns, AM Lew, WR Heath, GM Davey, CW Pouton

Journal article  |  2008  |  Vaccine

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Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues

Linda M Wakim, Thomas Gebhardt, William R Heath, Francis R Carbone

Journal article  |  2008  |  Journal of Immunology

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Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

Louise J Young, Nicholas S Wilson, Petra Schnorrer, Anna Proietto, Toine ten Broeke, Yohei Matsuki, Adele M Mount, Gabrielle T Belz, Meredith O'Keeffe, Mari Ohmura-Hoshino, Satoshi Ishido, Willem Stoorvogel, William R Heath, Ken Shortman, Jose A Villadangos

Journal article  |  2008  |  Nature Immunology

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The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

Irina Caminschi, Anna I Proietto, Fatma Ahmet, Susie Kitsoulis, Joo Shin Teh, Jennifer CY Lo, Alexandra Rizzitelli, Li Wu, David Vremec, Serani LH van Dommelen, Ian K Campbell, Eugene Maraskovsky, Hal Braley, Gayle M Davey, Patricia Mottram, Nicholas van De Velde, Kent Jensen, Andrew M Lew, Mark D Wright, William R Heath, et al.

Journal article  |  2008  |  Blood

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Blood-stage Plasmodium infection induces CD8( ) T lymphocytes to parasite-expressed antigens, largely regulated by CD8 alpha( ) dendritic cells

Rachel J Lundie, Tania F de Koning-Ward, Gayle M Davey, Catherine Q Nie, Diana S Hansen, Lei Shong Lau, Justine D Mintern, Gabrielle T Belz, Louis Schofield, Francis R Carbone, Jose A Villadangos, Brendan S Crabb, William R Heath

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

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Cutting edge: Enhanced IL-2 signaling can convert self-specific T cell response from tolerance to autoinimunity

Jason Waithman, Thomas Gebhardt, Gayle M Davey, William R Heath, Francis R Carbone

Journal article  |  2008  |  Journal of Immunology

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A specific anti-Aire antibody reveals Aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery

Francois-Xavier Hubert, Sarah A Kinkel, Kylie E Webster, Ping Cannon, Pauline E Crewther, Anna I Proeitto, Li Wu, William R Heath, Hamish S Scott

Journal article  |  2008  |  Journal of Immunology

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Multiple Dendritic Cell Populations Activate CD4( ) T Cells after Viral Stimulation

Adele M Mount, Christopher M Smith, Fiona Kupresanin, Kristina Stoermer, William R Heath, Gabrielle T Belz

Journal article  |  2008  |  PLoS One

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Selective suicide of cross-presenting CD8( ) dendritic cells by cytochrome c injection shows functional heterogeneity within this subset

Ming Lee Lin, Yifan Zhan, Anna I Projetto, Sandro Prato, Li Wu, William R Heath, Jose A Villadangos, Andrew M Lew

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

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Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Nicholas S Wilson, Louise J Young, Fiona Kupresanin, Shalin H Naik, David Vremec, William R Heath, Shizuo Akira, Ken Shortman, Jeff Boyle, Eugene Maraskovsky, Gabrielle T Belz, Jose A Villadangos

Journal article  |  2008  |  Immunology and Cell Biology

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Too dangerous to ignore: self-tolerance and the control of ignorant autoreactive T cells

Ian A Parish, William R Heath

Journal article  |  2008  |  Immunology and Cell Biology

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Dendritic cell-induced memory T cell activation in nonlymphoid tissues

Linda M Wakim, Jason Waithman, Nico van Rooijen, William R Heath, Francis R Carbone

Journal article  |  2008  |  Science

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Induction of antigen-specific T cell responses following blood-stage Plasmodium infection occurs mainly via CD8 alpha dendritic cells but is short-lived.

Rachel J Lundie, Tania F de Koning-Ward, Gayle M Davey, Catherine Q Nie, Diana S Hansen, Louis Schofield, Gabrielle T Belz, Francis R Carbone, Jose A Villadangos, Brendan S Crabb, William R Heath

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

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Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar typhimurium

Jason D Price, Kim R Simpfendorfer, Radhakrishnam R Mantena, James Holden, William R Heath, Nico van Rooijen, Richard A Strugnell, Odilia LC Wijburg

Journal article  |  2007  |  Infection and Immunity

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Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

Louise J Young, Nicholas S Wilson, Petra Schnorrer, Adele Mount, Rachel J Lundie, Nicole L La Gruta, Brendan S Crabb, Gabrielle T Belz, William R Heath, Jose A Villadangos

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

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Erratum: The clonal selection theory: 50 years since the revolution (Nature Immunology (2007) vol. 8 (1019-1026))

PD Hodgkin, WR Heath, AG Baxter

Journal article  |  2007  |  Nature Immunology

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Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells

Irina Caminschi, Fatma Ahmet, Klaus Heger, Jason Brady, Stephen L Nutt, David Vremec, Suzanne Pietersz, Mireille H Lahoud, Louis Schofi Eld, Diana S Hansen, Meredith O'Keeffe, Mark J Smyth, Sammy Bedoui, Gayle M Davey, Jose A Villadangos, William R Heath, Ken Shortman

Journal article  |  2007  |  JOURNAL OF EXPERIMENTAL MEDICINE

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Skin-derived dendritic cells can mediate deletional tolerance of class I-Restricted self-reactive T cells

Jason Waithman, Rhys S Allan, Hiroshi Kosaka, Hiroaki Azukizawa, Ken Shortman, Manfred B Lutz, William R Heath, Francis R Carbone, Gabrielle T Belz

Journal article  |  2007  |  Journal of Immunology

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The clonal selection theory: 50 years since the revolution

Philip D Hodgkin, William R Heath, Alan G Baxter

Journal article  |  2007  |  Nature Immunology

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Minimal activation of memory CD8 T cell by tissue-derived dendritic cells favors the stimulation of naive CD8 T cells

Gabrielle T Belz, Sammy Bedoui, Fiona Kupresanin, Francis R Carbone, William R Heath

Journal article  |  2007  |  Nature Immunology

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Optimization of TCR transgenic T cells for in vivo tracking of immune responses

Angus T Stock, Scott N Mueller, Lauren M Kleinert, William R Heath, Francis R Carbone, Claerwen M Jones

Journal article  |  2007  |  Immunology and Cell Biology

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A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection

Daniel P Barr, Gabrielle T Belz, Patrick C Reading, Magdalena Wojtasiak, Paul G Whitney, William R Heath, Francis R Carbone, Andrew G Brooks

Journal article  |  2007  |  European Journal of Immunology

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Outside looking in: the inner workings of the crosspresentation pathway within dendritic cells

Jose A Villadangos, William R Heath, Francis R Carbone

Journal article  |  2007  |  Trends in Immunology (formerly Immunology Today)

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CTL response compensation for the loss of an immunodominant class I-restricted HSV-1 determinant

Angus T Stock, Claerwen M Jones, William R Heath, Francis R Carbone

Journal article  |  2006  |  Immunology and Cell Biology

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Cutting edge: Central memory T cells do not show accelerated proliferation or tissue infiltration in response to localized herpes simplex virus-1 infection

Angus T Stock, Claerwen M Jones, William R Heath, Francis R Carbone

Journal article  |  2006  |  The Journal of Immunology

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The dominant role of CD8( ) dendritic cells in cross-presentation is not dictated by antigen capture

Petra Schnorrer, Georg MN Behrens, Nicholas S Wilson, Joanne L Pooley, Christopher M Smith, Dima EI-Sukkari, Gayle Davey, Fiona Kupresanin, Ming Li, Eugene Maraskovsky, Gabrielle T Belz, Francis R Carbone, Ken Shortman, William R Heath, Jose A Villadangos

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

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Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming

Rhys S Allan, Jason Waithman, Sammy Bedoui, Claerwen M Jones, Jose A Villadangos, Yifan Zhan, Andrew M Lew, Ken Shortman, William R Heath, Francis R Carbone

Journal article  |  2006  |  Immunity

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CD4 T cells can protect APC from CTL-mediated elimination

Scott N Mueller, Claerwen M Jones, Angus T Stock, Mark Suter, William R Heath, Francis R Carbone

Journal article  |  2006  |  Journal of Immunology

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Bone marrow-derived cells expand memory CD8( ) T cells in response to viral infections of the lung and skin

GT Belz, NS Wilson, CM Smith, AM Mount, FR Carbone, WR Heath

Journal article  |  2006  |  European Journal of Immunology

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Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

NS Wilson, GMN Behrens, RJ Lundie, CM Smith, J Waithman, L Young, SP Forehan, A Mount, RJ Steptoe, KD Shortman, TF de Koning-Ward, GT Belz, FR Carbone, BS Crabb, WR Heath, JA Villadangos

Journal article  |  2006  |  NATURE IMMUNOLOGY

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SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated dinflammation

GM Davey, WR Heath, R Starr

Journal article  |  2006  |  Tissue Antigens

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Latent infection with herpes simplex virus is associated with ongoing CD8 T-cell stimulation by parenchymal cells within sensory ganglia

AL van Lint, L Kleinert, SRM Clarke, A Stock, WR Heath, FR Carbone

Journal article  |  2005  |  Journal of Virology

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Co-operation between dendritic cell subsets is required to prime CD4( ) T cells following influenza a virus infection

AM Mount, J Tan, F Kupresanin, CM Smith, WR Heath, GT Belz

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Self tolerance to organ-specific antigens

WR Heath, IA Parish, J Waithman, GM Davey, GT Belz, FR Carbone

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Antigen presentation in rodent malaria

RJ Lundie, TF De Koning-Ward, GM Davey, GT Belz, NS Wilson, L Young, JA Villadangos, WR Heath, BS Crabb

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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SOCS-1 deficiency results in IL-15 dependent proliferation of antigen naive CD8 T cells

GM Davey, AL Cornish, JT Burghardt, WS Alexander, FR Carbone, CD Surh, R Starr, WR Heath

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Dendritic cell presentation of skin derived self-antigen

J Waithman, WR Heath, GT Belz, FR Carbone

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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The unique ability of CD8 DC to cross-present is not due to selective antigen capture

P Schnorrer, GMN Behrens, NS Wilson, JL Pooley, GT Belz, FR Carbone, K Shortman, WR Heath, JA Villadangos

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Defining the molecular signature of peripheral CD8( ) T cell tolerance

IA Parish, GK Smyth, S Rao, WR Heath

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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A role for plasmacytoid dendritic cells in MHC class II-Restricted antigen presentation?

LJ Young, NS Wilson, GT Belz, CM Smith, D El-Sukkari, M O'Keeffe, WR Heath, KD Shortman, JA Villadangos

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

GM Davey, R Starr, AL Cornish, JT Burghardt, WS Alexander, FR Carbone, CD Surh, WR Heath

Journal article  |  2005  |  Journal of Experimental Medicine

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Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: Limitations of the Langerhans cells paradigm

JA Villadangos, WR Heath

Journal article  |  2005  |  Seminars in Immunology

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CD8 alpha( ) dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo

GT Belz, K Shortman, MJ Bevan, WR Heath

Journal article  |  2005  |  Journal of Immunology

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Coupling and cross-presentation

WR Heath, FR Carbone

Journal article  |  2005  |  Nature

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Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens

EE Hamilton-Williams, A Lang, D Benke, GM Davey, KH Wiesmuller, C Kurts

Journal article  |  2005  |  Journal of Immunology

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No driving without a license

WR Heath, JA Villadangos

Journal article  |  2005  |  Nature Immunology

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Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity

FR Carbone, GT Belz, WR Heath

Journal article  |  2004  |  Trends in Immunology (formerly Immunology Today)

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Cognate CD4( ) T cell licensing of dendritic cells in CD8( ) T cell immunity

CM Smith, NS Wilson, J Waithman, JA Villadangos, FR Carbone, WR Heath, GT Belz

Journal article  |  2004  |  NATURE IMMUNOLOGY

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Cutting edge: Prolonged antigen presentation after herpes simplex virus-1 skin infection

AT Stock, SN Mueller, AL van Lint, WR Heath, FR Carbone

Journal article  |  2004  |  JOURNAL OF IMMUNOLOGY

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Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

GT Belz, CM Smith, L Kleinert, P Reading, A Brooks, K Shortman, FR Carbone, WR Heath

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

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Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens

WR Heath, GT Belz, GMN Behrens, CM Smith, SP Forehan, IA Parish, GM Davey, NS Wilson, FR Carbone, JA Villadangos

Journal article  |  2004  |  Immunological Reviews

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Negative selection of seminature CD4( )8(-)HSA( ) thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

A Villunger, VS Marsden, YF Zhan, M Erlacher, AM Lew, P Bouillet, S Berzins, DI Godfrey, WR Heath, A Strasser

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

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Helper requirements for generation of effector CTL to islet beta cell antigens

GMN Behrens, M Li, GM Davey, J Allison, RA Flavell, FR Carbone, WR Heath

Journal article  |  2004  |  Journal of Immunology

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Cutting edge: Conventional CD8 alpha( ) dendritic cells are generally involved in priming CTL immunity to viruses

GT Belz, CM Smith, D Eichner, K Shortman, G Karupiah, FR Carbone, WK Heath

Journal article  |  2004  |  Journal of Immunology

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Helper T cells, dendritic cells and CTL immunity

G Behrens, M Li, CM Smith, GT Belz, J Mintern, FR Carbone, WR Heath

Journal article  |  2004  |  Immunology and Cell Biology

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Herpes simplex virus-specific CD8( ) T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation

A van Lint, M Ayers, AG Brooks, RM Coles, WR Heath, FR Carbone

Journal article  |  2004  |  Journal of Immunology

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Immunology - Dangerous liaisons

WR Heath, FR Carbone

Journal article  |  2003  |  Nature

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Epidermal viral immunity induced by CD8 alpha( ) dendritic cells but not by Langerhans cells

RS Allan, CM Smith, GT Belz, AL van Lint, LM Wakim, WR Heath, FR Carbone

Journal article  |  2003  |  Science

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Most lymphoid organ dendritic cell types are phenotypically and functionally immature

NS Wilson, D El-Sukkari, GT Belz, CM Smith, RJ Steptoe, WR Heath, K Shortman, JA Villadangos

Journal article  |  2003  |  Blood

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The role of dendritic cell subsets in immunity to viruses

FR Carbone, WR Heath

Journal article  |  2003  |  Current Opinion in Immunology

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Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes

H Azukizawa, H Kosaka, S Sano, WR Heath, I Takahashi, XH Gao, Y Sumikawa, M Okabe, K Yoshikawa, S Itami

Journal article  |  2003  |  European Journal of Immunology

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Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes

RM Coles, CM Jones, AG Brooks, PU Cameron, WR Heath, FR Carbone

Journal article  |  2003  |  European Journal of Immunology

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Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells

AK Nowak, RA Lake, AL Marzo, B Scott, WR Heath, EJ Collins, JA Frelinger, BWS Robinson

Journal article  |  2003  |  Journal of Immunology

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Cutting edge: Conventional CD8 alpha( ) dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1

CM Smith, GT Belz, NS Wilson, JA Villadangos, K Shortman, FR Carbone, WR Heath

Journal article  |  2003  |  Journal of Immunology

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Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

YF Zhan, JF Purton, DI Godfrey, TJ Cole, WR Heath, AM Lew

Journal article  |  2003  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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The early expression of glycoprotein B from herpes simplex virus can be detected by antigen-specific CD8( ) T cells

SN Mueller, CM Jones, WS Chen, Y Kawaoka, MR Castrucci, WR Heath, FR Carbone

Journal article  |  2003  |  Journal of Virology

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Suppressor of cytokine signaling-1 has IFn-gamma-independent actions in T cell homeostasis

AL Cornish, GM Davey, D Metcalf, JF Purton, JE Corbin, CJ Greenhalgh, R Darwiche, L Wu, NA Nicola, DI Godfrey, WR Heath, DJ Hilton, WS Alexander, R Starr

Journal article  |  2003  |  Journal of Immunology

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Immunology - Education and promiscuity

WR Heath, HS Scott

Journal article  |  2002  |  Nature

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The CD8 alpha( ) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens

GT Belz, GMN Behrens, CM Smith, JFAP Miller, C Jones, K Lejon, CG Fathman, SN Mueller, K Shortman, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Experimental Medicine

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Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim

GM Davey, C Kurts, JFAP Miller, P Bouillet, A Strasser, AG Brooks, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Experimental Medicine

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The role of dendritic cell subsets in selection between tolerance and immunity

GT Belz, WR Heath, FR Carbone

Journal article  |  2002  |  Immunology and Cell Biology

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CD36 is differentially expressed by CD8( ) splenic dendritic cells but is not required for cross-presentation in vivo

GT Belz, D Vremec, M Febbraio, L Corcoran, K Shortman, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Immunology

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Characterization of two TCR transgenic mouse lines specific for herpes simplex virus

SN Mueller, WR Heath, JD McLain, FR Carbone, CM Jones

Journal article  |  2002  |  Immunology and Cell Biology

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Constitutive, but not inflammatory, cross-presentation is disabled in the pancreas of young mice

JD Mintern, RM Sutherland, AM Lew, K Shortman, FR Carbone, WR Heath

Journal article  |  2002  |  European Journal of Immunology

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The cross-priming APC requires a Rel-dependent signal to induce CTL

JD Mintern, G Belz, S Gerondakis, FR Carbone, WR Heath

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

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Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus

SN Mueller, CM Jones, CM Smith, WR Heath, FR Carbone

Journal article  |  2002  |  JOURNAL OF EXPERIMENTAL MEDICINE

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Cutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells

JD Mintern, GM Davey, GT Belz, FR Carbone, WR Heath

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

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Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

Arno Hänninen, Nathan R Martinez, Gayle M Davey, William R Heath, Leonard C Harrison

Journal article  |  2002  |  Journal of Clinical Investigation

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Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1

RM Coles, SN Mueller, WR Heath, FR Carbone, AG Brooks

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

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Cross-presentation of antigens by dendritic cells

GT Belz, FR Carbone, WR Heath

Journal article  |  2002  |  Critical Reviews in Immunology

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Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

A Hanninen, NR Martinez, GM Davey, WR Heath, LC Harrison

Journal article  |  2002  |  Journal of Clinical Investigation

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γδ T cells: Have we been looking in the wrong direction?

WR Heath

Journal article  |  2002  |  Trends in Molecular Medicine

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Cross-presentation in viral immunity and self-tolerance

William R Heath, Francis R Carbone

Journal article  |  2001  |  Nature Reviews Immunology

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Immunity or tolerance? That is the question for dendritic cells

K Shortman, WR Heath

Journal article  |  2001  |  Nature Immunology

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Cross-presentation in viral immunity and self-tolerance

WR Heath, FR Carbone

Journal article  |  2001  |  Nature Reviews Immunology

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A new approach to tumor immunotherapy

WR Heath

Journal article  |  2001  |  Trends in Immunology

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A new IFN-like cytokine, limitin modulates the immune response without influencing thymocyte development

I Takahashi, H Kosaka, K Oritani, WR Heath, J Ishikawa, Y Okajima, M Ogawa, S Kawamoto, M Yamada, H Azukizawa, S Itami, K Yoshikawa, Y Tomiyama, Y Matsuzawa

Journal article  |  2001  |  The Journal of Immunology

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Kidney protection against autoreactive CD8( ) T cells distinct from immunoprivilege and sequestration

C Kurts, I Klebba, GM Davey, KM Koch, JFAP Miller, WR Heath, J Floege

Journal article  |  2001  |  Kidney International

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Ligand density determines the efficiency of negative selection in the thymus

D Romermann, WR Heath, J Allison, B Bayer, Y Sorge, JFAP Miller, MW Hoffmann

Journal article  |  2001  |  Transplantation

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Motility is more important than [correction of that] stealth.

WR Heath

Journal article  |  2001  |  Trends in Immunology

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Motility is more important that stealth

William R Heath

Journal article  |  2001  |  Trends in Immunology

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A key role for ICAM-I in generating effector cells mediating inflammatory responses

SA Camacho, WR Heath, FR Carbone, N Sarvetnick, A LeBon, L Karlsson, PA Peterson, SR Webb

Journal article  |  2001  |  NATURE IMMUNOLOGY

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Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo

M Li, GM Davey, RM Sutherland, C Kurts, AM Lew, C Hirst, FR Carbone, WR Heath

Journal article  |  2001  |  Journal of Immunology

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Cutting edge: Intravenous soluble antigen is presented to CD4 T cells by CD8(-) dendritic cells, but cross-presented to CD8 T cells by CD8( ) dendritic cells

JL Pooley, WR Heath, K Shortman

Journal article  |  2001  |  The Journal of Immunology

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Mucosal antigen primes diabetogenic cytotoxic T-Lymphocytes regardless of dose or delivery route

A Hanninen, A Braakhuis, WR Heath, LC Harrison

Journal article  |  2001  |  Diabetes

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The secret of CD45

WR Heath

Journal article  |  2001  |  Trends in Immunology

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Cross-presentation, dendrttic cells, tolerance and immunity

WR Heath, FR Carbone

Journal article  |  2001  |  Annual Review of Immunology

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Thymocyte differentiation: a new way of thinking

WR Heath

Journal article  |  2000  |  Immunology Today

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Erratum: Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells (Nature (1999) 398: (341-344))

C Kurts, FR Carbone, MF Krummel, KM Koch, JFAP Miller, WR Heath

Journal article  |  2000  |  Nature

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Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection

SRM Clarke, M Barnden, C Kurts, FR Carbone, JF Miller, WR Heath

Journal article  |  2000  |  Immunology and Cell Biology

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A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4( ) and CD8( ) T cells

E Blanas, GM Davey, FR Carbone, WR Heath

Journal article  |  2000  |  The Journal of Immunology

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Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection

CM Jones, SC Cose, RM Coles, AC Winterhalter, AG Brooks, WR Heath, FR Carbone

Journal article  |  2000  |  Journal of Virology

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Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus

CM Jones, SC Cose, JM McNally, SR Jennings, WR Heath, FR Carbone

Journal article  |  2000  |  Journal of General Virology

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Effect of pre-existing cytotoxic T lymphocytes on therapeutic vaccines

Martina A Sherritt, Joy Gardner, Suzanne L Elliott, Christopher Schmidt, David Purdie, Georgia Deliyannis, William R Heath, Andreas Suhrbier

Journal article  |  2000  |  European Journal of Immunology

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Effect of pre-existing cytotoxic T lymphocytes on therapeutic vaccines

MA Sherritt, J Gardner, SL Elliott, C Schmidt, D Purdie, G Deliyannis, WR Heath, A Suhrbier

Journal article  |  2000  |  European Journal of Immunology

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Cytotoxic T lymphocytes and cross-priming

WR Heath, SMR Clarke, GM Davey, C Kurts, AM Lew, M Li, J Mintern, RM Sutherland, FR Carbone, JFAP Miller

Journal article  |  2000  |  Immunologist

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The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo

J Mintern, M Li, GM Davey, E Blanas, C Kurts, FR Carbone, WR Heath

Journal article  |  1999  |  Immunology and Cell Biology

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CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

C Kurts, RM Sutherland, G Davey, M Li, AM Lew, E Blanas, FR Carbone, JFAP Miller, WR Heath

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

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Differential coupling of second signals for cytotoxicity and proliferation in CD8( ) T cell effecters: Amplification of the lytic potential by B7

MF Krummel, WR Heath, J Allison

Journal article  |  1999  |  Journal of Immunology

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The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant

ME Wallace, R Keating, WR Heath, FR Carbone

Journal article  |  1999  |  Journal of Virology

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Inhibition of naive class I-restricted T cells by altered peptide ligands

C Koniaras, FR Carbone, WR Heath, AM Lew

Journal article  |  1999  |  Immunology and Cell Biology

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Cytotoxic T lymphocyte activation by cross-priming

WR Heath, FR Carbone

Journal article  |  1999  |  Current Opinion in Immunology

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CD30 prevents T-cell responses to non-lymphoid tissues

WR Heath, C Kurts, I Caminschi, FR Carbone, JFAP Miller

Journal article  |  1999  |  Immunological Reviews

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Ontogeny of T cell tolerance to peripherally expressed antigens

DJ Morgan, C Kurts, HTC Kreuwel, KL Holst, WR Heath, LA Sherman

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

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Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

C Kurts, FR Carbone, MF Krummel, KM Koch, JFAP Miller, WR Heath

Journal article  |  1999  |  Nature

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Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

P Hoglund, J Mintern, C Waltzinger, W Heath, C Benoist, D Mathis

Journal article  |  1999  |  Journal of Experimental Medicine

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Oral administration of antigen can lead to the onset of autoimmune disease.

E Blanas, WR Heath

Journal article  |  1999  |  International Reviews of Immunology

Oral administration of antigen is known to induce a state of specific immunological unresponsiveness to a subsequent challenge wit..

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B cells directly tolerize CD8( ) T cells

SRM Bennett, FR Carbone, T Toy, JFAP Miller, WR Heath

Journal article  |  1998  |  Journal of Experimental Medicine

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Induction of peripheral CD8( ) T-cell tolerance by cross-presentation of self antigens

JFAP Miller, C Kurts, J Allison, H Kosaka, F Carbone, WR Heath

Journal article  |  1998  |  Immunological Reviews

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Cross-presentation: A general mechanism for CTL immunity and tolerance

FR Carbone, C Kurts, SRM Bennett, JFAP Miller, WR Heath

Journal article  |  1998  |  Immunology Today

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The peripheral deletion of autoreactive CD8( ) T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1)

C Kurts, WR Heath, H Kosaka, JFAP Miller, FR Carbone

Journal article  |  1998  |  Journal of Experimental Medicine

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Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction

C Kurts, JFAP Miller, RM Subramaniam, FR Carbone, WR Heath

Journal article  |  1998  |  Journal of Experimental Medicine

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Help for cytotoxic-T-cell responses is mediated by CD40 signalling

SRM Bennett, FR Carbone, F Karamalis, RA Flavell, JFAP Miller, WR Heath

Journal article  |  1998  |  Nature

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Cross-tolerance: A pathway for inducing tolerance to peripheral tissue antigens

WR Heath, C Kurts, JFAP Miller, FR Carbone

Journal article  |  1998  |  Journal of Experimental Medicine

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Induction of peripheral tolerance among CD8 T cells specific for a self-antigen expressed on pancreatic islet B-cells

DJ Morgan, S Fleck, C Kurts, WR Heath, LA Sherman

Journal article  |  1998  |  FASEB Journal

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The threshold for autoimmune T cell killing is influenced by B7-1

J Allison, LA Stephens, TW Kay, C Kurts, WR Heath, JFAP Miller, MF Krummel

Journal article  |  1998  |  European Journal of Immunology

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T cell unresponsiveness in vitro can be due to activation in vivo

C Koniaras, WR Heath, AM Lew

Journal article  |  1998  |  International Immunology

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Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements

MJ Barnden, J Allison, WR Heath, FR Carbone

Journal article  |  1998  |  Immunology and Cell Biology

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Cross-presentation of self antigens to CD8 T cells: the balance between tolerance and autoimmunity.

C Kurts, WR Heath, FR Carbone, H Kosaka, JF Miller

Journal article  |  1998  |  Novartis Foundation symposium

Upon encounter with foreign antigen, tissue-associated antigen-presenting cells (APCs) migrate to draining lymph nodes to prime sp..

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Loss of antiviral cytotoxic T-lymphocyte activity during high-level antigen stimulation

MS Rolph, KI Matthaei, FR Carbone, WR Heath, IA Ramshaw

Journal article  |  1998  |  Viral Immunology

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CD4( ) T cell help impairs CD8( ) T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity

C Kurts, FR Carbone, M Barnden, E Blanas, J Allison, WR Heath, JFAP Miller

Journal article  |  1997  |  Journal of Experimental Medicine

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Activation and migration of CD8 T cells in the intestinal mucosa

SK Kim, DS Reed, WR Heath, F Carbone, L Lefrancois

Journal article  |  1997  |  Journal of Immunology

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Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ

C Koniaras, SRM Bennett, FR Carbone, WR Heath, AM Lew

Journal article  |  1997  |  International Immunology

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Antigen-specific CD8( ) T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection

SC Cose, CM Jones, ME Wallace, WR Heath, FR Carbone

Journal article  |  1997  |  European Journal of Immunology

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Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8( ) T cells

C Kurts, H Kosaka, FR Carbone, JFAP Miller, WR Heath

Journal article  |  1997  |  Journal of Experimental Medicine

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Induction of a CD8( ) cytotoxic T lymphocyte response by cross-priming requires cognate CD4( ) T cell help

SRM Bennett, FR Carbone, F Karamalis, JFAP Miller, WR Heath

Journal article  |  1997  |  Journal of Experimental Medicine

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Down-modulation of CD8 beta-chain in response to an altered peptide ligand enables developing thymocytes to escape negative selection

MJ Barnden, WR Heath, FR Carbone

Journal article  |  1997  |  Cellular Immunology

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T cell tolerance and autoimmunity.

JF Miller, WR Heath, J Allison, G Morahan, M Hoffmann, C Kurts, H Kosaka

Journal article  |  1997  |  CIBA Foundation Symposia

Many T cells with auto-aggressive potential are deleted in the thymus. Although some of these escape to the general circulation, t..

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Induction of autoimmune diabetes by oral administration of autoantigen

E Blanas, FR Carbone, J Allison, JFAP Miller, WR Heath

Journal article  |  1996  |  Science

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Subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production

V Kronin, K Winkel, G Suss, A Kelso, W Heath, J Kirberg, H vonBoehmer, K Shortman

Journal article  |  1996  |  Journal of Immunology

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Constitutive class I-restricted exogenous presentation of self antigens in vivo

C Kurts, WR Heath, FR Carbone, J Allison, JFAP Miller, H Kosaka

Journal article  |  1996  |  The Journal of Experimental Medicine

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DELETION OF HIGH-AVIDITY T-CELLS BY THYMIC EPITHELIUM

MW HOFFMANN, WR HEATH, D RUSCHMEYER, JFAP MILLER

Journal article  |  1995  |  Proceedings of the National Academy of Sciences

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AUTOIMMUNITY CAUSED BY IGNORANT CD8( ) T-CELLS IS TRANSIENT AND DEPENDS ON AVIDITY

WR HEATH, F KARAMALIS, J DONOGHUE, JFAP MILLER

Journal article  |  1995  |  JOURNAL OF IMMUNOLOGY

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PERIPHERAL DELETION OF AUTOREACTIVE CD8( ) T-CELLS IN TRANSGENIC MICE EXPRESSING H-2K(B) IN THE LIVER

P BERTOLINO, WR HEATH, CL HARDY, G MORAHAN, JFAP MILLER

Journal article  |  1995  |  European Journal of Immunology

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EXPRESSION OF 2 T-CELL RECEPTOR-ALPHA CHAINS ON THE SURFACE OF NORMAL MURINE T-CELLS

WR HEATH, FR CARBONE, P BERTOLINO, J KELLY, S COSE, JFAP MILLER

Journal article  |  1995  |  European Journal of Immunology

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Intermediate steps in positive selection: differentiation of CD4 8int TCRint thymocytes into CD4-8 TCRhi thymocytes.

K Lundberg, W Heath, F Köntgen, FR Carbone, K Shortman

Journal article  |  1995  |  The Journal of Experimental Medicine

The differentiation potential of putative intermediates between CD4+8+ thymocytes and mature T cells has been examined. Such inter..

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Split tolerance in spleen chimeras.

J Sprent, M Hurd, M Schaefer, W Heath

Journal article  |  1995  |  Journal of Immunology

Transferring small doses of T cells to heavily irradiated F1 mice expressing isolated MHC class I or class II differences invariab..

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PEPTIDE ANTAGONISTS THAT PROMOTE POSITIVE SELECTION ARE INEFFICIENT AT T-CELL ACTIVATION AND THYMOCYTE DELETION

MJ BARNDEN, WR HEATH, S RODDA, FR CARBONE

Journal article  |  1994  |  European Journal of Immunology

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PROFOUND ATROPHY OF THE BONE-MARROW REFLECTING MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II-RESTRICTED DESTRUCTION OF STEM-CELLS BY CD4 CELLS

J SPRENT, CD SURH, D AGUS, M HURD, S SUTTON, WR HEATH

Journal article  |  1994  |  The Journal of Experimental Medicine

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T-CELL RECEPTOR ANTAGONIST PEPTIDES INDUCE POSITIVE SELECTION

KA HOGQUIST, SC JAMESON, WR HEATH, JL HOWARD, MJ BEVAN, FR CARBONE

Journal article  |  1994  |  Cell

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AVIDITY FOR ANTIGEN CAN INFLUENCE THE HELPER DEPENDENCE OF CD8 T-LYMPHOCYTES

WR HEATH, L KJERNIELSEN, MW HOFFMANN

Journal article  |  1993  |  Journal of Immunology

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FAILURE OF A PROTECTIVE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULE TO DELETE AUTOREACTIVE T-CELLS IN AUTOIMMUNE DIABETES

RM SLATTERY, JFAP MILLER, WR HEATH, B CHARLTON

Journal article  |  1993  |  Proceedings of the National Academy of Sciences

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EXPRESSION OF 2 ALPHA-CHAINS ON THE SURFACE OF T-CELLS IN T-CELL RECEPTOR TRANSGENIC MICE

WR HEATH, JFAP MILLER

Journal article  |  1993  |  The Journal of Experimental Medicine

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SELF-IGNORANCE IN THE PERIPHERAL T-CELL POOL

JFAP MILLER, WR HEATH

Journal article  |  1993  |  Immunological Reviews

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MEDULLARY THYMIC EPITHELIUM INDUCES TOLERANCE TO ALLOGENEIC MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ANTIGENS

MW HOFFMANN, WR HEATH, J ALLISON, JFAP MILLER

Journal article  |  1993  |  Transplantation proceedings

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PROTECTION AGAINST GRAFT-VERSUS-HOST DISEASE BY LARGE DOSES OF DONOR CD4 T-CELLS - A NOVEL-APPROACH TO BONE-MARROW TRANSPLANTATION

WR HEATH, JFAP MILLER, J SPRENT

Journal article  |  1993  |  Transplantation proceedings

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CD8( ) T-CELL TOLERANCE AND AUTOIMMUNITY TO EXTRA-THYMIC ANTIGENS

WR HEATH, J ALLISON, JFAP MILLER

Journal article  |  1993  |  Autoimmunity

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Medullary thymic epithelium induces tolerance to allogeneic major histocompatibility complex class I antigens

MW Hoffmann, WR Heath, J Allison, JFAP Miller

Conference Proceedings  |  1993  |  Transplantation Proceedings

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Protection against graft-versus-host disease by large doses of donor CD4 T cells: A novel approach to bone marrow transplantation

WR Heath, JFAP Miller, J Sprent

Conference Proceedings  |  1993  |  Transplantation Proceedings

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AUTOIMMUNE DIABETES AS A CONSEQUENCE OF LOCALLY PRODUCED INTERLEUKIN-2

WR HEATH, J ALLISON, MW HOFFMANN, G SCHONRICH, G HAMMERLING, B ARNOLD, JFAP MILLER

Journal article  |  1992  |  Nature

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Does interleukin-2 abrogate peripheral immunologic self-tolerance in vivo?

J Allison, W Heath, JF Miller

Journal article  |  1992  |  Seminars in Immunology

Transgenic mice that constitutively expressed murine IL-2 in islet beta cells (RIP-IL-2 mice) had pancreatitis from birth which re..

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POSTTHYMIC T-CELL TOLERANCE OR INDIFFERENCE - THAT IS THE QUESTION

JFAP MILLER, WR HEATH

Journal article  |  1992  |  Research in Immunology

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The T cell receptor V alpha 11 gene family. Analysis of allelic sequence polymorphism and demonstration of J alpha region-dependent recognition by allele-specific antibodies.

SC Jameson, PB Nakajima, JL Brooks, W Heath, O Kanagawa, NR Gascoigne

Journal article  |  1991  |  Journal of Immunology

Allelic polymorphism in TCR loci may play an important role in shaping the T cell repertoire and in disease susceptibility. We hav..

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ALLOREACTIVE T-CELLS DISCRIMINATE AMONG A DIVERSE SET OF ENDOGENOUS PEPTIDES

WR HEATH, KP KANE, MF MESCHER, LA SHERMAN

Journal article  |  1991  |  Proceedings of the National Academy of Sciences

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CELL-TYPE-SPECIFIC RECOGNITION OF ALLOGENEIC CELLS BY ALLOREACTIVE CYTOTOXIC T-CELLS - A CONSEQUENCE OF PEPTIDE-DEPENDENT ALLORECOGNITION

WR HEATH, LA SHERMAN

Journal article  |  1991  |  European Journal of Immunology

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ANALYSIS OF NOVEL RESIDUES OF CLASS-I INVOLVED IN RECOGNITION BY ALLOREACTIVE T-CELLS

WR HEATH, ME HURD, R MURRAY, J FRELINGER, LA SHERMAN

Journal article  |  1990  |  Immunogenetics

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PEPTIDE-DEPENDENT RECOGNITION OF H-2KB BY ALLOREACTIVE CYTO-TOXIC LYMPHOCYTES-T

WR HEATH, ME HURD, FR CARBONE, LA SHERMAN

Journal article  |  1989  |  Nature

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SPECIES-RESTRICTED INTERACTIONS BETWEEN CD8 AND THE ALPHA-3 DOMAIN OF CLASS-I INFLUENCE THE MAGNITUDE OF THE XENOGENEIC RESPONSE

MJ IRWIN, WR HEATH, LA SHERMAN

Journal article  |  1989  |  Journal of Experimental Medicine

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MAPPING OF EPITOPES RECOGNIZED BY ALLOREACTIVE CYTO-TOXIC LYMPHOCYTES-T USING INHIBITION BY MHC PEPTIDES

WR HEATH, A VITIELLO, LA SHERMAN

Journal article  |  1989  |  Journal of Immunology

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CONSEQUENCES OF SELF-PRESENTATION OF PEPTIDE ANTIGEN BY CYTOLYTIC LYMPHOCYTES-T

A VITIELLO, WR HEATH, LA SHERMAN

Journal article  |  1989  |  Journal of Immunology

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ROLE OF CLASS-II ANTIGENS IN DIFFERENT ROUTES OF ALLOACTIVATION

R SUTHERLAND, W HEATH, W BOYLE

Journal article  |  1986  |  Transplantation Proceedings

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In vivo and in vitro analyses of the immunogenicity of B16 melanoma cells.

W Heath, W Boyle

Journal article  |  1985  |  Australian Journal of Experimental Biology and Medical Science

In vitro grown B16, an H-2b melanoma cell line, was found to kill B10 (H-2b), B10.BR (H-2k), CBA (H-2k), and BALB/c (H-2d) but not..

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B16 melanoma as a model for leukocyte-depleted grafts.

W Heath, W Boyle

Journal article  |  1985  |  Transplantation Proceedings

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Scholarly Works

Keyword Analysis

Immunology
Clinical Health (organs, Diseases and Abnormal Conditions)
Clinical (organs, Diseases and Abnormal Conditions)
Medical Microbiology
Biochemistry and Cell Biology
Expanding Knowledge
Clinical Sciences
Indigenous Health
Microbiology
Neurosciences

News

Displaying the most recent news article by William Heath.

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Armour against malaria

Daniel Fernandez Ruiz, William Heath

September 28, 2016

1

News Articles

Honours, Awards and Fellowships

2008

FAA - Fellow of the Australian Academy of Science

1

Award

Credentials

Positions

Professor

Microbiology And Immunology

Education

Doctor of Philosophy

University of Melbourne

Bachelor of Science

University of Melbourne

Links