William Heath

CD8 and CD4 T Cells Infiltrate into the Brain during Plasmodium berghei ANKA Infection and Form Long-Term Resident Memory.

Nazanin Ghazanfari, Julia L Gregory, Sapna Devi, Daniel Fernandez-Ruiz, Lynette Beattie, Scott N Mueller, William R Heath

Journal article  |  2021  |  J Immunol

In the Plasmodium berghei ANKA mouse model of malaria, accumulation of CD8+ T cells and infected RBCs in the brain promotes the de..

Elucidating the Motif for CpG Oligonucleotide Binding to the Dendritic Cell Receptor DEC-205 Leads to Improved Adjuvants for Liver-Resident Memory.

Jessica Li, Fatma Panetta, Meredith O'Keeffe, Ingrid M Leal Rojas, Kristen J Radford, Jian-Guo Zhang, Daniel Fernandez-Ruiz, Gayle M Davey, Benjamin S Gully, Kirsteen M Tullett, Jamie Rossjohn, Richard Berry, Chin-Nien Lee, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2021  |  J Immunol

DEC-205 is a cell-surface receptor that transports bound ligands into the endocytic pathway for degradation or release within lyso..

Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

Angela D Pack, Patrick Schwartzhoff, Zeb R Zacharias, Daniel Fernandez-Ruiz, William R Heath, Prajwal Gurung, Kevin L Legge, Chris J Janse, Noah S Butler

Journal article  |  2021  |  CELL REPORTS

During acute malaria, most individuals mount robust inflammatory responses that limit parasite burden. However, long-lived sterili..

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various org..

CD49d marks Th1 and Tfh-like antigen-specific CD4( ) T cells during Plasmodium chabaudi infection

Jiun-Yu Jian, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Mana Miyakoda, Daisuke Kimura, Kazumi Kimura, Eriko Nozaki, Takuya Sakurai, Daniel Fernandez-Ruiz, William R Heath, Katsuyuki Yui

Journal article  |  2021  |  INTERNATIONAL IMMUNOLOGY

Upon activation, specific CD4+ T cells up-regulate the expression of CD11a and CD49d, surrogate markers of pathogen-specific CD4+ ..

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

Sapna Devi, Yannick O Alexandre, Joon Keit Loi, Ryan Gillis, Nazanin Ghazanfari, Sarah J Creed, Lauren E Holz, David Shackleford, Laura K Mackay, William R Heath, Erica K Sloan, Scott N Mueller

Journal article  |  2021  |  IMMUNITY

The sympathetic nervous system (SNS) controls various physiological functions via the neurotransmitter noradrenaline. Activation o..

Development of Plasmodium-specific liver-resident memory CD8( ) T cells after heat-killed sporozoite immunization in mice

Sonia Ghilas, Matthias H Enders, Rose May, Lauren E Holz, Daniel Fernandez-Ruiz, Anton Cozijnsen, Vanessa Mollard, Ian A Cockburn, Geoffrey McFadden, William R Heath, Lynette Beattie

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Malaria remains a major cause of mortality in the world and an efficient vaccine is the best chance of reducing the disease burden..

High expression of CD38 and MHC class II on CD8 T cells during severe influenza disease reflects bystander activation and trogocytosis

Xiaoxiao Jia, Brendon Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshanski, William Heath, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska

Journal article  |  2021

Although co-expression of CD38 and HLA-DR on CD8 + T cells reflects activation during influenza, SARS-CoV-2, Dengue, Ebola and HIV..

Harnessing liver-resident memory T cells for protection against malaria

Daniel Fernandez-Ruiz, Maria N de Menezes, Lauren E Holz, Sonia Ghilas, William R Heath, Lynette Beattie

Journal article  |  2021  |  EXPERT REVIEW OF VACCINES

INTRODUCTION: Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in pe..

Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity

Fionna A Surette, Jenna J Guthmiller, Lei Li, Alexandria J Sturtz, Rahul Vijay, Rosemary L Pope, Brandon L McClellan, Angela D Pack, Ryan A Zander, Peng Shao, Linda Yu-Ling Lan, Daniel Fernandez-Ruiz, William R Heath, Patrick C Wilson, Noah S Butler

Journal article  |  2021  |  PLOS PATHOGENS

Immunity against malaria depends on germinal center (GC)-derived antibody responses that are orchestrated by T follicular helper (..