William Heath

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses.

Sapna Devi, Yannick O Alexandre, Joon Keit Loi, Ryan Gillis, Nazanin Ghazanfari, Sarah J Creed, Lauren E Holz, David Shackleford, Laura K Mackay, William R Heath, Erica K Sloan, Scott N Mueller

Journal article  |  2021  |  Immunity

The sympathetic nervous system (SNS) controls various physiological functions via the neurotransmitter noradrenaline. Activation o..

Development of Plasmodium-specific liver-resident memory CD8( ) T cells after heat-killed sporozoite immunization in mice

Sonia Ghilas, Matthias H Enders, Rose May, Lauren E Holz, Daniel Fernandez-Ruiz, Anton Cozijnsen, Vanessa Mollard, Ian A Cockburn, Geoffrey McFadden, William R Heath, Lynette Beattie

Conference Proceedings  |  2021  |  European Journal of Immunology

High expression of CD38 and MHC class II on CD8 T cells during severe influenza disease reflects bystander activation and trogocytosis

Xiaoxiao Jia, Brendon Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshanski, William Heath, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska

Journal article  |  2021

Although co-expression of CD38 and HLA-DR on CD8 + T cells reflects activation during influenza, SARS-CoV-2, Dengue, Ebola and HIV..

Harnessing liver-resident memory T cells for protection against malaria

Daniel Fernandez-Ruiz, Maria N de Menezes, Lauren E Holz, Sonia Ghilas, William R Heath, Lynette Beattie

Journal article  |  2021  |  Expert Review of Vaccines

INTRODUCTION: Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in pe..

Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity

Fionna A Surette, Jenna J Guthmiller, Lei Li, Alexandria J Sturtz, Rahul Vijay, Rosemary L Pope, Brandon L McClellan, Angela D Pack, Ryan A Zander, Peng Shao, Linda Yu-Ling Lan, Daniel Fernandez-Ruiz, William R Heath, Patrick C Wilson, Noah S Butler

Journal article  |  2021  |  PLoS Pathogens

Immunity against malaria depends on germinal center (GC)-derived antibody responses that are orchestrated by T follicular helper (..

Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

Yannick O Alexandre, Sapna Devi, Simone L Park, Laura K Mackay, William R Heath, Scott N Mueller

Journal article  |  2020  |  Cell Reports

Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered..

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, et al.

Journal article  |  2020  |  eLife

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction o..

The cryo-EM structure of the endocytic receptor DEC-205.

Benjamin S Gully, Hariprasad Venugopal, Alex J Fulcher, Zhihui Fu, Jessica Li, Felix A Deuss, Carmen Llerena, William R Heath, Mireille H Lahoud, Irina Caminschi, Jamie Rossjohn, Richard Berry

Journal article  |  2020  |  Journal of Biological Chemistry

DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cel..

Resident Memory T Cells and Their Role within the Liver

Sonia Ghilas, Ana-Maria Valencia-Hernandez, Matthias H Enders, William R Heath, Daniel Fernandez-Ruiz

Journal article  |  2020  |  International Journal of Molecular Sciences

Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection i..

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

James G Bedford, Melanie Heinlein, Alexandra L Garnham, Thi HO Nguyen, Tom Loudovaris, Chenghao Ge, Stuart Mannering, Michael Elliott, Stuart G Tangye, Katherine Kedzierska, Daniel HD Gray, William R Heath, Linda M Wakim

Journal article  |  2020  |  Science Immunology

The nasal-associated lymphoid tissues (NALTs) are mucosal-associated lymphoid organs embedded in the submucosa of the nasal passag..