Joanne Hildebrand

The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of Disease

Emma C Tovey Crutchfield, Sarah E Garnish, Joanne M Hildebrand

Journal article  |  2021  |  BIOMOLECULES

Necroptosis is an inflammatory form of lytic programmed cell death that is thought to have evolved to defend against pathogens. Ge..

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

Sarah E Garnish, Yanxiang Meng, Akiko Koide, Jarrod J Sandow, Eric Denbaum, Annette V Jacobsen, Wayland Yeung, Andre L Samson, Christopher R Horne, Cheree Fitzgibbon, Samuel N Young, Phoebe PC Smith, Andrew I Webb, Emma J Petrie, Joanne M Hildebrand, Natarajan Kannan, Peter E Czabotar, Shohei Koide, James M Murphy

Journal article  |  2021  |  NATURE COMMUNICATIONS

Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL oligomerization, translocation to, and permeabilization..

A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes

Joanne M Hildebrand, Bernice Lo, Sara Tomei, Valentina Mattei, Samuel N Young, Cheree Fitzgibbon, James M Murphy, Abeer Fadda

Journal article  |  2021  |  CELL DEATH & DISEASE

Maturity-onset diabetes of the young, MODY, is an autosomal dominant disease with incomplete penetrance. In a family with multiple..

A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells

Andre L Samson, Cheree Fitzgibbon, Komal M Patel, Joanne M Hildebrand, Lachlan W Whitehead, Joel S Rimes, Annette V Jacobsen, Christopher R Horne, Xavier J Gavin, Samuel N Young, Kelly L Rogers, Edwin D Hawkins, James M Murphy

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by..

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling

Andre L Samson, Sarah E Garnish, Joanne M Hildebrand, James M Murphy

Journal article  |  2021  |  SCIENCE SIGNALING

Necroptosis is a lytic, proinflammatory cell death pathway, which has been implicated in host defense and, when dysregulated, the ..

Necroptotic movers and shakers: cell types, inflammatory drivers and diseases

Ashley Weir, Sebastian Hughes, Maryam Rashidi, Joanne M Hildebrand, James E Vince

Journal article  |  2021  |  CURRENT OPINION IN IMMUNOLOGY

The necroptotic cell death pathway has received significant attention for its ability to trigger inflammatory responses and its po..

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M Murphy, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Warren S Alexander, Emma C Josefsson

Journal article  |  2021  |  CELL DEATH & DISEASE

Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). P..

Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway

Catia L Pierotti, Maria C Tanzer, Annette Jacobsen, Joanne M Hildebrand, Jean-Marc Garnier, Pooja Sharma, Isabelle S Lucet, Angus D Cowan, Wilhelmus JA Kersten, Meng-Xiao Luo, Lung-Yu Liang, Cheree Fitzgibbon, Sarah E Garnish, Anne Hempel, Ueli Nachbur, David CS Huang, Peter E Czabotar, John Silke, Mark F van Delft, James M Murphy, et al.

Journal article  |  2020  |  ACS CHEMICAL BIOLOGY

Necroptosis is an inflammatory form of programmed cell death that has been implicated in various human diseases. Compound 2 is a m..

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a singl..

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Andre L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-medi..