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Understanding The Cellular Causes Of Motor Neurone Disease To Progress Development Of Trul..
A versatile quantitative microdroplet elemental imaging method optimised for integration i..
Ferroxidase Dysfunction Drives Glial Ferroptotic Stress And Motor Neurone Death Via Neurot..
Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1
Displaying the 5 most recent projects by James Hilton.
Displaying the 8 most recent scholarly works by James Hilton.
Superoxide dismutase 1 in health and disease: How a front-line antioxidant becomes neurotoxic.
Benjamin Trist, James B Hilton, Peter J Crouch, Dominic J Hare, Kay Lorraine Double
Journal article | 2020 | Angewandte Chemie International Edition
Cu/Zn superoxide dismutase (SOD1) is a front-line antioxidant enzyme catalysing superoxide breakdown and is important for most for..
The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1(G37R) mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1
James B Hilton, Kai Kysenius, Anthony R White, Peter J Crouch
Journal article | 2018 | Experimental Neurology
Cu-II(atsm) improves the neurological phenotype and survival of SOD1(G93A) mice and selectively increases enzymatically active SOD1 in the spinal cord
James B Hilton, Stephen W Mercer, Nastasia KH Lim, Noel G Faux, Gojko Buncic, Joseph S Beckman, Blaine R Roberts, Paul S Donnelly, Anthony R White, Peter J Crouch
Journal article | 2017 | SCIENTIFIC REPORTS
Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain
Nastasia KH Lim, Lin W Hung, Terence Y Pang, Catriona A Mclean, Jeffrey R Liddell, James B Hilton, Qiao-Xin Li, Anthony R White, Anthony J Hannan, Peter J Crouch
Journal article | 2014 | Human Molecular Genetics