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Dr

James Hilton

Research Fellow
Pharmacology And Therapeutics
animals
science & technology
humans
life sciences & biomedicine
copper
mice, transgenic
mice
motor-neuron disease
biochemistry & molecular biology
James Hilton's Profile Picture
Dr

James Hilton

 
Division
Medicine, Dentistry And Health Sciences
James Hilton's Profile Picture
Dr

James Hilton

 

Projects

Displaying the 5 most recent projects by James Hilton.

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Understanding The Cellular Causes Of Motor Neurone Disease To Progress Development Of Truly Effective Therapeutics

2019 - 2022
Active
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Ferroxidase Dysfunction Drives Glial Ferroptotic Stress And Motor Neurone Death Via Neurotoxic A1 Astrocyte Conversion

2019 - 2021
Active
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The Neurotoxic Consequences Of Glial Iron Accumulation In Mnd

2019 - 2019
Completed
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A Therapeutic Copper Compound To Treat Progressive Multiple Sclerosis

2018 - 2020
Active
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A Therapeutic Copper Compound To Treat Progressive Multiple Sclerosis

2018 - 2020
Active

5

Projects

Project Types

5

Research Grant

Scholarly Works

Displaying the 8 most recent scholarly works by James Hilton.

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Superoxide dismutase 1 in health and disease: How a front-line antioxidant becomes neurotoxic.

Benjamin Trist, James B Hilton, Peter J Crouch, Dominic J Hare, Kay Lorraine Double

Journal article  |  2020  |  Angewandte Chemie International Edition

Cu/Zn superoxide dismutase (SOD1) is a front-line antioxidant enzyme catalysing superoxide breakdown and is important for most for..

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A versatile quantitative microdroplet elemental imaging method optimised for integration in biochemical workflows for low-volume samples

Kai Kysenius, Bence Paul, James B Hilton, Jeffrey R Liddell, Dominic J Hare, Peter J Crouch

Journal article  |  2019  |  Analytical and Bioanalytical Chemistry

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Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1

K Kysenius, JB Hilton, B Paul, DJ Hare, PJ Crouch

Journal article  |  2019  |  Metallomics

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The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1(G37R) mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1

James B Hilton, Kai Kysenius, Anthony R White, Peter J Crouch

Journal article  |  2018  |  Experimental Neurology

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Cu-II(atsm) improves the neurological phenotype and survival of SOD1(G93A) mice and selectively increases enzymatically active SOD1 in the spinal cord

James B Hilton, Stephen W Mercer, Nastasia KH Lim, Noel G Faux, Gojko Buncic, Joseph S Beckman, Blaine R Roberts, Paul S Donnelly, Anthony R White, Peter J Crouch

Journal article  |  2017  |  SCIENTIFIC REPORTS

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Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS

JB Hilton, AR White, PJ Crouch

Journal article  |  2016  |  Metallomics

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Metal-deficient SOD1 in amyotrophic lateral sclerosis

James B Hilton, Anthony R White, Peter J Crouch

Journal article  |  2015  |  Journal of Molecular Medicine

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Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain

Nastasia KH Lim, Lin W Hung, Terence Y Pang, Catriona A Mclean, Jeffrey R Liddell, James B Hilton, Qiao-Xin Li, Anthony R White, Anthony J Hannan, Peter J Crouch

Journal article  |  2014  |  Human Molecular Genetics

8

Scholarly Works

Keyword Analysis

Neurosciences
Expanding Knowledge
Clinical Health (organs, Diseases and Abnormal Conditions)
Medicinal and Biomolecular Chemistry
Other Health
Inorganic Chemistry
Other Medical and Health Sciences

Credentials

Positions

Research Fellow

Pharmacology And Therapeutics

Education

Doctor of Philosophy

University of Melbourne

Bachelor of Science (Honours)

University of Melbourne

Links