James Vince

Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation.

Karla C Fischer, Carmel P Daunt, Cédric S Tremblay, Sheila Dias, James E Vince, Anissa M Jabbour

Journal article  |  2021  |  Cell Death & Disease

The IκB kinase complex, consisting of IKK1, IKK2 and the regulatory subunit NEMO, is required for NF-κB signalling following the a..

Necroptotic movers and shakers: cell types, inflammatory drivers and diseases.

Ashley Weir, Sebastian Hughes, Maryam Rashidi, Joanne M Hildebrand, James E Vince

Journal article  |  2020  |  Current Opinion in Immunology

The necroptotic cell death pathway has received significant attention for its ability to trigger inflammatory responses and its po..

Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases.

Maryam Rashidi, Ian P Wicks, James E Vince

Journal article  |  2020  |  Trends in Molecular Medicine

The accumulation of cellular and environmental microparticles has been linked to many diseases associated with tissue inflammation..

Receptor interacting protein kinases in cell death and inflammatory signalling.

James E Vince

Journal article  |  2020  |  Seminars in Cell & Developmental Biology

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

Pankaj Deo, Seong H Chow, Mei-Ling Han, Mary Speir, Cheng Huang, Ralf B Schittenhelm, Subhash Dhital, Jack Emery, Jian Li, Benjamin T Kile, James E Vince, Kate E Lawlor, Thomas Naderer

Journal article  |  2020  |  Nature Microbiology

Sensing of microbes activates the innate immune system, depending on functional mitochondria. However, pathogenic bacteria inhibit..

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Sarah A Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E Vince, Vivek Rathi, Gavin M Wright, Matthew E Ritchie, Kate D Sutherland

Journal article  |  2019  |  Nature Communications

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1 beta Release

Maryam Rashidi, Daniel S Simpson, Anne Hempel, Daniel Frank, Emma Petrie, Angelina Vince, Rebecca Feltham, Jane Murphy, Simon M Chatfield, Guy S Salvesen, James M Murphy, Ian P Wicks, James E Vince

Journal article  |  2019  |  The Journal of Immunology

The pyroptotic cell death effector gasdermin D (GSDMD) is required for murine models of hereditary inflammasome-driven, IL-1β-depe..

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham

Journal article  |  2019  |  Cell Death & Differentiation

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Ziv Erlich, Inbar Shlomovitz, Liat Edry-Botzer, Hadar Cohen, Daniel Frank, Hanging Wang, Andrew M Lew, Kate E Lawlor, Yifan Zhan, James E Vince, Motti Gerlic

Journal article  |  2019  |  Nature Immunology