James Vince

The ubiquitylation of IL-1 beta limits its cleavage by caspase-1 and targets it for proteasomal degradation

Swarna L Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S Simpson, Gregor Ebert, Angelina Vince, Marco J Herold, Andrew Kueh, Jaclyn S Pearson, Laura F Dagley, James M Murphy, Andrew I Webb, Kate E Lawlor, James E Vince

Journal article  |  2021  |  NATURE COMMUNICATIONS

Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of o..

Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis

Arpeeta Sharma, Judy SY Choi, Nada Stefanovic, Annas Al-Sharea, Daniel S Simpson, Nigora Mukhamedova, Karin Jandeleit-Dahm, Andrew J Murphy, Dmitri Sviridov, James E Vince, Rebecca H Ritchie, Judy B de Haan

Journal article  |  2021  |  DIABETES

Low-grade persistent inflammation is a feature of diabetes-driven vascular complications, in particular activation of the Nod-like..

Necroptotic movers and shakers: cell types, inflammatory drivers and diseases

Ashley Weir, Sebastian Hughes, Maryam Rashidi, Joanne M Hildebrand, James E Vince

Journal article  |  2021  |  CURRENT OPINION IN IMMUNOLOGY

The necroptotic cell death pathway has received significant attention for its ability to trigger inflammatory responses and its po..

Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation

Karla C Fischer, Carmel P Daunt, Cedric S Tremblay, Sheila Dias, James E Vince, Anissa M Jabbour

Journal article  |  2021  |  CELL DEATH & DISEASE

The IκB kinase complex, consisting of IKK1, IKK2 and the regulatory subunit NEMO, is required for NF-κB signalling following the a..

Receptor interacting protein kinases in cell death and inflammatory signalling

James E Vince

Journal article  |  2021  |  SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases

Maryam Rashidi, Ian P Wicks, James E Vince

Journal article  |  2020  |  TRENDS IN MOLECULAR MEDICINE

The accumulation of cellular and environmental microparticles has been linked to many diseases associated with tissue inflammation..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  IMMUNITY

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

Pankaj Deo, Seong H Chow, Mei-Ling Han, Mary Speir, Cheng Huang, Ralf B Schittenhelm, Subhash Dhital, Jack Emery, Jian Li, Benjamin T Kile, James E Vince, Kate E Lawlor, Thomas Naderer

Journal article  |  2020  |  NATURE MICROBIOLOGY

Sensing of microbes activates the innate immune system, depending on functional mitochondria. However, pathogenic bacteria inhibit..

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Sarah A Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E Vince, Vivek Rathi, Gavin M Wright, Matthew E Ritchie, Kate D Sutherland

Journal article  |  2019  |  NATURE COMMUNICATIONS

The KRAS oncoprotein, a critical driver in 33% of lung adenocarcinoma (LUAD), has remained an elusive clinical target due to its p..

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1 beta Release

Maryam Rashidi, Daniel S Simpson, Anne Hempel, Daniel Frank, Emma Petrie, Angelina Vince, Rebecca Feltham, Jane Murphy, Simon M Chatfield, Guy S Salvesen, James M Murphy, Ian P Wicks, James E Vince

Journal article  |  2019  |  JOURNAL OF IMMUNOLOGY

The pyroptotic cell death effector gasdermin D (GSDMD) is required for murine models of hereditary inflammasome-driven, IL-1β-depe..