Laura Jacobson

Altered EEG power spectrum, but not sleep-wake architecture, in HCN1 knockout mice

Lauren E Bleakley, Ryan J Keenan, Rachel D Graven, Jeremy A Metha, Sherie Ma, Heather Daykin, Linda Cornthwaite-Duncan, Daniel Hoyer, Christopher A Reid, Laura H Jacobson

Journal article  |  2023  |  BEHAVIOURAL BRAIN RESEARCH

Sleep is a complex biological state characterized by large populations of neurons firing in a rhythmic or synchronized manner. HCN..

Default Mode Network Modulation by Psychedelics: A Systematic Review

James J Gattuso, Daniel Perkins, Simon Ruffell, Andrew J Lawrence, Daniel Hoyer, Laura H Jacobson, Christopher Timmermann, David Castle, Susan L Rossell, Luke A Downey, Broc A Pagni, Nicole L Galvao-Coelho, David Nutt, Jerome Sarris

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Psychedelics are a unique class of drug which commonly produce vivid hallucinations as well as profound psychological and mystical..

Orexin Signaling: A Complex, Multifaceted Process

Natasha C Dale, Daniel Hoyer, Laura H Jacobson, Kevin DG Pfleger, Elizabeth KM Johnstone

Journal article  |  2022  |  FRONTIERS IN CELLULAR NEUROSCIENCE

The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two e..

Losing sleep with age

Laura H Jacobson, Daniel Hoyer

Journal article  |  2022  |  SCIENCE

Hypocretin neuron hyperexcitability underlies disrupted sleep quality associated with age.

Differential sleep/wake response and sex differences following acute suvorexant, MK-1064 and zolpidem administration in the rTg4510 mouse model of tauopathy

Ryan J Keenan, Heather Daykin, Jiahui Chu, Linda Cornthwaite-Duncan, Giancarlo Allocca, Daniel Hoyer, Laura H Jacobson

Journal article  |  2022  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Transgenic mouse models of tauopathy display prominent sleep/wake disturbances which manifest primarily as..

Hypocretins (orexins): The ultimate translational neuropeptides

Laura H Jacobson, Daniel Hoyer, Luis de Lecea

Journal article  |  2022  |  JOURNAL OF INTERNAL MEDICINE

The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively in the lateral hypothalamus. They act o..

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease

Rainer Machauer, Rainer Lueoend, Konstanze Hurth, Siem J Veenstra, Heinrich Rueeger, Markus Voegtle, Marina Tintelnot-Blomley, Jean-Michel Rondeau, Laura H Jacobson, Grit Laue, Karen Beltz, Ulf Neumann

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

After identification of lead compound 6, 5-amino-1,4-oxazine BACE1 inhibitors were optimized in order to improve potency, brain pe..

Development of a LC-ESI-MRM method for the absolute quantification of orexin A in the CSF of individual mice

K Hopkins, S Mukherjee, D Ponce, J Mangum, LH Jacobson, D Hoyer

Journal article  |  2021  |  Medicine in Drug Discovery

Sleep-wakefulness is disrupted in most neurological and psychiatric disorders. Although clinical data implicate orexin (hypocretin..

Synthesis of the Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor NB-360

Heinrich Rueeger, Rainer Lueoend, Rainer Machauer, Siem J Veenstra, Philipp Holzer, Konstanze Hurth, Markus Voegtle, Mathias Frederiksen, Jean-Michel Rondeau, Marina Tintelnot-Blomley, Laura H Jacobson, Matthias Staufenbiel, Grit Laue, Ulf Neumann

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

Starting from lead compound 4, the 1,4-oxazine headgroup was optimized to improve potency and brain penetration. Focusing at the 6..

Reward Motivation and Cognitive Flexibility in Tau Null-Mutation Mice

Sara Oberrauch, Jeremy A Metha, Maddison L Brian, Samuel A Barnes, Travis J Featherby, Andrew J Lawrence, Daniel Hoyer, Carsten Murawski, Laura H Jacobson

Journal article  |  2021  |  Neurobiology of Aging

The reduction of tau or hyperphosphorylated tau (p-tau) has been proposed as a therapeutic strategy for Alzheimer's disease (AD) a..