Laura Jacobson

Reward Motivation and Cognitive Flexibility in Tau Null-Mutation Mice

Sara Oberrauch, Jeremy A Metha, Maddison L Brian, Samuel A Barnes, Travis J Featherby, Andrew J Lawrence, Daniel Hoyer, Carsten Murawski, Laura H Jacobson

Journal article  |  2021  |  Neurobiology of Aging

The reduction of tau or hyperphosphorylated tau (p-tau) has been proposed as a therapeutic strategy for Alzheimer's disease (AD) a..

Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510

Ryan J Keenan, Sara Oberrauch, Romke Bron, Cameron J Nowell, Leesa M Challis, Daniel Hoyer, Laura H Jacobson

Journal article  |  2021  |  Journal of Alzheimer's Disease

BACKGROUND: Sleep/wake disturbances (e.g., insomnia and sleep fragmentation) are common in neurodegenerative disorders, especially..

Effects of orexin receptor antagonism on human sleep architecture: A systematic review

Jacob W Clark, Maddison L Brian, Sean PA Drummond, Daniel Hoyer, Laura H Jacobson

Journal article  |  2020  |  Sleep Medicine Reviews

Orexin receptor antagonists are a relatively new hypnotic principle. Their influence on human sleep architecture is a point of deb..

Circadian disruption impairs fear extinction and memory of conditioned safety in mice

Jacob W Clark, Daniel Hoyer, Sean W Cain, Andrew Phillips, Sean PA Drummond, Laura H Jacobson

Journal article  |  2020  |  Behavioural Brain Research

Animal models of fear conditioning and fear inhibition are frequently employed in the study of associative learning and commonly d..

Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy

Haihan Jiao, Laura E Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J Keenan, Laura H Jacobson, Holly R Chinnery

Journal article  |  2020  |  Journal of Neuroinflammation

BACKGROUND: Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alz..

Hypnotics with novel modes of action

Daniel Hoyer, Andrew Allen, Laura H Jacobson

Journal article  |  2020  |  British Journal of Clinical Pharmacology

Insomnia and, more generally, lack of sleep are on the rise. Traditionally treated by classical hypnotics, such as benzodiazepines..

Separating Probability and Reversal Learning in a Novel Probabilistic Reversal Learning Task for Mice

Jeremy A Metha, Maddison L Brian, Sara Oberrauch, Samuel A Barnes, Travis J Featherby, Peter Bossaerts, Carsten Murawski, Daniel Hoyer, Laura H Jacobson

Journal article  |  2020  |  Frontiers in Behavioral Neuroscience

The exploration/exploitation tradeoff – pursuing a known reward vs. sampling from lesser known options in the hope of finding a be..

Sex differences in mouse models of fear inhibition: Fear extinction, safety learning, and fear-safety discrimination

Jacob W Clark, Sean PA Drummond, Daniel Hoyer, Laura H Jacobson

Journal article  |  2019  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Women are overrepresented in post-traumatic stress disorder (PTSD), a mental disorder characterised by ine..

Therapeutics for dementia and Alzheimer's disease: New directions for precision medicine

JA Duce, X Zhu, LH Jacobson, PM Beart

Journal article  |  2019  |  British Journal of Pharmacology

Novel alterations to the corneal neuroimmune phenotype in mice with central nervous system tauopathy

Haihan Jiao, Laura Elizabeth Downie, Sara Oberrauch, Mengliang Wu, Holly Rose Chinnery, Laura Jacobson

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE