Laura Jacobson

Circadian disruption impairs fear extinction and memory of conditioned safety in mice.

Jacob W Clark, Daniel Hoyer, Sean W Cain, Andrew Phillips, Sean PA Drummond, Laura H Jacobson

Journal article  |  2020  |  Behavioural Brain Research

Animal models of fear conditioning and fear inhibition are frequently employed in the study of associative learning and commonly d..

Effects of orexin receptor antagonism on human sleep architecture: A systematic review.

Jacob W Clark, Maddison L Brian, Sean PA Drummond, Daniel Hoyer, Laura H Jacobson

Journal article  |  2020  |  Sleep Medicine Reviews

Orexin receptor antagonists are a relatively new hypnotic principle. Their influence on human sleep architecture is a point of deb..

Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy

Haihan Jiao, Laura E Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J Keenan, Laura H Jacobson, Holly R Chinnery

Journal article  |  2020  |  Journal of Neuroinflammation

BACKGROUND: Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alz..

Hypnotics with novel modes of action

Daniel Hoyer, Andrew Allen, Laura H Jacobson

Journal article  |  2020  |  British Journal of Clinical Pharmacology

Insomnia and, more generally, lack of sleep are on the rise. Traditionally treated by classical hypnotics, such as benzodiazepines..

Separating Probability and Reversal Learning in a Novel Probabilistic Reversal Learning Task for Mice

Jeremy A Metha, Maddison L Brian, Sara Oberrauch, Samuel A Barnes, Travis J Featherby, Peter Bossaerts, Carsten Murawski, Daniel Hoyer, Laura H Jacobson

Journal article  |  2020  |  Frontiers in Behavioral Neuroscience

The exploration/exploitation tradeoff – pursuing a known reward vs. sampling from lesser known options in the hope of finding a be..

Sex differences in mouse models of fear inhibition: Fear extinction, safety learning, and fear-safety discrimination

Jacob W Clark, Sean PA Drummond, Daniel Hoyer, Laura H Jacobson

Journal article  |  2019  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Women are overrepresented in post-traumatic stress disorder (PTSD), a mental disorder characterised by ine..

Therapeutics for dementia and Alzheimer's disease: New directions for precision medicine

JA Duce, X Zhu, LH Jacobson, PM Beart

Journal article  |  2019  |  British Journal of Pharmacology

Novel alterations to the corneal neuroimmune phenotype in mice with central nervous system tauopathy

Haihan Jiao, Laura Elizabeth Downie, Sara Oberrauch, Mengliang Wu, Holly Rose Chinnery, Laura Jacobson

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease

Ulf Neumann, Mike Ufer, Laura H Jacobson, Marie-Laure Rouzade-Dominguez, Gunilla Huledal, Carine Kolly, Rainer M Luond, Rainer Machauer, Siem J Veenstra, Konstanze Hurth, Heinrich Rueeger, Marina Tintelnot-Blomley, Matthias Staufenbiel, Derya R Shimshek, Ludovic Perrot, Wilfried Frieauff, Valerie Dubost, Hilmar Schiller, Barbara Vogg, Karen Beltz, et al.

Journal article  |  2018  |  EMBO Molecular Medicine

The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours

Ryan J Keenan, Jacky Chan, Paul S Donnelly, Kevin J Barnham, Laura H Jacobson

Journal article  |  2018  |  Neurobiology of Stress

Lemborexant Dual orexin receptor antagonist Treatment of insomnia

D Hoyer, LH Jacobson

Journal article  |  2018  |  Drugs of the Future

Selective Na(V)1.1 activation rescues Dravet syndrome mice from seizures and premature death

Kay L Richards, Carol J Milligan, Robert J Richardson, Nikola Jancovski, Morten Grunnet, Laura H Jacobson, Eivind AB Undheim, Mehdi Mobli, Chun Yuen Chow, Volker Herzig, Agota Csoti, Gyorgy Panyi, Christopher A Reid, Glenn F King, Steven Petrou

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

Leah C Beauchamp, Jacky Chan, Lin W Hung, Benjamin S Padman, Laura J Vella, Xiang M Liu, Bradley Coleman, Ashley I Bush, Michael Lazarou, Andrew F Hill, Laura Jacobson, Kevin J Barnham

Journal article  |  2018  |  ACTA NEUROPATHOLOGICA COMMUNICATIONS

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

Siem Jakob Veenstra, Heinrich Rueeger, Markus Voegtle, Rainer Lueoend, Philipp Holzer, Konstanze Hurth, Marina Tintelnot-Blomley, Mathias Frederiksen, Jean-Michel Rondeau, Laura Jacobson, Matthias Staufenbiel, Ulf Neumann, Rainer Machauer

Journal article  |  2018  |  Bioorganic & Medicinal Chemistry Letters

The Gamma-Aminobutyric Acid B Receptor in Depression and Reward

Laura H Jacobson, Styliani Vlachou, David A Slattery, Xia Li, John F Cryan

Journal article  |  2018  |  Biological Psychiatry

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABA(B1a) but not GABA(B1b) subunit isoforms

Laura H Jacobson, Daniel Hoyer, Dominique Fehlmann, Bernhard Bettler, Klemens Kaupmann, John F Cryan

Journal article  |  2017  |  Psychopharmacology

Orexin OX2 Receptor Antagonists as Sleep Aids

Laura H Jacobson, Sui Chen, Sanjida Mir, Daniel Hoyer

Journal article  |  2017  |  Current topics in behavioral neurosciences

The discovery of the orexin system represents the single major progress in the sleep field of the last three to four decades. The ..

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitore-treated APP transgenic mice

Nicolau Beckmann, Arno Doelemeyer, Stefan Zurbruegg, Karine Bigot, Diethilde Theil, Wilfried Frieauff, Carine Kolly, Pierre Moulin, Daniel Neddermann, Robert Kreutzer, Ludovic Perrot, Irena Brzak, Laura H Jacobson, Matthias Staufenbiel, Ulf Neumann, Derya R Shimshek

Journal article  |  2016  |  Neurobiology of Aging

Neurological Dysfunction in Early Maturity of a Model for Niemann-Pick C1 Carrier Status

Ya Hui Hung, Mark Walterfang, Leonid Churilov, Lisa Bray, Laura H Jacobson, Kevin J Barnham, Nigel C Jones, Terence J O'Brien, Dennis Velakoulis, Ashley I Bush

Journal article  |  2016  |  NEUROTHERAPEUTICS

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

Derya R Shimshek, Laura H Jacobson, Carine Kolly, Natasa Zamurovic, Kamal Kumar Balavenkatraman, Laurent Morawiec, Robert Kreutzer, Juliane Schelle, Mathias Jucker, Barbara Bertschi, Diethilde Theil, Annabelle Heier, Karine Bigot, Karen Beltz, Rainer Machauer, Irena Brzak, Ludovic Perrot, Ulf Neumann

Journal article  |  2016  |  Scientific Reports

Differential roles of GABA(B1) subunit isoforms on locomotor responses to acute and repeated administration of cocaine

Laura H Jacobson, Fabian F Sweeney, Klemens Kaupmann, Olivia F O'Leary, Martin Gassmann, Bernhard Bettler, John F Cryan

Journal article  |  2016  |  Behavioural Brain Research

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs)

Dirk Behnke, Simona Cotesta, Samuel Hintermann, Markus Fendt, Christine E Gee, Laura H Jacobson, Grit Laue, Arndt Meyer, Trixie Wagner, Sangamesh Badiger, Vinod Chaudhari, Murali Chebrolu, Chetan Pandit, Daniel Hoyer, Claudia Betschart

Journal article  |  2015  |  Bioorganic & Medicinal Chemistry Letters

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-beta and neuroinflammation in APP transgenic mice

Ulf Neumann, Heinrich Rueeger, Rainer Machauer, Siem Jacob Veenstra, Rainer M Lueoend, Marina Tintelnot-Blomley, Grit Laue, Karen Beltz, Barbara Vogg, Peter Schmid, Wilfried Frieauff, Derya R Shimshek, Matthias Staufenbiel, Laura H Jacobson

Journal article  |  2015  |  Molecular Neurodegeneration

Suvorexant for the treatment of insomnia

Laura H Jacobson, Gabrielle E Callander, Daniel Hoyer

Journal article  |  2014  |  Expert Review of Clinical Pharmacology

Orexin in sleep, addiction and more: Is the perfect insomnia drug at hand?

Daniel Hoyer, Laura H Jacobson

Journal article  |  2013  |  Neuropeptides

Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia

Claudia Betschart, Samuel Hintermann, Dirk Behnke, Simona Cotesta, Markus Fendt, Christine E Gee, Laura H Jacobson, Grit Laue, Silvio Ofner, Vinod Chaudhari, Sangamesh Badiger, Chetan Pandit, Juergen Wagner, Daniel Hoyer

Journal article  |  2013  |  Journal of Medicinal Chemistry

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid beta-peptides

Heinrich Rueeger, Rainer Lueoend, Rainer Machauer, Siem Jacob Veenstra, Laura Helen Jacobson, Matthias Staufenbiel, Sandrine Desrayaud, Jean-Michel Rondeau, Henrik Moebitz, Ulf Neumann

Journal article  |  2013  |  Bioorganic and Medicinal Chemistry Letters

Enhanced Proteolytic Clearance of Plasma A beta by Peripherally Administered Neprilysin Does Not Result in Reduced Levels of Brain A beta in Mice

John R Walker, Reynand Pacoma, James Watson, Weijia Ou, Juliano Alves, Daniel E Mason, Eric C Peters, Hugo D Urbina, Gus Welzel, Alana Althage, Bo Liu, Tove Tuntland, Laura H Jacobson, Jennifer L Harris, Andrew M Schumacher

Journal article  |  2013  |  Journal of Neuroscience

Distinct effects of IPSU and suvorexant on mouse sleep architecture

Daniel Hoyer, Thomas Duerst, Markus Fendt, Laura H Jacobson, Claudia Betschart, Samuel Hintermann, Dirk Behnke, Simona Cotesta, Grit Laue, Silvio Ofner, Eric Legangneux, Christine E Gee

Journal article  |  2013  |  Frontiers in Neuroscience

Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors

Gabrielle E Callander, Morenike Olorunda, Dominique Monna, Edi Schuepbach, Daniel Langenegger, Claudia Betschart, Samuel Hintermann, Dirk Behnke, Simona Cotesta, Markus Fendt, Grit Laue, Silvio Ofner, Emmanuelle Briard, Christine E Gee, Laura H Jacobson, Daniel Hoyer

Journal article  |  2013  |  Frontiers in Neuroscience

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture

Samuel Hintermann, Claudia Betschart, Dirk Behnke, Simona Cotesta, Markus Fendt, Christine Gee, Laura Jacobson, Grit Laue, Silvio Ofner, Vinod Chaudhari, Sangamesh Badiger, Chetan Pandit, Juergen Wagner, Hoyer Daniel

Conference Proceedings  |  2012  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective beta-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid beta-Peptides

Heinrich Rueeger, Rainer Lueoend, Olivier Rogel, Jean-Michel Rondeau, Henrik Moebitz, Rainer Machauer, Laura Jacobson, Matthias Staufenbiel, Sandrine Desrayaud, Ulf Neumann

Journal article  |  2012  |  Journal of Medicinal Chemistry

BACE1 Inhibition Induces a Specific Cerebrospinal Fluid beta-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

Niklas Mattsson, Lawrence Rajendran, Henrik Zetterberg, Mikael Gustavsson, Ulf Andreasson, Maria Olsson, Gunnar Brinkmalm, Johan Lundkvist, Laura H Jacobson, Ludovic Perrot, Ulf Neumann, Herman Borghys, Marc Mercken, Deborah Dhuyvetter, Fredrik Jeppsson, Kaj Blennow, Erik Portelius

Journal article  |  2012  |  PLoS One

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

Laura H Jacobson, S Renee Commerford, Sarah P Gerber, Yu Alice Chen, Beatriz Dardik, Frederique Chaperon, Chad Schwartzkopf, Nguyen-Tran Van, Thomas Hollenbeck, Peter McNamara, Xiaohui He, Hong Liu, H Martin Seidel, Anne-Liese Jaton, Jesper Gromada, Sandra Teixeira

Journal article  |  2011  |  Naunyn-Schmiedeberg's Archives of Pharmacology

The Second-Generation Active A beta Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects

Christoph Wiessner, Karl-Heinz Wiederhold, Alain C Tissot, Peter Frey, Simone Danner, Laura H Jacobson, Gary T Jennings, Rainer Lueoend, Rainer Ortmann, Julia Reichwald, Mauro Zurini, Anis Mir, Martin F Bachmann, Matthias Staufenbiel

Journal article  |  2011  |  Journal of Neuroscience

Structure based design of cyclic sulfoxide hydroxyethylamine BACE1 inhibitors

Heinrich Rueeger, Sandrine Desrayaud, Laura Jacobson, Rainer Lueoend, Rainer Machauer, Henrik Moebitz, Neumann Ulf, Jean-Michel Rondeau, Matthias Staufenbiel, Siem Veenstra

Conference Proceedings  |  2011  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats

Steffen Klein, Laurent B Nicolas, Cristina Lopez-Lopez, Laura H Jacobson, Silvia Gatti McArthur, Christophe Grundschober, Eric P Prinssen

Journal article  |  2010  |  Psychopharmacology

RATIONALE: Increasing evidence suggests that defensive escape behavior in Lister-hooded (LH) rats induced by ultrasound applicatio..

Effect of abomasal prebiotic supplementation on sheep faecal microbiota

Y Li, J Mills, LH Jacobson, M Manley-Harris, GJ Le Roux, RG Bell

Journal article  |  2010  |  New Zealand Journal of Agricultural Research

Genetic Approaches to Modeling Anxiety in Animals

Laura H Jacobson, John F Cryan

Journal article  |  2010  |  Current Topics in Behavioral Neurosciences

Anxiety disorders are a growing health problem world-wide. However, the causative factors, etiology, and underlying mechanisms of ..

Induction of cerebral beta-amyloidosis: Intracerebral versus systemic A beta inoculation

Yvonne S Eisele, Tristan Bolmont, Mathias Heikenwalder, Franziska Langer, Laura H Jacobson, Zheng-Xin Yan, Klaus Roth, Adriano Aguzzi, Matthias Staufenbiel, Lary C Walker, Mathias Jucker

Journal article  |  2009  |  Proceedings of the National Academy of Sciences

Despite the importance of the aberrant polymerization of Abeta in the early pathogenic cascade of Alzheimer's disease, little is k..

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity

M Fendt, S Schmid, DR Thakker, LH Jacobson, R Yamamoto, K Mitsukawa, R Maier, F Natt, D Huesken, PH Kelly, KH McAllister, D Hoyer, H van der Putten, JF Cryan, PJ Flor

Journal article  |  2008  |  Molecular Psychiatry

Correlation of cellular changes and spatial memory during aging in rats

Laura Jacobson, Rong Zhang, Douglas Elliffe, Kuan-Fei Chen, Sam Mathai, Di McCarthy, Henry Waldvogel, Jian Guan

Journal article  |  2008  |  Experimental Gerontology

We describe neuronal density, neuroplasticity and vascular remodelling and their association with spatial memory in young (4-6 mon..

Evaluation of the anxiolytic-like profile of the GABA(B) receptor positive modulator CGP7930 in rodents

Laura H Jacobson, John F Cryan

Journal article  |  2008  |  Neuropharmacology

There is a growing body of data to support the notion that GABA(B) receptors may be a therapeutic target for anxiety disorders. Ho..

Recombinant extracellular domains of human neuronal nicotinic receptors: Preliminary studies on mutant forms for the improvement of solubility

M Zouridakis, P Zisimopoulou, E Eliopoulos, L Jacobson, K Poulas, SJ Tzartos

Conference Proceedings  |  2007  |  Neurophysiology

Specific roles of GABA(B(l)) receptor isoforms in cognition

Laura H Jacobson, Peter H Kelly, Bernhard Bettler, Klemens Kaupmann, John F Cryan

Journal article  |  2007  |  Behavioural Brain Research

The GABA(B) receptor is a heterodimer of GABA(B(1)) and GABA(B(2)) subunits. There are two isoforms of the GABA(B(1)) subunit: GAB..

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety

Laura H Jacobson, Bernhard Bettler, Klemens Kaupmann, John F Cryan

Journal article  |  2007  |  Psychopharmacology

RATIONALE: Emerging data support a role for GABA(B) receptors in anxiety. GABA(B) receptors are comprised of a heterodimeric compl..

Feeling strained? Influence of genetic background on depression-related behavior in mice: A review

LH Jacobson, JF Cryan

Journal article  |  2007  |  Behavior Genetics

Depression is a growing pandemic in developed societies. The use of inbred mouse strains in pre-clinical psychiatric research has ..

A genetic upper limit to whole-body protein deposition in a strain of growing pigs

PJ Moughan, LH Jacobson, PCH Morel

Journal article  |  2006  |  Journal of Animal Science

The genetic upper limit to daily whole-body protein deposition (Pdmax) is an important constraint on pig growth. The Pdmax was det..

GABA(B(1)) receptor subunit isoforms exert a differential influence on baseline but not GABA(B) receptor agonist-induced changes in mice

Laura H Jacobson, Bernhard Bettler, Klemens Kaupmann, John F Cryan

Journal article  |  2006  |  Journal of Pharmacology and Experimental Therapeutics

GABA(B) receptor agonists produce hypothermia and motor incoordination. Two GABA(B(1)) receptor subunit isoforms exist, but becaus..

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories

Laura H Jacobson, Peter H Kelly, Bernhard Bettler, Klemens Kaupmann, John F Cryan

Journal article  |  2006  |  Journal of Neuroscience

Conditioned taste aversion (CTA) is a form of aversive memory in which an association is made between a consumed substance and a s..

Differential compartmentalization and distinct functions of GABA(B) receptor variants

Rejan Vigot, Samuel Barbieri, Hans Brauner-Osborne, Rostislav Turecek, Ryuichi Shigemoto, Yan-Ping Zhang, Rafael Lujan, Laura H Jacobson, Barbara Biermann, Jean-Marc Fritschy, Claire-Marie Vacher, Matthias Mueller, Gilles Sansig, Nicole Guetg, John F Cryan, Klemens Kaupmann, Martin Gassmann, Thomas G Oertner, Bernhard Bettler

Journal article  |  2006  |  Neuron

GABAB receptors are the G protein-coupled receptors for the main inhibitory neurotransmitter in the brain, gamma-aminobutyric acid..

Differential sensitivity to the motor and hypothermic effects of the GABA(B) receptor agonist baclofen in various mouse strains

LH Jacobson, JF Cryan

Journal article  |  2005  |  Psychopharmacology

RATIONALE: Comparison of different mouse strains can provide valuable information about the genetic control of behavioural and mol..

Effect of feeding pasture-finished cattle different conserved forages on Escherichia coli in the rumen and faeces.

LH Jacobson, TA Nagle, NG Gregory, RG Bell, G Le Roux, JM Haines

Journal article  |  2002  |  Meat science

The effects of eight different pre-slaughter diets on gut microflora, pH and dry matter were evaluated in 112 slaughter-weight, pa..

Effect of feeding pasture-finished cattle different conserved forages on Escherichia coli in the rumen and faeces

LH Jacobson, TA Nagle, NG Gregory, RG Bell, G Le Roux, JM Haines

Journal article  |  2002  |  Meat Science

The effects of eight different pre-slaughter diets on gut microflora, pH and dry matter were evaluated in 112 slaughter-weight, pa..

Effect of preslaughter feeding system on weight loss, gut bacteria, and the physico-chemical properties of digesta in cattle

NG Gregory, LH Jacobson, TA Nagle, RW Muirhead, GJ Leroux

Journal article  |  2000  |  New Zealand Journal of Agricultural Research

Alpha-Bungarotoxin binding to human muscle acetylcholine receptor: measurement of affinity, delineation of AChR subunit residues crucial to binding, and protection of AChR function by synthetic peptides.

A Vincent, L Jacobson, L Curran

Journal article  |  1998  |  Neurochemistry International

Alpha-Bungarotoxin (alpha-BuTx) binds with high affinity to the nicotinic acetylcholine receptor (AChR) of most species, mainly to..

Partitioning psychological and physical sources of transport-related stress in young cattle

LH Jacobson, CJ Cook

Journal article  |  1998  |  The Veterinary Journal

Heart rate as a measure of adaptation to stress in cattle

CJ Cook, LH Jacobson

Journal article  |  1996  |  Australian Veterinary Journal

SALIVARY CORTISOL AS AN INDICATOR OF STRESS IN SHEEP (OVIS-OVIS)

CJ COOK, LH JACOBSON

Journal article  |  1995  |  New Zealand Veterinary Journal

ELECTRICAL HEAD-ONLY STUNNING OF FALLOW DEER (DAMA-DAMA)

CJ COOK, CE DEVINE, KV GILBERT, LH JACOBSON, DK BLACKMORE

Journal article  |  1994  |  New Zealand Veterinary Journal

An antagonist to vasoactive intestinal peptide affects cellular functions in the central nervous system.

I Gozes, SK McCune, L Jacobson, D Warren, TW Moody, M Fridkin, DE Brenneman

Journal article  |  1991  |  Journal of Pharmacology and Experimental Therapeutics

A vasoactive intestinal peptide (VIP) antagonist was synthesized and used to investigate the interactions of VIP with its receptor..