Alistair Chalk

Srsf2(P95H/ ) co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice

Jane Jialu Xu, Alistair M Chalk, Meaghan Wall, Wallace Y Langdon, Monique F Smeets, Carl R Walkley

Journal article  |  2022  |  LEUKEMIA

Recurrent mutations in RNA splicing proteins and epigenetic regulators contribute to the development of myelodysplastic syndrome (..

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation

Jane Jialu Xu, Alistair M Chalk, Iva Nikolic, Kaylene J Simpson, Monique F Smeets, Carl R Walkley

Journal article  |  2022  |  BLOOD ADVANCES

Current strategies to target RNA splicing mutant myeloid cancers proposes targeting the remaining splicing apparatus. This approac..

The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis

Alanna C Green, Gavin Tjin, Samuel C Lee, Alistair M Chalk, Lenny Straszkowski, Diannita Kwang, Emma K Baker, Julie M Quach, Takaharu Kimura, Joy Y Wu, Louise E Purton

Journal article  |  2021  |  BLOOD

Hematopoiesis is extrinsically controlled by cells of the bone marrow microenvironment, including skeletal lineage cells. The iden..

DNA REPAIR AND CELL CYCLE ARE SYNTHETIC LETHAL PATHWAYS IN SRSF2P95H MUTATED CELLS

undefined Janexu, Monique Smeets, Alistair Chalk, Iva Nikolic, Kaylene Simpson, Carl Walkley

Conference Proceedings  |  2020  |  EXPERIMENTAL HEMATOLOGY

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

Therese Vu, Jasmin Straube, Amy H Porter, Megan Bywater, Axia Song, Victoria Ling, Leanne Cooper, Gabor Pali, Claudia Bruedigam, Sebastien Jacquelin, Joanne Green, Graham Magor, Andrew Perkins, Alistair M Chalk, Carl R Walkley, Florian H Heidel, Pamela Mukhopadhyay, Nicole Cloonan, Stefan Groeschel, Jan-Philipp Mallm, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retrov..

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Alistair M Chalk, Scott Taylor, Jacki E Heraud-Farlow, Carl R Walkley

Journal article  |  2019  |  GENOME BIOLOGY

BACKGROUND: Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sit..

UNDERSTANDING THE BASIS OF CO-OPERATIVITY BETWEEN SRSF2P95H MUTATION AND TET2 DELETION IN A MOUSE MODEL OF MYELOPROLIFERATIVE/MYELODYSPLASTIC SYNDROMES

Jane Xu, Monique Smeets, Alistair Chalk, Louise Purton, Carl Walkley

Journal article  |  2019  |  Experimental Hematology

Defining the functions of adenosine-to-inosine RNA editing through hematology

Jacki E Heraud-Farlow, Alistair M Chalk, Carl R Walkley

Journal article  |  2019  |  CURRENT OPINION IN HEMATOLOGY

PURPOSE OF REVIEW: The direct modification of RNA is now understood to be widespread, evolutionarily conserved and of consequence ..

Using CAGE Data for Quantitative Expression

Michiel De Hoon, Nicolas Bertin, Alistair M Chalk

Book Chapter  |  2019

Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells

Monique F Smeets, Shuh Ying Tan, Jane Jialu Xu, Govardhan Anande, Ashwin Unnikrishnan, Alistair M Chalk, Scott R Taylor, John E Pimanda, Meaghan Wall, Louise E Purton, Carl R Walkley

Journal article  |  2018  |  BLOOD

Mutations in SRSF2 occur in myelodysplastic syndromes (MDS) and MDS/myeloproliferative neoplasms (MPN). SRSF2 mutations cluster at..