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Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from he..
Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and..
Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma..
Displaying the 17 most recent scholarly works by Alistair Chalk.
The majority of A-to-I RNA editing is not required for mammalian homeostasis
Alistair M Chalk, Scott Taylor, Jacki E Heraud-Farlow, Carl R Walkley
Journal article | 2019 | Genome Biology
BACKGROUND: Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sit..
Defining the functions of adenosine-to-inosine RNA editing through hematology
Jacki E Heraud-Farlow, Alistair M Chalk, Carl R Walkley
Journal article | 2019 | Current Opinion in Hematology
PURPOSE OF REVIEW: The direct modification of RNA is now understood to be widespread, evolutionarily conserved and of consequence ..
Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells
Monique F Smeets, Shuh Ying Tan, Jane Jialu Xu, Govardhan Anande, Ashwin Unnikrishnan, Alistair M Chalk, Scott R Taylor, John E Pimanda, Meaghan Wall, Louise E Purton, Carl R Walkley
Journal article | 2018 | Blood
Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis
Jacki E Heraud-Farlow, Alistair M Chalk, Sandra E Linder, Qin Li, Scott Taylor, Joshua M White, Lokman Pang, Brian J Liddicoat, Ankita Gupte, Jin Billy Li, Carl R Walkley
Journal article | 2017 | Genome Biology
Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis
Brian J Liddicoat, Jochen C Hartner, Robert Piskol, Gokul Ramaswami, Alistair M Chalk, Paul D Kingsley, Vijay G Sankaran, Meaghan Wall, Louise E Purton, Peter H Seeburg, James Palis, Stuart H Orkin, Jun Lu, Jin Billy Li, Carl R Walkley
Journal article | 2016 | Experimental Hematology
Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma
Ankita Gupte, Emma K Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A Shelat, Cathryn M Gould, Alistair M Chalk, Scott Taylor, Kurt Lackovic, Asa Karlstroem, Anthony J Mutsaers, Jayesh Desai, Piyush B Madhamshettiwar, Andrew CW Zannettino, Chris Burns, David CS Huang, Michael A Dyer, Kaylene J Simpson, Carl R Walkley
Journal article | 2015 | Clinical Cancer Research
BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
Emma K Baker, Scott Taylor, Ankita Gupte, Phillip P Sharp, Mannu Walia, Nicole C Walsh, Andrew CW Zannettino, Alistair M Chalk, Christopher J Burns, Carl R Walkley
Journal article | 2015 | Scientific Reports
Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma
Emma K Baker, Scott Taylor, Ankita Gupte, Alistair M Chalk, Shreya Bhattacharya, Alanna C Green, T John Martin, Dario Strbenac, Mark D Robinson, Louise E Purton, Carl R Walkley
Journal article | 2015 | Bone
Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms.
Alistair M Chalk, Brian JJ Liddicoat, Carl R Walkley, Sofie Singbrant
Journal article | 2014 | Genomics Data
The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its ope..
The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease
Sofie Singbrant, Meaghan Wall, Jennifer Moody, Goeran Karlsson, Alistair M Chalk, Brian Liddicoat, Megan R Russell, Carl R Walkley, Stefan Karlsson
Journal article | 2014 | Haematologica
Medicine - St Vincent'S Hospital