Craig Morton

A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein

Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balazs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, et al.

Journal article  |  2022  |  EMBO MOLECULAR MEDICINE

C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We re..

Heparin Inhibits SARS-CoV-2 Replication in Human Nasal Epithelial Cells

Leo Yi Yang Lee, Randy Suryadinata, Conor McCafferty, Vera Ignjatovic, Damian FJ Purcell, Phil Robinson, Craig J Morton, Michael W Parker, Gary P Anderson, Paul Monagle, Kanta Subbarao, Jessica A Neil

Journal article  |  2022  |  VIRUSES-BASEL

SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Vaccination, supported by social and public health measures, has prove..

C-reactive protein, immunothrombosis and venous thromboembolism

Caroline Dix, Johannes Zeller, Hannah Stevens, Steffen U Eisenhardt, Karen S Cheung Tung Shing, Tracy L Nero, Craig J Morton, Michael W Parker, Karlheinz Peter, James D McFadyen

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical pract..

Single-molecule analysis of the entire perfringolysin O pore formation pathway

Conall Mc Guinness, James C Walsh, Charles Bayly-Jones, Michelle A Dunstone, Michelle P Christie, Craig J Morton, Michael W Parker, Till Bocking

Journal article  |  2022  |  ELIFE

The cholesterol-dependent cytolysin perfringolysin O (PFO) is secreted by Clostridium perfringens as a bacterial virulence factor ..

Cholesterol-dependent cytolysins: The outstanding questions

Bronte A Johnstone, Riya Joseph, Michelle P Christie, Craig J Morton, Conall McGuiness, James C Walsh, Till Bocking, Rodney K Tweten, Michael W Parker

Journal article  |  2022  |  IUBMB LIFE

The cholesterol-dependent cytolysins (CDCs) are a major family of bacterial pore-forming proteins secreted as virulence factors by..

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

Stanley C Xie, Riley D Metcalfe, Elyse Dunn, Craig J Morton, Shih-Chung Huang, Tanya Puhalovich, Yawei Du, Sergio Wittlin, Shuai Nie, Madeline R Luth, Liting Ma, Mi-Sook Kim, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Carlo Giannangelo, Fiona J Houghton, Alisje Churchyard, Mufuliat T Famodimu, Daniel C Barry, David L Gillett, et al.

Journal article  |  2022  |  SCIENCE

Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I and II aaRSs as previously u..

Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases

J Zeller, B Bogner, JD McFadyen, J Kiefer, D Braig, G Pietersz, G Krippner, TL Nero, CJ Morton, KS Cheung Tung Shing, MW Parker, K Peter, SU Eisenhardt

Journal article  |  2022  |  PHARMACOLOGY & THERAPEUTICS

C-reactive protein (CRP) is the prototypic acute-phase reactant that has long been recognized almost exclusively as a marker of in..

Structural biology of cell surface receptors implicated in Alzheimer's disease.

Stefan J Hermans, Tracy L Nero, Craig J Morton, Jonathan H Gooi, Gabriela AN Crespi, Nancy C Hancock, Chen Gao, Kenta Ishii, Jasmina Markulić, Michael W Parker

Journal article  |  2022  |  Biophys Rev

Alzheimer's disease is a common and devastating age-related disease with no effective disease-modifying treatments. Human genetics..

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Craig J Morton, Yawei Du, Con Dogovski, Shih-Chung Huang, Jeffrey Ciavarri, Paul Hales, Robert J Griffin, Lawrence H Cohen, Bei-Ching Chuang, Sergio Wittlin, Ioanna Deni, Tomas Yeo, Kurt E Ward, Daniel C Barry, Boyin Liu, et al.

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Plasmodium falciparum proteasome is a potential antimalarial drug target. We have identified a series of amino-amide boronates..

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome

Yin-Huai Chen, Diane B Zastrow, Riley D Metcalfe, Lisa Gartner, Freia Krause, Craig J Morton, Shruti Marwaha, Laure Fresard, Yong Huang, Chunli Zhao, Colleen McCormack, David Bick, Elizabeth A Worthey, Christine M Eng, Jessica Gold, Stephen B Montgomery, Paul G Fisher, Euan A Ashley, Matthew T Wheeler, Michael W Parker, et al.

Journal article  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BACKGROUND: Biallelic variants in IL6ST, encoding GP130, cause a recessive form of hyper-IgE syndrome (HIES) characterized by high..