Craig Morton

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Andrew P Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Journal article  |  2019  |  Nature Microbiology

The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regula..

CRYO-EM OF THE MALARIA PARASITE PA28/20S PROTEASOME COMPLEX REVEALS AN UNUSUAL ACTIVATION MECHANISM WITH IMPLICATIONS FOR ARTEMISININ SENSITIVITY

Stanley Xie, Michael Griffin, Riley Metcalfe, Eric Hanssen, Tuo Yang, David Gilley, Andrew Leis, Craig Morton, Michael Kuiper, Michael Parker, Natalie Spillman, Wilson Wong, Christopher Tsu, Lawrence Dick, Leann Tilley

Conference Proceedings  |  2019  |  PROTEIN SCIENCE

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

Peter R Spackman, Li-Juan Yu, Craig J Morton, Michael W Parker, Charles S Bond, Mark A Spackman, Dylan Jayatilaka, Sajesh P Thomas

Journal article  |  2019  |  Angewandte Chemie International Edition

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation

Craig J Morton, Marc-Antoine Sani, Michael W Parker, Frances Separovic

Journal article  |  2019  |  Chemical Reviews

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial protein toxins specifically targeting eukaryotic cells throu..

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Anastasia De Luca, Lorien J Parker, Wee Han Ang, Carlo Rodolfo, Valentina Gabbarini, Nancy C Hancock, Francesca Palone, Anna P Mazzetti, Laure Menin, Craig J Morton, Michael W Parker, Mario Lo Bello, Paul J Dyson

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

An Intermolecular pi-Stacking Interaction Drives Conformational Changes Necessary to beta-Barrel Formation in a Pore-Forming Toxin

Joshua R Burns, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2019  |  mBio

The crystal structures of the soluble monomers of the pore-forming cholesterol-dependent cytolysins (CDCs) contain two α-helical b..

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease

Aimee L Hanson, Craig J Morton, Michael W Parker, Darrell Bessette, Tony J Kenna

Journal article  |  2019  |  Human Immunology

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin.

Kristin R Wade, Sara L Lawrence, Allison J Farrand, Eileen M Hotze, Michael J Kuiper, Michael A Gorman, Michelle P Christie, Santosh Panjikar, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2019  |  mBio

The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebra..

The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited

JJ Adams, CJ Morton, MW Parker

Journal article  |  2019  |  Australian Journal of Chemistry

Superoxide dismutase (SOD) is an almost ubiquitous metalloenzyme in aerobic organisms that catalyses the disproportionation of sup..

Protein structure and computational drug discovery

Tracy L Nero, Michael W Parker, Craig J Morton

Journal article  |  2018  |  Biochemical Society Transactions

Cholesterol-dependent cytolysins: from water-soluble state to membrane pore.

Michelle P Christie, Bronte A Johnstone, Rodney K Tweten, Michael W Parker, Craig J Morton

Journal article  |  2018  |  Biophysical Reviews

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial toxins that are important virulence factors for a number of ..

Characterization of Tfrc-mutant mice with microcytic phenotypes

Ashlee J Conway, Fiona C Brown, Gerhard Rank, Benjamin T Kile, Craig J Morton, Stephen M Jane, David J Curtis

Journal article  |  2018  |  Blood Advances

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Ashlee J Conway, Fiona C Brown, Elinor J Hortle, Gaetan Burgio, Simon J Foote, Craig J Morton, Stephen M Jane, David J Curti

Journal article  |  2018  |  Disease Models & Mechanisms

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile

Aimee L Hanson, Thomas Cuddihy, Katelin Haynes, Dorothy Loo, Craig J Morton, Udo Oppermann, Paul Leo, Gethin P Thomas, Le Cao Kim-Anh, Tony J Kenna, Matthew A Brown

Journal article  |  2018  |  Arthritis & Rheumatology

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  Nature Communications

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

Biswaranjan Mohanty, Kieran Rimmer, Roisin M McMahon, Stephen J Headey, Mansha Vazirani, Stephen R Shouldice, Mathieu Coincon, Stephanie Tay, Craig J Morton, Jamie S Simpson, Jennifer L Martin, Martin J Scanlon

Journal article  |  2017  |  PLOS ONE

Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme

Lorien J Parker, Alessio Bocedi, David B Ascher, Jade B Aitken, Hugh H Harris, Mario Lo Bello, Giorgio Ricci, Craig J Morton, Michael W Parker

Journal article  |  2017  |  Protein Science

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

David Braig, Tracy L Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R Thiele, Craig J Morton, Johannes Zeller, Jurij Kiefer, Lawrence A Potempa, Natalie A Mellett, Luke A Miles, Xiao-Jun Du, Peter J Meikle, Markus Huber-Lang, G Bjoern Stark, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt

Journal article  |  2017  |  Nature Communications

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

Sara L Lawrence, Michael A Gorman, Susanne C Feil, Terrence D Mulhern, Michael J Kuiper, Adam J Ratner, Rodney K Tweten, Craig J Morton, Michael W Parker

Journal article  |  2016  |  Structure

Going downstream - how does GH binding activate JAK2

Andrew Brooks, W Dai, ML O'Mara, D Abankwa, Y Chhabra, RA Pelekanos, O Gardon, KA Tunny, KM Blucher, CJ Morton, MW Parker, E Sierecki, Y Gambin, GA Gomez, K Alexandrov, IA Wilson, M Doxastakis, AE Mark, MJ Waters

Conference Proceedings  |  2016  |  CLINICAL ENDOCRINOLOGY

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

Roisin M McMahon, Mathieu Coincon, Stephanie Tay, Begona Heras, Craig J Morton, Martin J Scanlon, Jennifer L Martin

Journal article  |  2015  |  Acta Crystallographica Section D Biological Crystallography

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

Sara L Lawrence, Susanne C Feil, Craig J Morton, Allison J Farrand, Terrence D Mulhern, Michael A Gorman, Kristin R Wade, Rodney K Tweten, Michael W Parker

Journal article  |  2015  |  Scientific Reports

The biological function of an insect antifreeze protein simulated by molecular dynamics

Michael J Kuiper, Craig J Morton, Sneha E Abraham, Angus Gray-Weale

Journal article  |  2015  |  eLife

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin

Kristin R Wade, Eileen M Hotze, Michael J Kuiper, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate

Silas Bond, Alistair G Draffan, Jennifer E Fenner, John Lambert, Chin Yu Lim, Bo Lin, Angela Luttick, Jeffrey P Mitchell, Craig J Morton, Roland H Nearn, Vanessa Sanford, Kelly H Anderson, Penelope A Mayes, Simon P Tucker

Journal article  |  2015  |  Bioorganic & Medicinal Chemistry Letters

The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1

Silas Bond, Alistair G Draffan, Jennifer E Fenner, John Lambert, Chin Yu Lim, Bo Lin, Angela Luttick, Jeffrey P Mitchell, Craig J Morton, Roland H Nearn, Vanessa Sanford, Pauline C Stanislawski, Simon P Tucker

Journal article  |  2015  |  Bioorganic & Medicinal Chemistry Letters

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

Stefan J Hermans, David B Ascher, Nancy C Hancock, Jessica K Holien, Belinda J Michell, Siew Yeen Chai, Craig J Morton, Michael W Parker

Journal article  |  2015  |  Protein Science

The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster

Emily J Remnant, Craig J Morton, Phillip J Daborn, Christopher Lumb, Ying Ting Yang, Hooi Ling Ng, Michael W Parker, Philip Batterham

Journal article  |  2014  |  Insect Biochemistry and Molecular Biology

Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents

Alistair G Draffan, Barbara Frey, Benjamin H Fraser, Brett Pool, Carlie Gannon, Edward M Tyndall, Julia Cianci, Michael Harding, Michael Lilly, Richard Hufton, Rosliana Halim, Saba Jahangiri, Silas Bond, Tyrone P Jeynes, Van TT Nguyen, Veronika Wirth, Angela Luttick, Danielle Tilmanis, Melinda Pryor, Kate Porter, et al.

Journal article  |  2014  |  Bioorganic & Medicinal Chemistry Letters

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors

James T Palmer, Lorraine C Axford, Stephanie Barker, James M Bennett, Michael Blair, Ian Collins, David T Davies, Leigh Ford, Carlie T Gannon, Paul Lancett, Alastair Logan, Christopher J Lunniss, Craig J Morton, Daniel A Offermann, Gary RW Pitt, B Narasinga Rao, Amit K Singh, Tarun Shukla, Anil Srivastava, Neil R Stokes, et al.

Journal article  |  2014  |  Bioorganic & Medicinal Chemistry Letters

Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents

Alistair G Draffan, Barbara Frey, Brett Pool, Carlie Gannon, Edward M Tyndall, Michael Lilly, Paula Francom, Richard Hufton, Rosliana Halim, Saba Jahangiri, Silas Bond, Van TT Nguyen, Tyrone P Jeynes, Veronika Wirth, Angela Luttick, Danielle Tilmanis, Jesse D Thomas, Melinda Pryor, Kate Porter, Craig J Morton, et al.

Journal article  |  2014  |  ACS Medicinal Chemistry Letters

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

Andrew J Brooks, Wei Dai, Megan L O'Mara, Daniel Abankwa, Yash Chhabra, Rebecca A Pelekanos, Olivier Gardon, Kathryn A Tunny, Kristopher M Blucher, Craig J Morton, Michael W Parker, Emma Sierecki, Yann Gambin, Guillermo A Gomez, Kirill Alexandrov, Ian A Wilson, Manolis Doxastakis, Alan E Mark, Michael J Waters

Journal article  |  2014  |  Science

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

David B Ascher, Jerome Wielens, Tracy L Nero, Larissa Doughty, Craig J Morton, Michael W Parker

Journal article  |  2014  |  Scientific Reports

Oncogenic protein interfaces: small molecules, big challenges

Tracy L Nero, Craig J Morton, Jessica K Holien, Jerome Wielens, Michael W Parker

Journal article  |  2014  |  Nature Reviews Cancer

Discovery of Phosphodiesterase-4 Inhibitors: Serendipity and Rational Drug Design

Susanne C Feil, Jessica K Holien, Craig Morton, Nancy C Hancock, Philip E Thompson, Michael W Parker

Journal article  |  2014  |  Australian Journal of Chemistry

Design and Evaluation of the Performance of an NMR Screening Fragment Library

Bradley C Doak, Craig J Morton, Jamie S Simpson, Martin J Scanlon

Journal article  |  2013  |  Australian Journal of Chemistry

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus

Susanne C Feil, Stephanie Hamilton, Guy Y Krippner, Bo Lin, Angela Luttick, Darryl B McConnell, Roland Nearn, Michael W Parker, Jane Ryan, Pauline C Stanislawski, Simon P Tucker, Keith G Watson, Craig J Morton

Journal article  |  2012  |  ACS Medicinal Chemistry Letters

Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2

Jacob L Nankervis, Susanne C Feil, Nancy C Hancock, Zhaohua Zheng, Hooi-Ling Ng, Craig J Morton, Jessica K Holien, Patricia WM Ho, Mark M Frazzetto, Ian G Jennings, David T Manallack, T John Martin, Philip E Thompson, Michael W Parker

Journal article  |  2011  |  Bioorganic and Medicinal Chemistry Letters

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

Lorien J Parker, Louis C Italiano, Craig J Morton, Nancy C Hancock, David B Ascher, Jade B Aitken, Hugh H Harris, Pablo Campomanes, Ursula Rothlisberger, Anastasia De Luca, Mario Lo Bello, Wee Han Ang, Paul J Dyson, Michael W Parker

Journal article  |  2011  |  Chemistry - A European Journal

Regulation of Insulin-Regulated Membrane Aminopeptidase Activity by Its C-Terminal Domain

David B Ascher, Brett A Cromer, Craig J Morton, Irene Volitakis, Robert A Cherny, Anthony L Albiston, Siew Yeen Chai, Michael W Parker

Journal article  |  2011  |  Biochemistry

Phenylalanine-544 Plays a Key Role in Substrate and Inhibitor Binding by Providing a Hydrophobic Packing Point at the Active Site of Insulin-Regulated Aminopeptidase

Anthony L Albiston, Vi Pham, Siying Ye, Leelee Ng, Rebecca A Lew, Philip E Thompson, Jessica K Holien, Craig J Morton, Michael W Parker, Siew Yeen Chai

Journal article  |  2010  |  Molecular Pharmacology

Recognition and Detoxification of the Insecticide DDT by Drosophila melanogaster Glutathione S-Transferase D1

Wai Yee Low, Susanne C Feil, Hooi Ling Ng, Michael A Gorman, Craig J Morton, James Pyke, Malcolm J McConville, Michael Bieri, Yee-Foong Mok, Charles Robin, Paul R Gooley, Michael W Parker, Philip Batterham

Journal article  |  2010  |  Journal of Molecular Biology

Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stability

Indalecio Quesada-Soriano, Lorien J Parker, Alessandra Primavera, Juan M Casas-Solvas, Antonio Vargas-Berenguel, Carmen Baron, Craig J Morton, Anna Paola Mazzetti, Mario Lo Bello, Michael W Parker, Luis Garcia-Fuentes

Journal article  |  2009  |  Protein Science

Rational Design of an Organometallic Glutathione Transferase Inhibitor

Wee Han Ang, Lorien J Parker, Anastasia De Luca, Lucienne Juillerat-Jeanneret, Craig J Morton, Mario Lo Bello, Michael W Parker, Paul J Dyson

Journal article  |  2009  |  Angewandte Chemie

Rational Design of an Organometallic Glutathione Transferase Inhibitor

Wee Han Ang, Lorien J Parker, Anastasia De Luca, Lucienne Juillerat-Jeanneret, Craig J Morton, Mario Lo Bello, Michael W Parker, Paul J Dyson

Journal article  |  2009  |  Angewandte Chemie - International Edition

Novel Therapeutic Approaches to Treat Alzheimer’s Disease and Memory Disorders

David B Ascher, Gabriela AN Crespi, Hooi Ling Ng, Craig J Morton, Michael W Parker, Luke A Miles

Journal article  |  2008  |  Journal of Proteomics & Bioinformatics

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

Mary C Pearce, Craig J Morton, Susanne C Feil, Guido Hansen, Julian J Adams, Michael W Parker, Stephen P Bottomley

Journal article  |  2008  |  Protein Science

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

Anthony L Albiston, Craig J Morton, Hooi Ling Ng, Vi Pham, Holly R Yeatman, Siying Ye, Ruani N Fernando, Dimitri De Bundel, David B Ascher, Frederick AO Mendelsohn, Michael W Parker, Siew Yeen Chai

Journal article  |  2008  |  FASEB Journal

Design of a Conformationally Defined and Proteolytically Stable Circular Mimetic of Brain-derived Neurotrophic Factor

Jordan M Fletcher, Craig J Morton, Richard A Zwar, Simon S Murray, Paul D O'Leary, Richard A Hughes

Journal article  |  2008  |  Journal of Biological Chemistry

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: Kinetic properties and crystallographic characterisation of allelic variants

Lorien J Parker, Sarah Ciccone, Louis C Italiano, Alessandra Primavera, Aaron J Oakley, Craig J Morton, Nancy C Hancock, Mario Lo Bello, Michael W Parker

Journal article  |  2008  |  Journal of Molecular Biology

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

Siying Ye, Siew Yeen Chai, Rebecca A Lew, David B Ascher, Craig J Morton, Michael W Parker, Anthony L Albiston

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Copper binding to the Alzheimer's disease amyloid precursor protein

Geoffrey K-W Kong, Luke A Miles, Gabriela AN Crespi, Craig J Morton, Hooi Ling Ng, Kevin J Barnham, William J McKinstry, Roberto Cappai, Michael W Parker

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

Structural studies of glutathione S-transferase complexed to commonly used chemotherapy agents

Lorien J Parker, Craig J Morton, Mario Lo Bello, Michael W Parker

Conference Proceedings  |  2008  |  Acta Crystallographica Section A Foundations of Crystallography

Molecular evolution of glutathione S-transferases in the genus drosophila

Wai Yee Low, Hooi Ling Ng, Craig J Morton, Michael W Parker, Philip Batterham, Charles Robin

Journal article  |  2007  |  Genetics

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric g protein-coupled receptor Ligands

Vimesh A Avlani, Karen J Gregory, Craig J Morton, Michael W Parker, Patrick M Sexton, Arthur Christopoulos

Journal article  |  2007  |  Journal of Biological Chemistry

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins

Jamie Rossjohn, Galina Polekhina, Susanne C Feil, Craig J Morton, Rodney K Tweten, Michael W Parker

Journal article  |  2007  |  Journal of Molecular Biology

An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric Acid(a) receptors: Correlation with comparative models

T Clayton, JL Chen, M Ernst, L Richter, BA Cromer, CJ Morton, H Ng, CC Kaczorowski, FJ Helmstetter, R Furtmueller, G Ecker, MW Parker, W Sieghart, JM Cook

Journal article  |  2007  |  Current Medicinal Chemistry

Understanding the molecular details of extracellular ligand-binding sites of the GABAA receptor

Brett A Cromer, Belinda Rizzo, Brett Bennetts, Craig J Morton, Hooi-li Ng ng, Alison L Clarke, Steven Petrou, Michael Parker

Conference Proceedings  |  2006  |  ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Effect of linker length on avidin binding to biotinylated gramicidin A

Aphrodite Anastasiadis, Craig J Morton, Gert H Talbo, Roger E Koeppe, Frances Separovic

Journal article  |  2006  |  International Journal of Peptide Research and Therapeutics

Hsp90 increases LIM kinase activity by promoting its homo-dimerization

Rong Li, Juliana Soosairajah, Daniel Harari, Ami Citri, John Price, Hooi Ling Ng, Craig J Morton, Michael W Parker, Yosef Yarden, Ora Bernard

Journal article  |  2006  |  FASEB Journal

Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1

R Tellez-Sanz, E Cesareo, M Nuccetelli, AM Aguilera, C Baron, LJ Parker, JJ Adams, CJ Morton, M Lo Bello, MW Parker, L Garcia-Fuentes

Journal article  |  2006  |  Protein Science

Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels

B Bennetts, GY Rychkov, HL Ng, CJ Morton, D Stapleton, MW Parker, BA Cromer

Journal article  |  2005  |  Journal of Biological Chemistry

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

V Pham, MQ Dong, JD Wade, LJ Miller, CJ Morton, H Ng, MW Parker, PM Sexton

Journal article  |  2005  |  Journal of Biological Chemistry

Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus

GM Scott, HL Ng, CJ Morton, MW Parker, WD Rawlinson

Journal article  |  2005  |  Journal of General Virology

Identifying antagonists towards a G-protein coupled receptor using the structure of a hormone complexed to a neutralizing monoclonal antibody.

Galina Polekhina, William J McKinstry, Hannelore Diefenbach-Jagger, Patricia WM Ho, Craig J Morton, Koh Sato, Etsuro Onuma, Matthew T Gillespie, T John Martin, Michael W Parker

Conference Proceedings  |  2004  |  Acta Crystallographica Section A Foundations of Crystallography

Intrasteric control of AMPK via the gamma(1) subunit AMP allosteric regulatory site

J Adams, ZP Chen, BJW Van Denderen, CJ Morton, MW Parker, LA Witters, D Stapleton, BE Kemp

Journal article  |  2004  |  Protein Science

Insights into the structural basis for zinc inhibition of the glycine receptor

ST Nevin, BA Cromer, JL Haddrill, CJ Morton, MW Parker, JW Lynch

Journal article  |  2003  |  Journal of Biological Chemistry

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay

CJ Morton, R Cameron, LJ Lawrence, B Lin, M Lowe, A Luttick, A Mason, J McKimm-Breschkin, MW Parker, J Ryan, M Smout, J Sullivan, SP Tucker, PR Young

Journal article  |  2003  |  Virology

Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: Misannotation of a genome clarified by protein structural analysis

JM Johnston, VL Arcus, CJ Morton, MW Parker, EN Baker

Journal article  |  2003  |  Journal of Bacteriology

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

KJ Barnham, WJ McKinstry, G Multhaup, D Galatis, CJ Morton, CC Curtain, NA Williamson, AR White, MG Hinds, RS Norton, K Beyreuther, CL Masters, MW Parker, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Conversion of a transmembrane to a watersoluble protein complex by a single point mutation

Y Tsitrin, CJ Morton, C El Bez, P Paumard, MC Velluz, M Adrian, J Dubochet, MW Parker, S Lanzavecchia, FG van der Goot

Journal article  |  2002  |  Nature Structural Biology

Solid-state NMR conformational studies of a melittin-inhibitor complex

YH Lam, CJ Morton, F Separovic

Journal article  |  2002  |  European Biophysics Journal with Biophysics Letters

From glutathione transferase to pore in a CLIC

BA Cromer, CJ Morton, PG Board, MW Parker

Journal article  |  2002  |  European Biophysics Journal with Biophysics Letters

Electrostatic and hydrophobic forces tether the proximal region of the angiotensin II receptor (AT(1A)) carboxyl terminus to anionic lipids

H Mozsolits, S Unabia, A Ahmad, CJ Morton, WG Thomas, MI Aguilar

Journal article  |  2002  |  Biochemistry

Anxiety over GABA(A) receptor structure relieved by AChBP

BA Cromer, CJ Morton, MW Parker

Journal article  |  2002  |  Trends in Biochemical Sciences

Solid-state NMR structure determination of melittin in a lipid environment

YH Lam, SR Wassall, CJ Morton, R Smith, F Separovic

Journal article  |  2001  |  Biophysical Journal

The speciation of gold and copper cyanide complexes on ion-exchange resins containing different functional groups

GC Lukey, JSJ van Deventer, RL Chowdhury, DC Shallcross, ST Huntington, CJ Morton

Journal article  |  2000  |  Reactive and Functional Polymers

Probing the nature of interactions in SH2 binding interfaces - Evidence from electrospray ionization mass spectrometry

EW Chung, DA Henriques, D Renzoni, CJ Morton, TD Mulhern, MC Pitkeathly, JE Ladbury, CV Robinson

Journal article  |  1999  |  Protein Science

Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy

JI Guijarro, CJ Morton, KW Plaxco, ID Campbell, CM Dobson

Journal article  |  1998  |  Journal of Molecular Biology

The folding kinetics and thermodynamics of the Fyn-SH3 domain

KW Plaxco, JI Guijarro, CJ Morton, M Pitkeathly, ID Campbell, CM Dobson

Journal article  |  1998  |  Biochemistry

The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity

TD Mulhern, GL Shaw, CJ Morton, AJ Day, ID Campbell

Journal article  |  1997  |  Structure

The effects of guanidine hydrochloride on the 'random coil' conformations and NMR chemical shifts of the peptide series GGXGG

KW Plaxco, CJ Morton, SB Grimshaw, JA Jones, M Pitkeathly, ID Campbell, CM Dobson

Journal article  |  1997  |  Journal of Biomolecular NMR

Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase

DA Renzoni, DJR Pugh, G Siligardi, P Das, CJ Morton, C Rossi, MD Waterfield, ID Campbell, JE Ladbury

Journal article  |  1996  |  Biochemistry

Water mediated protein-DNA interactions: The relationship of thermodynamics to structural detail

CJ Morton, JE Ladbury

Journal article  |  1996  |  Protein Science

Solution structure of the link module: A hyaluronan-binding domain involved in extracellular matrix stability and cell migration

D Kohda, CJ Morton, AA Parkar, H Hatanaka, FM Inagaki, ID Campbell, AJ Day

Journal article  |  1996  |  Cell

Solution structure and peptide binding of the SH3 domain from human Fyn

CJ Morton, DJR Pugh, ELJ Brown, JD Kahmann, DAC Renzoni, ID Campbell

Journal article  |  1996  |  Structure

NMR-STUDIES OF THE SOLUTION PROPERTIES OF RECOMBINANT MURINE INTERLEUKIN-6

CJ MORTON, HP BAI, JG ZHANG, A HAMMACHER, RS NORTON, RJ SIMPSON, BC MABBUTT

Journal article  |  1995  |  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

SH3 DOMAINS - MOLECULAR VELCRO

CJ MORTON, ID CAMPBELL

Journal article  |  1994  |  Current Biology

SOLUTION STRUCTURE OF SYNTHETIC PEPTIDES CORRESPONDING TO THE C-TERMINAL HELIX OF INTERLEUKIN-6

CJ MORTON, RJ SIMPSON, RS NORTON

Journal article  |  1994  |  European Journal of Biochemistry

ROLE OF THE C-TERMINUS IN THE ACTIVITY, CONFORMATION, AND STABILITY OF INTERLEUKIN-6

LD WARD, A HAMMACHER, JG ZHANG, J WEINSTOCK, K YASUKAWA, CJ MORTON, RS NORTON, RJ SIMPSON

Journal article  |  1993  |  Protein Science

ROLE OF C-TERMINAL REGION OF MURINE INTERLEUKIN-6 IN BIOLOGICAL-ACTIVITY AND STRUCTURAL CONFORMATION

LD WARD, A HAMMACHER, JG ZHANG, J DISCOLO, GF TU, RL MORITZ, CJ MORTON, RS NORTON, RJ SIMPSON

Conference Proceedings  |  1993  |  JOURNAL OF CELLULAR BIOCHEMISTRY

COMPLETE AMINO-ACID-SEQUENCE OF TENEBROSIN-C, A CARDIAC STIMULATORY AND HEMOLYTIC PROTEIN FROM THE SEA-ANEMONE ACTINIA-TENEBROSA

RJ SIMPSON, GE REID, RL MORITZ, C MORTON, RS NORTON

Journal article  |  1990  |  European Journal of Biochemistry