Craig Morton

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome

Yin-Huai Chen, Diane B Zastrow, Riley D Metcalfe, Lisa Gartner, Freia Krause, Craig J Morton, Shruti Marwaha, Laure Fresard, Yong Huang, Chunli Zhao, Colleen McCormack, David Bick, Elizabeth A Worthey, Christine M Eng, Jessica Gold, Stephen B Montgomery, Paul G Fisher, Euan A Ashley, Matthew T Wheeler, Michael W Parker, et al.

Journal article  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BACKGROUND: Biallelic variants in IL6ST, encoding GP130, cause a recessive form of hyper-IgE syndrome (HIES) characterized by high..

X-ray crystallography shines a light on pore-forming toxins.

Bronte A Johnstone, Michelle P Christie, Craig J Morton, Michael W Parker

Book Chapter  |  2021  |  Methods in Enzymology

A common form of cellular attack by pathogenic bacteria is to secrete pore-forming toxins (PFTs). Capable of forming transmembrane..

A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins

Jordan C Evans, Bronte A Johnstone, Sara L Lawrence, Craig J Morton, Michelle P Christie, Michael W Parker, Rodney K Tweten

Journal article  |  2020  |  MBIO

The cholesterol-dependent cytolysins (CDCs) are bacterial, β-barrel, pore-forming toxins. A central enigma of the pore-forming mec..

The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement

Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick CJ Dobson, Michael W Parker, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..

The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited

Julian J Adams, Craig J Morton, Michael W Parker

Journal article  |  2020  |  AUSTRALIAN JOURNAL OF CHEMISTRY

Superoxide dismutase (SOD) is an almost ubiquitous metalloenzyme in aerobic organisms that catalyses the disproportionation of sup..

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

Peter R Spackman, Li‐Juan Yu, Craig J Morton, Michael W Parker, Charles S Bond, Mark A Spackman, Dylan Jayatilaka, Sajesh P Thomas

Journal article  |  2019  |  Angewandte Chemie

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Andrew P Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Journal article  |  2019  |  NATURE MICROBIOLOGY

The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regula..

CRYO-EM OF THE MALARIA PARASITE PA28/20S PROTEASOME COMPLEX REVEALS AN UNUSUAL ACTIVATION MECHANISM WITH IMPLICATIONS FOR ARTEMISININ SENSITIVITY

Stanley Xie, Michael Griffin, Riley Metcalfe, Eric Hanssen, Tuo Yang, David Gilley, Andrew Leis, Craig Morton, Michael Kuiper, Michael Parker, Natalie Spillman, Wilson Wong, Christopher Tsu, Lawrence Dick, Leann Tilley

Conference Proceedings  |  2019  |  PROTEIN SCIENCE

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

Peter R Spackman, Li-Juan Yu, Craig J Morton, Michael W Parker, Charles S Bond, Mark A Spackman, Dylan Jayatilaka, Sajesh P Thomas

Journal article  |  2019  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Most structure-based drug discovery methods utilize crystal structures of receptor proteins. Crystal engineering, on the other han..

Structure and Function of the Proteasome Activator PA28 of the Malaria Parasite Plasmodium falciparum

Riley Metcalf, Eric Hanssen, Stanley C Xie, David Gillett, Andrew Leis, Craig Morton, Michael W Parker, Wilson Wong, Michael Griffin, Leann Tilley

Journal article  |  2019  |  Microscopy and Microanalysis