Craig Morton

A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins

Jordan C Evans, Bronte A Johnstone, Sara L Lawrence, Craig J Morton, Michelle P Christie, Michael W Parker, Rodney K Tweten

Journal article  |  2020  |  mBio

The cholesterol-dependent cytolysins (CDCs) are bacterial, β-barrel, pore-forming toxins. A central enigma of the pore-forming mec..

The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement

Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick CJ Dobson, Michael W Parker, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Journal article  |  2020  |  Journal of Biological Chemistry

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..

The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited

Julian J Adams, Craig J Morton, Michael W Parker

Journal article  |  2020  |  Australian Journal of Chemistry

Superoxide dismutase (SOD) is an almost ubiquitous metalloenzyme in aerobic organisms that catalyses the disproportionation of sup..

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Andrew P Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Journal article  |  2019  |  Nature Microbiology

The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regula..

CRYO-EM OF THE MALARIA PARASITE PA28/20S PROTEASOME COMPLEX REVEALS AN UNUSUAL ACTIVATION MECHANISM WITH IMPLICATIONS FOR ARTEMISININ SENSITIVITY

Stanley Xie, Michael Griffin, Riley Metcalfe, Eric Hanssen, Tuo Yang, David Gilley, Andrew Leis, Craig Morton, Michael Kuiper, Michael Parker, Natalie Spillman, Wilson Wong, Christopher Tsu, Lawrence Dick, Leann Tilley

Conference Proceedings  |  2019  |  PROTEIN SCIENCE

Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals

Peter R Spackman, Li-Juan Yu, Craig J Morton, Michael W Parker, Charles S Bond, Mark A Spackman, Dylan Jayatilaka, Sajesh P Thomas

Journal article  |  2019  |  Angewandte Chemie International Edition

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation

Craig J Morton, Marc-Antoine Sani, Michael W Parker, Frances Separovic

Journal article  |  2019  |  Chemical Reviews

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial protein toxins specifically targeting eukaryotic cells throu..

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Anastasia De Luca, Lorien J Parker, Wee Han Ang, Carlo Rodolfo, Valentina Gabbarini, Nancy C Hancock, Francesca Palone, Anna P Mazzetti, Laure Menin, Craig J Morton, Michael W Parker, Mario Lo Bello, Paul J Dyson

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Intermolecular pi-Stacking Interaction Drives Conformational Changes Necessary to beta-Barrel Formation in a Pore-Forming Toxin

Joshua R Burns, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2019  |  mBio

The crystal structures of the soluble monomers of the pore-forming cholesterol-dependent cytolysins (CDCs) contain two α-helical b..

The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease

Aimee L Hanson, Craig J Morton, Michael W Parker, Darrell Bessette, Tony J Kenna

Journal article  |  2019  |  Human Immunology