Lev Kats

Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia.

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R Devlin, Simon J Hogg, Lev Kats, Izabela Todorovski, Zheng Fan, Thomas C Abrehart, Giovanna Pomilio, Andrew Wei, Gareth P Gregory, Stephin J Vervoort, Kristin K Brown, Ricky W Johnstone

Journal article  |  2021  |  Cancer Discovery

Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of poor prognosis acute myeloid leukae..

IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors

Lauren Giuffrida, Kevin Sek, Melissa A Henderson, Imran G House, Junyun Lai, Amanda XY Chen, Kirsten L Todd, Emma Petley, Sherly Mardiana, Izabela Todorovski, Emily Gruber, Madison J Kelly, Benjamin J Solomon, Stephin J Vervoort, Ricky W Johnstone, Ian A Parish, Paul J Neeson, Lev M Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Molecular Therapy

Chimeric antigen receptor (CAR) T cell therapy has been highly successful in hematological malignancies leading to their US Food a..

Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer

Kevin Sek, Lev M Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Current Opinion in Pharmacology

Adoptive cellular therapy involves the ex vivo expansion of immune cells, conventionally T cells, before reinfusion back to the pa..

Distinct and overlapping mechanisms of resistance to azacytidine and guadecitabine in acute myeloid leukemia

Emily Gruber, Rheana L Franich, Jake Shortt, Ricky W Johnstone, Lev M Kats

Journal article  |  2020  |  Leukemia

Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Lev Kats, Carolyn Shembrey, Thomas Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew Wei, Gareth Gregory, Stephin Vervoort, Kristin Brown, Ricky Johnstone

Journal article  |  2020

Activating FMS-like tyrosine kinase 3 ( FLT3 ) mutations occur in approximately 30% of all acute myeloid leukaemias (AMLs) and are..

Rapid and Durable Complete Remission of Refractory AITL with Azacitidine Treatment in Absence of TET2 Mutation or Concurrent MDS

Gareth P Gregory, Michael Dickinson, Costas K Yannakou, Jonathan Wong, Piers Blombery, Greg Corboy, Lev Kats, Tim ME Crozier, Beena Kumar, H Miles Prince, Stephen S Opat, Jake Shortt

Journal article  |  2019  |  HemaSphere

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

Madison J Kelly, Joan So, Amy J Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D Gearhart, Vivian J Bardwell, Ricky W Johnstone, Stephin J Vervoort, Lev M Kats

Journal article  |  2019  |  Nature Communications

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

Kevin Sek, Christina Molck, Gregory D Stewart, Lev Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BCOR Regulates Cell Fate Transition, Myeloid Differentiation and Leukaemogenesis

Lev M Kats, Madison J Kelly, Gareth Gregory, Ricky W Johnstone, Stephin J Vervoort

Conference Proceedings  |  2018  |  Blood

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Sang-Kyu Kim, Deborah A Knight, Lisa R Jones, Stephin Vervoort, Ashley P Ng, John F Seymour, James E Bradner, Michaela Waibel, Lev Kats, Ricky W Johnstone

Journal article  |  2018  |  Genes and Develpment