Lev Kats

Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer.

Kevin Sek, Lev M Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Current Opinion in Pharmacology

Adoptive cellular therapy involves the ex vivo expansion of immune cells, conventionally T cells, before reinfusion back to the pa..

IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors.

Lauren Giuffrida, Kevin Sek, Melissa A Henderson, Imran G House, Junyun Lai, Amanda XY Chen, Kirsten L Todd, Emma V Petley, Sherly Mardiana, Izabela Todorovski, Emily Gruber, Madison J Kelly, Benjamin J Solomon, Stephin J Vervoort, Ricky W Johnstone, Ian A Parish, Paul J Neeson, Lev M Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Molecular Therapy

Chimeric antigen receptor (CAR) T cell therapy has been highly successful in hematological malignancies leading to their US Food a..

Distinct and overlapping mechanisms of resistance to azacytidine and guadecitabine in acute myeloid leukemia

Emily Gruber, Rheana L Franich, Jake Shortt, Ricky W Johnstone, Lev M Kats

Journal article  |  2020  |  Leukemia

Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Lev Kats, Carolyn Shembrey, Thomas Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew Wei, Gareth Gregory, Stephin Vervoort, Kristin Brown, Ricky Johnstone

Journal article  |  2020

Abstract Activating FMS-like tyrosine kinase 3 ( FLT3 ) mutations occur in approximately 30% of all acute myeloid leukaemias (AMLs..

Rapid and Durable Complete Remission of Refractory AITL with Azacitidine Treatment in Absence of TET2 Mutation or Concurrent MDS

Gareth P Gregory, Michael Dickinson, Costas K Yannakou, Jonathan Wong, Piers Blombery, Greg Corboy, Lev Kats, Tim ME Crozier, Beena Kumar, H Miles Prince, Stephen S Opat, Jake Shortt

Journal article  |  2019  |  HemaSphere

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

Madison J Kelly, Joan So, Amy J Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D Gearhart, Vivian J Bardwell, Ricky W Johnstone, Stephin J Vervoort, Lev M Kats

Journal article  |  2019  |  Nature Communications

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

Kevin Sek, Christina Molck, Gregory D Stewart, Lev Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BCOR Regulates Cell Fate Transition, Myeloid Differentiation and Leukaemogenesis

Lev M Kats, Madison J Kelly, Gareth Gregory, Ricky W Johnstone, Stephin J Vervoort

Conference Proceedings  |  2018  |  Blood

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Sang-Kyu Kim, Deborah A Knight, Lisa R Jones, Stephin Vervoort, Ashley P Ng, John F Seymour, James E Bradner, Michaela Waibel, Lev Kats, Ricky W Johnstone

Journal article  |  2018  |  Genes and Develpment

A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML

LM Kats, SJ Vervoort, R Cole, AJ Rogers, GP Gregory, E Vidacs, J Li, R Nagaraja, KE Yen, RW Johnstone

Journal article  |  2017  |  Leukemia

Genomic characterisation of E mu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Marcus Lefebure, Richard W Tothill, Elizabeth Kruse, Edwin D Hawkins, Jake Shortt, Geoffrey M Matthews, Gareth P Gregory, Benjamin P Martin, Madison J Kelly, Izabela Todorovski, Maria A Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan Bywater, Lev Kats, et al.

Journal article  |  2017  |  Nature Communications

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Jane K Mills, Kevin Sek, Ryan S Cross, Alexander J Davenport, Liza B John, Sherly Mardiana, Clare Y Slaney, Ricky W Johnstone, Joseph A Trapani, John Stagg, Sherene Loi, Lev Kats, David Gyorki, Michael H Kershaw, Phillip K Darcy

Journal article  |  2017  |  Journal of Clinical Investigation

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Margherita Ghisi, Lev Kats, Frederick Masson, Jason Li, Tobias Kratina, Eva Vidacs, Omer Gilan, Maria A Doyle, Andrea Newbold, Jessica E Bolden, Kirsten A Fairfax, Carolyn A de Graaf, Matthew Firth, Johannes Zuber, Ross A Dickins, Lynn M Corcoran, Mark A Dawson, Gabrielle T Belz, Ricky W Johnstone

Journal article  |  2016  |  Cancer Cell

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia

Adele Baker, Gareth P Gregory, Inge Verbrugge, Lev Kats, Joshua J Hilton, Eva Vidacs, Erwin M Lee, Richard B Lock, Johannes Zuber, Jake Shortt, Ricky W Johnstone

Journal article  |  2016  |  Cancer Research

Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells

Lev M Kats, Nicholas I Proellocks, Donna W Buckingham, Lionel Blanc, John Hale, Xinhua Guo, Xinhong Pei, Susann Herrmann, Eric G Hanssen, Ross L Coppel, Narla Mohandas, Xiuli An, Brian M Cooke

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo

GP Gregory, SJ Hogg, LM Kats, E Vidacs, AJ Baker, O Gilan, M Lefebure, BP Martin, MA Dawson, RW Johnstone, J Shortt

Journal article  |  2015  |  Leukemia

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Shuo Wei, Shingo Kozono, Lev Kats, Morris Nechama, Wenzong Li, Jlenia Guarnerio, Manli Luo, Mi-Hyeon You, Yandan Yao, Asami Kondo, Hai Hu, Gunes Bozkurt, Nathan J Moerke, Shugeng Cao, Markus Reschke, Chun-Hau Chen, Eduardo M Rego, Francesco Lo-Coco, Lewis C Cantley, Tae Ho Lee, et al.

Journal article  |  2015  |  NATURE MEDICINE

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

Han Xie, Jun-ichi Hanai, Jian-Guo Ren, Lev Kats, Kerri Burgess, Parul Bhargava, Sabina Signoretti, Julia Billiard, Kevin J Duffy, Aaron Grant, Xiaoen Wang, Pawel K Lorkiewicz, Sabrina Schatzman, Michael Bousamra, Andrew N Lane, Richard M Higashi, Teresa WM Fan, Pier Paolo Pandolfi, Vikas P Sukhatme, Pankaj Seth

Journal article  |  2014  |  Cell Metabolism

An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells

Lev M Kats, Kate M Fernandez, Fiona K Glenister, Susann Herrmann, Donna W Buckingham, Ghizal Siddiqui, Laveena Sharma, Rebecca Bamert, Isabelle Lucet, Micheline Guillotte, Odile Mercereau-Puijalon, Brian M Cooke

Journal article  |  2014  |  International Journal for Parasitology

Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance

Lev M Kats, Markus Reschke, Riccardo Taulli, Olga Pozdnyakova, Kerri Burgess, Parul Bhargava, Kimberly Straley, Rahul Karnik, Alexander Meissner, Donald Small, Shinsan M Su, Katharine Yen, Jiangwen Zhang, Pier Paolo Pandolfi

Journal article  |  2014  |  Cell Stem Cell

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia

Guilherme Augusto dos Santos, Lev Kats, Pier Paolo Pandolfi

Journal article  |  2013  |  The Journal of Experimental Medicine

The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation

Su Jung Song, Keisuke Ito, Ugo Ala, Lev Kats, Kaitlyn Webster, Su Ming Sun, Mojca Jongen-Lavrencic, Katia Manova-Todorova, Julie Teruya-Feldstein, David E Avigan, Ruud Delwel, Pier Paolo Pandolfi

Journal article  |  2013  |  Cell Stem Cell

Bioinformatic prediction of the exportome of Babesia bovis and identification of novel proteins in parasite-infected red blood cells

Sejal Gohil, Lev M Kats, Torsten Seemann, Kate M Fernandez, Ghizal Siddiqui, Brian M Cooke

Journal article  |  2013  |  International journal for parasitology

Tumor suppressor genes

M Reschke, LM Kats, PP Pandolfi

Book Chapter  |  2012

Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs

Yvonne Tay, Lev Kats, Leonardo Salmena, Dror Weiss, Shen Mynn Tan, Ugo Ala, Florian Karreth, Laura Poliseno, Paolo Provero, Ferdinando Di Cunto, Judy Lieberman, Isidore Rigoutsos, Pier Paolo Pandolfi

Journal article  |  2011  |  Cell

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi

Journal article  |  2011  |  Cell

Recent insights into alteration of red blood cells by Babesia bovis: moovin' forward

Sejal Gohil, Lev M Kats, Angelika Sturm, Brian M Cooke

Journal article  |  2010  |  Trends in Parasitology

Characterisation of PfRON6, a Plasmodium falciparum rhoptry neck protein with a novel cysteine-rich domain

Nicholas I Proellocks, Lev M Kats, David A Sheffield, Eric Harissen, Casilda G Black, Karena L Waller, Ross L Coppel

Journal article  |  2009  |  International Journal for Parasitology

Identification of Rhoptry Trafficking Determinants and Evidence for a Novel Sorting Mechanism in the Malaria Parasite Plasmodium falciparum

Dave Richard, Lev M Kats, Christine Langer, Casilda G Black, Khosse Mitri, Justin A Boddey, Alan F Cowman, Ross L Coppel

Journal article  |  2009  |  PLoS Pathogens

Functional alteration of red blood cells by a megadalton protein of Plasmodium falciparum

Fiona K Glenister, Kate M Fernandez, Lev M Kats, Eric Hanssen, Narla Mohandas, Ross L Coppel, Brian M Cooke

Journal article  |  2009  |  Blood

In vivo studies support the role of trafficking and cytoskeletal-binding motifs in the interaction of MESA with the membrane skeleton of Plasmodium falciparum-infected red blood cells

Casilda G Black, Nicholas I Proellocks, Lev M Kats, Brian M Cooke, Narla Mohandas, Ross L Coppel

Journal article  |  2008  |  Molecular and Biochemical Parasitology

Active immunisation with RAMA does not provide protective immunity against Plasmodium yoelii challenge despite its association with protective responses in endemic populations

Lev M Kats, Lina Wang, E Elsa Herdiana Murhandarwati, Khosse Mitri, Casilda G Black, Ross L Coppel

Journal article  |  2008  |  Vaccine

Protein trafficking to apical organelles of malaria parasites - Building an invasion machine

Lev M Kats, Brian M Cooke, Ross L Coppel, Casilda G Black

Journal article  |  2008  |  Traffic

Plasmodium falciparum Pf34, a novel GPI-anchored rhoptry protein found in detergent-resistant microdomains

Nicholas I Proellocks, Svetozar Kovacevic, David JP Ferguson, Lev M Kats, Belinda J Morahan, Casilda G Black, Karena L Waller, Ross L Coppel

Journal article  |  2007  |  International Journal for Parasitology

A set of glycosylphosphatidyl inositol-anchored membrane proteins of Plasmodium falciparum is refractory to genetic deletion

Paul R Sanders, Lev M Kats, Damien R Drew, Rebecca A O'Donnell, Matthew O'Neill, Alexander G Maier, Ross L Coppel, Brendan S Crabb

Journal article  |  2006  |  Infection and Immunity

Plasmodium rhoptries: how things went pear-shaped

Lev M Kats, Casilda G Black, Nicholas I Proellocks, Ross L Coppel

Journal article  |  2006  |  Trends in Parasitology