Michael Roy

Synthesis of C-Mannosylated Glycopeptides Enabled by Ni-Catalyzed Photoreductive Cross-Coupling Reactions

Runyu Mao, Shiyi Xi, Sayali Shah, Michael J Roy, Alan John, James P Lingford, Gerd Gade, Nichollas E Scott, Ethan D Goddard-Borger

Journal article  |  2021  |  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The biological functions of tryptophan C-mannosylation are poorly understood, in part, due to a dearth of methods for preparing pu..

BAK core dimers bind lipids and can be bridged by them

Angus D Cowan, Nicholas A Smith, Jarrod J Sandow, Eugene A Kapp, Yepy H Rustam, James M Murphy, Jason M Brouwer, Jonathan P Bernardini, Michael J Roy, Ahmad Z Wardak, Iris K Tan, Andrew I Webb, Jacqueline M Gulbis, Brian J Smith, Gavin E Reid, Grant Dewson, Peter M Colman, Peter E Czabotar

Journal article  |  2020  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of t..

The PEAK family of pseudokinases, their role in cell signalling and cancer

Onisha Patel, Michael J Roy, James M Murphy, Isabelle S Lucet

Journal article  |  2019  |  FEBS JOURNAL

The study of pseudokinases has uncovered that catalysis-independent functions play a critical role in cell signalling regulation. ..