Paul Beavis

IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors

Lauren Giuffrida, Kevin Sek, Melissa A Henderson, Imran G House, Junyun Lai, Amanda XY Chen, Kirsten L Todd, Emma Petley, Sherly Mardiana, Izabela Todorovski, Emily Gruber, Madison J Kelly, Benjamin J Solomon, Stephin J Vervoort, Ricky W Johnstone, Ian A Parish, Paul J Neeson, Lev M Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Molecular Therapy

Chimeric antigen receptor (CAR) T cell therapy has been highly successful in hematological malignancies leading to their US Food a..

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

Florida Voli, Emanuele Valli, Luigi Lerra, Kathleen Kimpton, Federica Saletta, Federico M Giorgi, Daniele Mercatelli, Jourdin RC Rouaen, Sylvie Shen, Jayne E Murray, Aria Ahmed-Cox, Giuseppe Cirillo, Chelsea Mayoh, Paul A Beavis, Michelle Haber, Joseph A Trapani, Maria Kavallaris, Orazio Vittorio

Journal article  |  2020  |  Cancer Research

Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically ..

Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer

Kevin Sek, Lev M Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Current Opinion in Pharmacology

Adoptive cellular therapy involves the ex vivo expansion of immune cells, conventionally T cells, before reinfusion back to the pa..

A New Safety Approach Allowing Reversible Control of CAR T Cell Responses

Amanda XY Chen, Imran G House, Paul A Beavis, Phillip K Darcy

Journal article  |  2020  |  Molecular Therapy

p38 Kinase: A Key Target for Driving Potent T Cells for Adoptive Immunotherapy

Jack D Chan, Paul A Beavis, Phillip K Darcy

Journal article  |  2020  |  Cancer Cell

Tissue-resident memory T cells in breast cancer control and immunotherapy responses

Ann Byrne, Peter Savas, Sneha Sant, Ran Li, Balaji Virassamy, Stephen J Luen, Paul A Beavis, Laura K Mackay, Paul J Neeson, Sherene Loi

Journal article  |  2020  |  Nature Reviews Clinical Oncology

The presence of tumour-infiltrating lymphocytes (TILs) is associated with favourable outcomes in patients with breast cancer as we..

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G House, Kevin Sek, Melissa A Henderson, Lauren Giuffrida, Amanda XY Chen, Kirsten L Todd, Emma Petley, Jack D Chan, Emma M Carrington, Andrew M Lew, Benjamin J Solomon, Joseph A Trapani, Katherine Kedzierska, Maximilien Evrard, Stephin J Vervoort, Jason Waithman, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Nature Immunology

Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of im..

Promising Immuno-Oncology Options for the Future: Cellular Therapies and Personalized Cancer Vaccines.

Benjamin J Solomon, Paul A Beavis, Philip K Darcy

Journal article  |  2020  |  American Society of Clinical Oncology Educational Book

A common pathway for an effective immune anticancer response involves recognition of tumor neoantigens and subsequent targeting of..

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies

Simone Nussing, Imran G House, Conor J Kearney, Amanda XY Chen, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article  |  2020  |  The Journal of Immunology

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2020  |  Nature

Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..