Michael Roche

Persistence of envelopes in different CD4 T-cell subsets in antiretroviral therapy-suppressed people with HIV.

Matthew J Gartner, Carolin Tumpach, Ashanti Dantanarayana, Jared Stern, Jennifer M Zerbato, J Judy Chang, Thomas A Angelovich, Jenny L Anderson, Jori Symons, Steve G Deeks, Jacqueline K Flynn, Sharon R Lewin, Melissa J Churchill, Paul R Gorry, Michael Roche

Journal article  |  2023  |  AIDS

OBJECTIVES: Despite suppressive antiretroviral therapy (ART), HIV can persist in a diverse range of CD4+ T-cell subsets. Through l..

HIV DNA persists in hepatocytes in people with HIV-hepatitis B co-infection on antiretroviral therapy.

Jennifer M Zerbato, Anchalee Avihingsanon, Kasha P Singh, Wei Zhao, Claire Deleage, Elias Rosen, Mackenzie L Cottrell, Ajantha Rhodes, Ashanti Dantanarayana, Carolin Tumpach, Surekha Tennakoon, Megan Crane, David J Price, Sabine Braat, Hugh Mason, Michael Roche, Angela DM Kashuba, Peter A Revill, Jennifer Audsley, Sharon R Lewin

Journal article  |  2023  |  EBioMedicine

BACKGROUND: HIV can infect multiple cells in the liver including hepatocytes, Kupffer cells and infiltrating T cells, but whether ..

Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders.

Sarah J Byrnes, Thomas A Angelovich, Kathleen Busman-Sahay, Catherine R Cochrane, Michael Roche, Jacob D Estes, Melissa J Churchill

Journal article  |  2022  |  Viruses

Human Immunodeficiency virus (HIV)-associated neurocognitive disorders are a major burden for people living with HIV whose viremia..

Experimental Quantification of Interactions Between Drug Delivery Systems and Cells In Vitro: A Guide for Preclinical Nanomedicine Evaluation

Paula M Cevaal, Michael Roche, Sharon R Lewin, Frank Caruso, Matthew Faria

Journal article  |  2022  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

A major component of designing drug delivery systems concerns how to amplify or attenuate interactions with specific cell types. F..

The role of latency reversal in HIV cure strategies

Kiho Tanaka, Youry Kim, Michael Roche, Sharon R Lewin

Journal article  |  2022  |  JOURNAL OF MEDICAL PRIMATOLOGY

One strategy to eliminate latently infected cells that persist in people with HIV on antiretroviral therapy is to activate virus t..

Factors associated with weak positive SARS-CoV-2 diagnosis by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR)

Priyank Rawat, Jennifer M Zerbato, Ajantha Rhodes, Chris Chiu, Thomas Tran, Thomas A Rasmussen, Julian Druce, Sharon R Lewin, Michael Roche

Journal article  |  2022  |  PATHOLOGY

During the COVID-19 pandemic, the reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay has been the primar..

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART

Catherine R Cochrane, Thomas A Angelovich, Sarah J Byrnes, Emily Waring, Aleks C Guanizo, Gemma S Trollope, Jingling Zhou, Judith Vue, Lachlan Senior, Emma Wanicek, Janna Jamal Eddine, Matthew J Gartner, Trisha A Jenkins, Paul R Gorry, Bruce J Brew, Sharon R Lewin, Jacob D Estes, Michael Roche, Melissa J Churchill

Journal article  |  2022  |  ANNALS OF NEUROLOGY

OBJECTIVE: Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier ..

Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy

Thomas S Uldrick, Scott Adams, Remi Fromentin, Michael Roche, Steven P Fling, Priscila H Goncalves, Kathryn Lurain, Ramya Ramaswami, Chia-Ching Jackie Wang, Robert J Gorelick, Jorden L Welker, Liz O'Donoghue, Harleen Choudhary, Jeffrey D Lifson, Thomas A Rasmussen, Ajantha Rhodes, Carolin Tumpach, Robert Yarchoan, Frank Maldarelli, Martin A Cheever, et al.

Journal article  |  2022  |  SCIENCE TRANSLATIONAL MEDICINE

In people living with HIV (PLWH) on antiretroviral therapy (ART), virus persists in a latent form where there is minimal transcrip..

Cell-Associated Human Immunodeficiency Virus (HIV) Ribonucleic Acid Has a Circadian Cycle in Males With HIV on Antiretroviral Therapy

Jared Stern, Ajantha Solomon, Ashanti Dantanarayana, Rachel Pascoe, Arnold Reynaldi, Miles P Davenport, Jeffrey Milush, Steven G Deeks, Wendy Hartogensis, Frederick M Hecht, Leslie Cockerham, Michael Roche, Sharon R Lewin

Journal article  |  2021  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Circadian transcription factors that regulate cell-autonomous circadian clocks can also increase human immunodeficienc..

Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells.

Christina Fichter, Anupriya Aggarwal, Andrew Kam Ho Wong, Samantha McAllery, Vennila Mathivanan, Bailey Hao, Hugh MacRae, Melissa J Churchill, Paul R Gorry, Michael Roche, Lachlan R Gray, Stuart Turville

Journal article  |  2021  |  Viruses

Gene/cell therapies are promising strategies for the many presently incurable diseases. A key step in this process is the efficien..