Michael Roche

Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells.

Christina Fichter, Anupriya Aggarwal, Andrew Kam Ho Wong, Samantha McAllery, Vennila Mathivanan, Bailey Hao, Hugh MacRae, Melissa J Churchill, Paul R Gorry, Michael Roche, Lachlan R Gray, Stuart Turville

Journal article  |  2021  |  Viruses

Gene/cell therapies are promising strategies for the many presently incurable diseases. A key step in this process is the efficien..

The role of oxidative stress in HIV-associated neurocognitive disorders

Sarah Buckley, Sarah Byrnes, Catherine Cochrane, Michael Roche, Jacob D Estes, Stavros Selemidis, Thomas A Angelovich, Melissa J Churchill

Journal article  |  2021  |  Brain, Behavior, & Immunity - Health

A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls

James H McMahon, Jennifer M Zerbato, Jillian SY Lau, Jaclyn L Lange, Michael Roche, Carolin Tumpach, Ashanti Dantanarayana, Ajantha Rhodes, Judy Chang, Thomas A Rasmussen, Charlene A Mackenzie, Karen Alt, Michelle Hagenauer, Janine Roney, Jessica O'Bryan, Alexandra Carey, Richard McIntyre, Paul Beech, Graeme J O'Keefe, Christian W Wichmann, et al.

Journal article  |  2021  |  EBIOMEDICINE

BACKGROUND: A research priority in finding a cure for HIV is to establish methods to accurately locate and quantify where and how ..

Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

Jennifer M Zerbato, Georges Khoury, Wei Zhao, Matthew J Gartner, Rachel D Pascoe, Ajantha Rhodes, Ashanti Dantanarayana, Megan Gooey, Jenny Anderson, Peter Bacchetti, Steven G Deeks, James McMahon, Michael Roche, Thomas A Rasmussen, Damian FJ Purcell, Sharon R Lewin

Journal article  |  2021  |  EBIOMEDICINE

BACKGROUND: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretro..

Longitudinal analysis of subtype C envelope tropism for memory CD4( )T cell subsets over the first 3 years of untreated HIV-1 infection

Matthew J Gartner, Paul R Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J Judy Chang, Thomas A Angelovich, Paula Ellenberg, Annemarie E Laumaea, Molati Nonyane, Penny L Moore, Sharon R Lewin, Melissa J Churchill, Jacqueline K Flynn, Michael Roche

Journal article  |  2020  |  RETROVIROLOGY

BACKGROUND: HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of ent..

CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4( ) T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained

Michael Roche, Carolin Tumpach, Jori Symons, Matthew Gartner, Jenny L Anderson, Gabriela Khoury, Kieran Cashin, Paul U Cameron, Melissa J Churchill, Steven G Deeks, Paul R Gorry, Sharon R Lewin

Journal article  |  2020  |  JOURNAL OF VIROLOGY

HIV can persist in people living with HIV (PLWH) on antiretroviral therapy (ART) in multiple CD4+ T cell subsets, including naive ..

Understanding the mechanisms driving the spread of subtype C HIV-1

Matthew J Gartner, Michael Roche, Melissa J Churchill, Paul R Gorry, Jacqueline K Flynn

Journal article  |  2020  |  EBIOMEDICINE

Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is the most prevalent form of HIV-1 globally, accounting for approxi..

Human Immunodeficiency Virus (HIV)-Infected CCR6( ) Rectal CD4( ) T Cells and HIV Persistence On Antiretroviral Therapy

Jenny L Anderson, Gabriela Khoury, Remi Fromentin, Ajantha Solomon, Nicolas Chomont, Elizabeth Sinclair, Jeffrey M Milush, Wendy Hartogensis, Peter Bacchetti, Michael Roche, Carolin Tumpach, Matthew Gartner, Matthew C Pitman, Christine Lorrie Epling, Rebecca Hoh, Frederick M Hecht, Ma Somsouk, Paul U Cameron, Steven G Deeks, Sharon R Lewin

Journal article  |  2020  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Identifying where human immunodeficiency virus (HIV) persists in people living with HIV and receiving antiretroviral t..

Cell-associated HIV RNA and the ratio of HIV RNA to DNA have circadian cycles in HIV-positive individuals on antiretoviral therapy

J Stern, M Roche, A Solomon, A Dantanarayana, A Reynaldi, M Davenport, SG Deeks, W Hartogenesis, FM Hecht, L Cockerham, SR Lewin

Journal article  |  2019  |  Journal of Virus Eradication

Variation in cell-associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator brain-and-muscle-ARNT-like-1

Christina C Chang, Vivek Naranbhai, Jared Stern, Michael Roche, Ashanti Dantanarayana, Ruian Ke, Surekha Tennakoon, Ajantha Solomon, Rebecca Hoh, Wendy Hartogensis, Frederick M Hecht, Ken Sikaris, David J Price, Julian H Elliott, Steven G Deeks, Melissa Churchill, Paul U Cameron, Nicolas Hengartner, Alan S Perelson, Sharon R Lewin

Journal article  |  2018  |  AIDS

OBJECTIVE(S): To determine whether variation in cell-associated unspliced (CA-US) HIV RNA in HIV-infected individuals on antiretro..