Michael Roche

CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4( ) T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained

Michael Roche, Carolin Tumpach, Jori Symons, Matthew Gartner, Jenny L Anderson, Gabriela Khoury, Kieran Cashin, Paul U Cameron, Melissa J Churchill, Steven G Deeks, Paul R Gorry, Sharon R Lewin

Journal article  |  2020  |  Journal of Virology

HIV can persist in people living with HIV (PLWH) on antiretroviral therapy (ART) in multiple CD4+ T cell subsets, including naïve,..

Understanding the mechanisms driving the spread of subtype C HIV-1

Matthew J Gartner, Michael Roche, Melissa J Churchill, Paul R Gorry, Jacqueline K Flynn

Journal article  |  2020  |  EBioMedicine

Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is the most prevalent form of HIV-1 globally, accounting for approxi..

Human Immunodeficiency Virus (HIV)-Infected CCR6( ) Rectal CD4( ) T Cells and HIV Persistence On Antiretroviral Therapy

Jenny L Anderson, Gabriela Khoury, Remi Fromentin, Ajantha Solomon, Nicolas Chomont, Elizabeth Sinclair, Jeffrey M Milush, Wendy Hartogensis, Peter Bacchetti, Michael Roche, Carolin Tumpach, Matthew Gartner, Matthew C Pitman, Christine Lorrie Epling, Rebecca Hoh, Frederick M Hecht, Ma Somsouk, Paul U Cameron, Steven G Deeks, Sharon R Lewin

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: Identifying where human immunodeficiency virus (HIV) persists in people living with HIV and receiving antiretroviral t..

Variation in cell-associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator brain-and-muscle-ARNT-like-1

Christina C Chang, Vivek Naranbhai, Jared Stern, Michael Roche, Ashanti Dantanarayana, Ruian Ke, Surekha Tennakoon, Ajantha Solomon, Rebecca Hoh, Wendy Hartogensis, Frederick M Hecht, Ken Sikaris, David J Price, Julian H Elliott, Steven G Deeks, Melissa Churchill, Paul U Cameron, Nicolas Hengartner, Alan S Perelson, Sharon R Lewin

Journal article  |  2018  |  AIDS

Analysis of Clinical HIV-1 Strains with Resistance to Maraviroc Reveals Strain-Specific Resistance Mutations, Variable Degrees of Resistance, and Minimal Cross-Resistance to Other CCR5 Antagonists

Jacqueline K Flynn, Paula Ellenberg, Renee Duncan, Anne Ellett, Jingling Zhou, Jasminka Sterjovski, Kieran Cashin, Katharina Borm, Lachlan R Gray, Marilyn Lewis, Becky Jubb, Mike Westby, Benhur Lee, Sharon R Lewin, Melissa Churchill, Michael Roche, Paul R Gorry

Journal article  |  2017  |  AIDS Research and Human Retroviruses

Impact of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy with Sezary syndrome

Thomas A Rasmussen, James McMahon, J Judy Chang, Jori Symons, Michael Roche, Ashanti Dantanarayana, Afam Okoye, Bonnie Hiener, Sarah Palmer, Wen Shi Lee, Stephen J Kent, Carrie Van der Weyden, H Miles Prince, Paul U Cameron, Sharon R Lewin

Journal article  |  2017  |  AIDS

HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells

Yin Xu, Chansavath Phetsouphanh, Kazuo Suzuki, Anu Aggrawal, Stephanie Graff-Dubois, Michael Roche, Michelle Bailey, Sheilajen Alcantara, Kieran Cashin, Rahuram Sivasubramaniam, Kersten K Koelsch, Brigitte Autran, Richard Harvey, Paul R Gorry, Arnaud Moris, David A Cooper, Stuart Turville, Stephen J Kent, Anthony D Kelleher, John Zaunders

Journal article  |  2017  |  Frontiers in Immunology

Vancomycin

IC Gyssens, NE Holmes

Book Chapter  |  2017

Artemether-lumefantrine

RJ Commons, JA Simpson, RN Price

Book Chapter  |  2017

Chloramphenicol and thiamphenicol

G MacLaren, F Shann

Book Chapter  |  2017

Lamivudine

J Audsley, M Giles, SR Lewin

Book Chapter  |  2017

Benzylpenicillin (penicillin G)

AM Geddes, IM Gould, JA Roberts, JA Trubiano, M Lindsay Grayson

Book Chapter  |  2017

Discontinued hepatitis agent: Clevudine

R Chin, J Torresi, J Mills

Book Chapter  |  2017

Delavirdine

J Mills, SM Crowe

Book Chapter  |  2017

Entecavir

AC Cheng, J Sasadeusz

Book Chapter  |  2017

Indinavir

MA Boyd, SM Crowe

Book Chapter  |  2017

Discontinued herpesvirus agent: Vidarabine

SM Crowe, J Mills

Book Chapter  |  2017

Investigational antiviral drugs

J Mills, SM Crowe, M Martinello

Book Chapter  |  2017

Darunavir

AC Cheng, R Muttucumaru, SM Crowe

Book Chapter  |  2017

Foscarnet

J Mills, SM Crowe

Book Chapter  |  2017

Kucers’ the use of antibiotics: A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs, seventh edition

ML Grayson, SE Cosgrove, SM Crowe, W Hope, JS McCarthy, J Mills, JW Mouton, DL Paterson

Book Chapter  |  2017

Sparfloxacin

PGP Charles

Book Chapter  |  2017

Lomefloxacin

PGP Charles

Book Chapter  |  2017

Enoxacin

PGP Charles

Book Chapter  |  2017

Rufloxacin

PGP Charles

Book Chapter  |  2017

Artemisinins

K Thriemer, JA Simpson, JS McCarthy, RN Price

Book Chapter  |  2017

Capreomycin

PDR Johnson

Book Chapter  |  2017

Cycloserine and terizidone

PDR Johnson

Book Chapter  |  2017

Amdoxovir

SM Crowe, J Mills

Book Chapter  |  2017

Maraviroc

M Roche, SR Lewin, PR Gorry

Book Chapter  |  2017

Pefloxacin

PGP Charles

Book Chapter  |  2017

Abacavir

PU Cameron, JA Trubiano

Book Chapter  |  2017

Nelfinavir

SM Crowe, L Ostergaard, J Mills

Book Chapter  |  2017

Principles of antimicrobial use

ML Grayson, SE Cosgrove, SM Crowe, JS McCarthy, W Hope, J Mills, JW Mouton, DL Paterson

Book Chapter  |  2017

Discontinued hepatitis agents: Torcitabine and valtorcitabine

J Mills, SM Crowe

Book Chapter  |  2017

Apricitabine

SM Crowe, J Mills

Book Chapter  |  2017

Amantadine and rimantadine

J Mills, SM Crowe

Book Chapter  |  2017

Ticarcillin-clavulanic acid

K Buising

Book Chapter  |  2017

Streptomycin

PDR Johnson

Book Chapter  |  2017

Ethionamide and prothionamide

PDR Johnson

Book Chapter  |  2017

Thiacetazone

PDR Johnson

Book Chapter  |  2017

Sulfonamides

NE Holmes, M Lindsay Grayson

Book Chapter  |  2017

Pyronaridine-artesunate

H Karunajeewa

Book Chapter  |  2017

Linezolid

SJ Sparham, BP Howden

Book Chapter  |  2017

Tosufloxacin

PGP Charles

Book Chapter  |  2017

Trimethoprim and trimethoprim-sulfamethoxazole (cotrimoxazole)

JA Trubiano, M Lindsay Grayson

Book Chapter  |  2017

Halofantrine

RN Price, JA Simpson, JS McCarthy

Book Chapter  |  2017

Preface

ML Grayson

Book Chapter  |  2017

Dihydroartemisinin-piperaquine

H Karunajeewa

Book Chapter  |  2017

Artesunate

RJ Commons, JA Simpson, JS McCarthy, RN Price

Book Chapter  |  2017

Zalcitabine

SM Crowe, J Mills

Book Chapter  |  2017

Zidovudine

CL Cherry, SM Crowe

Book Chapter  |  2017

Ribavirin

E Woolnough, A Wade, J Sasadeusz

Book Chapter  |  2017

Fosamprenavir

SM Crowe, C Katlama, R Murphy

Book Chapter  |  2017

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

Katharina Borm, Martin R Jakobsen, Kieran Cashin, Jacqueline K Flynn, Paula Ellenberg, Lars Ostergaard, Benhur Lee, Melissa J Churchill, Michael Roche, Paul R Gorry

Journal article  |  2016  |  Retrovirology

i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4

Katherine Griffiths, Olan Dolezal, Benjamin Cao, Susan K Nilsson, Heng B See, Kevin DG Pfleger, Michael Roche, Paul R Gorry, Andrew Pow, Katerina Viduka, Kevin Lim, Bernadine GC Lu, Denison HC Chang, Thomas Murray-Rust, Marc Kvansakul, Matthew A Perugini, Con Dogovski, Marcel Doerflinger, Yuan Zhang, Kathy Parisi, et al.

Journal article  |  2016  |  Journal of Biological Chemistry

Molecular Gymnastics: Mechanisms of HIV-1 Resistance to CCR5 Antagonists and Impact on Virus Phenotypes

Michael Roche, Katharina Borm, Jacqueline K Flynn, Sharon R Lewin, Melissa J Churchill, Paul R Gorry

Journal article  |  2016  |  CURRENT TOPICS IN MEDICINAL CHEMISTRY

Reliable Genotypic Tropism Tests for the Major HIV-1 Subtypes

Kieran Cashin, Lachlan R Gray, Katherine L Harvey, Danielle Perez-Bercoff, Guinevere Q Lee, Jasminka Sterjovski, Michael Roche, James F Demarest, Fraser Drummond, P Richard Harrigan, Melissa J Churchill, Paul R Gorry

Journal article  |  2015  |  Scientific Reports

Is the central nervous system a reservoir of HIV-1?

Lachlan R Gray, Michael Roche, Jacqueline K Flynn, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill

Journal article  |  2014  |  Current Opinion in HIV and AIDS

Site-Selective Solid-Phase Synthesis of a CCR5 Sulfopeptide Library To Interrogate HIV Binding and Entry

Xuyu Liu, Lara R Malins, Michael Roche, Jasminka Sterjovski, Renee Duncan, Mary L Garcia, Nadine C Barnes, David A Anderson, Martin J Stone, Paul R Gorry, Richard J Payne

Journal article  |  2014  |  ACS Chemical Biology

HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles

Lachlan R Gray, Stuart G Turville, Tina L HItchen, Wan-Jung Cheng, Anne M Ellett, Hamid Salimi, Michael J Roche, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill

Journal article  |  2014  |  PLoS One

Quantifying Susceptibility of CD4( ) Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains

Jacqueline K Flynn, Geza Paukovics, Kieran Cashin, Katharina Borm, Anne Ellett, Michael Roche, Martin R Jakobsen, Melissa J Churchill, Paul R Gorry

Journal article  |  2014  |  Viruses

Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection

Kieran Cashin, Martin R Jakobsen, Jasminka Sterjovski, Michael Roche, Anne Ellett, Jacqueline K Flynn, Katharina Borm, Maelenn Gouillou, Melissa J Churchill, Paul R Gorry

Journal article  |  2013  |  Retrovirology

The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets

Jacqueline K Flynn, Geza Paukovics, Miranda S Moore, Anne Ellett, Lachlan R Gray, Renee Duncan, Hamid Salimi, Becky Jubb, Mike Westby, Damian FJ Purcell, Sharon R Lewin, Benhur Lee, Melissa J Churchill, Paul R Gorry, Michael Roche

Journal article  |  2013  |  Virology

Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naive Subjects with Progressive HIV-1 Subtype C Infection

Martin R Jakobsen, Kieran Cashin, Michael Roche, Jasminka Sterjovski, Anne Ellett, Katharina Borm, Jacqueline Flynn, Christian Erikstrup, Maelenn Gouillou, Lachlan R Gray, Nitin K Saksena, Bin Wang, Damian FJ Purcell, Per Kallestrup, Rutendo Zinyama-Gutsire, Exnevia Gomo, Henrik Ullum, Lars Ostergaard, Benhur Lee, Paul A Ramsland, et al.

Journal article  |  2013  |  PLoS One

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Michael Roche, Hamid Salimi, Renee Duncan, Brendan L Wilkinson, Kelechi Chikere, Miranda S Moore, Nicholas E Webb, Helena Zappi, Jasminka Sterjovski, Jacqueline K Flynn, Anne Ellett, Lachlan R Gray, Benhur Lee, Becky Jubb, Mike Westby, Paul A Ramsland, Sharon R Lewin, Richard J Payne, Melissa J Churchill, Paul R Gorry

Journal article  |  2013  |  RETROVIROLOGY

The NRTIs Lamivudine, Stavudine and Zidovudine Have Reduced HIV-1 Inhibitory Activity in Astrocytes

Lachlan R Gray, Gilda Tachedjian, Anne M Ellett, Michael J Roche, Wan-Jung Cheng, Gilles J Guillemin, Bruce J Brew, Stuart G Turville, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill

Journal article  |  2013  |  PLoS One

CoRSeq(V3-C): a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm

Kieran Cashin, Lachlan R Gray, Martin R Jakobsen, Jasminka Sterjovski, Melissa J Churchill, Paul R Gorry

Journal article  |  2013  |  Retrovirology

Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

Hamid Salimi, Michael Roche, Nicholas Webb, Lachlan R Gray, Kelechi Chikere, Jasminka Sterjovski, Anne Ellett, Steve L Wesselingh, Paul A Ramsland, Benhur Lee, Melissa J Churchill, Paul R Gorry

Journal article  |  2013  |  Journal of Leukocyte Biology

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

Michael Roche, Martin R Jakobsen, Anne Ellett, Hamid Salimiseyedabad, Becky Jubb, Mike Westby, Benhur Lee, Sharon R Lewin, Melissa J Churchill, Paul R Gorry

Journal article  |  2011  |  RETROVIROLOGY

Alternative Coreceptor Requirements for Efficient CCR5-and CXCR4-Mediated HIV-1 Entry into Macrophages

Kieran Cashin, Michael Roche, Jasminka Sterjovski, Anne Ellett, Lachlan R Gray, Anthony L Cunningham, Paul A Ramsland, Melissa J Churchill, Paul R Gorry

Journal article  |  2011  |  Journal of Virology

HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism

Michael Roche, Martin R Jakobsen, Jasminka Sterjovski, Anne Ellett, Filippo Posta, Benhur Lee, Becky Jubb, Mike Westby, Sharon R Lewin, Paul A Ramsland, Melissa J Churchill, Paul R Gorry

Journal article  |  2011  |  Journal of Virology

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity

Jasminka Sterjovski, Melissa J Churchill, Michael Roche, Anne Ellett, William Farrugia, Steven L Wesselingh, Anthony L Cunningham, Paul A Ramsland, Paul R Gorry

Journal article  |  2011  |  Virology

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

Jasminka Sterjovski, Michael Roche, Melissa J Churchill, Anne Ellett, William Farrugia, Lachlan R Gray, Daniel Cowley, Pantelis Poumbourios, Benhur Lee, Steven L Wesselingh, Anthony L Cunningham, Paul A Ramsland, Paul R Gorry

Journal article  |  2010  |  Virology

X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells

Kate L Jones, Michael Roche, Michael P Gantier, Nasim A Begum, Tasuku Honjo, Salvatore Caradonna, Bryan RG Williams, Johnson Mak

Journal article  |  2010  |  Journal of Biological Chemistry

Enhanced CD4 cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection

Jessica Wade, Jasminka Sterjovski, Lachlan Gray, Ichael Roche, Lisa Chiavaroli, Anne Ellett, Martin R Jakobsen, Daniel Cowley, Candida da Fonseca Pereira, Nitin Saksena, Bin Wang, Damian FJ Purcell, Ingrid Karlsson, Eva-Maria Fenyoe, Melissa Churchill, Paul R Gorry

Journal article  |  2010  |  Virology

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain (vol 83, pg 5430, 2009)

Lachlan Gray, Michael Roche, Melissa J Churchill, Jasminka Sterjovski, Anne Ellett, Pantelis Poumbourios, Shameem Sherieff, Bin Wang, Nitin Saksena, Damian FJ Purcell, Steven Wesselingh, Anthony L Cunningham, Bruce J Brew, Dana Gabuzda, Paul R Gorry

Journal article  |  2009  |  Journal of Virology

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

Lachlan Gray, Michael Roche, Melissa J Churchill, Jasminka Sterjovski, Anne Ellett, Pantelis Poumbourios, Shameem Sheffief, Bin Wang, Nitin Saksena, Damian FJ Purcell, Steven Wesselingh, Anthony L Cunningham, Bruce J Brew, Dana Gabuzda, Paul R Gorry

Journal article  |  2009  |  Journal of Virology

Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS

Jasminka Sterjovski, Melissa J Churchill, Anne Ellett, Lachlan R Gray, Michael J Roche, Rebecca L Dunfee, Damian Fj Purcell, Nitin Saksena, Bin Wang, Secondo Sonza, Steven L Wesselingh, Ingrid Karlsson, Eva-Maria Fenyo, Dana Gabuzda, Anthony L Cunningham, Paul R Gorry

Journal article  |  2007  |  Retrovirology

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

Paul R Gorry, Dale A McPhee, Erin Verity, Wayne B Dyer, Steven L Wesselingh, Jennifer Learmont, John S Sullivan, Michael Roche, John J Zaunders, Dana Gabuzda, Suzanne M Crowe, John Mills, Sharon R Lewin, Bruce J Brew, Anthony L Cunningham, Melissa J Churchill

Journal article  |  2007  |  RETROVIROLOGY