Richard Birkinshaw

Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax

Anthony N Hodder, Janni Christensen, Stephen Scally, Tony Triglia, Anna Ngo, Richard W Birkinshaw, Brodie Bailey, Paola Favuzza, Melanie H Dietrich, Wai-Hong Tham, Peter E Czabotar, Kym Lowes, Zhuyan Guo, Nicholas Murgolo, Manuel de Lera Ruiz, John A McCauley, Brad E Sleebs, David Olsen, Alan F Cowman

Journal article  |  2022  |  STRUCTURE

Plasmepsins IX (PMIX) and X (PMX) are essential aspartyl proteases for Plasmodium spp. egress, invasion, and development. WM4 and ..

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

Dale J Calleja, Nathan Kuchel, Bernadine GC Lu, Richard W Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P Cooney, Liana Mackiewicz, Amanda E Au, Yu Q Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E Jarman, Melissa J Call, Bernhard C Lechtenberg, Peter E Czabotar, Marc Pellegrini, Susan A Charman, et al.

Journal article  |  2022  |  FRONTIERS IN CHEMISTRY

The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalizati..

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the alpha 1-alpha 2 loop in BAK activation

Adeline Y Robin, Michelle S Miller, Sweta Iyer, Melissa X Shi, Ahmad Z Wardak, Daisy Lio, Nicholas A Smith, Brian J Smith, Richard W Birkinshaw, Peter E Czabotar, Ruth M Kluck, Peter M Colman

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Pro-apoptotic BAK and BAX are activated by BH3-only proteins to permeabilise the outer mitochondrial membrane. The antibody 7D10 a..

VDAC2 and the BCL-2 family of proteins

Zheng Yuan, Grant Dewson, Peter E Czabotar, Richard W Birkinshaw

Journal article  |  2021  |  BIOCHEMICAL SOCIETY TRANSACTIONS

The BCL-2 protein family govern whether a cell dies or survives by controlling mitochondrial apoptosis. As dysregulation of mitoch..

Dynamic reconfiguration of pro-apoptotic BAK on membranes

Jarrod J Sandow, Iris Kl Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew Webb, Grant Dewson

Journal article  |  2021  |  EMBO JOURNAL

BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associat..

Structure of detergent-activated BAK dimers derived from the inert monomer

Richard W Birkinshaw, Sweta Iyer, Daisy Lio, Cindy S Luo, Jason M Brouwer, Michelle S Miller, Adeline Y Robin, Rachel T Uren, Grant Dewson, Ruth M Kluck, Peter M Colman, Peter E Czabotar

Journal article  |  2021  |  MOLECULAR CELL

A body of data supports the existence of core (α2-α5) dimers of BAK and BAX in the oligomeric, membrane-perturbing conformation of..

A new crystal form of GABARAPL2

Kristen Scicluna, Grant Dewson, Peter E Czabotar, Richard W Birkinshaw

Journal article  |  2021  |  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

The Atg8 protein family comprises the GABA type A receptor-associated proteins (GABARAPs) and microtubule-associated protein 1 lig..

Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X-L and BCL-2

Michael J Roy, Amelia Vom, Toru Okamoto, Brian J Smith, Richard W Birkinshaw, Hong Yang, Houda Abdo, Christine A White, David Segal, David CS Huang, Jonathan B Baell, Peter M Colman, Peter E Czabotar, Guillaume Lessene

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

The BCL-2 family of proteins (including the prosurvival proteins BCL-2, BCL-XL, and MCL-1) is an important target for the developm..

Challenges in small-molecule target identification: a commentary on "BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models" (vol 28, pg 1130, 2021)

Richard W Birkinshaw

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

A Correction to this paper has been published: https://doi.org/10.1038/s41418-021-00758-3.

Yeast- and antibody-based tools for studying tryptophan C-mannosylation

Alan John, Michael A Jarva, Sayali Shah, Runyu Mao, Stephane Chappaz, Richard W Birkinshaw, Peter E Czabotar, Alvin W Lo, Nichollas E Scott, Ethan D Goddard-Borger

Journal article  |  2021  |  NATURE CHEMICAL BIOLOGY

Tryptophan C-mannosylation is an unusual co-translational protein modification performed by metazoans and apicomplexan protists. T..