Nichollas Scott

Conservation, abundance, glycosylation profile, and localization of the TSP protein family in Cryptosporidium parvum.

Alan John, Stefanie M Bader, Niccolay Madiedo Soler, Kharizta Wiradiputri, Swapnil Tichkule, Sean T Smyth, Stuart A Ralph, Aaron R Jex, Nichollas E Scott, Christopher J Tonkin, Ethan D Goddard-Borger

Journal article  |  2023  |  J Biol Chem

Cryptosporidium parvum is a zoonotic apicomplexan parasite and a common cause of diarrheal disease worldwide. The development of v..

Discovery and characterization of a new class of O-linking oligosaccharyltransferases from the Moraxellaceae family.

Cory J Knoot, Paeton L Wantuch, Lloyd S Robinson, David A Rosen, Nichollas E Scott, Christian M Harding

Journal article  |  2023  |  Glycobiology

Bacterial protein glycosylation is commonly mediated by oligosaccharyltransferases (OTases) that transfer oligosaccharides en bloc..

Characterisation of N-linked protein glycosylation in the bacterial pathogen Campylobacter hepaticus.

Jamieson B McDonald, Nichollas E Scott, Greg J Underwood, Daniel M Andrews, Thi Thu Hao Van, Robert J Moore

Journal article  |  2023  |  Sci Rep

Campylobacter hepaticus is an important pathogen which causes Spotty Liver Disease (SLD) in layer chickens. SLD results in an incr..

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Joel S Bloch, Alan John, Runyu Mao, Somnath Mukherjee, Jeremy Boilevin, Rossitza N Irobalieva, Tamis Darbre, Nichollas E Scott, Jean-Louis Reymond, Anthony A Kossiakoff, Ethan D Goddard-Borger, Kaspar P Locher

Journal article  |  2023  |  NATURE CHEMICAL BIOLOGY

C-linked glycosylation is essential for the trafficking, folding and function of secretory and transmembrane proteins involved in ..

Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1.

Gloria Polanco, Nichollas E Scott, Lon F Lye, Stephen M Beverley

Journal article  |  2022  |  Microbiol Spectr

The trypanosomatid protozoan parasite Leishmania has a significant impact on human health globally. Understanding the pathways ass..

Immunogenicity and protective efficacy of a prototype pneumococcal bioconjugate vaccine.

Javid Aceil, Amy V Paschall, Cory J Knoot, Lloyd S Robinson, Nichollas E Scott, Mario F Feldman, Christian M Harding, Fikri Y Avci

Journal article  |  2022  |  Vaccine

Capsular polysaccharides (CPSs), with which most pathogenic bacterial surfaces are decorated, have been used as the main component..

Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli.

Georgina L Pollock, Andrey M Grishin, Cristina Giogha, Jiyao Gan, Clare V Oates, Paul J McMillan, Isabella Gaeta, Matthew J Tyska, Jaclyn S Pearson, Nichollas E Scott, Miroslaw Cygler, Elizabeth L Hartland

Journal article  |  2022  |  Proc Natl Acad Sci U S A

Attaching and effacing (AE) lesion formation on enterocytes by enteropathogenic Escherichia coli (EPEC) requires the EPEC type III..

Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission (vol 13, 1400, 2022)

Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan WJ Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal article  |  2022  |  NATURE COMMUNICATIONS

The original version of this Article incorrectly cited reference 85 instead of reference 84 in the methods section ‘An. stephensi ..

Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission

Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan WJ Steel, Cindy Evelyn, Matthew T O'Neill, Niccolay Madiedo Soler, Nichollas E Scott, Kelly L Rogers, Ethan D Goddard-Borger, Justin A Boddey

Journal article  |  2022  |  NATURE COMMUNICATIONS

Tryptophan C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmo..

The Phenylacetic Acid Catabolic Pathway Regulates Antibiotic and Oxidative Stress Responses in Acinetobacter.

Anna J Hooppaw, Jenna C McGuffey, Gisela Di Venanzio, Juan C Ortiz-Marquez, Brent S Weber, Tasia Joy Lightly, Tim van Opijnen, Nichollas E Scott, Silvia T Cardona, Mario F Feldman

Journal article  |  2022  |  mBio

The opportunistic pathogen Acinetobacter baumannii is responsible for a wide range of infections that are becoming increasingly di..