Nichollas Scott

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI Insight

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Arginine glycosylation enhances methylglyoxal detoxification

Samir El Qaidi, Nichollas E Scott, Philip R Hardwidge

Journal article  |  2021  |  Scientific Reports

Type III secretion system effector proteins have primarily been characterized for their interactions with host cell proteins and t..

Yeast- and antibody-based tools for studying tryptophan C-mannosylation

Alan John, Michael A Jarva, Sayali Shah, Runyu Mao, Stephane Chappaz, Richard W Birkinshaw, Peter E Czabotar, Alvin W Lo, Nichollas E Scott, Ethan D Goddard-Borger

Journal article  |  2021  |  Nature Chemical Biology

Tryptophan C-mannosylation is an unusual co-translational protein modification performed by metazoans and apicomplexan protists. T..

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells

Conor J Kearney, Stephin J Vervoort, Kelly M Ramsbottom, Izabela Todorovski, Emily J Lelliott, Magnus Zethoven, Lizzy Pijpers, Ben P Martin, Timothy Semple, Luciano Martelotto, Joseph A Trapani, Ian A Parish, Nichollas E Scott, Jane Oliaro, Ricky W Johnstone

Journal article  |  2021  |  Science Advances

Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular different..

Editorial overview: Systems biology and the rise and rise of omics approaches.

Nichollas E Scott, Laura E Edgington-Mitchell

Journal article  |  2021  |  Current Opinion in Chemical Biology

Editorial overview: Systems biology and the rise and rise of omics approaches.

Nichollas E Scott, Laura E Edgington-Mitchell

Journal article  |  2021  |  Current Opinion in Chemical Biology

A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for detection of glanders infections

Guanbo Wang, Lena Glaser, Nichollas E Scott, Yasmine Fathy Mohamed, Rebecca Ingram, Karine Laroucau, Miguel A Valvano

Journal article  |  2021  |  Virulence

We recently described a protein O-glycosylation pathway conserved in all species of the Burkholderia genus that results in the syn..

What Are We Missing by Using Hydrophilic Enrichment? Improving Bacterial Glycoproteome Coverage Using Total Proteome and FAIMS Analyses

Ameera Raudah Ahmad Izaham, Ching-Seng Ang, Shuai Nie, Lauren E Bird, Nicholas A Williamson, Nichollas E Scott

Journal article  |  2021  |  Journal of Proteome Research

Hydrophilic interaction liquid chromatography (HILIC) glycopeptide enrichment is an indispensable tool for the high-throughput cha..

Proteomic Identification of Coxiella burnetii Effector Proteins Targeted to the Host Cell Mitochondria During Infection.

Laura F Fielden, Nichollas E Scott, Catherine S Palmer, Chen Ai Khoo, Hayley J Newton, Diana Stojanovski

Journal article  |  2020  |  Molecular & Cellular Proteomics

Modulation of the host cell is integral to the survival and replication of microbial pathogens. Several intracellular bacterial pa..

Glycoproteomics: growing up fast.

David R Thomas, Nichollas E Scott

Journal article  |  2020  |  Current Opinion in Structural Biology

Glycoproteomics is a rapidly growing field which seeks to identify and characterise glycosylation events at a proteome scale. Over..