Stanley Xie

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

Stanley C Xie, Riley D Metcalfe, Elyse Dunn, Craig J Morton, Shih-Chung Huang, Tanya Puhalovich, Yawei Du, Sergio Wittlin, Shuai Nie, Madeline R Luth, Liting Ma, Mi-Sook Kim, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Carlo Giannangelo, Fiona J Houghton, Alisje Churchyard, Mufuliat T Famodimu, Daniel C Barry, David L Gillett, et al.

Journal article  |  2022  |  SCIENCE

Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I and II aaRSs as previously u..

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Craig J Morton, Yawei Du, Con Dogovski, Shih-Chung Huang, Jeffrey Ciavarri, Paul Hales, Robert J Griffin, Lawrence H Cohen, Bei-Ching Chuang, Sergio Wittlin, Ioanna Deni, Tomas Yeo, Kurt E Ward, Daniel C Barry, Boyin Liu, et al.

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Plasmodium falciparum proteasome is a potential antimalarial drug target. We have identified a series of amino-amide boronates..

High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials

Lydia Mata-Cantero, Stanley C Xie, Mercedes Garcia, Joanne Coyle, Raquel Fernandez, Alvaro Cortes Cabrera, David L Gillett, Benigno Crespo, Francisco-Javier Gamo, Esther Fernandez, Leann Tilley, Maria G Gomez-Lorenzo

Journal article  |  2021  |  ACS INFECTIOUS DISEASES

The Ubiquitin Proteasome System is the main proteolytic pathway in eukaryotic cells, playing a role in key cellular processes. The..

K13, the Cytostome, and Artemisinin Resistance

Stanley C Xie, Stuart A Ralph, Leann Tilley

Journal article  |  2020  |  TRENDS IN PARASITOLOGY

Artemisinins - the frontline antimalarial drug class - are compromised by emerging resistance, putting at risk the lives of hundre..

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  CELL REPORTS

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch1..

The proteasome as a target for protozoan parasites

Stanley C Xie, Lawrence R Dick, Alexandra Gould, Stephen Brand, Leann Tilley

Journal article  |  2019  |  EXPERT OPINION ON THERAPEUTIC TARGETS

Introduction: The proteasome is a multi-subunit enzyme complex responsible for the turnover of short-lived, abnormal or damaged pr..

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Andrew P Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Journal article  |  2019  |  NATURE MICROBIOLOGY

The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regula..

Structure and Function of the Proteasome Activator PA28 of the Malaria Parasite Plasmodium falciparum

Riley Metcalf, Eric Hanssen, Stanley C Xie, David Gillett, Andrew Leis, Craig Morton, Michael W Parker, Wilson Wong, Michael Griffin, Leann Tilley

Journal article  |  2019  |  Microscopy and Microanalysis

The structure of the Plasmodium falciparum 20S proteasome in complex with the PA28 activator

Riley D Metcalfe, Stanley C Xie, Eric Hanssen, Tuo Yang, David L Gillett, Andrew Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Conference Proceedings  |  2019  |  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

Stanley C Xie, David L Gillett, Natalie J Spillman, Christopher Tsu, Madeline R Luth, Sabine Ottilie, Sandra Duffy, Alexandra E Gould, Paul Hales, Benjamin A Seager, Carlie L Charron, Frank Bruzzese, Xiaofeng Yang, Xiansi Zhao, Shih-Chung Huang, Craig A Hutton, Jeremy N Burrows, Elizabeth A Winzeler, Vicky M Avery, Lawrence R Dick, et al.

Journal article  |  2018  |  JOURNAL OF MEDICINAL CHEMISTRY

The Plasmodium proteasome represents a potential antimalarial drug target for compounds with activity against multiple life cycle ..