Stanley Xie

K13, the Cytostome, and Artemisinin Resistance

Stanley C Xie, Stuart A Ralph, Leann Tilley

Journal article  |  2020  |  Trends in Parasitology

Artemisinins - the frontline antimalarial drug class - are compromised by emerging resistance, putting at risk the lives of hundre..

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  Cell Reports

The proteasome as a target for protozoan parasites

Stanley C Xie, Lawrence R Dick, Alexandra Gould, Stephen Brand, Leann Tilley

Journal article  |  2019  |  Expert Opinion on Therapeutic Targets

Introduction: The proteasome is a multi-subunit enzyme complex responsible for the turnover of short-lived, abnormal or damaged pr..

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Andrew P Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Journal article  |  2019  |  Nature Microbiology

The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regula..

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

Stanley C Xie, David L Gillett, Natalie J Spillman, Christopher Tsu, Madeline R Luth, Sabine Ottilie, Sandra Duffy, Alexandra E Gould, Paul Hales, Benjamin A Seager, Carlie L Charron, Frank Bruzzese, Xiaofeng Yang, Xiansi Zhao, Shih-Chung Huang, Craig A Hutton, Jeremy N Burrows, Elizabeth A Winzeler, Vicky M Avery, Lawrence R Dick, et al.

Journal article  |  2018  |  JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Jessica L Bridgford, Stanley C Xie, Simon A Cobbold, Charisse Flerida A Pasaje, Susann Herrmann, Tuo Yang, David L Gillett, Lawrence R Dick, Stuart A Ralph, Con Dogovski, Natalie J Spillman, Leann Tilley

Journal article  |  2018  |  NATURE COMMUNICATIONS

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum

Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, James M McCaw

Journal article  |  2017  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

Tuo Yang, Stanley C Xie, Pengxing Cao, Carlo Giannangelo, James McCaw, Darren J Creek, Susan A Charman, Nectarios Klonis, Leann Tilley

Journal article  |  2016  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Hao Li, Anthony J O'Donoghue, Wouter A van der Linden, Stanley C Xie, Euna Yoo, Ian T Foe, Leann Tilley, Charles S Craik, Paula CA da Fonseca, Matthew Bogyo

Journal article  |  2016  |  NATURE

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

Stanley C Xie, Con Dogovski, Eric Hanssen, Francis Chiu, Tuo Yang, Maria P Crespo, Che Stafford, Steven Batinovic, Silvia Teguh, Susan Charman, Nectarios Klonis, Leann Tilley

Journal article  |  2016  |  Journal of Cell Science

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnaedig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley

Journal article  |  2015  |  PLOS BIOLOGY

Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins

Stanley C Xie, Con Dogovski, Shannon Kenny, Leann Tilley, Nectarios Klonis

Journal article  |  2014  |  International Journal for Parasitology

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

Nectarios Klonis, Stanley C Xie, James M McCaw, Maria P Crespo-Ortiz, Sophie G Zaloumis, Julie A Simpson, Leann Tilley

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America