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Participation As A Visiting Scientist -Opportunity To Participate As A Visiting Scientist ..
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning..
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falcip..
Displaying the most recent project by Stanley Xie.
Displaying the 13 most recent scholarly works by Stanley Xie.
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance
Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold
Journal article | 2019 | Cell Reports
The proteasome as a target for protozoan parasites
Stanley C Xie, Lawrence R Dick, Alexandra Gould, Stephen Brand, Leann Tilley
Journal article | 2019 | Expert Opinion on Therapeutic Targets
Introduction: The proteasome is a multi-subunit enzyme complex responsible for the turnover of short-lived, abnormal or damaged pr..
The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis
Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Andrew P Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley
Journal article | 2019 | Nature Microbiology
The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regula..
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
Stanley C Xie, David L Gillett, Natalie J Spillman, Christopher Tsu, Madeline R Luth, Sabine Ottilie, Sandra Duffy, Alexandra E Gould, Paul Hales, Benjamin A Seager, Carlie L Charron, Frank Bruzzese, Xiaofeng Yang, Xiansi Zhao, Shih-Chung Huang, Craig A Hutton, Jeremy N Burrows, Elizabeth A Winzeler, Vicky M Avery, Lawrence R Dick, et al.
Journal article | 2018 | JOURNAL OF MEDICINAL CHEMISTRY
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
Jessica L Bridgford, Stanley C Xie, Simon A Cobbold, Charisse Flerida A Pasaje, Susann Herrmann, Tuo Yang, David L Gillett, Lawrence R Dick, Stuart A Ralph, Con Dogovski, Natalie J Spillman, Leann Tilley
Journal article | 2018 | NATURE COMMUNICATIONS
A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, James M McCaw
Journal article | 2017 | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains
Tuo Yang, Stanley C Xie, Pengxing Cao, Carlo Giannangelo, James McCaw, Darren J Creek, Susan A Charman, Nectarios Klonis, Leann Tilley
Journal article | 2016 | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
Stanley C Xie, Con Dogovski, Eric Hanssen, Francis Chiu, Tuo Yang, Maria P Crespo, Che Stafford, Steven Batinovic, Silvia Teguh, Susan Charman, Nectarios Klonis, Leann Tilley
Journal article | 2016 | Journal of Cell Science
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnaedig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley
Journal article | 2015 | PLOS BIOLOGY
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
Nectarios Klonis, Stanley C Xie, James M McCaw, Maria P Crespo-Ortiz, Sophie G Zaloumis, Julie A Simpson, Leann Tilley
Journal article | 2013 | Proceedings of the National Academy of Sciences of the United States of America
Biochemistry And Molecular Biology
University of Melbourne
Bachelor of Science (Honours)
University of Sydney
Bachelor of Science (Biotechnology)