Stanley Xie

High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials

Lydia Mata-Cantero, Stanley C Xie, Mercedes Garcia, Joanne Coyle, Raquel Fernandez, Alvaro Cortes Cabrera, David L Gillett, Benigno Crespo, Francisco-Javier Gamo, Esther Fernandez, Leann Tilley, Maria G Gomez-Lorenzo

Journal article  |  2021  |  ACS INFECTIOUS DISEASES

The Ubiquitin Proteasome System is the main proteolytic pathway in eukaryotic cells, playing a role in key cellular processes. The..

K13, the Cytostome, and Artemisinin Resistance

Stanley C Xie, Stuart A Ralph, Leann Tilley

Journal article  |  2020  |  TRENDS IN PARASITOLOGY

Artemisinins - the frontline antimalarial drug class - are compromised by emerging resistance, putting at risk the lives of hundre..

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Journal article  |  2019  |  CELL REPORTS

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch1..

The proteasome as a target for protozoan parasites

Stanley C Xie, Lawrence R Dick, Alexandra Gould, Stephen Brand, Leann Tilley

Journal article  |  2019  |  EXPERT OPINION ON THERAPEUTIC TARGETS

Introduction: The proteasome is a multi-subunit enzyme complex responsible for the turnover of short-lived, abnormal or damaged pr..

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Andrew P Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Journal article  |  2019  |  NATURE MICROBIOLOGY

The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regula..

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

Stanley C Xie, David L Gillett, Natalie J Spillman, Christopher Tsu, Madeline R Luth, Sabine Ottilie, Sandra Duffy, Alexandra E Gould, Paul Hales, Benjamin A Seager, Carlie L Charron, Frank Bruzzese, Xiaofeng Yang, Xiansi Zhao, Shih-Chung Huang, Craig A Hutton, Jeremy N Burrows, Elizabeth A Winzeler, Vicky M Avery, Lawrence R Dick, et al.

Journal article  |  2018  |  JOURNAL OF MEDICINAL CHEMISTRY

The Plasmodium proteasome represents a potential antimalarial drug target for compounds with activity against multiple life cycle ..

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Jessica L Bridgford, Stanley C Xie, Simon A Cobbold, Charisse Flerida A Pasaje, Susann Herrmann, Tuo Yang, David L Gillett, Lawrence R Dick, Stuart A Ralph, Con Dogovski, Natalie J Spillman, Leann Tilley

Journal article  |  2018  |  NATURE COMMUNICATIONS

Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum inf..

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum

Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, James M McCaw

Journal article  |  2017  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria, particularly in light ..

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

Tuo Yang, Stanley C Xie, Pengxing Cao, Carlo Giannangelo, James McCaw, Darren J Creek, Susan A Charman, Nectarios Klonis, Leann Tilley

Journal article  |  2016  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fully synthetic endoperoxide antimalarials, namely, OZ277 (RBx11160; also known as arterolane) and OZ439 (artefenomel), have been ..

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Hao Li, Anthony J O'Donoghue, Wouter A van der Linden, Stanley C Xie, Euna Yoo, Ian T Foe, Leann Tilley, Charles S Craik, Paula CA da Fonseca, Matthew Bogyo

Journal article  |  2016  |  NATURE

The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen p..