Najoua Lalaoui

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.

Andre L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, et al.

Journal article  |  2020  |  Nature Communications

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-medi..

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Najoua Lalaoui, Delphine Merino, Goknur Giner, Francois Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R Whittle, Nima Etemadi, Jean Berthelet, Julius Grasel, Cathrine Hall, Matthew E Ritchie, Matthias Ernst, Gordon K Smyth, David L Vaux, Jane E Visvader, Geoffrey J Lindeman, John Silke

Journal article  |  2020  |  Cell Death & Differentiation

Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Her..

MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells

Athena F Phoa, Ariadna Recasens, Fadi MS Gurgis, Tara A Betts, Sharleen V Menezes, Diep Chau, Kristiina Nordfors, Joonas Haapasalo, Hannu Haapasalo, Terrance G Johns, Brett W Stringer, Bryan W Day, Michael E Buckland, Najoua Lalaoui, Lenka Munoz

Journal article  |  2020  |  Cancers

MAPK-activated protein kinase 2 (MK2) has diverse roles in cancer. In response to chemotherapy, MK2 inhibition is synthetically le..

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Najoua Lalaoui, Steven E Boyden, Hirotsugu Oda, Geryl M Wood, Deborah L Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E Lawlor, Kristien JM Zaal, Patrycja M Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, et al.

Journal article  |  2020  |  Nature

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post..

Antagonism of IAPs enhances CAR T cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy

Journal article  |  2019  |  Cell Reports

Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Langerhans cells drive TNF induced chronic proliferative dermatitis in SHARPIN deficient mice

H Anderton, M Chopin, C Dawson, N Lalaoui, J Silke

Conference Proceedings  |  2019  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell death, and the microbiome in skin inflammation and disease

H Anderton, G Varigos, N Lalaoui, J Silke

Conference Proceedings  |  2019  |  AUSTRALASIAN JOURNAL OF DERMATOLOGY

Antagonism of IAPs Enhances CAR T-cell Efficacy

Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cancer Immunology Research

Recent advances in understanding inhibitor of apoptosis proteins

Najoua Lalaoui, David Lawrence Vaux

Journal article  |  2018  |  F1000Research

The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis..

TNF in anti-tumour immunity and resistance to immunotherapy

Jane Oliaro, Conor Kearney, Stephin Vervoort, Simon Hogg, Najoua Lalaoui, Kristin Brown, John Silke, Ricky Johnstone

Conference Proceedings  |  2018  |  CANCER SCIENCE

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

Recent advances in understanding inhibitor of apoptosis proteins.

Najoua Lalaoui, David Lawrence Vaux

Journal article  |  2018  |  F1000Research

The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis..

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation

Holly Anderton, James A Rickard, George A Varigos, Najoua Lalaoui, John Silke

Journal article  |  2017  |  Journal of Investigative Dermatology

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF

Conor J Kearney, Najoua Lalaoui, Andrew J Freeman, Kelly M Ramsbottom, John Silke, Jane Oliaro

Journal article  |  2017  |  Cell Death & Differentiation

The TNF Receptor Superfamily-NF-kappa B Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues

Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F Pascutti, Anna E Oja, Alexandra L Garnham, Renee Gloury, Jessica C Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W Kuijpers, Najoua Lalaoui, Lisa A Mielke, Vanessa L Bryant, Philip D Hodgkin, John Silke, Gordon K Smyth, Martijn A Nolte, Wei Shi, et al.

Journal article  |  2017  |  Cell Reports

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.

Journal article  |  2017  |  Science Translational Medicine

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier

Journal article  |  2017  |  Molecular Cell

Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia

N Narayan, L Morenos, B Phipson, SN Willis, G Brumatti, S Eggers, N Lalaoui, LM Brown, HJ Kosasih, RC Bartolo, L Zhou, D Catchpoole, R Saffery, A Oshlack, GJ Goodall, PG Ekert

Journal article  |  2017  |  Leukemia

Combination of IAP antagonist and IFN gamma activates novel caspase-10-and RIPK1-dependent cell death pathways

Maria C Tanzer, Nufail Khan, James A Rickard, Nima Etemadi, Najoua Lalaoui, Sukhdeep Kaur Spall, Joanne M Hildebrand, David Segal, Maria Miasari, Diep Chau, WendyWei-Lynn Wong, Mark McKinlay, Srinivas K Chunduru, Christopher A Benetatos, Stephen M Condon, James E Vince, Marco J Herold, John Silke

Journal article  |  2017  |  Cell Death & Differentiation

'Did He Who Made the Lamb Make Thee?' New Developments in Treating the `Fearful Symmetry' of Acute Myeloid Leukemia

Gabriela Brumatti, Najoua Lalaoui, Andrew H Wei, John Silke

Journal article  |  2017  |  Trends in Molecular Medicine

Jekyll & Hyde: The Other Life of the Death Ligand TRAIL

Najoua Lalaoui, John Silke

Journal article  |  2017  |  Molecular Cell

Relevance of necroptosis in cancer

Najoua Lalaoui, Gabriela Brumatti

Journal article  |  2017  |  Immunology & Cell Biology

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, et al.

Journal article  |  2016  |  NATURE COMMUNICATIONS

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser

Journal article  |  2016  |  Immunity

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (vol 29, pg 145, 2016)

Najoua Lalaoui, Kay Hanggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spaii, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Gabriela Brumatti, Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M Salmon, Natasha Silke, Giovanna Pomilio, Stefan P Glaser, Elisha de Valle, Raffi Gugasyan, Mark A Gurthridge, Stephen M Condon, Ricky W Johnstone, Richard Lock, Guy Salvesen, Andrew Wei, et al.

Journal article  |  2016  |  Science Translational Medicine

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Najoua Lalaoui, Kay Haenggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spall, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

Autophagy and AML-food for thought

N Lalaoui, R Johnstone, PG Ekert

Journal article  |  2016  |  Cell Death & Differentiation

The molecular relationships between apoptosis, autophagy and necroptosis

Najoua Lalaoui, Lisa M Lindqvist, Jarrod J Sandow, Paul G Ekert

Journal article  |  2015  |  Seminars in Cell & Developmental Biology

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

James A Rickard, Holly Anderton, Nima Etemadi, Ueli Nachbur, Maurice Darding, Nieves Peltzer, Najoua Lalaoui, Kate E Lawlor, Hannah Vanyai, Cathrine Hall, Aleks Bankovacki, Lahiru Gangoda, Wendy Wei-Lynn Wong, Jason Corbin, Chunzi Huang, Edward S Mocarski, James M Murphy, Warren S Alexander, Anne K Voss, David L Vaux, et al.

Journal article  |  2014  |  eLife

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K Spall, Toby J Phesse, Helen E Abud, Louise H Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst, et al.

Journal article  |  2014  |  Cell

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner

W Wei-Lynn Wong, James E Vince, Najoua Lalaoui, Kate E Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O'Reilly, Philipp J Jost, James M Murphy, Warren S Alexander, Andreas Strasser, David L Vaux, John Silke

Journal article  |  2014  |  Blood

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, et al.

Journal article  |  2013  |  Immunity

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

Y Estornes, F Toscano, F Virard, G Jacquemin, A Pierrot, B Vanbervliet, M Bonnin, N Lalaoui, P Mercier-Gouy, Y Pacheco, B Salaun, T Renno, O Micheau, S Lebecque

Journal article  |  2012  |  Cell Death & Differentiation

Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells

Guillaume Jacquemin, Virginie Granci, Anne Sophie Gallouet, Najoua Lalaoui, Aymeric Morle, Elisabetta Iessi, Alexandre Morizot, Carmen Garrido, Thierry Guillaudeux, Olivier Micheau

Journal article  |  2012  |  Haematologica

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

Najoua Lalaoui, Aymeric Morle, Delphine Merino, Guillaume Jacquemin, Elisabetta Iessi, Alexandre Morizot, Sarah Shirley, Bruno Robert, Eric Solary, Carmen Garrido, Olivier Micheau

Journal article  |  2011  |  PLOS ONE

Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level

A Morizot, D Merino, N Lalaoui, G Jacquemin, V Granci, E Iessi, D Lanneau, F Bouyer, E Solary, B Chauffert, P Saas, C Garrido, O Micheau

Journal article  |  2011  |  Cell Death & Differentiation

Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages

Arnaud Jacquel, Naima Benikhlef, Jerome Paggetti, Najoua Lalaoui, Leslie Guery, Erick K Dufour, Marion Ciudad, Cindy Racoeur, Olivier Micheau, Laurent Delva, Nathalie Droin, Eric Solary

Journal article  |  2009  |  Blood

p53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells

F Toscano, Z El Fajoui, F Gay, N Lalaoui, B Parmentier, J-A Chayvialle, J-Y Scoazec, O Micheau, J Abello, J-C Saurin

Journal article  |  2008  |  Oncogene

TRAIL in cancer therapy: present and future challenges

Delphine Merino, Najoua Lalaoui, Alexandre Morizot, Eric Solary, Olivier Micheau

Journal article  |  2007  |  Expert Opinion on Therapeutic Targets

Dynamics of HPV16 DNA load reflect the natural history of cervical HPV-associated lesions (vol 35, pg 270, 2006)

S Monnier-Benoit, V Dalstein, D Riethmuller, N Lalaoui, C Mougin, JL Pretet

Journal article  |  2006  |  Journal of Clinical Virology

Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2

Delphine Merino, Najoua Lalaoui, Alexandre Morizot, Pascal Schneider, Eric Solary, Olivier Micheau

Journal article  |  2006  |  Molecular and Cellular Biology

Dynamics of HPV16 DNA load reflect the natural history of cervical HPV-associated lesions

S Monnier-Benoit, V Dalstein, D Riethmuller, N Lalaoui, C Mougin, JL Pretet

Journal article  |  2006  |  Journal of Clinical Virology