Andrea Newbold

Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Lev Kats, Carolyn Shembrey, Thomas Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew Wei, Gareth Gregory, Stephin Vervoort, Kristin Brown, Ricky Johnstone

Journal article  |  2020

Abstract Activating FMS-like tyrosine kinase 3 ( FLT3 ) mutations occur in approximately 30% of all acute myeloid leukaemias (AMLs..

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B Baell, David J Leaver, Stefan J Hermans, Gemma L Kelly, Margs S Brennan, Natalie L Downer, Nghi Nguyen, Johannes Wichmann, Helen M Mcrae, Yuqing Yang, Ben Cleary, H Rachel Lagiakos, Stephen Mieruszynski, Guido Pacini, Hannah K Vanyai, Maria I Bergamasco, Rose E May, Bethany K Davey, Kimberly J Morgan, Andrew J Sealey, et al.

Journal article  |  2018  |  Nature

How do tumor cells respond to HDAC inhibition?

Andrea Newbold, Katrina J Falkenberg, H Miles Prince, Ricky W Johnstone

Journal article  |  2016  |  The FEBS Journal

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

Simon J Hogg, Andrea Newbold, Stephin J Vervoort, Leonie A Cluse, Benjamin P Martin, Gareth P Gregory, Marcus Lefebure, Eva Vidacs, Richard W Tothill, James E Bradner, Jake Shortt, Ricky W Johnstone

Journal article  |  2016  |  Molecular Cancer Therapeutics

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Margherita Ghisi, Lev Kats, Frederick Masson, Jason Li, Tobias Kratina, Eva Vidacs, Omer Gilan, Maria A Doyle, Andrea Newbold, Jessica E Bolden, Kirsten A Fairfax, Carolyn A de Graaf, Matthew Firth, Johannes Zuber, Ross A Dickins, Lynn M Corcoran, Mark A Dawson, Gabrielle T Belz, Ricky W Johnstone

Journal article  |  2016  |  Cancer Cell

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity

KJ Falkenberg, A Newbold, CM Gould, J Luu, JA Trapani, GM Matthews, KJ Simpson, RW Johnstone

Journal article  |  2016  |  Cell Death & Differentiation

Scribble acts as an oncogene in E mu-myc-driven lymphoma

ED Hawkins, J Oliaro, KM Ramsbottom, A Newbold, PO Humbert, RW Johnstone, SM Russell

Journal article  |  2016  |  Oncogene

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David CS Huang, Lyubomir T Vassilev, Andreas Strasser

Journal article  |  2016  |  CELL REPORTS

The role of p21(waf1/cip1) and p27(Kip1) in HDACi-mediated tumor cell death and cell cycle arrest in the E mu-myc model of B-cell lymphoma

A Newbold, JM Salmon, BP Martin, K Stanley, RW Johnstone

Journal article  |  2014  |  Oncogene

Measuring apoptosis in mammals in vivo.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Apoptosis is a mode of cell death that is essential in multicellular organisms for the removal of superfluous, damaged, or potenti..

Detection of apoptotic cells using immunohistochemistry.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Immunohistochemistry is commonly used to show the presence of apoptotic cells in situ. In this protocol, B-cell lymphoma cells are..

Detection of apoptotic cells using propidium iodide staining.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Flow cytometry assays are often used to detect apoptotic cells in in vitro cultures. Depending on the experimental model, these as..

Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in solid tumors.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Positron emission tomography (PET) is used to monitor the uptake of the labeled glucose analogue fluorodeoxyglucose (¹⁸F-FDG) by s..

Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in hematological tumors.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Positron emission tomography (PET) can be used to monitor the uptake of the labeled glucose analog fluorodeoxyglucose (¹⁸F-FDG), a..

Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities

Andrea Newbold, Geoffrey M Matthews, Michael Bots, Leonie A Cluse, Christopher JP Clarke, Kellie-Marie Banks, Carleen Cullinane, Jessica E Bolden, Ailsa J Christiansen, Ross A Dickins, Claudia Miccolo, Susanna Chiocca, Astrid M Kral, Nicole D Ozerova, Thomas A Miller, Joey L Methot, Victoria M Richon, J Paul Secrist, Saverio Minucci, Ricky W Johnstone

Journal article  |  2013  |  Molecular Cancer Therapeutics

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Jake Shortt, Benjamin P Martin, Andrea Newbold, Katherine M Hannan, Jennifer R Devlin, Adele J Baker, Rachael Ralli, Carleen Cullinane, Clemens A Schmitt, Maurice Reimann, Michael N Hall, Meaghan Wall, Ross D Hannan, Richard B Pearson, Grant A McArthur, Ricky W Johnstone

Journal article  |  2013  |  BLOOD

PIDDosome-independent tumor suppression by Caspase-2

C Manzl, L Peintner, G Krumschnabel, F Bock, V Labi, M Drach, A Newbold, R Johnstone, Andreas Villunger

Journal article  |  2012  |  Cell Death & Differentiation

Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors

A Newbold, SJ Vervoort, BP Martin, M Bots, RW Johnstone

Journal article  |  2012  |  Cell Death & Disease

Intrinsic and Extrinsic Apoptotic Pathway Signaling as Determinants of Histone Deacetylase Inhibitor Antitumor Activity

Geoffrey M Matthews, Andrea Newbold, Ricky W Johnstone

Book Chapter  |  2012  |  Advances in Cancer Research