Andrea Newbold

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x(L), Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Srividya B Balachander, Steven W Criscione, Kate F Byth, Justin Cidado, Ammar Adam, Paula Lewis, Terry Macintyre, Shenghua Wen, Deborah Lawson, Kathleen Burke, Tristan Lubinski, Jeffrey W Tyner, Stephen E Kurtz, Shannon K McWeeney, Jeffrey Varnes, R Bruce Diebold, Thomas Gero, Stephanos Ioannidis, Edward J Hennessy, William McCoull, et al.

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. W..

Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Lev Kats, Carolyn Shembrey, Thomas Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew Wei, Gareth Gregory, Stephin Vervoort, Kristin Brown, Ricky Johnstone

Journal article  |  2020

Activating FMS-like tyrosine kinase 3 ( FLT3 ) mutations occur in approximately 30% of all acute myeloid leukaemias (AMLs) and are..

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B Baell, David J Leaver, Stefan J Hermans, Gemma L Kelly, Margs S Brennan, Natalie L Downer, Nghi Nguyen, Johannes Wichmann, Helen M Mcrae, Yuqing Yang, Ben Cleary, H Rachel Lagiakos, Stephen Mieruszynski, Guido Pacini, Hannah K Vanyai, Maria I Bergamasco, Rose E May, Bethany K Davey, Kimberly J Morgan, Andrew J Sealey, et al.

Journal article  |  2018  |  Nature

How do tumor cells respond to HDAC inhibition?

Andrea Newbold, Katrina J Falkenberg, H Miles Prince, Ricky W Johnstone

Journal article  |  2016  |  The FEBS Journal

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

Simon J Hogg, Andrea Newbold, Stephin J Vervoort, Leonie A Cluse, Benjamin P Martin, Gareth P Gregory, Marcus Lefebure, Eva Vidacs, Richard W Tothill, James E Bradner, Jake Shortt, Ricky W Johnstone

Journal article  |  2016  |  Molecular Cancer Therapeutics

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Margherita Ghisi, Lev Kats, Frederick Masson, Jason Li, Tobias Kratina, Eva Vidacs, Omer Gilan, Maria A Doyle, Andrea Newbold, Jessica E Bolden, Kirsten A Fairfax, Carolyn A de Graaf, Matthew Firth, Johannes Zuber, Ross A Dickins, Lynn M Corcoran, Mark A Dawson, Gabrielle T Belz, Ricky W Johnstone

Journal article  |  2016  |  Cancer Cell

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity

KJ Falkenberg, A Newbold, CM Gould, J Luu, JA Trapani, GM Matthews, KJ Simpson, RW Johnstone

Journal article  |  2016  |  Cell Death & Differentiation

Scribble acts as an oncogene in E mu-myc-driven lymphoma

ED Hawkins, J Oliaro, KM Ramsbottom, A Newbold, PO Humbert, RW Johnstone, SM Russell

Journal article  |  2016  |  Oncogene

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David CS Huang, Lyubomir T Vassilev, Andreas Strasser

Journal article  |  2016  |  CELL REPORTS

The role of p21(waf1/cip1) and p27(Kip1) in HDACi-mediated tumor cell death and cell cycle arrest in the E mu-myc model of B-cell lymphoma

A Newbold, JM Salmon, BP Martin, K Stanley, RW Johnstone

Journal article  |  2014  |  Oncogene