Sean Grimmond

Inotuzumab ozogamicin resistance associated with a novelCD22truncating mutation in a case of B-acute lymphoblastic leukaemia

Georgina L Ryland, Allison Barraclough, Chun Yew Fong, Shaun Fleming, Ashish Bajel, Oliver Hofmann, David Westerman, Sean Grimmond, Piers Blombery

Journal article  |  2020  |  British Journal of Haematology

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosie Upstill-Goddard, Ulla-Maja Bailey, Ian M Garner, Craig Nourse, Stephan Dreyer, Marc Jones, Kim Moran-Jones, Derek W Wright, Viola Paulus-Hock, Colin Nixon, Gemma Thomson, Nigel B Jamieson, Grant A McGregor, Lisa Evers, Colin J McKay, Aditi Gulati, Rachel Brough, et al.

Journal article  |  2020  |  Cell Reports

RAF1 rearrangements are common in pancreatic acinar cell carcinomas

Owen WJ Prall, Violeta Nastevski, Huiling Xu, Christopher RE McEvoy, Joep HA Vissers, David J Byrne, Elena Takano, Satwica Yerneni, Sarah Ellis, Thomas Green, Catherine A Mitchell, William K Murray, Clare L Scott, Sean M Grimmond, Oliver Hofmann, Anthony Papenfuss, Damien Kee, Andrew Fellowes, Ian S Brown, Gregory Miller, et al.

Journal article  |  2020  |  Modern Pathology

Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  Nature

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao, Gurnit Atwal, Paz Polak, Rosa Karlic, Edwin Cuppen, Alexandra Danyi, Jeroen de Ridder, Carla van Herpen, Martijn P Lolkema, Neeltje Steeghs, Gad Getz, Quaid Morris, Lincoln D Stein

Journal article  |  2020  |  Nature Communications

In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but i..

How can digital health be used to improve outcomes in pancreatic ductal adenocarcinoma (PDAC)? Examining the potential of the PURPLE translational pancreatic cancer platform

Belinda Lee, Julia Shapiro, Benjamin Thomson, Sumitra Ananda, Lara Lipton, Sue-Anne McLachlan, Rachel Wong, Prasad Cooray, Matthew Burge, Kate Clarke, Sharon Pattison, Mehrdad Nikfarjam, Niall Tebbutt, Marion Harris, Daniel Croagh, David Goldstein, Adnan Nagrial, Rob Zielinski, Amitesh Roy, Cheng Ean Chee, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Claire Vennin, Pauline Melenec, Romain Rouet, Max Nobis, Aurelie S Cazet, Kendelle J Murphy, David Herrmann, Daniel A Reed, Morghan C Lucas, Sean C Warren, Zehra Elgundi, Mark Pinese, Gabriella Kalna, Daniel Roden, Monisha Samuel, Anaiis Zaratzian, Shane T Grey, Andrew Da Silva, Wilfred Leung, Suresh Mathivanan, et al.

Journal article  |  2019  |  Nature Communications

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

Charles C Bell, Katie A Fenne, Yih-Chih Chan, Florian Rambow, Miriam M Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G Martelotto, Aljosja Rogiers, Brandon E Kremer, Olena Barbash, Helai P Mohammad, Timothy M Johanson, Marian L Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S Tyler, Laura MacPherson, et al.

Journal article  |  2019  |  Nature Communications

Platypus Induced Pluripotent Stem Cells: The Unique Pluripotency Signature of a Monotreme

Deanne J Whitworth, Ioannis J Limnios, Marie-Emilie Gauthier, Prasanna Weeratunga, Dmitry A Ovchinnikov, Gregory Baillie, Sean M Grimmond, Jennifer A Marshall Graves, Ernst J Wolvetang

Journal article  |  2019  |  Stem Cells and Development

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

Angela Chou, Danielle Froio, Adnan M Nagrial, Ashleigh Parkin, Kendelle J Murphy, Venessa T Chin, Dalia Wohl, Angela Steinmann, Rhys Stark, Alison Drury, Stacey N Walters, Claire Vennin, Andrew Burgess, Mark Pinese, Lorraine A Chantrill, Mark J Cowley, Timothy J Molloy, Nicola Waddell, Amber Johns, Sean M Grimmond, et al.

Journal article  |  2018  |  Gut

DRES-05. MOLECULAR EVOLUTION OF DIFFUSE GLIOMAS AND THE GLIOMA LONGITUDINAL ANALYSIS CONSORTIUM

Roel Verhaak, GLASS Consortium, Kenneth Aldape, Samirkumar Amin, David Ashley, Jill Barnholtz-Sloan, Amanda Bates, Rameen Beroukhim, Christoph Bock, Daniel Brat, Elizabeth Claus, Joseph Costello, John de Groot, Gaetano Finocchiaro, Pim French, Hui Gan, Brent Griffith, Christel Herold-Mende, Craig Horbinski, Antonio Iavarone, et al.

Journal article  |  2018  |  Neuro-Oncology

New horizons in translational research of cancer of unknown primary

Dariush Etemadamoghadam, Atara Posner, Alexandra Murray, Sean Grimmond, Oliver Hofmann, Penelope Schofield, David Bowtell, Linda Mileshkin, Richard W Tothill

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer

Ben Lawrence, Cherie Blenkiron, Kate Parker, Peter Tsai, Sandra Fitzgerald, Paula Shields, Tamsin Robb, Mee Ling Yeong, Nicole Kramer, Sarah James, Mik Black, Vicky Fan, Nooriyah Poonawala, Patrick Yap, Esther Coats, Braden Woodhouse, Reena Ramsaroop, Masato Yozu, Bridget Robinson, Kimiora Henare, et al.

Journal article  |  2018  |  npj Genomic Medicine

Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Kenneth Aldape, Samirkumar B Amin, David M Ashley, Jill S Barnholtz-Sloan, Amanda J Bates, Rameen Beroukhim, Christoph Bock, Daniel J Brat, Elizabeth B Claus, Joseph F Costello, John F de Groot, Gaetano Finocchiaro, Pim J French, Hui K Gan, Brent Griffith, Christel C Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N Kalkanis, Konstantina Karabatsou, et al.

Journal article  |  2018  |  Neuro-Oncology

Telomere sequence content can be used to determine ALT activity in tumours

Michael Lee, Erdahl T Teber, Oliver Holmes, Katia Nones, Ann-Marie Patch, Rebecca A Dagg, Loretta MS Lau, Joyce H Lee, Christine E Napier, Jonathan W Arthur, Sean M Grimmond, Nicholas K Hayward, Peter A Johansson, Graham J Mann, Richard A Scolyer, James S Wilmott, Roger R Reddel, John V Pearson, Nicola Waddell, Hilda A Pickett

Journal article  |  2018  |  Nucleic Acids Research

BRAF Mutations in Low-Grade Serous Ovarian Cancer and Response to BRAF Inhibition

Tania Moujaber, Dariush Etemadmoghadam, Catherine J Kennedy, Yoke-Eng Chiew, Rosemary L Balleine, Catherine Saunders, Gerard Wain, Bo Gao, Russell Hogg, Sivatharsny Srirangan, Casina Kan, Sian Fereday, Nadia Traficante, Ann-Marie Patch, John Pearson, Nicola Waddell, Sean M Grimmond, Alexander Dobrovic, David DL Bowtell, Paul R Harnett, et al.

Journal article  |  2018  |  JCO Precision Oncology

Exome-Wide Association Study of Pancreatic Cancer Risk

Robert C Grant, Robert E Denroche, Ayelet Borgida, Carl Virtanen, Natalie Cook, Alyssa L Smith, Ashton A Connor, Julie M Wilson, Gloria Peterson, Nicholas J Roberts, Alison P Klein, Sean M Grimmond, Andrew Biankin, Sean Cleary, Malcolm Moore, Mathieu Lemire, George Zogopoulos, Lincoln Stein, Steven Gallinger

Journal article  |  2018  |  Gastroenterology

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer

Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, et al.

Journal article  |  2018  |  Clinical Cancer Research

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Vinod P Balachandran, Marta Luksza, Julia N Zhao, Vladimir Makarov, John Alec Moral, Romain Remark, Brian Herbst, Gokce Askan, Umesh Bhanot, Yasin Senbabaoglu, Daniel K Wells, Charles Ian Ormsby Cary, Olivera Grbovic-Huezo, Marc Attiyeh, Benjamin Medina, Jennifer Zhang, Jennifer Loo, Joseph Saglimbeni, Mohsen Abu-Akeel, Roberta Zappasodi, et al.

Journal article  |  2017  |  Nature

EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-Grade Serous Ovarian Carcinomas

Dariush Etemadmoghadam, Walid J Azar, Ying Lei, Tania Moujaber, Dale W Garsed, Catherine J Kennedy, Sian Fereday, Chris Mitchell, Yoke-Eng Chiew, Joy Hendley, Raghwa Sharma, Paul R Harnett, Jason Li, Elizabeth L Christie, Ann-Marie Patch, Joshy George, George Au-Yeung, Gisela Mir Arnau, Timothy P Holloway, Timothy Semple, et al.

Journal article  |  2017  |  Cancer Research

Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma

Michael E Feigin, Tyler Garvin, Peter Bailey, Nicola Waddell, David K Chang, David R Kelley, Shimin Shuai, Steven Gallinger, John D McPherson, Sean M Grimmond, Ekta Khurana, Lincoln D Stein, Andrew V Biankin, Michael C Schatz, David A Tuveson

Journal article  |  2017  |  Nature Genetics

Whole-genome landscapes of major melanoma subtypes

Nicholas K Hayward, James S Wilmott, Nicola Waddell, Peter A Johansson, Matthew A Field, Katia Nones, Ann-Marie Patch, Hojabr Kakavand, Ludmil B Alexandrov, Hazel Burke, Valerie Jakrot, Stephen Kazakoff, Oliver Holmes, Conrad Leonard, Radhakrishnan Sabarinathan, Loris Mularoni, Scott Wood, Qinying Xu, Nick Waddell, Varsha Tembe, et al.

Journal article  |  2017  |  Nature

Lost in translation: returning germline genetic results in genome-scale cancer research

Amber L Johns, Skye H Mckay, Jeremy L Humphris, Mark Pinese, Lorraine A Chantrill, R Scott Mead, Katherine Tucker, Lesley Andrews, Annabel Goodwin, Conrad Leonard, Hilda A High, Katia Nones, Ann-Marie Patch, Neil D Merrett, Nick Pavlakis, Karin S Kassahn, Jaswinder S Samra, David K Miller, David K Chang, Marina Pajic, et al.

Journal article  |  2017  |  Genome Medicine

Whole-genome landscape of pancreatic neuroendocrine tumours

Aldo Scarpa, David K Chang, Katia Nones, Vincenzo Corbo, Ann-Marie Patch, Peter Bailey, Rita T Lawlor, Amber L Johns, David K Miller, Andrea Mafficini, Borislav Rusev, Maria Scardoni, Davide Antonello, Stefano Barbi, Katarzyna O Sikora, Sara Cingarlini, Caterina Vicentini, Skye McKay, Michael CJ Quinn, Timothy JC Bruxner, et al.

Journal article  |  2017  |  Nature

Mitochondrial mutations and metabolic adaptation in pancreatic cancer

Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V Pearson, Sean M Grimmond, Leonid Sazanov, Andrew V Biankin, Silas Villas-Boas, Andrew J Hoy, Nigel Turner, Darren N Saunders

Journal article  |  2017  |  Cancer & Metabolism

Hypermutation In Pancreatic Cancer

Jeremy L Humphris, Ann-Marie Patch, Katia Nones, Peter J Bailey, Amber L Johns, Skye Mckay, David K Chang, David K Miller, Marina Pajic, Karin S Kassahn, Michael CJ Quinn, Timothy JC Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh, Andrew Stone, Peter J Wilson, et al.

Journal article  |  2017  |  Gastroenterology

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

Sheela A Abraham, Lisa EM Hopcroft, Emma Carrick, Mark E Drotar, Karen Dunn, Andrew JK Williamson, Koorosh Korfi, Pablo Baquero, Laura E Park, Mary T Scott, Francesca Pellicano, Andrew Pierce, Mhairi Copland, Craig Nourse, Sean M Grimmond, David Vetrie, Anthony D Whetton, Tessa L Holyoake

Journal article  |  2016  |  Nature

Whole Exome Sequencing in Patients with White Matter Abnormalities

Adeline Vanderver, Cas Simons, Guy Helman, Joanna Crawford, Nicole I Wolf, Genevieve Bernard, Amy Pizzino, Johanna L Schmidt, Asako Takanohashi, David Miller, Amirah Khouzam, Vani Rajan, Erica Ramos, Shimul Chowdhury, Tina Hambuch, Kelin Ru, Gregory J Baillie, Sean M Grimmond, Ljubica Caldovic, Joseph Devaney, et al.

Journal article  |  2016  |  Annals of Neurology

Uncovering the BCR-ABL1 tyrosine kinase independent signature in chronic myeloid leukaemia stem cells

E Gomez-Castaneda, LEM Hopcroft, S Rogers, HG Jorgensen, F Pellicano, D Vetrie, M Copland, S Grimmond, TL Holyoake

Conference Proceedings  |  2016  |  BRITISH JOURNAL OF HAEMATOLOGY

Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma

Lutz Krause, Katia Nones, Kelly A Loffler, Derek Nancarrow, Harald Oey, Yue Hang Tang, Nicola J Wayte, Ann Marie Patch, Kalpana Patel, Sandra Brosda, Suzanne Manning, Guy Lampe, Andrew Clouston, Janine Thomas, Jens Stoye, Damian J Hussey, David I Watson, Reginald V Lord, Wayne A Phillips, David Gotley, et al.

Journal article  |  2016  |  Carcinogenesis

Genomic analyses identify molecular subtypes of pancreatic cancer

Peter Bailey, David K Chang, Katia Nones, Amber L Johns, Ann-Marie Patch, Marie-Claude Gingras, David K Miller, Angelika N Christ, Tim JC Bruxner, Michael C Quinn, Craig Nourse, L Charles Murtaugh, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Ehsan Nourbakhsh, Shivangi Wani, Lynn Fink, Oliver Holmes, Vencssa Chin, et al.

Journal article  |  2016  |  NATURE

Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation

Marie-Claude Gingras, Kyle R Covington, David K Chang, Lawrence A Donehower, Anthony J Gill, Michael M Ittmann, Chad J Creighton, Amber L Johns, Eve Shinbrot, Ninad Dewal, William E Fisher, Christian Pilarsky, Robert Gruetzmann, Michael J Overman, Nigel B Jamieson, George Van Buren, Jennifer Drummond, Kimberly Walker, Oliver A Hampton, Liu Xi, et al.

Journal article  |  2016  |  CELL REPORTS

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

Tyler S Alioto, Ivo Buchhalter, Sophia Derdak, Barbara Hutter, Matthew D Eldridge, Eivind Hovig, Lawrence E Heisler, Timothy A Beck, Jared T Simpson, Laurie Tonon, Anne-Sophie Sertier, Ann-Marie Patch, Natalie Jaeger, Philip Ginsbach, Ruben Drews, Nagarajan Paramasivam, Rolf Kabbe, Sasithorn Chotewutmontri, Nicolle Diessl, Christopher Previti, et al.

Journal article  |  2015  |  Nature Communications

SOX9 regulates ERBB signalling in pancreatic cancer development

Adrien Grimont, Andreia V Pinho, Mark J Cowley, Cecile Augereau, Amanda Mawson, Marc Giry-Laterriere, Geraldine Van den Steen, Nicola Waddell, Marina Pajic, Christine Sempoux, Jianmin Wu, Sean M Grimmond, Andrew V Biankin, Frederic P Lemaigre, Ilse Rooman, Patrick Jacquemin

Journal article  |  2015  |  Gut

Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

Jodi M Saunus, Michael CJ Quinn, Ann-Marie Patch, John V Pearson, Peter J Bailey, Katia Nones, Amy E McCart Reed, David Miller, Peter J Wilson, Fares Al-Ejeh, Mythily Mariasegaram, Queenie Lau, Teresa Withers, Rosalind L Jeffree, Lynne E Reid, Leonard Da Silva, Admire Matsika, Colleen M Niland, Margaret C Cummings, Timothy JC Bruxner, et al.

Journal article  |  2015  |  The Journal of Pathology

Pancreatic cancer genomics: where can the science take us?

JS Graham, NB Jamieson, R Rulach, SM Grimmond, DK Chang, AV Biankin

Journal article  |  2015  |  Clinical Genetics

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae

John M Atack, Yogitha N Srikhanta, Kate L Fox, Joseph A Jurcisek, Kenneth L Brockman, Tyson A Clark, Matthew Boitano, Peter M Power, Freda E-C Jen, Alastair G McEwan, Sean M Grimmond, Arnold L Smith, Stephen J Barenkamp, Jonas Korlach, Lauren O Bakaletz, Michael P Jennings

Journal article  |  2015  |  Nature Communications

Whole-genome characterization of chemoresistant ovarian cancer

Ann-Marie Patch, Elizabeth L Christie, Dariush Etemadmoghadam, Dale W Garsed, Joshy George, Sian Fereday, Katia Nones, Prue Cowin, Kathryn Alsop, Peter J Bailey, Karin S Kassahn, Felicity Newell, Michael CJ Quinn, Stephen Kazakoff, Kelly Quek, Charlotte Wilhelm-Benartzi, Ed Curry, Huei San Leong, Anne Hamilton, Linda Mileshkin, et al.

Journal article  |  2015  |  Nature

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

Darrell C Bessette, Erik Tilch, Tatjana Seidens, Michael CJ Quinn, Adrian P Wiegmans, Wei Shi, Sibylle Cocciardi, Amy McCart-Reed, Jodi M Saunus, Peter T Simpson, Sean M Grimmond, Sunil R Lakhani, Kum Kum Khanna, Nic Waddell, Fares Al-Ejeh, Georgia Chenevix-Trench

Journal article  |  2015  |  PLOS ONE

Recommendations for Accurate Resolution of Gene and Isoform Allele-Specific Expression in RNA-Seq Data

David LA Wood, Katia Nones, Anita Steptoe, Angelika Christ, Ivon Harliwong, Felicity Newell, Timothy JC Bruxner, David Miller, Nicole Cloonan, Sean M Grimmond

Journal article  |  2015  |  PLOS ONE

PGTools: A Software Suite for Proteogenomic Data Analysis and Visualization

Shivashankar H Nagaraj, Nicola Waddell, Anil K Madugundu, Scott Wood, Alun Jones, Ramya A Mandyam, Katia Nones, John V Pearson, Sean M Grimnnond

Journal article  |  2015  |  Journal of Proteome Research

Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial

Lorraine A Chantrill, Adnan M Nagrial, Clare Watson, Amber L Johns, Mona Martyn-Smith, Skye Simpson, Scott Mead, Marc D Jones, Jaswinder S Samra, Anthony J Gill, Nicole Watson, Venessa T Chin, Jeremy L Humphris, Angela Chou, Belinda Brown, Adrienne Morey, Marina Pajic, Sean M Grimmond, David K Chang, David Thomas, et al.

Journal article  |  2015  |  Clinical Cancer Research

New RAS-Mutant Pancreatic Adenocarcinoma With Combined BRAF and MEK Inhibition for Metastatic Melanoma

Matteo S Carlino, Vu Kwan, David K Miller, Catherine AB Saunders, Desmond Yip, Adnan M Nagrial, Jeanne Tomlinson, Sean M Grimmond, Richard A Scolyer, Richard F Kefford, Andrew V Biankin, Georgina V Long

Journal article  |  2015  |  Journal of Clinical Oncology

Towards the Systematic Mapping and Engineering of the Protein Prenylation Machinery in Saccharomyces cerevisiae

Viktor Stein, Marta H Kubala, Jason Steen, Sean M Grimmond, Kirill Alexandrov

Journal article  |  2015  |  PLOS ONE

Whole genomes redefine the mutational landscape of pancreatic cancer

Nicola Waddell, Marina Pajic, Ann-Marie Patch, David K Chang, Karin S Kassahn, Peter Bailey, Amber L Johns, David Miller, Katia Nones, Kelly Quek, Michael CJ Quinn, Alan J Robertson, Muhammad ZH Fadlullah, Tim JC Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh, et al.

Journal article  |  2015  |  Nature

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Cas Simons, Lachlan D Rash, Joanna Crawford, Linlin Ma, Ben Cristofori-Armstrong, David Miller, Kelin Ru, Gregory J Baillie, Yasemin Alanay, Adeline Jacquinet, Francois-Guillaume Debray, Alain Verloes, Joseph Shen, Gozde Yesil, Serhat Guler, Adnan Yuksel, John G Cleary, Sean M Grimmond, Julie McGaughran, Glenn F King, et al.

Journal article  |  2015  |  Nature Genetics

Divergent reprogramming routes lead to alternative stem-cell states

Peter D Tonge, Andrew J Corso, Claudio Monetti, Samer MI Hussein, Mira C Puri, Iacovos P Michael, Mira Li, Dong-Sung Lee, Jessica C Mar, Nicole Cloonan, David L Wood, Maely E Gauthier, Othmar Korn, Jennifer L Clancy, Thomas Preiss, Sean M Grimmond, Jong-Yeon Shin, Jeong-Sun Seo, Christine A Wells, Ian M Rogers, et al.

Journal article  |  2014  |  Nature

Genome-wide characterization of the routes to pluripotency

Samer MI Hussein, Mira C Puri, Peter D Tonge, Marco Benevento, Andrew J Corso, Jennifer L Clancy, Rowland Mosbergen, Mira Li, Dong-Sung Lee, Nicole Cloonan, David LA Wood, Javier Munoz, Robert Middleton, Othmar Korn, Hardip R Patel, Carl A White, Jong-Yeon Shin, Maely E Gauthier, Kim-Anh Le Cao, Jong-Il Kim, et al.

Journal article  |  2014  |  Nature

Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks

Marco Benevento, Peter D Tonge, Mira C Puri, Samer MI Hussein, Nicole Cloonan, David L Wood, Sean M Grimmond, Andras Nagy, Javier Munoz, Albert JR Heck

Journal article  |  2014  |  Nature Communications

An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator

Dong-Sung Lee, Jong-Yeon Shin, Peter D Tonge, Mira C Puri, Seungbok Lee, Hansoo Park, Won-Chul Lee, Samer MI Hussein, Thomas Bleazard, Ji-Young Yun, Jihye Kim, Mira Li, Nicole Cloonan, David Wood, Jennifer L Clancy, Rowland Mosbergen, Jae-Hyuk Yi, Kap-Seok Yang, Hyungtae Kim, Hwanseok Rhee, et al.

Journal article  |  2014  |  Nature Communications

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors

Preston SK Ng, Raphael Boehm, Lauren E Hartley-Tassell, Jason A Steen, Hui Wang, Samuel W Lukowski, Paula L Hawthorne, Ann EO Trezise, Peter J Coloe, Sean M Grimmond, Thomas Haselhorst, Mark von Itzstein, Adrienne W Paton, James C Paton, Michael P Jennings

Journal article  |  2014  |  Nature Communications

Clinical and Pathologic Features of Familial Pancreatic Cancer

Jeremy L Humphris, Amber L Johns, Skye H Simpson, Mark J Cowley, Marina Pajic, David K Chang, Adnan M Nagrial, Venessa T Chin, Lorraine A Chantrill, Mark Pinese, R Scott Mead, Anthony J Gill, Jaswinder S Samra, James G Kench, Elizabeth A Musgrove, Katherine M Tucker, Allan D Spigelman, Nic Waddell, Sean M Grimmond, Andrew V Biankin

Journal article  |  2014  |  Cancer

Small RNA changes en route to distinct cellular states of induced pluripotency

Jennifer L Clancy, Hardip R Patel, Samer MI Hussein, Peter D Tonge, Nicole Cloonan, Andrew J Corso, Mira Li, Dong-Sung Lee, Jong-Yeon Shin, Justin JL Wong, Charles G Bailey, Marco Benevento, Javier Munoz, Aaron Chuah, David Wood, John EJ Rasko, Albert JR Heck, Sean M Grimmond, Ian M Rogers, Jeong-Sun Seo, et al.

Journal article  |  2014  |  Nature Communications

Sox9 Regulates Erbb Signalling In Pancreatic Cancer Development

A Grimont, AV Pinho, MJ Cowley, C Augereau, A Mawson, M Giry-Laterriere, G Van den Steen, N Waddell, M Pajic, C Sempoux, J Wu, SM Grimmond, AV Biankin, FP Lemaigre, P Jacquemin, I Rooman

Conference Proceedings  |  2014  |  PANCREAS

Elucidating mechanisms of resistance to FGFR inhibitors in endometrial cancer

L Packer, S Byron, C Mahon, D Loch, A Wortmann, K Nones, S Grimmond, J Pearson, N Waddell, P Pollock

Conference Proceedings  |  2014  |  European Journal of Cancer

Elucidating mechanisms of resistance to FGFR inhibitors in endometrial cancer

Leisl M Packer, Sara Byron, David Loch, Farhad Dehkhoda, Andreas Wortmann, Xinyan Geng, Katia Nones, Sean Grimmond, John Pearson, Nic Waddell, Pamela Pollock

Conference Proceedings  |  2014  |  Experimental and Molecular Therapeutics

SOX9 regulates EGFR/ERBB signaling in pancreatic cancer

Andreia V Pinho, Adrien Grimont, Mark J Cowley, Cecile Augereau, Amanda Mawson, Marc Giry-Laterriere, Geraldine Van den Steen, Nicola Waddell, Marina Pajic, Christine Sempoux, Jianmin Wu, Sean M Grimmond, Andrew V Biankin, Frederic P Lemaigre, Patrick Jacquemin, Ilse Rooman

Conference Proceedings  |  2014  |  Molecular and Cellular Biology

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

Katia Nones, Nicola Waddell, Nicci Wayte, Ann-Marie Patch, Peter Bailey, Felicity Newell, Oliver Holmes, J Lynn Fink, Michael CJ Quinn, Yue Hang Tang, Guy Lampe, Kelly Quek, Kelly A Loffler, Suzanne Manning, Senel Idrisoglu, David Miller, Qinying Xu, Nick Waddell, Peter J Wilson, Timothy JC Bruxner, et al.

Journal article  |  2014  |  Nature Communications

Pancreatic cancer: Challenges for therapeutic development

NB Jamieson, SM Grimmond, AV Biankin, DK Chang, undefined Australian Pancreatic Cancer Genome Initiative

Book Chapter  |  2014

Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling

Katia Nones, Nic Waddell, Sarah Song, Ann-Marie Patch, David Miller, Amber Johns, Jianmin Wu, Karin S Kassahn, David Wood, Peter Bailey, Lynn Fink, Suzanne Manning, Angelika N Christ, Craig Nourse, Stephen Kazakoff, Darrin Taylor, Conrad Leonard, David K Chang, Marc D Jones, Michelle Thomas, et al.

Journal article  |  2014  |  International Journal of Cancer

Targeting mTOR dependency in pancreatic cancer

Douglas C Morran, Jianmin Wu, Nigel B Jamieson, Agata Mrowinska, Gabriela Kalna, Saadia A Karim, Amy YM Au, Christopher J Scarlett, David K Chang, Malgorzata Z Pajak, Karin A Oien, Colin J McKay, C Ross Carter, Gerry Gillen, Sue Champion, Sally L Pimlott, Kurt I Anderson, TR Jeffry Evans, Sean M Grimmond, Andrew V Biankin, et al.

Journal article  |  2014  |  Gut

Rapid Identification of a Novel Complex I MT-ND3 m.10134C>A Mutation in a Leigh Syndrome Patient

David K Miller, Minal J Menezes, Cas Simons, Lisa G Riley, Sandra T Cooper, Sean M Grimmond, David R Thorburn, John Christodoulou, Ryan J Taft

Journal article  |  2014  |  PLOS ONE

Transcriptional switching in macrophages associated with the peritoneal foreign body response

Jane E Mooney, Kim M Summers, Milena Gongora, Sean M Grimmond, Julie H Campbell, David A Hume, Barbara E Rolfe

Journal article  |  2014  |  Immunology & Cell Biology

PRMT2 and ROR gamma Expression Are Associated With Breast Cancer Survival Outcomes

Tae Gyu Oh, Peter Bailey, Eloise Dray, Aaron G Smith, Joel Goode, Natalie Eriksson, John W Funder, Peter J Fuller, Evan R Simpson, Wayne D Tilley, Peter J Leedman, Christine L Clarke, Sean Grimmond, Dennis H Dowhan, George EO Muscat

Journal article  |  2014  |  Molecular Endocrinology

A workflow to increase verification rate of chromosomal structural rearrangements using high-throughput next-generation sequencing

Kelly Quek, Katia Nones, Ann-Marie Patch, J Lynn Fink, Felicity Newell, Nicole Cloonan, David Miller, Muhammad ZH Fadlullah, Karin Kassahn, Angelika N Christ, Timothy JC Bruxner, Suzanne Manning, Ivon Harliwong, Senel Idrisoglu, Craig Nourse, Ehsan Nourbakhsh, Shivangi Wani, Anita Steptoe, Matthew Anderson, Oliver Holmes, et al.

Journal article  |  2014  |  BioTechniques

Gemcitabine and CHK1 Inhibition Potentiate EGFR-Directed Radioimmunotherapy against Pancreatic Ductal Adenocarcinoma

Fares Al-Ejeh, Marina Pajic, Wei Shi, Murugan Kalimutho, Mariska Miranda, Adnan M Nagrial, Angela Chou, Andrew V Biankin, Sean M Grimmond, Michael P Brown, Kum Kum Khanna

Journal article  |  2014  |  Clinical Cancer Research

Breast Cancer and Metastasis Free Survival Are Effected By PRMT2 and Rory; Expression: Understanding the Role of DNA Repair

Tae Gyu Oh, Peter Bailey, Eloise Dray, Joel Goode, Natalie Eriksson, John W Funder, Peter J Fuller, Evan R Simpson, Wayne D Tilley, Peter J Leedman, Christine L Clarke, Sean Grimmond, Dennis H Dowhan, George EO Muscat

Conference Proceedings  |  2014  |  ENDOCRINE REVIEWS

Returning individual research results for genome sequences of pancreatic cancer

Amber L Johns, David K Miller, Skye H Simpson, Anthony J Gill, Karin S Kassahn, Jeremy L Humphris, Jaswinder S Samra, Katherine Tucker, Lesley Andrews, David K Chang, Nicola Waddell, Marina Pajic, John V Pearson, Sean M Grimmond, Andrew V Biankin, Nikolajs Zeps

Journal article  |  2014  |  Genome Medicine

Stratified Medicine for Pancreatic Cancer

DK Chang, NB Jamieson, SM Grimmond, AV Biankin

Book Chapter  |  2014

Can we move towards personalised pancreatic cancer therapy?

Nigel Balfour Jamieson, David K Chang, Sean M Grimmond, Andrew V Biankin

Journal article  |  2014  |  Expert Review of Gastroenterology & Hepatology

Mining the genomes of exceptional responders

David K Chang, Sean M Grimmond, TR Jeffry Evans, Andrew V Biankin

Journal article  |  2014  |  Nature Reviews Cancer

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Diwakar R Pattabiraman, Crystal McGirr, Konstantin Shakhbazov, Valerie Barbier, Keerthana Krishnan, Pamela Mukhopadhyay, Paula Hawthorne, Ann Trezise, Jianmin Ding, Sean M Grimmond, Peter Papathanasiou, Warren S Alexander, Andrew C Perkins, Jean-Pierre Levesque, Ingrid G Winkler, Thomas J Gonda

Journal article  |  2014  |  Blood

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor beta Signaling

Susann Weissmueller, Eusebio Manchado, Michael Saborowski, John P Morris, Elvin Wagenblast, Carrie A Davis, Sung-Hwan Moon, Neil T Pfister, Darjus F Tschaharganeh, Thomas Kitzing, Daniela Aust, Elke K Markert, Jianmin Wu, Sean M Grimmond, Christian Pilarsky, Carol Prives, Andrew V Biankin, Scott W Lowe

Journal article  |  2014  |  Cell

SnapShot-Seq: A Method for Extracting Genome-Wide, In Vivo mRNA Dynamics from a Single Total RNA Sample

Jesse M Gray, David A Harmin, Sarah A Boswell, Nicole Cloonan, Thomas E Mullen, Joseph J Ling, Nimrod Miller, Scott Kuersten, Yong-Chao Ma, Steven A McCarroll, Sean M Grimmond, Michael Springer

Journal article  |  2014  |  PLoS ONE

Minor class splicing shapes the zebrafish transcriptome during development

Sebastian Markmiller, Nicole Cloonan, Rea M Lardelli, Karen Doggett, Maria-Cristina Keightley, Yeliz Boglev, Andrew J Trotter, Annie Y Ng, Simon J Wilkins, Heather Verkade, Elke A Ober, Holly A Field, Sean M Grimmond, Graham J Lieschke, Didier YR Stainier, Joan K Heath

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

In vivo evolution of antimicrobial resistance in a series of Staphylococcus aureus patient isolates: the entire picture or a cautionary tale?

Sebastiaan J van Hal, Jason A Steen, Bjoern A Espedido, Sean M Grimmond, Matthew A Cooper, Matthew TG Holden, Stephen D Bentley, Iain B Gosbell, Slade O Jensen

Journal article  |  2014  |  Journal of Antimicrobial Chemotherapy

Pancreatic cancer genomics

David K Chang, Sean M Grimmond, Andrew V Biankin

Journal article  |  2014  |  Current Opinion in Genetics & Development

GENOMIC CLASSIFIER FOR PANCREATIC DUCTAL ADENOCARCINOMA THERAPEUTIC RESPONSE

A Nagrial, V Chin, A Steinmann, A Chou, S Grimmond, L Horvath, M Pajic, A Biankin

Conference Proceedings  |  2014  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

10. Clinicopathological features of HER2 amplified pancreatic cancer

Angela Chou, Nicola Waddell, Mark J Cowley, Sean M Grimmond, undefined APGI, Anthony J Gill, Adrienne L Morey, Andrew V Biankin

Journal article  |  2014  |  Pathology

Identification of a Novel de Novo p.Phe932lle KCNT1 Mutation in a Patient With Leukoencephalopathy and Severe Epilepsy

Adeline Vanderver, Cas Simons, Johanna L Schmidt, Philip L Pearl, Miriam Bloom, Bennett Lavenstein, David Miller, Sean M Grimmond, Ryan J Taft

Journal article  |  2014  |  Pediatric Neurology

From functional genomics to precision medicine: Using well annotated models to define personalised treatment strategies for pancreatic cancer

Angela Chou, Venessa T Chin, Adnan M Nagrial, Anthony J Gill, Paul Timpson, David K Chang, Nicola Waddell, Jianmin Wu, Sean M Grimmond, Andrew V Biankin, Marina Pajic

Conference Proceedings  |  2014  |  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs

Hilary C Martin, Shivangi Wani, Anita L Steptoe, Keerthana Krishnan, Katia Nones, Ehsan Nourbakhsh, Alexander Vlassov, Sean M Grimmond, Nicole Cloonan

Journal article  |  2014  |  Genome Biology

Stromal Protein Ecm1 Regulates Ureteric Bud Patterning and Branching

Suneeta S Paroly, Fengwei Wang, Lee Spraggon, Joseph Merregaert, Ekatherina Batourina, Benjamin Tycko, Kai M Schmidt-Ott, Sean Grimmond, Melissa Little, Cathy Mendelsohn

Journal article  |  2013  |  PLoS ONE

Assessment of transcript reconstruction methods for RNA-seq

Tamara Steijger, Josep F Abril, Par G Engstrom, Felix Kokocinski, Tim J Hubbard, Roderic Guigo, Jennifer Harrow, Paul Bertone

Journal article  |  2013  |  Nature Methods

miR-139-5p is a regulator of metastatic pathways in breast cancer

Keerthana Krishnan, Anita L Steptoe, Hilary C Martin, Diwakar R Pattabiraman, Katia Nones, Nic Waddell, Mythily Mariasegaram, Peter T Simpson, Sunil R Lakhani, Alexander Vlassov, Sean M Grimmond, Nicole Cloonan

Journal article  |  2013  |  RNA

Somatic Point Mutation Calling in Low Cellularity Tumors

Karin S Kassahn, Oliver Holmes, Katia Nones, Ann-Marie Patch, David K Miller, Angelika N Christ, Ivon Harliwong, Timothy J Bruxner, Qinying Xu, Matthew Anderson, Scott Wood, Conrad Leonard, Darrin Taylor, Felicity Newell, Sarah Song, Senel Idrisoglu, Craig Nourse, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani, et al.

Journal article  |  2013  |  PLoS ONE

Proteogenomic Analysis of Bradyrhizobium japonicum USDA110 Using Genosuite, an Automated Multi-algorithmic Pipeline

Dhirendra Kumar, Amit Kumar Yadav, Puneet Kumar Kadimi, Shivashankar H Nagaraj, Sean M Grimmond, Debasis Dash

Journal article  |  2013  |  Molecular & Cellular Proteomics

The IMPaCT trial: Individualised Molecular Pancreatic Cancer Therapy. A pilot, randomized, open label Phase II trial assessing first line treatment with gemcitabine or personalized treatment based on tumour molecular signature in patients with metastatic pancreatic cancer.

Lorraine Chantrill, Amber Johns, Adnan Nagrial, Venessa Chin, Angela Chou, Mark Pinese, Scott Mead, Val Gebski, Katrin Sjoguist, Chee Lee, Sonia Yip, Danielle Miller, Lucille Sebastian, Ray Asghari, Sandra Harvey, Nick Paviakis, Sanjay Mukhedkar, Peter Grimison, David Miller, John Pearson, et al.

Conference Proceedings  |  2013  |  Clinical Trials

Clinical and molecular characterization of HER2 amplified-pancreatic cancer

Angela Chou, Nicola Waddell, Mark J Cowley, Anthony J Gill, David K Chang, Ann-Marie Patch, Katia Nones, Jianmin Wu, Mark Pinese, Amber L Johns, David K Miller, Karin S Kassahn, Adnan M Nagrial, Harpreet Wasan, David Goldstein, Christopher W Toon, Venessa Chin, Lorraine Chantrill, Jeremy Humphris, R Scott Mead, et al.

Journal article  |  2013  |  Genome Medicine

Signatures of mutational processes in human cancer

Ludmil B Alexandrov, Serena Nik-Zainal, David C Wedge, Samuel AJR Aparicio, Sam Behjati, Andrew V Biankin, Graham R Bignell, Niccolo Bolli, Ake Borg, Anne-Lise Borresen-Dale, Sandrine Boyault, Birgit Burkhardt, Adam P Butler, Carlos Caldas, Helen R Davies, Christine Desmedt, Roland Eils, Jorunn Erla Eyfjord, John A Foekens, Mel Greaves, et al.

Journal article  |  2013  |  Nature

Understanding pancreatic cancer genomes

Mark J Cowley, David K Chang, Marina Pajic, Amber L Johns, Nicola Waddell, Sean M Grimmond, Andrew V Biankin

Journal article  |  2013  |  Journal of Hepato-Biliary-Pancreatic Sciences

Identification of Unsafe Human Induced Pluripotent Stem Cell Lines Using a Robust Surrogate Assay for Pluripotency

Juan Carlos Polanco, Mirabelle SH Ho, Bei Wang, Qi Zhou, Ernst Wolvetang, Elizabeth Mason, Christine A Wells, Gabriel Kolle, Sean M Grimmond, Ivan Bertoncello, Carmel O'Brien, Andrew L Laslett

Journal article  |  2013  |  Stem Cells

Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial alpha 5 Integrin

Ying Cao, Luke H Hoeppner, Steven Bach, E Guangqi, Yan Guo, Enfeng Wang, Jianmin Wu, Mark J Cowley, David K Chang, Nicola Waddell, Sean M Grimmond, Andrew V Biankin, Roger J Daly, Xiaohui Zhang, Debabrata Mukhopadhyay

Journal article  |  2013  |  Cancer Research

Caveolin-1 Is Necessary for Hepatic Oxidative Lipid Metabolism: Evidence for Crosstalk between Caveolin-1 and Bile Acid Signaling

Manuel A Fernandez-Rojo, Milena Gongora, Rebecca L Fitzsimmons, Nick Martel, Sheree D Martin, Susan J Nixon, Andrew J Brooks, Maria P Ikonomopoulou, Sally Martin, Harriet P Lo, Stephen A Myers, Christina Restall, Charles Ferguson, Paul F Pilch, Sean L McGee, Robin L Anderson, Michael J Waters, John F Hancock, Sean M Grimmond, George EO Muscat, et al.

Journal article  |  2013  |  Cell Reports

MicroRNAs-140-5p/140-3p Modulate Leydig Cell Numbers in the Developing Mouse Testis

Joanna Rakoczy, Selene L Fernandez-Valverde, Evgeny A Glazov, Elanor N Wainwright, Tempei Sato, Shuji Takada, Alexander N Combes, Darren J Korbie, David Miller, Sean M Grimmond, Melissa H Little, Hiroshi Asahara, John S Mattick, Ryan J Taft, Dagmar Wilhelm

Journal article  |  2013  |  Biology of Reproduction

Characterization of an ntrX Mutant of Neisseria gonorrhoeae Reveals a Response Regulator That Controls Expression of Respiratory Enzymes in Oxidase-Positive Proteobacteria

John M Atack, Yogitha N Srikhanta, Karrera Y Djoko, Jessica P Welch, Norain HM Hasri, Christopher T Steichen, Rachel N Vanden Hoven, Sean M Grimmond, Dk Seti Maimonah Pg Othman, Ulrike Kappler, Michael A Apicella, Michael P Jennings, Jennifer L Edwards, Alastair G McEwan

Journal article  |  2013  |  Journal of Bacteriology

From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.

Venessa T Chin, Adrian Nagrial, Lorraine A Chantrill, David K Chang, Angela Chou, Jeremy Humprhis, Mark Cowley, Jiamin Wu, Renee DiPetro, Clare Watson, Calan Spielman, Angela Steinmann, Mark Pinese, Jessica Pettitt, Amber Johns, Nicola Waddell, Sean Grimmond, Paul Timpson, Andrew Victor Biankin, Marina Pajic

Conference Proceedings  |  2013  |  JOURNAL OF CLINICAL ONCOLOGY

A De Novo Mutation in the beta-Tubulin Gene TUBB4A Results in the Leukoencephalopathy Hypomyelination with Atrophy of the Basal Ganglia and Cerebellum

Cas Simons, Nicole I Wolf, Nathan McNeil, Ljubica Caldovic, Joseph M Devaney, Asako Takanohashi, Joanna Crawford, Kelin Ru, Sean M Grimmond, David Miller, Davide Tonduti, Johanna L Schmidt, Robert S Chudnow, Rudy van Coster, Lieven Lagae, Jill Kisler, Juergen Sperner, Marjo S van der Knaap, Raphael Schiffmann, Ryan J Taft, et al.

Journal article  |  2013  |  The American Journal of Human Genetics

Mutations in DARS Cause Hypomyelination with Brain Stem and Spinal Cord Involvement and Leg Spasticity

Ryan J Taft, Adeline Vanderver, Richard J Leventer, Stephen A Damiani, Cas Simons, Sean M Grimmond, David Miller, Johanna Schmidt, Paul J Lockhart, Kate Pope, Kelin Ru, Joanna Crawford, Tena Rosser, Irenaeus FM de Coo, Monica Juneja, Ishwar C Verma, Prab Prabhakar, Susan Blaser, Julian Raiman, Petra JW Pouwels, et al.

Journal article  |  2013  |  American Journal of Human Genetics

Whole Genome Sequence Analysis of the First Australian OXA-48-Producing Outbreak-Associated Klebsiella pneumoniae Isolates: The Resistome and In Vivo Evolution

Bjoern A Espedido, Jason A Steen, Helen Ziochos, Sean M Grimmond, Matthew A Cooper, Iain B Gosbell, Sebastiaan J van Hal, Slade O Jensen

Journal article  |  2013  |  PLoS ONE

Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology

James A Briggs, Jane Sun, Jill Shepherd, Dmitry A Ovchinnikov, Tung-Liang Chung, Sam P Nayler, Li-Pin Kao, Carl A Morrow, Nilay Y Thakar, Set-Yen Soo, Teija Peura, Sean Grimmond, Ernst J Wolvetang

Journal article  |  2013  |  STEM CELLS

Novel cancer drivers: mining the kinome

Andrew V Biankin, Sean M Grimmond

Journal article  |  2013  |  Genome Medicine

MicroRNA-182-5p targets a network of genes involved in DNA repair

Keerthana Krishnan, Anita L Steptoe, Hilary C Martin, Shivangi Wani, Katia Nones, Nic Waddell, Mythily Mariasegaram, Peter T Simpson, Sunil R Lakhani, Brian Gabrielli, Alexander Vlassov, Nicole Cloonan, Sean M Grimmond

Journal article  |  2013  |  RNA

Interaction of c-Myb with p300 Is Required for the Induction of Acute Myeloid Leukemia by Human AML Oncogenes, and Represents a Potential Therapeutic Target

Diwakar R Pattabiraman, Konstantin Shakhbazov, Valerie Barbier, Crystal McGirr, Keerthana Krishnan, Pamela Mukhopadhyay, Paula Hawthorne, Ann Trezise, Sean Grimmond, Peter Papathanasiou, Andrew C Perkins, Jean-Pierre Levesque, Warren S Alexander, Ingrid G Winkler, Thomas J Gonda

Conference Proceedings  |  2012  |  Blood

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Andrew V Biankin, Nicola Waddell, Karin S Kassahn, Marie-Claude Gingras, Lakshmi B Muthuswamy, Amber L Johns, David K Miller, Peter J Wilson, Ann-Marie Patch, Jianmin Wu, David K Chang, Mark J Cowley, Brooke B Gardiner, Sarah Song, Ivon Harliwong, Senel Idrisoglu, Craig Nourse, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani, et al.

Journal article  |  2012  |  Nature

RESEARCH PRIORITIES IN OBSERVING AND MODELING URBAN WEATHER AND CLIMATE

Fei Chen, Robert Bornstein, Sue Grimmond, Ju Li, Xudong Liang, Alberto Martilli, Shiguang Miao, James Voogt, Yingchun Wang

Journal article  |  2012  |  Bulletin of the American Meteorological Society

qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles

Sarah Song, Katia Nones, David Miller, Ivon Harliwong, Karin S Kassahn, Mark Pinese, Marina Pajic, Anthony J Gill, Amber L Johns, Matthew Anderson, Oliver Holmes, Conrad Leonard, Darrin Taylor, Scott Wood, Qinying Xu, Felicity Newell, Mark J Cowley, Jianmin Wu, Peter Wilson, Lynn Fink, et al.

Journal article  |  2012  |  PLoS ONE

RON is not a prognostic marker for resectable pancreatic cancer

Carole M Tactacan, David K Chang, Mark J Cowley, Emily S Humphrey, Jianmin Wu, Anthony J Gill, Angela Chou, Katia Nones, Sean M Grimmond, Robert L Sutherland, Andrew V Biankin, Roger J Daly

Journal article  |  2012  |  BMC Cancer

Integrated genome analysis suggests that most conserved non-coding sequences are regulatory factor binding sites

Martin Hemberg, Jesse M Gray, Nicole Cloonan, Scott Kuersten, Sean Grimmond, Michael E Greenberg, Gabriel Kreiman

Journal article  |  2012  |  Nucleic Acids Research

INDIVIDUALISED MEASUREMENT OF TUMOUR-DERIVED CIRCULATING DNA IN PATIENTS WITH PANCREATIC CANCER: A MARKER OF PROGNOSIS AND THERAPEUTIC RESPONSE

VT Chin, N Waddell, K Nones, K Quek, A Mawson, A Johns, S Grimmond, A Biankin

Conference Proceedings  |  2012  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Identification of Novel Markers of Mouse Fetal Ovary Development

Huijun Chen, James S Palmer, Rathi D Thiagarajan, Marcel E Dinger, Emmanuelle Lesieur, Hansheng Chiu, Alexandra Schulz, Cassy Spiller, Sean M Grimmond, Melissa H Little, Peter Koopman, Dagmar Wilhelm

Journal article  |  2012  |  PLOS ONE

Proffered Paper: Testing Individualised Treatment Strategies in Preclinical Models of Pancreatic Cancer

M Pajic, DK Chang, KS Kassahn, J Wu, M Cowley, N Waddell, A Johns, SM Grimmond, AV Biankin

Conference Proceedings  |  2012  |  European Journal of Cancer

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

Pedro A Perez-Mancera, Alistair G Rust, Louise van der Weyden, Glen Kristiansen, Allen Li, Aaron L Sarver, Kevin AT Silverstein, Robert Gruetzmann, Daniela Aust, Petra Ruemmele, Thomas Knoesel, Colin Herd, Derek L Stemple, Ross Kettleborough, Jacqueline A Brosnan, Ang Li, Richard Morgan, Spencer Knight, Jun Yu, Shane Stegeman, et al.

Journal article  |  2012  |  Nature

Carriage of an ACME II Variant May Have Contributed to Methicillin-Resistant Staphylococcus aureus Sequence Type 239-Like Strain Replacement in Liverpool Hospital, Sydney, Australia

BA Espedido, JA Steen, T Barbagiannakos, J Mercer, DL Paterson, SM Grimmond, MA Cooper, IB Gosbell, SJ van Hal, SO Jensen

Journal article  |  2012  |  Antimicrobial Agents and Chemotherapy

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney

Jing Yu, M Todd Valerius, Mary Duah, Karl Staser, Jennifer K Hansard, Jin-jin Guo, Jill McMahon, Joe Vaughan, Diane Faria, Kylie Georgas, Bree Rumballe, Qun Ren, A Michaela Krautzberger, Jan P Junker, Rathi D Thiagarajan, Philip Machanick, Paul A Gray, Alexander van Oudenaarden, David H Rowitch, Charles D Stiles, et al.

Journal article  |  2012  |  Development

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

Karen M Mann, Jerrold M Ward, Christopher Chin Kuan Yew, Anne Kovochich, David W Dawson, Michael A Black, Benjamin T Brett, Todd E Sheetz, Adam J Dupuy, David K Chang, Andrew V Biankin, Nicola Waddell, Karin S Kassahn, Sean M Grimmond, Alistair G Rust, David J Adams, Nancy A Jenkins, Neal G Copeland

Journal article  |  2012  |  Proceedings of the National Academy of Sciences

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

Kate Schroder, Katharine M Irvine, Martin S Taylor, Nilesh J Bokil, Kim-Anh Le Cao, Kelly-Anne Masterman, Larisa I Labzin, Colin A Semple, Ronan Kapetanovic, Lynsey Fairbairn, Altuna Akalin, Geoffrey J Faulkner, John Kenneth Baillie, Milena Gongora, Carsten O Daub, Hideya Kawaji, Geoffrey J McLachlan, Nick Goldman, Sean M Grimmond, Piero Carninci, et al.

Journal article  |  2012  |  Proceedings of the National Academy of Sciences

The genomic landscape of pancreatic cancer: from discovery to patient care

Andrew V Biankin, Sean M Grimmond

Conference Proceedings  |  2012  |  Molecular and Cellular Biology

Genomic analysis reveals roles for chromatin modification and axon guidance in pancreatic cancer

Andrew V Biankin, John D McPherson, Richard A Gibbs, Sean M Grimmond

Conference Proceedings  |  2012  |  Molecular and Cellular Biology

Molecular diagnostics in pancreatic cancer

DK Chang, SM Grimmond, AV Biankin

Book Chapter  |  2012

Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities

Rebecca A Pelekanos, Joan Li, Milena Gongora, Vashe Chandrakanthan, Janelle Scown, Norseha Suhaimi, Gary Brooke, Melinda E Christensen, Tram Doan, Alison M Rice, Geoffrey W Osborne, Sean M Grimmond, Richard P Harvey, Kerry Atkinson, Melissa H Little

Journal article  |  2012  |  Stem Cell Research

PINA v2.0: mining interactome modules

Mark J Cowley, Mark Pinese, Karin S Kassahn, Nic Waddell, John V Pearson, Sean M Grimmond, Andrew V Biankin, Sampsa Hautaniemi, Jianmin Wu

Journal article  |  2012  |  Nucleic Acids Research

Phasevarion Mediated Epigenetic Gene Regulation in Helicobacter pylori

Yogitha N Srikhanta, Rebecca J Gorrell, Jason A Steen, Jayde A Gawthorne, Terry Kwok, Sean M Grimmond, Roy M Robins-Browne, Michael P Jennings

Journal article  |  2011  |  PLoS One

Deep-transcriptome and ribonome sequencing redefines the molecular networks of pluripotency and the extracellular space in human embryonic stem cells

Gabriel Kolle, Jill L Shepherd, Brooke Gardiner, Karin S Kassahn, Nicole Cloonan, David LA Wood, Ehsan Nourbakhsh, Darrin F Taylor, Shivangi Wani, Hun S Chy, Qi Zhou, Kevin McKernan, Scott Kuersten, Andrew L Laslett, Sean M Grimmond

Journal article  |  2011  |  Genome Research

Returning Genetic Research Results to Individuals: The International Cancer Genome Consortium Initiative Experience

AL Johns, N Zeps, L Chantrill, AJ Gill, DK Chang, CJ Scarlett, SM Grimmond, AV Biankin

Conference Proceedings  |  2011  |  PANCREAS

Refining transcriptional programs in kidney development by integration of deep RNA-sequencing and array-based spatial profiling

Rathi D Thiagarajan, Nicole Cloonan, Brooke B Gardiner, Tim R Mercer, Gabriel Kolle, Ehsan Nourbakhsh, Shivangi Wani, Dave Tang, Keerthana Krishnan, Kylie M Georgas, Bree A Rumballe, Han S Chiu, Jason A Steen, John S Mattick, Melissa H Little, Sean M Grimmond

Journal article  |  2011  |  BMC Genomics

A High-Throughput Platform for Lentiviral Overexpression Screening of the Human ORFeome

Dubravka Skalamera, Max V Ranall, Benjamin M Wilson, Paul Leo, Amy S Purdon, Carolyn Hyde, Ehsan Nourbakhsh, Sean M Grimmond, Simon C Barry, Brian Gabrielli, Thomas J Gonda

Journal article  |  2011  |  PLoS ONE

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

CE Smart, A Wronski, JD French, SL Edwards, M-L Asselin-Labat, N Waddell, K Peters, BL Brewster, K Brooks, K Simpson, N Manning, SR Lakhani, S Grimmond, GJ Lindeman, JE Visvader, MA Brown

Journal article  |  2011  |  Oncogene

Identification of Anchor Genes during Kidney Development Defines Ontological Relationships, Molecular Subcompartments and Regulatory Pathways

Rathi D Thiagarajan, Kylie M Georgas, Bree A Rumballe, Emmanuelle Lesieur, Han Sheng Chiu, Darrin Taylor, Dave TP Tang, Sean M Grimmond, Melissa H Little

Journal article  |  2011  |  PLoS ONE

X-MATE: a flexible system for mapping short read data

David LA Wood, Qinying Xu, John V Pearson, Nicole Cloonan, Sean M Grimmond

Journal article  |  2011  |  Bioinformatics

The uniqueome: a mappability resource for short-tag sequencing

Ryan Koehler, Hadar Issac, Nicole Cloonan, Sean M Grimmond

Journal article  |  2011  |  Bioinformatics

MicroRNAs and their isomiRs function cooperatively to target common biological pathways

Nicole Cloonan, Shivangi Wani, Qinying Xu, Jian Gu, Kristi Lea, Sheila Heater, Catalin Barbacioru, Anita L Steptoe, Hilary C Martin, Ehsan Nourbakhsh, Keerthana Krishnan, Brooke Gardiner, Xiaohui Wang, Katia Nones, Jason A Steen, Nicholas A Matigian, David L Wood, Karin S Kassahn, Nic Waddell, Jill Shepherd, et al.

Journal article  |  2011  |  Genome Biology

Sequencing transcriptomes in toto

Karin S Kassahn, Nic Waddell, Sean M Grimmond

Journal article  |  2011  |  Integrative Biology

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells (vol 20, pg 1052, 2010)

Michael R Tallack, Tom Whitington, Wai Shan Yuen, Elanor N Wainwright, Janelle R Keys, Brooke B Gardiner, Ehsan Nourbakhsh, Nicole Cloonan, Sean M Grimmond, Timothy L Bailey, Andrew C Perkins

Journal article  |  2010  |  GENOME RESEARCH

Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome

Tim R Mercer, Marcel E Dinger, Cameron P Bracken, Gabriel Kolle, Jan M Szubert, Darren J Korbie, Marjan E Askarian-Amiri, Brooke B Gardiner, Gregory J Goodall, Sean M Grimmond, John S Mattick

Journal article  |  2010  |  Genome Research

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells (Genome Research (2010) 20, (1052-1063))

MR Tallack, T Whitington, WS Yuen, EN Wainwright, JR Keys, BB Gardiner, E Nourbakhsh, N Cloonan, SM Grimmond, TL Bailey, AC Perkins

Journal article  |  2010  |  Genome Research

Profiling Gene Expression Induced by Protease-Activated Receptor 2 (PAR2) Activation in Human Kidney Cells

Jacky Y Suen, Brooke Gardiner, Sean Grimmond, David P Fairlie

Journal article  |  2010  |  PLoS ONE

Simultaneous Isolation of DNA, RNA and Proteins for Genetic, Epigenetic and Transcriptomic Analysis of Pancreatic Cancer

A Johns, C Toon, M Jones, A Mawson, M Brancato, A Gill, S Grimmond, A Biankin

Conference Proceedings  |  2010  |  PANCREAS

The clinical potential and challenges of sequencing cancer genomes for personalized medical genomics

Nicole Cloonan, Nic Waddell, Sean M Grimmond

Journal article  |  2010  |  IDrugs

Ascorbate Promotes Epigenetic Activation of CD30 in Human Embryonic Stem Cells

Tung-Liang Chung, Jennifer P Turner, Nilay Y Thaker, Gabriel Kolle, Justin J Cooper-White, Sean M Grimmond, Martin F Pera, Ernst J Wolvetang

Journal article  |  2010  |  Stem Cells

Vitamin C Promotes Widespread Yet Specific DNA Demethylation of the Epigenome in Human Embryonic Stem Cells

Tung-Liang Chung, Romulo M Brena, Gabriel Kolle, Sean M Grimmond, Benjamin P Berman, Peter W Laird, Martin F Pera, Ernst Jurgen Wolvetang

Journal article  |  2010  |  Stem Cells

Simplifying complexity

Nicole Cloonan, Sean M Grimmond

Journal article  |  2010  |  Nature Methods

Subtypes of familial breast tumours revealed by expression and copy number profiling

Nic Waddell, Jeremy Arnold, Sibylle Cocciardi, Leonard da Silva, Anna Marsh, Joan Riley, Cameron N Johnstone, Mohammed Orloff, Guillaume Assie, Charis Eng, Lynne Reid, Patricia Keith, Max Yan, Stephen Fox, Peter Devilee, Andrew K Godwin, Frans BL Hogervorst, Fergus Couch, Sean Grimmond, James M Flanagan, et al.

Journal article  |  2010  |  Breast Cancer Research and Treatment

Subfractionation of Differentiating Human Embryonic Stem Cell Populations Allows the Isolation of a Mesodermal Population Enriched for Intermediate Mesoderm and Putative Renal Progenitors

S Adelia Lin, Gabriel Kolle, Sean M Grimmond, Qi Zhou, Elizabeth Doust, Melissa H Little, Bruce Aronow, Sharon D Ricardo, Martin F Pera, John F Bertram, Andrew L Laslett

Journal article  |  2010  |  Stem Cells and Development

Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation

Han Sheng Chiu, John C Szucsik, Kylie M Georgas, Julia L Jones, Bree A Rumballe, Dave Tang, Sean M Grimmond, Alfor G Lewis, Bruce J Aronow, James L Lessard, Melissa H Little

Journal article  |  2010  |  Developmental Biology

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

Michael R Tallack, Tom Whitington, Wai Shan Yuen, Elanor N Wainwright, Janelle R Keys, Brooke B Gardiner, Ehsan Nourbakhsh, Nicole Cloonan, Sean M Grimmond, Timothy L Bailey, Andrew C Perkins

Journal article  |  2010  |  Genome Research

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man (vol 140, pg 744, 2010)

Timothy Ravasi, Harukazu Suzuki, Carlo Vittorio Cannistraci, Shintaro Katayama, Vladimir B Bajic, Kai Tan, Altuna Akalin, Sebastian Schmeier, Mutsumi Kanamori-Katayama, Nicolas Bertin, Piero Carninci, Carsten O Daub, Alistair RR Forrest, Julian Gough, Sean Grimmond, Jung-Hoon Han, Takehiro Hashimoto, Winston Hide, Oliver Hofmann, Atanas Kamburov, et al.

Journal article  |  2010  |  Cell

International network of cancer genome projects

Thomas J Hudson, Warwick Anderson, Axel Aretz, Anna D Barker, Cindy Bell, Rosa R Bernabe, MK Bhan, Fabien Calvo, Iiro Eerola, Daniela S Gerhard, Alan Guttmacher, Mark Guyer, Fiona M Hemsley, Jennifer L Jennings, David Kerr, Peter Klatt, Patrik Kolar, Jun Kusuda, David P Lane, Frank Laplace, et al.

Journal article  |  2010  |  Nature

Redirection of renal mesenchyme to stromal and chondrocytic fates in the presence of TGF-beta 2

Sunder Sims-Lucas, Richard J Young, Gemma Martinez, Darrin Taylor, Sean M Grimmond, Rohan Teasdale, Melissa H Little, John F Bertram, Georgina Caruana

Journal article  |  2010  |  Differentiation

Gene expression profile of the fibrotic response in the peritoneal cavity

SJ Le, M Gongora, B Zhang, S Grimmond, GR Campbell, JH Campbell, BE Rolfe

Journal article  |  2010  |  Differentiation

Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae

Hsing-Ju Wu, Kate L Seib, Yogitha N Srikhanta, Jennifer Edwards, Stephen P Kidd, Tina L Maguire, Amanda Hamilton, Kuan-Tin Pan, He-Hsuan Hsiao, Chen-Wen Yao, Sean M Grimmond, Michael A Apicella, Alastair G McEwan, Andrew H-J Wang, Michael P Jennings

Journal article  |  2010  |  Proteomics

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

Timothy Ravasi, Harukazu Suzuki, Carlo Vittorio Cannistraci, Shintaro Katayama, Vladimir B Bajic, Kai Tan, Altuna Akalin, Sebastian Schmeier, Mutsumi Kanamori-Katayama, Nicolas Bertin, Piero Carninci, Carsten O Daub, Alistair RR Forrest, Julian Gough, Sean Grimmond, Jung-Hoon Han, Takehiro Hashimoto, Winston Hide, Oliver Hofmann, Hideya Kawaji, et al.

Journal article  |  2010  |  Cell

Use of DNA-Damaging Agents and RNA Pooling to Assess Expression Profiles Associated with BRCA1 and BRCA2 Mutation Status in Familial Breast Cancer Patients

Logan C Walker, Bryony A Thompson, Nic Waddell, Sean M Grimmond, Amanda B Spurdle

Journal article  |  2010  |  PLoS Genetics

Setting CAGE Tags in a Genomic Context

Geoffrey J Faulkner, Sean M Grimmond

Book Chapter  |  2010

Klf1 Regulatory Networks in Primary Erythroid Cells.

Michael Tallack, Thomas Whitington, Brooke Gardiner, Eleanor Wainwright, Janelle Keys, Marion Monet, Ehsan Nourbakhsh, Nicole Cloonan, Sean Grimmond, Timothy Bailey, Andrew Charles Perkins

Conference Proceedings  |  2009  |  BLOOD

A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells

Shelley R Hough, Andrew L Laslett, Sean B Grimmond, Gabriel Kolle, Martin F Pera

Journal article  |  2009  |  PLoS One

Development of a Biological Resource for Genomic Characterisation of Pancreatic Cancer

AL Johns, EK Colvin, M Pinese, AJ Gill, RH Hruban, JR Eshleman, A Maitra, SM Grimmond, AV Biankin

Conference Proceedings  |  2009  |  PANCREAS

Identification of Human Embryonic Stem Cell Surface Markers by Combined Membrane-Polysome Translation State Array Analysis and Immunotranscriptional Profiling

Gabriel Kolle, Mirabelle Ho, Qi Zhou, Hun S Chy, Keerthana Krishnan, Nicole Cloonan, Ivan Bertoncello, Andrew L Laslett, Sean M Grimmond

Journal article  |  2009  |  Stem Cells

RNA-MATE: a recursive mapping strategy for high-throughput RNA-sequencing data

Nicole Cloonan, Qinying Xu, Geoffrey J Faulkner, Darrin F Taylor, Dave TP Tang, Gabriel Kolle, Sean M Grimmond

Journal article  |  2009  |  Bioinformatics

Probabilistic resolution of multi-mapping reads in massively parallel sequencing data using MuMRescueLite

Takehiro Hashimoto, Michiel JL de Hoon, Sean M Grimmond, Carsten O Daub, Yoshihide Hayashizaki, Geoffrey J Faulkner

Journal article  |  2009  |  Bioinformatics

Gene-expression ontologies and tag-based expression profiling

O Hofmann, W Hide

Book Chapter  |  2009

p53 is required for etoposide-induced apoptosis of human embryonic stem cells (vol 1, pg 116, 2008)

C Grandela, MF Pera, SM Grimmond, G Kolle, EJ Wolvetang

Journal article  |  2009  |  Stem Cell Research

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment

Kylie Georgas, Bree Rumballe, M Todd Valerius, Han Sheng Chiu, Rathi D Thiagarajan, Ernmanuelle Lesieur, Bruce J Aronow, Eric W Brunskill, Alexander N Combes, Dave Tang, Darrin Taylor, Sean M Grimmond, S Steven Potter, Andrew P McMahon, Melissa H Little

Journal article  |  2009  |  Developmental Biology

GUDMAP - An online genitourinary resource

Simon Harding, Jamie Davies, Jane Armstrong, Jane Brennan, Sue Lloyd-MacGlip, Derek Houghton, Mehran Sharghi, Xingjun Pi, Ying Cheng, Bruce Aronow, Sean Grimmond, Peter Koopman, James Lessard, Melissa Little, Andy McMahon, Cathy Mendelsohn, Steve Potter, Michelle Southard-Smith, Duncan Davidson

Conference Proceedings  |  2009  |  Mechanisms of Development

Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009)

Ryan J Taft, Evgeny A Glazov, Nicole Cloonan, Cas Simons, Stuart Stephen, Geoffrey J Faulkner, Timo Lassmann, Alistair RR Forrest, Sean M Grimmond, Kate Schroder, Katharine Irvine, Takahiro Arakawa, Mari Nakamura, Atsutaka Kubosaki, Kengo Hayashida, Chika Kawazu, Mitsuyoshi Murata, Hiromi Nishiyori, Shiro Fukuda, Jun Kawai, et al.

Journal article  |  2009  |  Nature Genetics

Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse

PA Dawson, S Huxley, B Gardiner, T Tran, JL McAuley, S Grimmond, MA McGuckin, D Markovich

Journal article  |  2009  |  Gut

Genome-Wide Identification of Long Noncoding RNAs in CD8( ) T Cells

Ken C Pang, Marcel E Dinger, Tim R Mercer, Lorenzo Malquori, Sean M Grimmond, Weisan Chen, John S Mattick

Journal article  |  2009  |  Journal of Immunology

Transcriptome-Wide Prediction of miRNA Targets in Human and Mouse Using FASTH

Chikako Ragan, Nicole Cloonan, Sean M Grimmond, Michael Zuker, Mark A Ragan

Journal article  |  2009  |  PLoS ONE

The regulated retrotransposon transcriptome of mammalian cells

Geoffrey J Faulkner, Yasumasa Kimura, Carsten O Daub, Shivangi Wani, Charles Plessy, Katharine M Irvine, Kate Schroder, Nicole Cloonan, Anita L Steptoe, Timo Lassmann, Kazunori Waki, Nadine Hornig, Takahiro Arakawa, Hazuki Takahashi, Jun Kawai, Alistair RR Forrest, Harukazu Suzuki, Yoshihide Hayashizaki, David A Hume, Valerio Orlando, et al.

Journal article  |  2009  |  Nature Genetics

Tiny RNAs associated with transcription start sites in animals

Ryan J Taft, Evgeny A Glazov, Nicole Cloonan, Cas Simons, Stuart Stephen, Geoffrey J Faulkner, Timo Lassmann, Alistair RR Forrest, Sean M Grimmond, Kate Schroder, Katharine Irvine, Takahiro Arakawa, Mari Nakamura, Atsutaka Kubosaki, Kengo Hayashida, Chika Kawazu, Mitsuyoshi Murata, Hiromi Nishiyori, Shiro Fukuda, Jun Kawai, et al.

Journal article  |  2009  |  Nature Genetics

Making sense of the transcriptome

S Grimmond

Journal article  |  2009  |  Australian Life Scientist

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

Harukazu Suzuki, Alistair RR Forrest, Erik van Nimwegen, Carsten O Daub, Piotr J Balwierz, Katharine M Irvine, Timo Lassmann, Timothy Ravasi, Yuki Hasegawa, Michiel JL de Hoon, Shintaro Katayama, Kate Schroder, Piero Carninci, Yasuhiro Tomaru, Mutsumi Kanamori-Katayama, Atsutaka Kubosaki, Altuna Akalin, Yoshinari Ando, Erik Arner, Maki Asada, et al.

Journal article  |  2009  |  Nature Genetics

Phasevarions Mediate Random Switching of Gene Expression in Pathogenic Neisseria

Yogitha N Srikhanta, Stefanie J Dowideit, Jennifer L Edwards, Megan L Falsetta, Hsing-Ju Wu, Odile B Harrison, Kate L Fox, Kate L Seib, Tina L Maguire, Andrew H-J Wang, Martin C Maiden, Sean M Grimmond, Michael A Apicella, Michael P Jennings

Journal article  |  2009  |  PLoS Pathogens

Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution (vol 15, pg 781, 2008)

Eric W Brunskill, Bruce J Aronow, Kylie Georgas, Bree Rumballe, M Todd Valerius, Jeremy Aronow, Vivek Kaimal, Anil G Jegga, Jing Yu, Sean Grimmond, Andrew P McMahon, Larry T Patterson, Melissa H Little, S Steven Potter

Journal article  |  2009  |  Developmental Cell

Genome sequencing approaches and successes.

Michael Imelfort, Jacqueline Batley, Sean Grimmond, David Edwards

Journal article  |  2009  |  Methods in Molecular Biology

Sequence data is crucial to our understanding of crop growth and development, as differences in DNA sequence are responsible for a..

NRED: a database of long noncoding RNA expression

Marcel E Dinger, Ken C Pang, Tim R Mercer, Mark L Crowe, Sean M Grimmond, John S Mattick

Journal article  |  2009  |  Nucleic Acids Research

Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution

Eric W Brunskill, Bruce J Aronow, Kylie Georgas, Bree Rumballe, M Todd Valerius, Jeremy Aronow, Vivek Kaimal, Anil G Jegga, Sean Grimmond, Andrew P McMahon, Larry T Patterson, Melissa H Little, S Steven Potter

Journal article  |  2008  |  Developmental Cell

Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers

Logan C Walker, Nic Waddell, Anette Ten Haaf, Sean Grimmond, Amanda B Spurdle

Journal article  |  2008  |  Breast Cancer Research and Treatment

Kidney transcriptome reveals altered steroid homeostasis in NaS1 sulfate transporter null mice

Paul Anthony Dawson, Brooke Gardiner, Soohyun Lee, Sean Grimmond, Daniel Markovich

Journal article  |  2008  |  The Journal of Steroid Biochemistry and Molecular Biology

MOLECULAR MECHANISMS LEADING TO A REDUCED NEPHRON ENDOWMENT FOLLOWING PRENATAL GLUCOCORTICOID EXPOSURE IN THE MOUSE

K Moritz, H Dickinson, S Grimmond, B Gardiner, W-M Boon, J Bertram, L Cullen-Mcewen, J Cuffe, C Slattery, P Poronnik, G Caruana

Conference Proceedings  |  2008  |  NEPHROLOGY

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation

Marcel E Dinger, Paulo P Amaral, Tim R Mercer, Ken C Pang, Stephen J Bruce, Brooke B Gardiner, Marjan E Askarian-Amiri, Kelin Ru, Giulia Solda, Cas Simons, Susan M Sunkin, Mark L Crowe, Sean M Grimmond, Andrew C Perkins, John S Mattick

Journal article  |  2008  |  Genome Research

Stem cell transcriptome profiling via massive-scale mRNA sequencing

Nicole Cloonan, Alistair RR Forrest, Gabriel Kolle, Brooke BA Gardiner, Geoffrey J Faulkner, Mellissa K Brown, Darrin F Taylor, Anita L Steptoe, Shivangi Wani, Graeme Bethel, Alan J Robertson, Andrew C Perkins, Stephen J Bruce, Clarence C Lee, Swati S Ranade, Heather E Peckham, Jonathan M Manning, Kevin J McKernan, Sean M Grimmond

Journal article  |  2008  |  Nature Methods

p53 is required for etoposide-induced apoptosis of human embryonic stem cells

C Grandela, MF Pera, EJ Wolvetang

Journal article  |  2008  |  Stem Cell Research

BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression

Nic Waddell, Anette Ten Haaf, Anna Marsh, Julie Johnson, Logan C Walker, Milena Gongora, Melissa Brown, Piyush Grover, Mark Girolami, Sean Grimmond, Georgia Chenevix-Trench, Amanda B Spurdle

Journal article  |  2008  |  PLoS Genetics

GUDMAP: The Genitourinary Developmental Molecular Anatomy Project

Andrew P McMahon, Bruce J Aronow, Duncan R Davidson, Jamie A Davies, Kevin W Gaido, Sean Grimmond, James L Lessard, Melissa H Little, S Steven Potter, Elizabeth L Wilder, Pumin Zhang

Journal article  |  2008  |  Journal of the American Society of Nephrology

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)

Eric W Deutsch, Catherine A Ball, Jules J Berman, G Steven Bova, Alvis Brazma, Roger E Bumgarner, David Campbell, Helen C Causton, Jeffrey H Christiansen, Fabrice Daian, Delphine Dauga, Duncan R Davidson, Gregory Gimenez, Young Ah Goo, Sean Grimmond, Thorsten Henrich, Bernhard G Herrmann, Michael H Johnson, Martin Korb, Jason C Mills, et al.

Journal article  |  2008  |  Nature Biotechnology

A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE

Geoffrey J Faulkner, Alistair RR Forrest, Alistair M Chalk, Kate Schroder, Yoshihide Hayashizaki, Piero Carninci, David A Hume, Sean M Grimmond

Journal article  |  2008  |  Genomics

Transcriptome content and dynamics at single-nucleotide resolution

Nicole Cloonan, Sean M Grimmond

Journal article  |  2008  |  Genome Biology

The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

Nicole Cloonan, Mellissa K Brown, Anita L Steptoe, Shivangi Wani, Wei Ling Chan, Alistair Rr Forrest, Gabriel Kolle, Brian Gabrielli, Sean M Grimmond

Journal article  |  2008  |  Genome Biology

SEQUENCING THE TRANSCRIPTOME IN TOTO

Sean M Grimmond

Conference Proceedings  |  2008  |  Genome Informatics 2008

Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-free(BMP4) culture

Stephen J Bruce, Brooke B Gardiner, Les J Burke, Milena Gongora, Sean M Grimmond, Andrew C Perkins

Journal article  |  2007  |  BMC Genomics

POSTNATAL KIDNEY DEVELOPMENT IN THE MOUSE: FOCUS ON WHEN AND HOW NEPHRON FORMATION CEASES

T Gilbert, B Gardiner, SM Grimmond, MH Little

Conference Proceedings  |  2007  |  NEPHROLOGY

A global role for zebrafish klf4 in embryonic erythropoiesis

MR Gardiner, MM Gongora, SM Grimmond, AC Perkins

Journal article  |  2007  |  Mechanisms of Development

Genome-wide analysis of mammalian promoter architecture and evolution (vol 38, pg 626, 2006)

Piero Carninci, Albin Sandelin, Boris Lenhard, Shintaro Katayama, Kazuro Shimokawa, Jasmina Ponjavic, Colin AM Semple, Martin S Taylor, Paer G Engstroem, Martin C Frith, Alistair RR Forrest, Wynand B Alkema, Sin Lam Tan, Charles Plessy, Rimantas Kodzius, Timothy Ravasi, Takeya Kasukawa, Shiro Fukuda, Mutsumi Kanamori-Katayama, Yayoi Kitazume, et al.

Journal article  |  2007  |  Nature Genetics

Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter

Fiona Rae, Kyra Woods, Tedjo Sasmono, Naomi Campanale, Darrin Taylor, Dmitry A Ovchinnikov, Sean M Grimmond, David A Hume, Sharon D Ricardo, Melissa H Little

Journal article  |  2007  |  Developmental Biology

Transcriptional analysis of early lineage commitment in human embryonic stem cells

Andrew L Laslett, Sean Grimmond, Brooke Gardiner, Lincon Stamp, Adelia Lin, Susan M Hawes, Sam Wormald, David Nikolic-Paterson, David Haylock, Martin F Pera

Journal article  |  2007  |  BMC Developmental Biology

Zebrafish klf4 plays a global role in primitive erythropoiesis

MR Gardiner, M Gongora, B Gardiner, S Grimmond, AC Perkins

Conference Proceedings  |  2007  |  Blood Cells, Molecules, and Diseases

Characterization of the OxyR regulon of Neisseria gonorrhoeae

Kate L Seib, Hsing-Ju Wu, Yogitha N Srikhanta, Jennifer L Edwards, Megan L Falsetta, Amanda J Hamilton, Tina L Maguire, Sean M Grimmond, Michael A Apicella, Alastair G McEwan, Michael P Jennings

Journal article  |  2007  |  Molecular Microbiology

HESC adaptation, selection and stability

C Grandela, E Wolvetang

Journal article  |  2007  |  Stem Cell Reviews

Transcription factors, non-coding RNAs and ES cell differentiation in vitro and in vivo

Andrew Perkins, Stephen Bruce, Marcel Dinger, Brooke Gardiner, Anita Steptoe, Lez Burke, John Mattick, Sean Grimmond

Conference Proceedings  |  2006  |  TRANSGENIC RESEARCH

Characterization of the breast cancer associated ATM 7271T > G (V2424G) mutation by gene expression profiling

Nic Waddell, Jyoti Jonnalagadda, Anna Marsh, Scott Grist, Mark Jenkins, Karen Hobson, Malcolm Taylor, Geoff J Lindeman, Sean V Tavtigian, Graeme Suthers, David Goldgar, Peter J Oefner, Darrin Taylor, Sean Grimmond, Kum Kum Khanna, Georgia Chenevix-Trench

Journal article  |  2006  |  Genes, Chromosomes & Cancer

Spatial gene expression in the T-stage mouse metanephros

Georgina Caruana, Luise Cullen-McEwen, Amy L Nelson, Xenia Kostoulias, Kyra Woods, Brooke Gardiner, Melissa J Davis, Darrin F Taylor, Rohan D Teasdale, Sean M Grimmond, Melissa H Little, John F Bertram

Journal article  |  2006  |  Gene Expression Patterns

Transcriptional profile reveals altered hepatic lipid and cholesterol metabolism in hyposulfatemic NaS1 null mice

Paul Anthony Dawson, Brooke Gardiner, Sean Grimmond, Daniel Markovich

Journal article  |  2006  |  Physiological Genomics

Differential gene expression in the developing mouse ureter

EKL Mitchell, DF Taylor, K Woods, MJ Davis, AL Nelson, RD Teasdale, SM Grimmond, MH Little, JF Bertram, G Caruana

Journal article  |  2006  |  Gene Expression Patterns

Development of the Minimum Information Specification for in situ Hybridization and Immunohistochemistry Experiments (MISFISHIE)

Eric W Deutsch, Catherine A Ball, G Steven Bova, Alvis Brazma, Roger E Bumgarner, David Campbell, Helen C Causton, Jeff Christiansen, Duncan Davidson, Lillian J Eichner, Young Ah Goo, Sean Grimmond, Thorsten Henrich, Michael H Johnson, Martin Korb, Jason C Mills, Asa Oudes, Helen E Parkinson, Laura E Pascal, John Quackenbush, et al.

Journal article  |  2006  |  OMICS: A Journal of Integrative Biology

Genome-wide analysis of mammalian promoter architecture and evolution

Piero Carninci, Albin Sandelin, Boris Lenhard, Shintaro Katayama, Kazuro Shimokawa, Jasmina Ponjavic, Colin AM Semple, Martin S Taylor, Par G Engstrom, Martin C Frith, Alistair RR Forrest, Wynand B Alkema, Sin Lam Tan, Charles Plessy, Rimantas Kodzius, Timothy Ravasi, Takeya Kasukawa, Shiro Fukuda, Mutsumi Kanamori-Katayama, Yayoi Kitazume, et al.

Journal article  |  2006  |  Nature Genetics

Definition and spatial annotation of the dynamic secretome during early kidney development

Gemma Martinez, Kylie Georgas, Grant A Challen, Bree Rumhalle, Melissa J Davis, Darrin Taylor, Rohan D Teasdale, Sean M Grimmond, Melissa H Little

Journal article  |  2006  |  Developmental Dynamics

Subcellular localization of mammalian type II membrane proteins

RN Aturaliya, JL Fink, MJ Davis, MS Teasdale, KA Hanson, KC Miranda, ARR Forrest, SM Grimmond, H Suzuki, M Kanamori, C Kai, J Kawai, P Carninci, Y Hayashizaki, RD Teasdale

Journal article  |  2006  |  Traffic

A global role for EKLF in definitive and primitive erythropoiesis

D Hodge, E Coghill, J Keys, T Maguire, B Hartmann, A McDowall, M Weiss, S Grimmond, A Perkins

Journal article  |  2006  |  Blood

PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae

HJ Wu, KL Seib, YN Srikhanta, SP Kidd, JL Edwards, TL Maguire, SM Grimmond, MA Apicella, AG McEwan, MP Jennings

Journal article  |  2006  |  Molecular Microbiology

The abundance of short proteins in the mammalian proteome

Martin C Frith, Alistair R Forrest, Ehsan Nourbakhsh, Ken C Pang, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Timothy L Bailey, Sean M Grimmond

Journal article  |  2006  |  PLoS Genetics

PhosphoregDB: The tissue and sub-cellular distribution of mammalian protein kinases and phosphatases

ARR Forrest, DF Taylor, JL Fink, MM Gongora, C Flegg, RD Teasdale, H Suzuki, M Kanamori, C Kai, Y Hayashizaki, SM Grimmond

Journal article  |  2006  |  BMC Bioinformatics

Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases

ARR Forrest, DF Taylor, ML Crowe, AM Chalk, NJ Waddell, G Kolle, GJ Faulkner, K Rimantas, S Katayama, C Wells, C Kai, J Kawai, P Carninci, Y Hayashizaki, SM Grimmond

Journal article  |  2006  |  Genome Biology

Alternate transcription of the Toll-like receptor signaling cascade

CA Wells, AM Chalk, A Forrest, D Taylor, N Waddell, K Schroder, SR Himes, G Faulkner, S Lo, T Kasukawa, H Kawaji, C Kai, J Kawai, S Katayama, P Carninci, Y Hayashizaki, DA Hume, SM Grimmond

Journal article  |  2006  |  Genome Biology

Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome

T Ravasi, H Suzuki, KC Pang, S Katayama, M Furuno, R Okunishi, S Fukuda, KL Ru, MC Frith, MM Gongora, SM Grimmond, DA Hume, Y Hayashizaki, JS Mattick

Journal article  |  2006  |  Genome Research

A global role for EKLF in definitive and primitive erythropoiesis.

AC Perkins, E Coghill, T Maguire, B Hartmann, A McDowall, M Weiss, S Grimmond, J Keys, D Hodge

Conference Proceedings  |  2005  |  BLOOD

Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development

E McGlinn, KL van Bueren, S Fiorenza, R Mo, AM Poh, A Forrest, MB Soares, MD Bonaldo, S Grimmond, CC Hui, B Wainwright, C Wicking

Journal article  |  2005  |  Mechanisms of Development

Temporal and spatial transcriptional programs in murine kidney development

G Challen, B Gardiner, G Caruana, X Kostoulias, G Martinez, M Crowe, DF Taylor, J Bertram, M Little, SM Grimmond

Journal article  |  2005  |  Physiological Genomics

The transcriptional landscape of the mammalian genome

P Carninci, T Kasukawa, S Katayama, J Gough, MC Frith, N Maeda, R Oyama, T Ravasi, B Lenhard, C Wells, R Kodzius, K Shimokawa, VB Bajic, SE Brenner, S Batalov, ARR Forrest, M Zavolan, MJ Davis, LG Wilming, V Aidinis, et al.

Journal article  |  2005  |  Science

Functional analysis of secreted factors during murine metanephric development using explant culture

F Rae, G Martinez, G Challen, M Davis, D Taylor, M Crowe, R Teasdale, S Grimmond, M Little

Conference Proceedings  |  2005  |  MECHANISMS OF DEVELOPMENT

Development of the mouse ureter: A histological and global gene expression study

E Mitchell, D Taylor, B Rumballe, K Woods, MJ Davis, AL Nelson, RD Teasdale, SM Grimmond, MH Little, JF Bertram, G Caruana

Conference Proceedings  |  2005  |  MECHANISMS OF DEVELOPMENT

EFFECT OF CHRONIC ADMINISTRATION OF CYCLOSPORIN A ON THE MRNA EXPRESSION AND PROTEIN ABUNDANCE OF RENAL SODIUM TRANSPORTERS

John Frederick Bertram, Eleanor KL Mitchell, Darrin Taylor, Bree Rumballe, Kyra Woods, Melissa J Davis, Amy L Nelson, Rohan D Teasdale, Sean M Grimmond, Melissa H Little, John F Bertram, Georgina Caruana

Conference Proceedings  |  2005  |  NEPHROLOGY

DEVELOPMENT AND GLOBAL GENE EXPRESSION OF THE MOUSE URETER

John Frederick Bertram, Eleanor KL Mitchell, Darrin Taylor, Bree Rumballe, Kyra Woods, Melissa J Davis, Amy L Nelson, Rohan D Teasdale, Sean M Grimmond, Melissa H Little, John F Bertram, Georgina Caruana

Conference Proceedings  |  2005  |  NEPHROLOGY

The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes

YN Srikhanta, TL Maguire, KJ Stacey, SM Grimmond, MP Jennings

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

Identifying the molecular phenotype of renal progenitor cells

GA Challen, G Martinez, MJ Davis, DF Taylor, M Crowe, RD Teasdale, SM Grimmond, MH Little

Journal article  |  2004  |  Journal of the American Society of Nephrology

Anlaysis of complementary expression profiles following WT1 induction versus repression reveals the cholesterol/fatty acid synthetic pathways as a possible major target of WT1

FK Rae, G Martinez, KR Gillinder, A Smith, G Shooter, AR Forrest, SM Grimmond, MH Little

Journal article  |  2004  |  Oncogene

Identification of three gene candidates for multicellular resistance in colon carcinoma

NE Timmins, TL Maguire, SM Grimmond, LK Nielsen

Journal article  |  2004  |  Cytotechnology

Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection

R Sousa-Nunes, AA Rana, R Kettleborough, JM Brickman, M Clements, A Forrest, S Grimmond, P Avner, JC Smith, SL Dunwoodie

Journal article  |  2003  |  GENOME RESEARCH

Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection.

Rita Sousa-Nunes, Amer Ahmed Rana, Ross Kettleborough, Joshua M Brickman, Melanie Clements, Alistair Forrest, Sean Grimmond, Philip Avner, James C Smith, Sally L Dunwoodie, Rosa SP Beddington

Journal article  |  2003  |  Genome Research

This article investigates the expression patterns of 160 genes that are expressed during early mouse development. The cDNAs were i..

Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome

T Ravasi, T Huber, M Zavolan, A Forrest, T Gaasterland, S Grimmond, DA Hume

Journal article  |  2003  |  Genome Research

Phosphoregulators: Protein kinases and protein phosphatases of mouse

ARR Forrest, T Ravasi, D Taylor, T Huber, DA Hume, S Grimmond

Journal article  |  2003  |  Genome Research

Mouse proteome analysis

A Kanapin, S Batalov, MJ Davis, J Gough, S Grimmond, H Kawaji, M Magrane, H Matsuda, C Schonbach, RD Teasdale, Z Yuan

Journal article  |  2003  |  Genome Research

Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set

ARR Forrest, D Taylor, S Grimmond

Journal article  |  2003  |  Genome Research

Analysis of the mouse transcriptome for genes involved in the function of the nervous system

S Gustincich, S Batalov, KW Beisel, H Bono, P Carninci, CF Fletcher, S Grimmond, N Hirokawa, ED Jarvis, T Jegla, Y Kawasawa, J LeMieux, H Miki, E Raviola, RD Teasdale, N Tominaga, K Yagi, A Zimmer, Y Hayashizaki, Y Okazaki

Journal article  |  2003  |  Genome Research

The mouse secretome: Functional classification of the proteins secreted into the extracellular environment

SM Grimmond, KC Miranda, Z Yuan, MJ Davis, DA Hume, K Yagi, N Tominaga, H Bono, Y Hayashizaki, Y Okazaki, RD Teasdale

Journal article  |  2003  |  Genome Research

Effects of A(1) adenosine receptor overexpression on normoxic and post-ischemic gene expression

KJ Ashton, K Holmgren, J Peart, AR Lankford, GP Matherne, S Grimmond, JP Headrick

Journal article  |  2003  |  Cardiovascular Research

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Y Okazaki, M Furuno, T Kasukawa, J Adachi, H Bono, S Kondo, I Nikaido, N Osato, R Saito, H Suzuki, I Yamanaka, H Kiyosawa, K Yagi, Y Tomaru, Y Hasegawa, A Nogami, C Schonbach, T Gojobori, R Baldarelli, DP Hill, et al.

Journal article  |  2002  |  Nature

Tissue-specific gene expression in soybean (Glycine max) detected by cDNA microarray analysis

TL Maguire, S Grimmond, A Forrest, I Iturbe-Ormaetxe, K Meksem, P Gresshoff

Journal article  |  2002  |  Journal of Plant Physiology

Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells

WJ Ingram, CA Wicking, SM Grimmond, AR Forrest, BJ Wainwright

Journal article  |  2002  |  Oncogene

Analysis of E-cadherin trafficking by reverse transfection: Rac1 and Cdc42 regulate cell surface delivery

B Wang, A Forrest, T Maguire, R Teasdale, S Grimmond, JL Stow

Conference Proceedings  |  2002  |  MOLECULAR BIOLOGY OF THE CELL

Gene expression profiles involved in ischemic tolerance and adenosine-mediated cardioprotection

K Ashton, K Holmgren, J Peart, S Grimmond, P Matherne, J Headrick

Conference Proceedings  |  2002  |  DRUG DEVELOPMENT RESEARCH

Generation of diversity in the innate immune system: Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes (vol 168, pg 44, 2002)

T Ravasi, C Wells, A Forrest, N Walsh, DM Underhill, BJ Wainwright, A Aderem, S Grimmond, DA Hume

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

Generation of diversity in the innate immune system: Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes

T Ravasi, C Wells, A Forrest, DM Underhill, BJ Wainwright, A Aderem, S Grimmond, DA Hume

Journal article  |  2002  |  The Journal of Immunology

Transcriptional responses to ischemia in A(1)AR transgenic and wild-type hearts

K Ashton, K Holmgren, S Grimmond, P Matherne, J Headrick

Journal article  |  2001  |  Journal of Molecular and Cellular Cardiology

Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development

S Grimmond, R Larder, N Van Hateren, P Siggers, S Morse, T Hacker, R Arkell, A Greenfield

Journal article  |  2001  |  Mechanisms of Development

Expression Profiling with cDNA Microarrays: A User’s Perspective and Guide

Sean Grimmond, Andy Greenfield

Book Chapter  |  2001

An integrated functional genomics and genetics approach for the plant's function in symbiotic nodulation

PM Gresshoff, AE Men, T Maguire, S Grimmond, D Lohar, S Ayanru, K Meksem, D Lightfoot, J Stiller

Conference Proceedings  |  2001  |  MOLECULAR BREEDING OF FORAGE CROPS

Generation of diversity in the innate immune system. Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes.

T Ravasi, C Wells, A Forest, DM Underhill, BJ Wainwright, A Aderem, S Grimmond, DA Hume

Conference Proceedings  |  2001  |  JOURNAL OF LEUKOCYTE BIOLOGY

Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1)

S Grimmond, R Larder, N Van Hateren, P Siggers, TJM Hulsebos, R Arkell, A Greenfield

Journal article  |  2000  |  Genomics

Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor

J Clyde-Smith, G Silins, M Gartside, S Grimmond, M Etheridge, A Apolloni, N Hayward, JF Hancock

Journal article  |  2000  |  Journal of Biological Chemistry

Identification of somatic mutations of the MEN1 gene in sporadic endocrine tumours

L Bergman, C Boothroyd, J Palmer, S Grimmond, M Walters, B Teh, J Shepherd, L Hartley, N Hayward

Journal article  |  2000  |  British Journal of Cancer

Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development

S Grimmond, N Van Hateren, P Siggers, R Arkell, R Larder, MB Soares, MD Bonaldo, L Smith, Z Tymowska-Lalanne, C Wells, A Greenfield

Journal article  |  2000  |  Human Molecular Genetics

Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia

D Bellomo, JP Headrick, GU Silins, CA Paterson, PS Thomas, M Gartside, A Mould, MM Cahill, ID Tonks, SM Grimmond, S Townson, C Wells, M Little, MC Cummings, NK Hayward, GF Kay

Journal article  |  2000  |  Circulation Research

Sixth International Workshop on Human Chromosome 11 Mapping, Nice, Paris, 2-5 May, 1998

P Gaudray, GF Carle, DS Gerhard, M Gessler, MM Mannens, M Athanasiou, J Bliek, A Calender, LV Debelenko, MD Devignes, GA Evans, R Favier, S Forbes, G Gaudray, B Gawin, M Gordon, S Grimmond, P Grossfeld, J Harris, M Hattori, et al.

Conference Proceedings  |  1999  |  Cytogenetics and Cell Genetics

A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13

L Bergman, G Silins, S Grimmond, H Hummerich, C Stewart, P Little, N Hayward

Journal article  |  1999  |  Genomics

Report of the Sixth International Workshop on Human Chromosome 11 Mapping 1998. Nice, France, May 2-5, 1998.

P Gaudray, GF Carle, DS Gerhard, M Gessler, MM Mannens, M Athanasiou, J Bliek, A Calender, LV Debelenko, M Devignes, GA Evans, R Favier, S Forbes, G Gaudray, B Gawin, M Gordon, S Grimmond, P Grossfeld, J Harris, M Hattori, et al.

Journal article  |  1999  |  Cytogenetic and Genome Research

Characterization of the mouse Men1 gene and its expression during development

C Stewart, F Parente, F Piehl, F Farnebo, D Quincey, G Silins, L Bergman, GF Carle, I Lemmens, S Grimmond, CZ Xian, S Khodei, BT Teh, J Lagercrantz, P Siggers, A Calender, V Van de Vem, K Kas, G Weber, N Hayward, et al.

Journal article  |  1998  |  Oncogene

The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region

S Mazeyrat, N Saut, CA Sargent, S Grimmond, G Longepied, IE Ehrmann, PS Ellis, A Greenfield, NA Affara, MJ Mitchell

Journal article  |  1998  |  Human Molecular Genetics

Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism

BT Teh, S Kytola, F Farnebo, L Bergman, FK Wong, G Weber, N Hayward, C Larsson, B Skogseid, A Beckers, C Phelan, M Edwards, M Epstein, F Alford, D Hurley, S Grimmond, G Silins, M Walters, C Stewart, J Cardinal, et al.

Journal article  |  1998  |  Journal of Clinical Endocrinology & Metabolism

The search for the MEN1 gene

I Lemmes, WJM Van de Ven, K Kas, CX Zhang, S Giraud, V Wautot, N Buisson, M Pugeat, JL Peix, A Caldener, F Parente, D Quincey, A Courseaux, GF Carle, P Gaudray, MJ De Wit, CJM Lips, JWM Hoppener, S Khodaei, AL Grant, et al.

Journal article  |  1998  |  Journal of Internal Medicine

Characterisation of a new human and murine member of the DnaJ family of proteins

G Silins, S Grimmond, N Hayward

Journal article  |  1998  |  Biochemical and Biophysical Research Communications

Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene - The European consortium on type 1 (MEN1) gene

I Lemmens, J Merregaert, WJM VandeVen, K Kas, CX Zhang, S Giraud, V Wautot, N Buisson, K DeWitte, J Salandre, G Lenoir, A Calender, F Parente, D Quincey, A Courseaux, GF Carle, P Gaudray, MJ DeWit, CJM Lips, JWM Hoppener, et al.

Journal article  |  1997  |  Genomics