Sean Grimmond

Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology.

Vaidehi Jobanputra, Kazimierz O Wrzeszczynski, Reinhard Buttner, Carlos Caldas, Edwin Cuppen, Sean Grimmond, Torsten Haferlach, Charles Mullighan, Anna Schuh, Olivier Elemento

Journal article  |  2021  |  Semin Cancer Biol

Whole-genome sequencing either alone or in combination with whole-transcriptome sequencing has started to be used to analyze clini..

Novel RET Fusion RET-SEPTIN9 Predicts Response to Selective RET Inhibition With Selpercatinib in Malignant Pheochromocytoma

Angela Mweempwa, Huiling Xu, Joseph HA Vissers, Richard W Tothill, Andrew D Pattison, Andrew P Fellowes, David M Thomas, Gary Richardson, Rodney J Hicks, Sean M Grimmond, Stephen B Fox, Stephen J Luen, Jayesh Desai, Benjamin J Solomon

Journal article  |  2021  |  JCO Precision Oncology

Clinical utility of whole-genome sequencing in precision oncology.

Richard Rosenquist, Edwin Cuppen, Reinhard Buettner, Carlos Caldas, Helene Dreau, Olivier Elemento, Geert Frederix, Sean Grimmond, Torsten Haferlach, Vaidehi Jobanputra, Manja Meggendorfer, Charles G Mullighan, Sarah Wordsworth, Anna Schuh

Journal article  |  2021  |  Semin Cancer Biol

Precision diagnostics is one of the two pillars of precision medicine. Sequencing efforts in the past decade have firmly establish..

Analytical demands to use whole-genome sequencing in precision oncology.

Manja Meggendorfer, Vaidehi Jobanputra, Kazimierz O Wrzeszczynski, Paul Roepman, Ewart de Bruijn, Edwin Cuppen, Reinhard Buttner, Carlos Caldas, Sean Grimmond, Charles G Mullighan, Olivier Elemento, Richard Rosenquist, Anna Schuh, Torsten Haferlach

Journal article  |  2021  |  Semin Cancer Biol

Interrogating the tumor genome in its entirety by whole-genome sequencing (WGS) offers an unprecedented insight into the biology a..

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Vanessa Lakis, Rita T Lawlor, Felicity Newell, Ann-Marie Patch, Andrea Mafficini, Anguraj Sadanandam, Lambros T Koufariotis, Rebecca L Johnston, Conrad Leonard, Scott Wood, Borislav Rusev, Vincenzo Corbo, Claudio Luchini, Sara Cingarlini, Luca Landoni, Roberto Salvia, Michele Milella, David Chang, Peter Bailey, Nigel B Jamieson, et al.

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and ..

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Stephan B Dreyer, Rosie Upstill-Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloise Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker, Zachary Galluzzo, Holly Brunton, Richard Cunningham, Mathias Tesson, Craig Nourse, Ulla-Maja Bailey, Marc Jones, Kim Moran-Jones, Derek W Wright, Fraser Duthie, et al.

Journal article  |  2021  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set ..

Inotuzumab ozogamicin resistance associated with a novel CD22 truncating mutation in a case of B-acute lymphoblastic leukaemia

Georgina L Ryland, Allison Barraclough, Chun Yew Fong, Shaun Fleming, Ashish Bajel, Oliver Hofmann, David Westerman, Sean Grimmond, Piers Blombery

Journal article  |  2020  |  BRITISH JOURNAL OF HAEMATOLOGY

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosie Upstill-Goddard, Ulla-Maja Bailey, Ian M Garner, Craig Nourse, Stephan Dreyer, Marc Jones, Kim Moran-Jones, Derek W Wright, Viola Paulus-Hock, Colin Nixon, Gemma Thomson, Nigel B Jamieson, Grant A McGregor, Lisa Evers, Colin J McKay, Aditi Gulati, Rachel Brough, et al.

Journal article  |  2020  |  CELL REPORTS

Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classic..

RAF1 rearrangements are common in pancreatic acinar cell carcinomas

Owen WJ Prall, Violeta Nastevski, Huiling Xu, Christopher RE McEvoy, Joep HA Vissers, David J Byrne, Elena Takano, Satwica Yerneni, Sarah Ellis, Thomas Green, Catherine A Mitchell, William K Murray, Clare L Scott, Sean M Grimmond, Oliver Hofmann, Anthony Papenfuss, Damien Kee, Andrew Fellowes, Ian S Brown, Gregory Miller, et al.

Journal article  |  2020  |  MODERN PATHOLOGY

There is now evidence that gene fusions activating the MAPK pathway are relatively common in pancreatic acinar cell carcinoma with..

Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs.

John Kokkinos, Rosa Mistica C Ignacio, George Sharbeen, Cyrille Boyer, Estrella Gonzales-Aloy, David Goldstein, undefined Australian Pancreatic Cancer Genome Initiative Apgi, Joshua A McCarroll, Phoebe A Phillips

Journal article  |  2020  |  Biomaterials

Pancreatic cancer is predicted to be the second leading cause of cancer-related death by 2025. The best chemotherapy only extends ..