Vihandha Wickramasinghe

Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice

Stephane Chappaz, Charity W Law, Mark R Dowling, Kirstyn T Carey, Rachael M Lane, Linh H Ngo, Vihandha O Wickramasinghe, Gordon K Smyth, Matthew E Ritchie, Benjamin T Kile

Journal article  |  2020  |  Blood Advances

In eukaryotic cells, messenger RNA (mRNA) molecules are exported from the nucleus to the cytoplasm, where they are translated. The..

A systems view of spliceosomal assembly and branchpoints with iCLIP

Michael Briese, Nejc Haberman, Christopher R Sibley, Rupert Faraway, Andrea S Elser, Anob M Chakrabarti, Zhen Wang, Julian Koenig, David Perera, Vihandha O Wickramasinghe, Ashok R Venkitaraman, Nicholas M Luscombe, Luciano Saieva, Livio Pellizzoni, Christopher WJ Smith, Tomaz Curk, Jernej Ule

Journal article  |  2019  |  Nature Structural & Molecular Biology

Complex-centric proteome profiling by SEC-SWATH-MS

Isabell Bludau, Moritz Heusel, George Rosenberger, Robin Hafen, Max Frank, Amir Banaei-Esfahani, Claudia Martelli, Charlotte Nicod, Peng Xue, Yujia Cai, Yansheng Liu, Ashok Venkitaraman, Vihandha Wickramasinghe, Hannes Roest, Ben Collins, Matthias Gstaiger, Ruedi Aebersold

Conference Proceedings  |  2019  |  MOLECULAR & CELLULAR PROTEOMICS

A systems view of spliceosomal assembly and branchpoints with iCLIP

Michael Briese, Nejc Haberman, Christopher Sibley, Anob Chakrabarti, Zhen Wang, Julian König, David Perera, Vihandha Wickramasinghe, Ashok Venkitaraman, Nicholas Luscombe, Christopher Smith, Tomaž Curk, Jernej Ule

Journal article  |  2018

Abstract Studies of spliceosomal interactions are challenging due to their dynamic nature. Here we employed spliceosome iCLIP, whi..

Regulatory Potential of the RNA Processing Machinery: Implications for Human Disease

Kirstyn T Carey, Vihandha O Wickramasinghe

Journal article  |  2018  |  Trends in Genetics

Nuclear export of RNA: Different sizes, shapes and functions

Tobias Williams, Linh H Ngo, Vihandha O Wickramasinghe

Journal article  |  2018  |  Seminars in Cell & Developmental Biology

Impact of Alternative Splicing on the Human Proteome

Yansheng Liu, Mar Gonzalez-Porta, Sergio Santos, Alvis Brazma, John C Marioni, Ruedi Aebersold, Ashok R Venkitaraman, Vihandha O Wickramasinghe

Journal article  |  2017  |  Cell Reports

RNA Processing and Genome Stability: Cause and Consequence

Vihandha O Wickramasinghe, Ashok R Venkitaraman

Journal article  |  2016  |  Molecular Cell

Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5 ' splice site strength

Vihandha O Wickramasinghe, Mar Gonzalez-Porta, David Perera, Arthur R Bartolozzi, Christopher R Sibley, Martina Hallegger, Jernej Ule, John C Marioni, Ashok R Venkitaraman

Journal article  |  2015  |  Genome Biology

Control of mammalian gene expression by selective mRNA export

Vihandha O Wickramasinghe, Ronald A Laskey

Journal article  |  2015  |  Nature Reviews Molecular Cell Biology

Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP

Vihandha O Wickramasinghe, Robert Andrews, Peter Ellis, Cordelia Langford, John B Gurdon, Murray Stewart, Ashok R Venkitaraman, Ronald A Laskey

Journal article  |  2014  |  Nucleic Acids Research

Human Inositol Polyphosphate Multikinase Regulates Transcript-Selective Nuclear mRNA Export to Preserve Genome Integrity

Vihandha O Wickramasinghe, Jane M Savill, Sreenivas Chavali, Asta B Jonsdottir, Eeson Rajendra, Tamara Gruener, Ronald A Laskey, M Madan Babu, Ashok R Venkitaraman

Journal article  |  2013  |  Molecular Cell

Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export

Divyang Jani, Sheila Lutz, Ed Hurt, Ronald A Laskey, Murray Stewart, Vihandha O Wickramasinghe

Journal article  |  2012  |  Nucleic Acids Research

MCM3AP Is Transcribed from a Promoter within an Intron of the Overlapping Gene for GANP

Vihandha O Wickramasinghe, Paul IA McMurtrie, Jackie Marr, Yoko Amagase, Sarah Main, Anthony D Mills, Ronald A Laskey, Yoshinori Takei

Journal article  |  2011  |  Journal of Molecular Biology

GANP enhances the efficiency of mRNA nuclear export in mammalian cells

Vihandha O Wickramasinghe, Murray Stewart, Ronald A Laskey

Journal article  |  2010  |  Nucleus

mRNA Export from Mammalian Cell Nuclei Is Dependent on GANP

Vihandha O Wickramasinghe, Paul IA McMurtrie, Anthony D Mills, Yoshinori Takei, Sue Penrhyn-Lowe, Yoko Amagase, Sarah Main, Jackie Marr, Murray Stewart, Ronald A Laskey

Journal article  |  2010  |  Current Biology