Kristin Brown

Multi-substrate metabolic tracing reveals marked heterogeneity and dependency on fatty acid metabolism in human prostate cancer.

Gio Fidelito, David P De Souza, Birunthi Niranjan, William de Nardo, Shivakumar Keerthikumar, Kristin Brown, Renea A Taylor, Matthew J Watt

Journal article  |  2022  |  Mol Cancer Res

Cancer cells undergo metabolic reprogramming to meet increased bioenergetic demands. Studies in cells and mice have highlighted th..

Glutamine addiction promotes glucose oxidation in triple-negative breast cancer

Lake-Ee Quek, Michelle van Geldermalsen, Yi Fang Guan, Kanu Wahi, Chelsea Mayoh, Seher Balaban, Angel Pang, Qian Wang, Mark J Cowley, Kristin K Brown, Nigel Turner, Andrew J Hoy, Jeff Holst

Journal article  |  2022  |  ONCOGENE

Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear how consuming glutamine in excess of..

YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

Srimayee Vaidyanathan, Talhah M Salmi, Rasan M Sathiqu, Malcolm J McConville, Andrew G Cox, Kristin K Brown

Journal article  |  2022  |  DEVELOPMENTAL CELL

The coordinated regulation of growth control and metabolic pathways is required to meet the energetic and biosynthetic demands ass..

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK Dependent Cell Death

Sylvain Garciaz, Andrew A Guirguis, Sebastian Muller, Fiona C Brown, Yih-Chih Chan, Ali Motazediani, Caitlin L Rowe, James A Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid YN Lam, Tatiana Caneque, Marian L Burr, Veronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Cancer cell metabolism is increasingly recognized as providing an exciting therapeutic opportunity. However, a drug th..

Pharmacological Reduction of Mitochondrial Iron in AML Triggers a BAX/BAK Dependent Non-Canonical Cell Death Synergistic with Venetoclax

Sylvain Garciaz, Sebastian Muller, Andew Guirguis, Fiona C Brown, Yih Chih Chan, Mathilde Paplineau, Kevin Tran, Kah-Lok Chan, Laura Mac Pherson, Brian Liddicoat, Enid YN Lam, Tatiana Caneque, Marian L Burr, Veronique Litalien, Giovanna Pomilio, Estelle Duprez, David CS Huang, Sarah-Jane Dawson, Georg Ramm, Andrew G Cox, et al.

Conference Proceedings  |  2021  |  BLOOD

Abstract Although the BCL2 inhibitor venetoclax have been transformative in the management of AML, therapeutic resi..

AMPK CA(R)Sts a new light on amino acid sensing

Kristin K Brown

Journal article  |  2021  |  EMBO JOURNAL

AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and AD..

Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R Devlin, Simon J Hogg, Lev Kats, Izabela Todorovski, Zheng Fan, Thomas C Abrehart, Giovanna Pomilio, Andrew Wei, Gareth P Gregory, Stephin J Vervoort, Kristin K Brown, Ricky W Johnstone

Journal article  |  2021  |  CANCER DISCOVERY

Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of all acute myeloid leukemias (AML). ..

REPROGRAMMING OF SERINE METABOLISM IS A METABOLIC VULNERABILITY IN FMS-LIKE TYROSINE KINASE 3 (FLT3) MUTANT ACUTE MYELOID LEUKAEMIA

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Thomas Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew Wei, Gareth Gregory, Stephin Vervoort, Kristin Brown, Ricky Johnstone

Conference Proceedings  |  2020  |  EXPERIMENTAL HEMATOLOGY

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S Lee, Samuel J Rodgers, Fuyi Li, Cheng Huang, Ralf B Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K Brown, Christina A Mitchell, Kaylene J Simpson, Roger J Daly

Journal article  |  2019  |  NATURE COMMUNICATIONS

Despite significant progress, our understanding of how specific oncogenes transform cells is still limited and likely underestimat..

TNF in anti-tumour immunity and resistance to immunotherapy

Jane Oliaro, Conor Kearney, Stephin Vervoort, Simon Hogg, Najoua Lalaoui, Kristin Brown, John Silke, Ricky Johnstone

Conference Proceedings  |  2018  |  CANCER SCIENCE