Kristin Brown

Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Lev Kats, Carolyn Shembrey, Thomas Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew Wei, Gareth Gregory, Stephin Vervoort, Kristin Brown, Ricky Johnstone

Journal article  |  2020

Abstract Activating FMS-like tyrosine kinase 3 ( FLT3 ) mutations occur in approximately 30% of all acute myeloid leukaemias (AMLs..

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S Lee, Samuel J Rodgers, Fuyi Li, Cheng Huang, Ralf B Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K Brown, Christina A Mitchell, Kaylene J Simpson, Roger J Daly

Journal article  |  2019  |  Nature Communications

TNF in anti-tumour immunity and resistance to immunotherapy

Jane Oliaro, Conor Kearney, Stephin Vervoort, Simon Hogg, Najoua Lalaoui, Kristin Brown, John Silke, Ricky Johnstone

Conference Proceedings  |  2018  |  CANCER SCIENCE

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

Andrew G Cox, Allison Tsomides, Dean Yimlamai, Katie L Hwang, Joel Miesfeld, Giorgio G Galli, Brendan H Fowl, Michael Fort, Kimberly Y Ma, Mark R Sullivan, Aaron M Hosios, Erin Snay, Min Yuan, Kristin K Brown, Evan C Lien, Sagar Chhangawala, Matthew L Steinhauser, John M Asara, Yariv Houvras, Brian Link, et al.

Journal article  |  2018  |  The EMBO Journal

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

Kristin K Brown, Jessica B Spinelli, John M Asara, Alex Toker

Journal article  |  2017  |  Cancer Discovery

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

Andrew G Cox, Allison Tsomides, Andrew J Kim, Diane Saunders, Katie L Hwang, Kimberley J Evason, Jerry Heidel, Kristin K Brown, Min Yuan, Evan C Lien, Byung Cheon Lee, Sahar Nissim, Bryan Dickinson, Sagar Chhangawala, Christopher J Chang, John M Asara, Yariv Houvras, Vadim N Gladyshev, Wolfram Goessling

Journal article  |  2016  |  Proceedings of the National Academy of Sciences

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

Andrew G Cox, Katie L Hwang, Kristin K Brown, Kimberley J Evason, Sebastian Beltz, Allison Tsomides, Keelin O'Connor, Giorgio G Galli, Dean Yimlamai, Sagar Chhangawala, Min Yuan, Evan C Lien, Julia Wucherpfennig, Sahar Nissim, Akihiro Minami, David E Cohen, Fernando D Camargo, John M Asara, Yariv Houvras, Didier YR Stainier, et al.

Journal article  |  2016  |  NATURE CELL BIOLOGY

MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy

Kristin K Brown, Laleh Montaser-Kouhsari, Andrew H Beck, Alex Toker

Journal article  |  2015  |  Cell Reports

The phosphoinositide 3-kinase pathway and therapy resistance in cancer.

Kristin K Brown, Alex Toker

Journal article  |  2015  |  F1000Prime Reports

The phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling network is a master regulator of process..