Kristin Brown

Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia.

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R Devlin, Simon J Hogg, Lev Kats, Izabela Todorovski, Zheng Fan, Thomas C Abrehart, Giovanna Pomilio, Andrew Wei, Gareth P Gregory, Stephin J Vervoort, Kristin K Brown, Ricky W Johnstone

Journal article  |  2021  |  Cancer Discovery

Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of all acute myeloid leukemias (AML). ..

3002 – REPROGRAMMING OF SERINE METABOLISM IS A METABOLIC VULNERABILITY IN FMS-LIKE TYROSINE KINASE 3 (FLT3) MUTANT ACUTE MYELOID LEUKAEMIA

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Thomas Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew Wei, Gareth Gregory, Stephin Vervoort, Kristin Brown, Ricky Johnstone

Journal article  |  2020  |  Experimental Hematology

Yap reprograms de novo lipogenesis to fuel liver cancer

Talhah M Salmi, Srimayee Vaidyanathan, Malcolm J McConville, Kristin K Brown, Andrew G Cox

Conference Proceedings  |  2020  |  Bioinformatics, Convergence Science, and Systems Biology

Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Lev Kats, Carolyn Shembrey, Thomas Abrehart, Izabela Todorovski, Giovanna Pomilio, Andrew Wei, Gareth Gregory, Stephin Vervoort, Kristin Brown, Ricky Johnstone

Journal article  |  2020

Activating FMS-like tyrosine kinase 3 ( FLT3 ) mutations occur in approximately 30% of all acute myeloid leukaemias (AMLs) and are..

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S Lee, Samuel J Rodgers, Fuyi Li, Cheng Huang, Ralf B Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K Brown, Christina A Mitchell, Kaylene J Simpson, Roger J Daly

Journal article  |  2019  |  Nature Communications

Despite significant progress, our understanding of how specific oncogenes transform cells is still limited and likely underestimat..

TNF in anti-tumour immunity and resistance to immunotherapy

Jane Oliaro, Conor Kearney, Stephin Vervoort, Simon Hogg, Najoua Lalaoui, Kristin Brown, John Silke, Ricky Johnstone

Conference Proceedings  |  2018  |  CANCER SCIENCE

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

Andrew G Cox, Allison Tsomides, Dean Yimlamai, Katie L Hwang, Joel Miesfeld, Giorgio G Galli, Brendan H Fowl, Michael Fort, Kimberly Y Ma, Mark R Sullivan, Aaron M Hosios, Erin Snay, Min Yuan, Kristin K Brown, Evan C Lien, Sagar Chhangawala, Matthew L Steinhauser, John M Asara, Yariv Houvras, Brian Link, et al.

Journal article  |  2018  |  The EMBO Journal

The Hippo pathway and its nuclear effector Yap regulate organ size and cancer formation. While many modulators of Hippo activity h..

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of resistance remain poorly defined. We used a s..

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

Kristin K Brown, Jessica B Spinelli, John M Asara, Alex Toker

Journal article  |  2017  |  Cancer Discovery

Chemotherapy resistance is a major barrier to the treatment of triple-negative breast cancer (TNBC), and strategies to circumvent ..

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

Andrew G Cox, Allison Tsomides, Andrew J Kim, Diane Saunders, Katie L Hwang, Kimberley J Evason, Jerry Heidel, Kristin K Brown, Min Yuan, Evan C Lien, Byung Cheon Lee, Sahar Nissim, Bryan Dickinson, Sagar Chhangawala, Christopher J Chang, John M Asara, Yariv Houvras, Vadim N Gladyshev, Wolfram Goessling

Journal article  |  2016  |  Proceedings of the National Academy of Sciences of the United States of America

Selenium, an essential micronutrient known for its cancer prevention properties, is incorporated into a class of selenocysteine-co..