Michelle Christie

X-ray crystallography shines a light on pore-forming toxins.

Bronte A Johnstone, Michelle P Christie, Craig J Morton, Michael W Parker

Book Chapter  |  2021  |  Methods in Enzymology

A common form of cellular attack by pathogenic bacteria is to secrete pore-forming toxins (PFTs). Capable of forming transmembrane..

A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins

Jordan C Evans, Bronte A Johnstone, Sara L Lawrence, Craig J Morton, Michelle P Christie, Michael W Parker, Rodney K Tweten

Journal article  |  2020  |  mBio

The cholesterol-dependent cytolysins (CDCs) are bacterial, β-barrel, pore-forming toxins. A central enigma of the pore-forming mec..

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

Kristin R Wade, Sara L Lawrence, Allison J Farrand, Eileen M Hotze, Michael J Kuiper, Michael A Gorman, Michelle P Christie, Santosh Panjikar, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2019  |  MBIO

The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebra..

Studying Munc18:Syntaxin Interactions Using Small-Angle Scattering.

Andrew E Whitten, Russell J Jarrott, Shu-Hong Hu, Anthony P Duff, Gordon J King, Jennifer L Martin, Michelle P Christie

Book Chapter  |  2019  |  Methods in Molecular Biology

The interaction between the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein syntaxin (Sx) an..

Cholesterol-dependent cytolysins: from water-soluble state to membrane pore.

Michelle P Christie, Bronte A Johnstone, Rodney K Tweten, Michael W Parker, Craig J Morton

Journal article  |  2018  |  Biophysical Reviews

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial toxins that are important virulence factors for a number of ..

Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins

Michelle P Christie, Shu-Hong Hu, Andrew E Whitten, Asma Rehman, Russell J Jarrott, Gordon J King, Brett M Collins, Jennifer L Martin

Journal article  |  2017  |  PLOS ONE

The nature of the Syntaxin4 C-terminus affects Munc18c-supported SNARE assembly

Asma Rehman, Shu-Hong Hu, Zakir Tnimov, Andrew E Whitten, Gordon J King, Russell J Jarrott, Suzanne J Norwood, Kirill Alexandrov, Brett M Collins, Michelle P Christie, Jennifer L Martin

Journal article  |  2017  |  PLOS ONE

Nanosized, peptide-based multicomponent DNA delivery systems: optimization of endosome escape activity

Yu Wan, Peter M Moyle, Michelle P Christie, Istvan Toth

Journal article  |  2016  |  Nanomedicine

Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-L-lysine dendrons

Nurlina Rosli, Michelle P Christie, Peter M Moyle, Istvan Toth

Journal article  |  2015  |  Bioorganic & Medicinal Chemistry

A Drug Delivery Strategy: Binding Enkephalin to Asialoglycoprotein Receptor by Enzymatic Galactosylation

Michelle P Christie, Pavla Simerska, Freda E-C Jen, Waleed M Hussein, Mohamad FM Rawi, Lauren E Hartley-Tassell, Christopher J Day, Michael P Jennings, Istvan Toth

Journal article  |  2014  |  PLOS ONE