Michelle Christie

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

Kristin R Wade, Sara L Lawrence, Allison J Farrand, Eileen M Hotze, Michael J Kuiper, Michael A Gorman, Michelle P Christie, Santosh Panjikar, Craig J Morton, Michael W Parker, Rodney K Tweten

Journal article  |  2019  |  MBIO

The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebra..

Studying Munc18:Syntaxin Interactions Using Small-Angle Scattering.

Andrew E Whitten, Russell J Jarrott, Shu-Hong Hu, Anthony P Duff, Gordon J King, Jennifer L Martin, Michelle P Christie

Book Chapter  |  2019  |  Methods in Molecular Biology

The interaction between the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein syntaxin (Sx) an..

Cholesterol-dependent cytolysins: from water-soluble state to membrane pore.

Michelle P Christie, Bronte A Johnstone, Rodney K Tweten, Michael W Parker, Craig J Morton

Journal article  |  2018  |  Biophysical Reviews

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial toxins that are important virulence factors for a number of ..

Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins

Michelle P Christie, Shu-Hong Hu, Andrew E Whitten, Asma Rehman, Russell J Jarrott, Gordon J King, Brett M Collins, Jennifer L Martin

Journal article  |  2017  |  PLOS ONE

The nature of the Syntaxin4 C-terminus affects Munc18c-supported SNARE assembly

Asma Rehman, Shu-Hong Hu, Zakir Tnimov, Andrew E Whitten, Gordon J King, Russell J Jarrott, Suzanne J Norwood, Kirill Alexandrov, Brett M Collins, Michelle P Christie, Jennifer L Martin

Journal article  |  2017  |  PLOS ONE

Nanosized, peptide-based multicomponent DNA delivery systems: optimization of endosome escape activity

Yu Wan, Peter M Moyle, Michelle P Christie, Istvan Toth

Journal article  |  2016  |  Nanomedicine

Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-L-lysine dendrons

Nurlina Rosli, Michelle P Christie, Peter M Moyle, Istvan Toth

Journal article  |  2015  |  Bioorganic & Medicinal Chemistry

A Drug Delivery Strategy: Binding Enkephalin to Asialoglycoprotein Receptor by Enzymatic Galactosylation

Michelle P Christie, Pavla Simerska, Freda E-C Jen, Waleed M Hussein, Mohamad FM Rawi, Lauren E Hartley-Tassell, Christopher J Day, Michael P Jennings, Istvan Toth

Journal article  |  2014  |  PLOS ONE

Biophysical characterization of lectin-glycan interactions for therapeutics, vaccines and targeted drug-delivery.

Michelle P Christie, Istvan Toth, Pavla Simerská

Journal article  |  2014  |  Future Medicinal Chemistry

Lectin-glycan interactions play a role in biological processes, host-pathogen interactions and in disease. A more detailed underst..

Biophysical characterization of lectin-glycan interactions for therapeutics, vaccines and targeted drug delivery

Michelle P Christie, Istvan Toth, Pavla Simerska

Journal article  |  2014  |  FUTURE MEDICINAL CHEMISTRY

Milligram Quantities of Homogeneous Recombinant Full-Length Mouse Munc18c from Escherichia coli Cultures

Asma Rehman, Russell J Jarrott, Andrew E Whitten, Gordon J King, Shu-Hong Hu, Michelle P Christie, Brett M Collins, Jennifer L Martin

Journal article  |  2013  |  PLOS ONE

alpha-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins

Pavla Simerska, Michelle P Christie, Daryn Goodwin, Freda E-C Jen, Michael P Jennings, Istvan Toth

Journal article  |  2013  |  Journal of Molecular Catalysis B: Enzymatic

Liposomes for Improved Enzymatic Glycosylation of Lipid-Modified Lactose Enkephalin

Michelle P Christie, Pavla Simerska, Freda E-C Jen, Michael P Jennings, Istvan Toth

Journal article  |  2013  |  ChemPlusChem

The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane

Sally Martin, Vanesa M Tomatis, Andreas Papadopulos, Michelle P Christie, Nancy T Malintan, Rachel S Gormal, Shuzo Sugita, Jennifer L Martin, Brett M Collins, Frederic A Meunier

Journal article  |  2013  |  Journal of Cell Science

Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide

Michelle P Christie, Andrew E Whitten, Gordon J King, Shu-Hong Hu, Russell J Jarrott, Kai-En Chen, Anthony P Duff, Philip Callow, Brett M Collins, David E James, Jennifer L Martin

Journal article  |  2012  |  Proceedings of the National Academy of Sciences

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

Shu-Hong Hu, Michelle P Christie, Natalie J Saez, Catherine F Latham, Russell Jarrott, Linda HL Lua, Brett M Collins, Jennifer L Martin

Journal article  |  2011  |  Proceedings of the National Academy of Sciences