Ian Parish

NKG7 Enhances CD8 T Cell Synapse Efficiency to Limit Inflammation

Emily J Lelliott, Kelly M Ramsbottom, Mark R Dowling, Carolyn Shembrey, Tahereh Noori, Conor J Kearney, Jessica Michie, Ian A Parish, Margaret A Jordan, Alan G Baxter, Neil D Young, Amelia J Brennan, Jane Oliaro

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer c..

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

Alice Comberlato, Marianna M Koga, Simone Nuessing, Ian A Parish, Maartje MC Bastings

Journal article  |  2022  |  NANO LETTERS

First evidence of geometrical patterns and defined distances of biomolecules as fundamental parameters to regulate receptor bindin..

Uncontrolled CD21(low) age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

Etienne Masle-Farquhar, Timothy J Peters, Lisa A Miosge, Ian A Parish, Christoph Weigel, Christopher C Oakes, Joanne H Reed, Christopher C Goodnow

Journal article  |  2022  |  CELL REPORTS

CD21low age-associated or atypical memory B cells are autoantibody enriched and poised for plasma cell differentiation. These cell..

Quantification of Strand Accessibility in Biostable DNA Origami with Single-Staple Resolution

Alexandra S Eklund, Alice Comberlato, Ian A Parish, Ralf Jungmann, Maartje MC Bastings

Journal article  |  2021  |  ACS NANO

DNA-based nanostructures are actively gaining interest as tools for biomedical and therapeutic applications following the recent d..

CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Emily J Lelliott, Isabella Y Kong, Magnus Zethoven, Kelly M Ramsbottom, Luciano G Martelotto, Deborah Meyran, Joe Jiang Zhu, Matteo Costacurta, Laura Kirby, Jarrod J Sandow, Lydia Lim, Pilar M Dominguez, Izabela Todorovski, Nicole M Haynes, Paul A Beavis, Paul J Neeson, Edwin D Hawkins, Grant A McArthur, Ian A Parish, Ricky W Johnstone, et al.

Journal article  |  2021  |  CANCER DISCOVERY

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor-positive brea..

Ptpn2 and KLRG1 regulate the generation and in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Lauren Giuffrida, Kevin Sek, Melissa A Henderson, Junyun Lai, Amanda XY Chen, Deborah Meyran, Kirsten L Todd, Emma Petley, Sherly Mardiana, Christina Molck, Gregory D Stewart, Benjamin J Solomon, Ian A Parish, Paul J Neeson, Simon J Harrison, Lev M Kats, Imran G House, Phillip K Darcy, Paul A Beavis

Journal article  |  2021  |  NATURE COMMUNICATIONS

Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets includ..

Antigen-driven EGR2 expression is required for exhausted CD8( ) T cell stability and maintenance

Mayura Wagle, Stephin J Vervoort, Madison J Kelly, Willem Van der Byl, Timothy J Peters, Ben P Martin, Luciano G Martelotto, Simone Nuessing, Kelly M Ramsbottom, James R Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A Miosge, Debbie R Howard, Renee Gloury, Sarah S Gabriel, Daniel T Utzschneider, Jane Oliaro, Jonathan D Powell, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Chronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhau..

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells

Conor J Kearney, Stephin J Vervoort, Kelly M Ramsbottom, Izabela Todorovski, Emily J Lelliott, Magnus Zethoven, Lizzy Pijpers, Ben P Martin, Timothy Semple, Luciano Martelotto, Joseph A Trapani, Ian A Parish, Nichollas E Scott, Jane Oliaro, Ricky W Johnstone

Journal article  |  2021  |  SCIENCE ADVANCES

Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular different..

IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors

Lauren Giuffrida, Kevin Sek, Melissa A Henderson, Imran G House, Junyun Lai, Amanda XY Chen, Kirsten L Todd, Emma Petley, Sherly Mardiana, Izabela Todorovski, Emily Gruber, Madison J Kelly, Benjamin J Solomon, Stephin J Vervoort, Ricky W Johnstone, Ian A Parish, Paul J Neeson, Lev M Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  MOLECULAR THERAPY

Chimeric antigen receptor (CAR) T cell therapy has been highly successful in hematological malignancies leading to their US Food a..