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Dr

Laura Edgington-Mitchell

Grimwade Senior Research Fellow
science & technology
animals
life sciences & biomedicine
mice
humans
fluorescent dyes
biochemistry & molecular biology
apoptosis
cancer
Laura Edgington-Mitchell's Profile Picture
Dr

Laura Edgington-Mitchell

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Protease Biochemistry
Laura Edgington-Mitchell's Profile Picture
Dr

Laura Edgington-Mitchell

 

Dr. Laura Edgington-Mitchell obtained her PhD in Cancer Biology from Stanford University in California in 2012. Studying under Prof. Matthew Bogyo, she specialised in synthesising activity-based probes (ABPs) to study the activity and function of proteases involved in cell death and cancer.

She pioneered new methods to detect protease activity by noninvasive optical imaging. In 2013, Dr. Edgington-Mitchell initiated postdoctoral studies with Dr. Belinda Parker at La Trobe University. There, she used ABPs targeting cysteine cathepsin proteases to study their contribution during breast cancer metastasis to bone and revealed new functions for these enzymes during the differentiation of tumour-induced immune cells into osteoclasts. In 2015, she was awarded an NHMRC Peter Doherty Fellowship. Under the mentorship of Prof. Nigel Bunnett, she established an independent research program at the Monash Institute of Pharmaceutical Sciences. There, she continued to expand the repertoire of chemical tools to study diverse protease families and explored their roles in inflammatory bowel disease, irritable bowel syndrome, pancreatitis, and cancer. Her work on proteases in oral cancer in collaboration with Prof. Brian Schmidt led to an appointment as an Adjunct Associate Professor at the New York University College of Dentistry. In January 2018, Dr. Edgington-Mitchell was awarded a Grimwade Fellowship and an ARC DECRA Fellowship and joined the Department of Biochemistry and Molecular Biology, University of Melbourne, Bio21 Molecular Science and Biotechnology Institute as a laboratory head. Building on a foundation in chemical biology, her research group aims to validate proteases as therapeutic targets in cancer and inflammation, with a particular focus on proteases that activate G Protein-Coupled Receptors (GPCRs) such as protease-activated receptor 2 (PAR2).Extended Publication List on Google Scholar: https://scholar.google.com/citations?user=7julmp4AAAAJ&hl=en

Scholarly Works

Displaying the 34 most recent scholarly works by Laura Edgington-Mitchell.

Honours, Awards and Fellowships

2019

CASS Foundation Travel Award

2018

Gordon Research Conference Travel Award for Australasian Early Career Researcher

2017

Monash University Dean's Award for Early Career Research

2016

Gordon Research Conference Travel Award

2016

American Gastroenterological Society Fellows Award

2016

American Gastroenterological Society Fellows Award

2015

International Proteolysis Society Travel Award

2009

International Proteolysis Society Travel Award

2018

FARC - Fellow of the Australian Research Council


2018

Grimwade Research Fellowship


2015

NHMRCF - NHMRC Fellowship


11

Awards

Credentials

Positions


Grimwade Senior Research Fellow

Biochemistry And Molecular Biology

Member

Royal Australian Chemical Institute

Member

American Physiological Society Member

Member

American Gastroenterological Association

Member

ASCEPT

Member

Crohn's and Colitis Australia Member

Member

Australasian NeuroGastroenterology & Motility Association

Member

International Proteolysis Society

Member

American Chemical Society Member

Education


Doctor of Philosophy

Stanford University

Bachelor of Arts

Transylvania University