Ayenachew Bezawork-Geleta

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Martina Bajzikova, Jaromira Kovarova, Ana R Coelho, Stepana Boukalova, Sehyun Oh, Katerina Rohlenova, David Svec, Sona Hubackova, Berwini Endaya, Kristyna Judasova, Ayenachew Bezawork-Geleta, Katarina Kluckova, Laurent Chatre, Renata Zobalova, Anna Novakova, Katerina Vanova, Zuzana Ezrova, Ghassan J Maghzal, Silvia Magalhaes Novais, Marie Olsinova, et al.

Journal article  |  2019  |  Cell Metabolism

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

Ayenachew Bezawork-Geleta, He Wen, LanFeng Dong, Bing Yan, Jelena Vider, Stepana Boukalova, Linda Krobova, Katerina Vanova, Renata Zobalova, Margarita Sobol, Pavel Hozak, Silvia Magalhaes Novais, Veronika Caisova, Pavel Abaffy, Ravindra Naraine, Ying Pang, Thiri Zaw, Ping Zhang, Radek Sindelka, Mikael Kubista, et al.

Journal article  |  2018  |  Nature Communications

Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

Arnaud Ahier, Chuan-Yang Dai, Andrea Tweedie, Ayenachew Bezawork-Geleta, Ina Kirmes, Steven Zuryn

Journal article  |  2018  |  Nature Cell Biology

Mitochondrial Complex II: At the Crossroads

Ayenachew Bezawork-Geleta, Jakub Rohlena, Lanfeng Dong, Karel Pacak, Jiri Neuzil

Journal article  |  2017  |  Trends in Biochemical Sciences

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer

Katerina Rohlenova, Karishma Sachaphibulkij, Jan Stursa, Ayenachew Bezawork-Geleta, Jan Blecha, Berwini Endaya, Lukas Werner, Jiri Cerny, Renata Zobalova, Jacob Goodwin, Tomas Spacek, Elham Alizadeh Pesdar, Bing Yan, Maria Nga Nguyen, Magdalena Vondrusova, Margaryta Sobol, Petr Jezek, Pavel Hozak, Jaroslav Truksa, Jakub Rohlena, et al.

Journal article  |  2017  |  Antioxidants & Redox Signaling

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

Stepana Boukalova, Jan Stursa, Lukas Werner, Zuzana Ezrova, Jiri Cerny, Ayenachew Bezawork-Geleta, Alena Pecinova, Lanfeng Dong, Zdenek Drahota, Jiri Neuzil

Journal article  |  2016  |  Molecular Cancer Therapeutics

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells

Ayenachew Bezawork-Geleta, Lanfeng Dong, Jakub Rohlena, Jiri Neuzil

Journal article  |  2016  |  Journal of Biological Chemistry

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner

Bing Yan, Marina Stantic, Renata Zobalova, Ayenachew Bezawork-Geleta, Michael Stapelberg, Jan Stursa, Katerina Prokopova, Lanfeng Dong, Jiri Neuzil

Journal article  |  2015  |  BMC Cancer

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

An S Tan, James W Baty, Lan-Feng Dong, Ayenachew Bezawork-Geleta, Berwini Endaya, Jacob Goodwin, Martina Bajzikova, Jaromira Kovarova, Martin Peterka, Bing Yan, Elham Alizadeh Pesdar, Margarita Sobol, Anatolyj Filimonenko, Shani Stuart, Magdalena Vondrusova, Katarina Kluckova, Karishma Sachaphibulkij, Jakub Rohlena, Pavel Hozak, Jaroslav Truksa, et al.

Journal article  |  2015  |  Cell Metabolism

LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins

Ayenachew Bezawork-Geleta, Erica J Brodie, David A Dougan, Kaye N Truscott

Journal article  |  2015  |  Scientific Reports

Maintenance of mitochondrial protein homeostasis is critical for proper cellular function. Under normal conditions resident molecu..

Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON‐mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA

Ayenachew Bezawork‐Geleta, Tamanna Saiyed, David A Dougan, Kaye N Truscott

Journal article  |  2014  |  The FASEB Journal

Mitochondrial complex II, a novel target for anti-cancer agents

Katarina Kluckova, Ayanachew Bezawork-Geleta, Jakub Rohlena, Lanfeng Dong, Jiri Neuzil

Journal article  |  2013  |  Biochimica et Biophysica Acta (BBA) - Bioenergetics

Unfolded protein responses in bacteria and mitochondria: A central role for the ClpXP machine

Kaye N Truscott, Ayenachew Bezawork-Geleta, David A Dougan

Journal article  |  2011  |  IUBMB Life

AtnMat2, a nuclear-encoded maturase required for splicing of group-II introns in Arabidopsis mitochondria

I Keren, A Bezawork-Geleta, M Kolton, I Maayan, E Belausov, M Levy, A Mett, D Gidoni, F Shaya, O Ostersetzer-Biran

Journal article  |  2009  |  RNA

Characterization of the Molecular Basis of Group II Intron RNA Recognition by CRS1-CRM Domains

Ido Keren, Liron Klipcan, Ayenachew Bezawork-Geleta, Max Kolton, Felix Shaya, Oren Ostersetzer-Biran

Journal article  |  2008  |  Journal of Biological Chemistry

Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents

Elham Alizadeh Pasdar, Michael Smits, Michael Stapelberg, Martina Bajzikova, Marina Stantic, Jacob Goodwin, Bing Yan, Jan Stursa, Jaromira Kovarova, Karishma Sachaphibulkij, Ayenachew Bezawork-Geleta, Margaryta Sobol, Anatoly Filimonenko, Marco Tomasetti, Renata Zobalova, Pavel Hozak, Lan-Feng Dong, Jiri Neuzil

Journal article  |  PLOS ONE

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

Lan-Feng Dong, Jaromira Kovarova, Martina Bajzikova, Ayenachew Bezawork-Geleta, David Svec, Berwini Endaya, Karishma Sachaphibulkij, Ana R Coelho, Natasa Sebkova, Anna Ruzickova, An S Tan, Katarina Kluckova, Kristyna Judasova, Katerina Zamecnikova, Zuzana Rychtarcikova, Vinod Gopalan, Ladislav Andera, Margarita Sobol, Bing Yan, Bijay Pattnaik, et al.

Journal article  |  eLife

Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ0 cells) is linked to..

Correction: Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents

Elham Alizadeh Pasdar, Michael Smits, Michael Stapelberg, Martina Bajzikova, Marina Stantic, Jacob Goodwin, Bing Yan, Jan Stursa, Jaromira Kovarova, Karishma Sachaphibulkij, Ayenachew Bezawork-Geleta, Margaryta Sobol, Anatoly Filimonenko, Marco Tomasetti, Renata Zobalova, Pavel Hozak, Lan-Feng Dong, Jiri Neuzil

Journal article  |  PLOS ONE