Ayenachew Bezawork-Geleta

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Magdalene K Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta, David Roberts, Cheng Huang, Ralf B Schittenhelm, Andrew Ryan, Scott L Townley, Luke A Selth, Trevor J Biden, Gregory R Steinberg, Dorit Samocha-Bonet, Ruth CR Meex, Matthew J Watt

Journal article  |  2020  |  Science Translational Medicine

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have iden..

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Martina Bajzikova, Jaromira Kovarova, Ana R Coelho, Stepana Boukalova, Sehyun Oh, Katerina Rohlenova, David Svec, Sona Hubackova, Berwini Endaya, Kristyna Judasova, Ayenachew Bezawork-Geleta, Katarina Kluckova, Laurent Chatre, Renata Zobalova, Anna Novakova, Katerina Vanova, Zuzana Ezrova, Ghassan J Maghzal, Silvia Magalhaes Novais, Marie Olsinova, et al.

Journal article  |  2019  |  Cell Metabolism

Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they reconstitute oxidative phosphorylation (OXPHOS) by m..

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.

Ayenachew Bezawork-Geleta, He Wen, LanFeng Dong, Bing Yan, Jelena Vider, Stepana Boukalova, Linda Krobova, Katerina Vanova, Renata Zobalova, Margarita Sobol, Pavel Hozak, Silvia Magalhaes Novais, Veronika Caisova, Pavel Abaffy, Ravindra Naraine, Ying Pang, Thiri Zaw, Ping Zhang, Radek Sindelka, Mikael Kubista, et al.

Journal article  |  2018  |  Nature Communications

Cell growth and survival depend on a delicate balance between energy production and synthesis of metabolites. Here, we provide evi..

Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism.

Arnaud Ahier, Chuan-Yang Dai, Andrea Tweedie, Ayenachew Bezawork-Geleta, Ina Kirmes, Steven Zuryn

Journal article  |  2018  |  Nature Cell Biology

Although mitochondria are ubiquitous organelles, they exhibit tissue-specific morphology, dynamics and function. Here, we describe..

Mitochondrial Complex II: At the Crossroads.

Ayenachew Bezawork-Geleta, Jakub Rohlena, Lanfeng Dong, Karel Pacak, Jiri Neuzil

Journal article  |  2017  |  Trends in Biochemical Sciences

Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central purveyor of the reprogramming of metabolic..

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells.

Lan-Feng Dong, Jaromira Kovarova, Martina Bajzikova, Ayenachew Bezawork-Geleta, David Svec, Berwini Endaya, Karishma Sachaphibulkij, Ana R Coelho, Natasa Sebkova, Anna Ruzickova, An S Tan, Katarina Kluckova, Kristyna Judasova, Katerina Zamecnikova, Zuzana Rychtarcikova, Vinod Gopalan, Ladislav Andera, Margarita Sobol, Bing Yan, Bijay Pattnaik, et al.

Journal article  |  2017  |  eLife

Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ0 cells) is linked to..

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer.

Katerina Rohlenova, Karishma Sachaphibulkij, Jan Stursa, Ayenachew Bezawork-Geleta, Jan Blecha, Berwini Endaya, Lukas Werner, Jiri Cerny, Renata Zobalova, Jacob Goodwin, Tomas Spacek, Elham Alizadeh Pesdar, Bing Yan, Maria Nga Nguyen, Magdalena Vondrusova, Margaryta Sobol, Petr Jezek, Pavel Hozak, Jaroslav Truksa, Jakub Rohlena, et al.

Journal article  |  2017  |  Antioxidants & Redox Signaling

AIMS: Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenerge..

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer.

Stepana Boukalova, Jan Stursa, Lukas Werner, Zuzana Ezrova, Jiri Cerny, Ayenachew Bezawork-Geleta, Alena Pecinova, Lanfeng Dong, Zdenek Drahota, Jiri Neuzil

Journal article  |  2016  |  Molecular Cancer Therapeutics

Pancreatic cancer is one of the hardest-to-treat types of neoplastic diseases. Metformin, a widely prescribed drug against type 2 ..

The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells.

Ayenachew Bezawork-Geleta, Lanfeng Dong, Jakub Rohlena, Jiri Neuzil

Journal article  |  2016  |  Journal of Biological Chemistry

Mitochondrial complex II or succinate dehydrogenase (SDH) is at the crossroads of oxidative phosphorylation and the tricarboxylic ..

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner.

Bing Yan, Marina Stantic, Renata Zobalova, Ayenachew Bezawork-Geleta, Michael Stapelberg, Jan Stursa, Katerina Prokopova, Lanfeng Dong, Jiri Neuzil

Journal article  |  2015  |  BMC Cancer

BACKGROUND: Accumulating evidence suggests that breast cancer involves tumour-initiating cells (TICs), which play a role in initia..