Samantha Barton

Lipid Metabolism Is Dysregulated in the Motor Cortex White Matter in Amyotrophic Lateral Sclerosis

Gemma L Sadler, Katherine N Lewis, Vinod K Narayana, David P De Souza, Joel Mason, Catriona McLean, David G Gonsalvez, Bradley J Turner, Samantha K Barton

Journal article  |  2022  |  METABOLITES

Lipid metabolism is profoundly dysregulated in amyotrophic lateral sclerosis (ALS), yet the lipid composition of the white matter,..

alpha-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosis

Pardis F Zanganeh, Samantha K Barton, Katherine Lim, Elizabeth L Qian, Duncan E Crombie, Christopher R Bye, Bradley J Turner

Journal article  |  2022  |  BRAIN COMMUNICATIONS

Amyotrophic lateral sclerosis is a late-onset adult neurodegenerative disease, although there is mounting electrophysiological and..

Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis

Taide Wang, Doris Tomas, Nirma D Perera, Brittany Cuic, Sophia Luikinga, Aida Viden, Samantha K Barton, Catriona A McLean, Andre L Samson, Adam Southon, Ashley I Bush, James M Murphy, Bradley J Turner

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Amyotrophic lateral sclerosis (ALS) is caused by selective degeneration of motor neurons in the brain and spinal cord; however, th..

Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

Samantha K Barton, Jenna M Gregory, Siddharthan Chandran, Bradley J Turner

Journal article  |  2019  |  FRONTIERS IN MOLECULAR NEUROSCIENCE

One of the key pathways implicated in amyotrophic lateral sclerosis (ALS) pathogenesis is abnormal RNA processing. Studies to date..

Dose-dependent exacerbation of ventilation-induced lung injury by erythropoietin in preterm newborn lambs.

Beth J Allison, Domenic A LaRosa, Samantha K Barton, Stuart Hooper, Valerie Zahra, Mary Tolcos, Kyra YY Chan, Jade Barbuto, Ishmael M Inocencio, Timothy J Moss, Graeme R Polglase

Journal article  |  2019  |  J Appl Physiol (1985)

Erythropoietin (EPO) is being trialled in preterm infants to reduce brain injury, but high doses increase lung injury in ventilate..