Brian Dean

Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex.

Natalie Matosin, Janine Arloth, Darina Czamara, Katrina Z Edmond, Malosree Maitra, Anna S Fröhlich, Silvia Martinelli, Dominic Kaul, Rachael Bartlett, Amber R Curry, Nils C Gassen, Kathrin Hafner, Nikola S Müller, Karolina Worf, Ghalia Rehawi, Corina Nagy, Thorhildur Halldorsdottir, Cristiana Cruceanu, Miriam Gagliardi, Nathalie Gerstner, et al.

Journal article  |  2023  |  Acta Neuropathol

Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with ..

A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia.

Brian Dean, Geor Bakker, Hiroki R Ueda, Andrew B Tobin, Alastair Brown, Richard AA Kanaan

Journal article  |  2023  |  Front Cell Neurosci

Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic receptors in the molecular pathology of..

Common changes in rat cortical gene expression after chronic treatment with chlorpromazine and haloperidol may be related to their antipsychotic efficacy

Brian Dean, Elizabeth Scarr

Journal article  |  2023  |  Neuroscience Applied

Altered levels of dopamine transporter in the frontal pole and the striatum in mood disorders: A postmortem study.

Hirotaka Sekiguchi, Geoff Pavey, Brian Dean

Journal article  |  2023  |  J Affect Disord

Dopamine dysregulation is known to play a major role in the pathophysiology of major depressive disorders (MDD) and bipolar disord..

Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice.

Masayo Fujita, Yukiko Ochiai, Yoko Hagino, Kazuto Kobayashi, Geoffrey Pavey, Brian Dean, Kazutaka Ikeda

Journal article  |  2022  |  Mol Brain

Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the..

Evidence that the frontal pole has a significant role in the pathophysiology of schizophrenia

Megan Snelleksz, Susan L Rossell, Andrew Gibbons, Jess Nithianantharajah, Brian Dean

Journal article  |  2022  |  PSYCHIATRY RESEARCH

Different regions of the cortex have been implicated in the pathophysiology of schizophrenia. Recently published data suggested th..

Evidence that a working memory cognitive phenotype within schizophrenia has a unique underlying biology

Brian Dean, Elizabeth HX Thomas, Kiymet Bozaoglu, Eric J Tan, Tamsyn E Van Rheenen, Erica Neill, Philip J Sumner, Sean P Carruthers, Elizabeth Scarr, Susan L Rossell, Caroline Gurvich

Journal article  |  2022  |  PSYCHIATRY RESEARCH

It is suggested studying phenotypes within the syndrome of schizophrenia will accelerate understanding the complex molecular patho..

VARIANT-RISK-EXON INTERPLAY IMPACTS ON CELL-CELL INTERACTIONS IN THE HUMAN CORTEX IN SEVERE PSYCHIATRIC DISORDERS

Karolina Worf, Nathalie Gerstner, Natalie Matosin, Anna S Fröhlich, Brian Dean, Elisabeth E Binder, Nikola S Mueller, Janine Knauer-Arloth

Journal article  |  2022  |  European Neuropsychopharmacology

PET Imaging of brain muscarinic receptors with 18F-Fluorobenzyl-Dexetimide: A first in human study.

Christopher C Rowe, Natasha Krishnadas, Uwe Ackermann, Vincent Doré, Rachel YW Goh, Rodney Guzman, Lee Chong, Svetlana Bozinovski, Rachel Mulligan, Richard Kanaan, Brian Dean, Victor L Villemagne

Journal article  |  2021  |  Psychiatry Res Neuroimaging

M1 and M4 muscarinic receptor (mAChR) agonists are under development for the treatment of schizophrenia, Alzheimer's and Parkinson..

Changes in cortical gene expression in the muscarinic M1 receptor knockout mouse: potential relevance to schizophrenia, Alzheimer's disease and cognition

Brian Dean, Elizabeth Scarr

Journal article  |  2021  |  NPJ SCHIZOPHRENIA

Postmortem and neuroimaging studies show low levels of cortical muscarinic M1 receptors (CHRM1) in patients with schizophrenia whi..