Mohamed Fareh

De novo design of CRISPR-Cas13b enables efficient silencing of SARS-CoV-2 variants and tumour pathogenic RNAs with near single-base precision

Wenxin Hu, Wei Zhao, Amit Kumar, Gurjeet Jagjeet Singh, Shijiao Qi, Josh Casan, Carolyn Shembery, Danielle Fong, Jennifer M Zerbato, Jori Symons, Rajeev Rudraraju, Damian Purcell, Michelle Haber, Ilia Voskoboinik, Paul G Ekert, Sharon Lewin, Joseph Trapani, Mohamed Fareh

Conference Proceedings  |  2022  |  Pathology

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua ML Casan, Amit Kumar, Jori Symons, Jennifer M Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G Ekert, Rajeev Rudraraju, Damian FJ Purcell, Sharon R Lewin, Joseph A Trapani

Journal article  |  2021  |  NATURE COMMUNICATIONS

The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approa..

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Simon J Hogg, Olga Motorna, Leonie A Cluse, Timothy M Johanson, Hannah D Coughlan, Ramya Raviram, Robert M Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N Huskins, Conor J Kearney, Jennifer R Devlin, Zheng Fan, Jafar S Jabbari, Ben P Martin, Mohamed Fareh, Madison J Kelly, et al.

Journal article  |  2021  |  MOLECULAR CELL

To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigen..

Dynamics of MicroRNA Biogenesis

Mohamed Fareh

Book Chapter  |  2019

Probing RNA-Protein Interactions with Single-Molecule Pull-Down Assays

Mohamed Fareh, Chirlmin Joo

Journal article  |  2018  |  NANOSCALE IMAGING: METHODS AND PROTOCOLS

Recent advances in single-molecule techniques allow for dynamic observations of the interactions between various protein assemblie..