Chris Horne

Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL

Teresa Sadras, Fatimah BB Jalud, Hansen JJ Kosasih, Christopher RR Horne, Lauren MM Brown, Sam El-Kamand, Charles EE de Bock, Lachlan McAloney, Ashley PP Ng, Nadia MM Davidson, Louise EA Ludlow, Alicia Oshlack, Mark JJ Cowley, Seong LL Khaw, James MM Murphy, Paul GG Ekert

Journal article  |  2023  |  LEUKEMIA

The web of death: the expanding complexity of necroptotic signaling

Christopher R Horne, Andre L Samson, James M Murphy

Journal article  |  2023  |  TRENDS IN CELL BIOLOGY

The past decade has seen the emergence of the necroptosis programmed cell death pathway as an important contributor to the pathoph..

Nanobodies identify an activated state of the TRIB2 pseudokinase

Sam A Jamieson, Michael Pudjihartono, Christopher R Horne, Juan Salamanca Viloria, Jessica L Dunlop, Hamish D McMillan, Robert C Day, Karen Keeshan, James M Murphy, Peter D Mace

Journal article  |  2022  |  STRUCTURE

Tribbles proteins (TRIB1-3) are pseudokinases that recruit substrates to the COP1 ubiquitin ligase. TRIB2 was the first Tribbles o..

Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling

Yanxiang Meng, Christopher R Horne, Andre L Samson, Laura F Dagley, Samuel N Young, Jarrod J Sandow, Peter E Czabotar, James M Murphy

Journal article  |  2022  |  CELL DEATH & DISEASE

Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the termina..

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

Ashish Sethi, Christopher R Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine A Davies, Sarah E Garnish, Annette Jacobsen, Andre L Samson, Joanne M Hildebrand, Ahmad Wardak, Peter E Czabotar, Emma J Petrie, Paul R Gooley, James M Murphy

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Necroptosis is a lytic programmed cell death pathway with origins in innate immunity that is frequently dysregulated in inflammato..

Using cryo-EM to uncover mechanisms of bacterial

David M Wood, Renwick CJ Dobson, Christopher R Horne

Journal article  |  2021  |  BIOCHEMICAL SOCIETY TRANSACTIONS

Transcription is the principal control point for bacterial gene expression, and it enables a global cellular response to an intrac..

Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker

Bernhard C Lechtenberg, Marina P Gehring, Taylor P Light, Christopher R Horne, Mike W Matsumoto, Kalina Hristova, Elena B Pasquale

Journal article  |  2021  |  NATURE COMMUNICATIONS

Eph receptor tyrosine kinases play a key role in cell-cell communication. Lack of structural information on the entire multi-domai..

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

Yanxiang Meng, Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Christopher R Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D Cowan, Andre L Samson, Guillaume Lessene, Jarrod J Sandow, Peter E Czabotar, James M Murphy

Journal article  |  2021  |  NATURE COMMUNICATIONS

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in..

N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization

Michael J Currie, Lavanyaa Manjunath, Christopher R Horne, Phillip M Rendle, Ramaswamy Subramanian, Rosmarie Friemann, Antony J Fairbanks, Andrew C Muscroft-Taylor, Rachel A North, Renwick CJ Dobson

Journal article  |  2021  |  JOURNAL OF BIOLOGICAL CHEMISTRY

There are five known general catalytic mechanisms used by enzymes to catalyze carbohydrate epimerization. The amino sugar epimeras..

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs

Lung-Yu Liang, Michael Roy, Christopher R Horne, Jarrod J Sandow, Minglyanna Surudoi, Laura F Dagley, Samuel N Young, Toby Dite, Jeffrey J Babon, Peter W Janes, Onisha Patel, James M Murphy, Isabelle S Lucet

Journal article  |  2021  |  BIOCHEMICAL JOURNAL

EphB6 and EphA10 are two poorly characterised pseudokinase members of the Eph receptor family, which collectively serves as mediat..