Peter Crack

The Complexity of the cGAS-STING Pathway in CNS Pathologies

Amelia L Fryer, Amar Abdullah, Juliet M Taylor, Peter J Crack

Journal article  |  2021  |  FRONTIERS IN NEUROSCIENCE

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologie..

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis E Adamopoulos, Khosrow Adeli, Timon E Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat B Aggarwal, Maria Agnello, Patrizia Agostinis, et al.

Journal article  |  2021  |  AUTOPHAGY

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received inc..

STING-Mediated Autophagy Is Protective against H2O2-Induced Cell Death

Amar Abdullah, Frank Mobilio, Peter J Crack, Juliet M Taylor

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stimulator of interferon genes (STING)-mediated type-I interferon signaling is a well characterized instigator of the innate immun..

An altered glial phenotype in the NL3(R451C) mouse model of autism

Samantha M Matta, Zachery Moore, Frederick Rohan Walker, Elisa L Hill-Yardin, Peter J Crack

Journal article  |  2020  |  SCIENTIFIC REPORTS

Autism Spectrum Disorder (ASD; autism) is a neurodevelopmental disorder characterised by deficits in social communication, and res..

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects

Chaitanya Inampudi, Giuseppe D Ciccotosto, Roberto Cappai, Peter J Crack

Journal article  |  2020  |  JOURNAL OF NEUROTRAUMA

Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, du..

Abrogation of type-I interferon signalling alters the microglial response to A beta(1-42)

Zachery Moore, Frank Mobilio, Frederick R Walker, Juliet M Taylor, Peter J Crack

Journal article  |  2020  |  SCIENTIFIC REPORTS

Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogene..

The use of bioactive matrices in regenerative therapies for traumatic brain injury

Hui X Tan, Mark P Del Borgo, Marie-Isabel Aguilar, John S Forsythe, Juliet M Taylor, Peter J Crack

Journal article  |  2020  |  ACTA BIOMATERIALIA

Functional deficits due to neuronal loss are a common theme across multiple neuropathologies, including traumatic brain injury (TB..

Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling beta-Peptide Hydrogel

Sepideh Motamed, Mark P Del Borgo, Kun Zhou, Ketav Kulkarni, Peter J Crack, Tobias D Merson, Marie-Isabel Aguilar, David Finkelstein, John S Forsythe

Journal article  |  2019  |  FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

Neural stem cells, which are confined in localised niches are unable to repair large brain lesions because of an inability to migr..

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Kyria M Webster, Sandy R Shultz, Ezgi Ozturk, Larissa K Dill, Mujun Sun, Pablo Casillas-Espinosa, Nigel C Jones, Peter J Crack, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  EXPERIMENTAL NEUROLOGY

High mobility group box protein-1 (HMGB1) has been implicated as a key mediator of neuroinflammation and neurodegeneration in a ra..

Changes in the interface between bacteria and the brain in mouse models of neurodevelopmental disease

Elisa Hill-Yardin, Elisa Hill, Samantha Matta, Gayathri Balasuriya, Gabrielle Belz, Peter Crack, Samiha Sharna, Tanya Abo-Shaban, Suzanne Hosie, Ashley Franks

Journal article  |  2019  |  IBRO Reports