Peter Crack

STING-Mediated Autophagy Is Protective against H2O2-Induced Cell Death

Amar Abdullah, Frank Mobilio, Peter J Crack, Juliet M Taylor

Journal article  |  2020  |  International Journal of Molecular Sciences

Stimulator of interferon genes (STING)-mediated type-I interferon signaling is a well characterized instigator of the innate immun..

An altered glial phenotype in the NL3R451C mouse model of autism.

Samantha M Matta, Zachery Moore, Frederick Rohan Walker, Elisa L Hill-Yardin, Peter J Crack

Journal article  |  2020  |  Scientific Reports

Autism Spectrum Disorder (ASD; autism) is a neurodevelopmental disorder characterised by deficits in social communication, and res..

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects

Chaitanya Inampudi, Giuseppe D Ciccotosto, Roberto Cappai, Peter J Crack

Journal article  |  2020  |  Journal of Neurotrauma

Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, du..

Rediscovered Drawings by Giuseppe Piattoli

P Crack

Journal article  |  2020  |  Master Drawings

Abrogation of type-I interferon signalling alters the microglial response to A beta(1-42)

Zachery Moore, Frank Mobilio, Frederick R Walker, Juliet M Taylor, Peter J Crack

Journal article  |  2020  |  Scientific Reports

Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogene..

The use of bioactive matrices in regenerative therapies for traumatic brain injury

Hui X Tan, Mark P Del Borgo, Marie-Isabel Aguilar, John S Forsythe, Juliet M Taylor, Peter J Crack

Journal article  |  2020  |  Acta Biomaterialia

Functional deficits due to neuronal loss are a common theme across multiple neuropathologies, including traumatic brain injury (TB..

Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling beta-Peptide Hydrogel

Sepideh Motamed, Mark P Del Borgo, Kun Zhou, Ketav Kulkarni, Peter J Crack, Tobias D Merson, Marie-Isabel Aguilar, David Finkelstein, John S Forsythe

Journal article  |  2019  |  Frontiers in Bioengineering and Biotechnology

Neural stem cells, which are confined in localised niches are unable to repair large brain lesions because of an inability to migr..

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Kyria M Webster, Sandy R Shultz, Ezgi Ozturk, Larissa K Dill, Mujun Sun, Pablo Casillas-Espinosa, Nigel C Jones, Peter J Crack, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Experimental Neurology

High mobility group box protein-1 (HMGB1) has been implicated as a key mediator of neuroinflammation and neurodegeneration in a ra..

The involvement of microglia in Alzheimer's disease: a new dog in the fight

Zachery Moore, Juliet M Taylor, Peter J Crack

Journal article  |  2019  |  British Journal of Pharmacology

First described clinically in 1906, Alzheimer's disease (AD) is the most common neurodegenerative disease and form of dementia wor..

The influence of neuroinflammation in Autism Spectrum Disorder

Samantha M Matta, Elisa L Hill-Yardin, Peter J Crack

Journal article  |  2019  |  Brain Behavior and Immunity